Phenytoin (sodium)_AN3 CA Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in AN3 CA cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_AN3 CA drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MEST mesoderm specific transcript 0.292962
GSE1 Gse1 coiled-coil protein 0.100102
LOC112694756 uncharaterized LOC112694756 0.0702854
EIF4H eukaryotic translation initiation factor 4H 0.0621789
KAZN kazrin, periplakin interacting protein 0.0619421
TUBB tubulin, beta class I 0.0612843
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0583609
FGFR1 fibroblast growth factor receptor 1 0.0563655
VEGFA vascular endothelial growth factor A 0.0521881
MEOX2 mesenchyme homeobox 2 0.0513277
TPK1 thiamin pyrophosphokinase 1 0.0508971
PRRC2A proline-rich coiled-coil 2A 0.0504265
MKI67 marker of proliferation Ki-67 0.0500119
DLG1 discs, large homolog 1 (Drosophila) 0.0490123
SEPTIN11 septin 11 0.0473696
TMSB4X thymosin beta 4, X-linked 0.0459943
TSHZ2 teashirt zinc finger homeobox 2 0.0455707
FCHSD2 FCH and double SH3 domains 2 0.0440687
PDE4D phosphodiesterase 4D, cAMP-specific 0.0439257
PRRC2B proline-rich coiled-coil 2B 0.0426938
RPL3 ribosomal protein L3 0.0415901
SHROOM3 shroom family member 3 0.0409611
BTBD3 BTB (POZ) domain containing 3 0.0394399
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0378005
USP3 ubiquitin specific peptidase 3 0.0367145
RPLP0 ribosomal protein, large, P0 0.0347723
EYA1 EYA transcriptional coactivator and phosphatase 1 0.0339465
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0339287
EEF2 eukaryotic translation elongation factor 2 0.0338646
VCL vinculin 0.0335155
ADGRA3 adhesion G protein-coupled receptor A3 0.0331452
ITGAV integrin, alpha V 0.0331447
FTH1 ferritin, heavy polypeptide 1 0.0331183
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0330966
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0330278
RAD23B RAD23 homolog B (S. cerevisiae) 0.0329305
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0328307
RAD51B RAD51 paralog B 0.0309777
FLNA filamin A, alpha 0.0308559
KPNB1 karyopherin (importin) beta 1 0.0306988
ZFAND3 zinc finger, AN1-type domain 3 0.0303193
SOX6 SRY (sex determining region Y)-box 6 0.0300041
DOCK3 dedicator of cytokinesis 3 0.029761
SREK1 splicing regulatory glutamine/lysine-rich protein 1 0.0292851
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0287811
HSPA8 heat shock 70kDa protein 8 0.0282556
MATR3 matrin 3 0.0282003
CAPRIN1 cell cycle associated protein 1 0.0278911
PRKN parkin RBR E3 ubiquitin protein ligase 0.0277953
PELI1 pellino E3 ubiquitin protein ligase 1 0.0276193
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0270557
UBA6 ubiquitin-like modifier activating enzyme 6 0.0270212
TRAPPC9 trafficking protein particle complex 9 0.0269689
FIP1L1 factor interacting with PAPOLA and CPSF1 0.0268525
CAMTA1 calmodulin binding transcription activator 1 0.0268336
PIAS1 protein inhibitor of activated STAT, 1 0.0265294
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0263966
UTRN utrophin 0.0262091
RANBP17 RAN binding protein 17 0.0260311
SKIL SKI-like proto-oncogene 0.0259515
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.025516
HIPK2 homeodomain interacting protein kinase 2 0.0254877
TAPBP TAP binding protein (tapasin) 0.0254646
SECISBP2L SECIS binding protein 2-like 0.0254601
MACF1 microtubule-actin crosslinking factor 1 0.0250224
PDE4B phosphodiesterase 4B, cAMP-specific 0.0249671
ARID1A AT rich interactive domain 1A (SWI-like) 0.0249535
NIN ninein (GSK3B interacting protein) 0.0249437
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0247235
RHOA ras homolog family member A 0.0246816
RACK1 receptor for activated C kinase 1 0.024558
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0244415
NUMA1 nuclear mitotic apparatus protein 1 0.0242231
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 0.0241983
NFIX nuclear factor I/X (CCAAT-binding transcription factor) 0.0241607
ARL15 ADP-ribosylation factor-like 15 0.0239202
SRRM2 serine/arginine repetitive matrix 2 0.0235386
PPP1R9A protein phosphatase 1, regulatory subunit 9A 0.022967
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.0229382
DOCK1 dedicator of cytokinesis 1 0.0228226
PCDH7 protocadherin 7 0.0227886
PRKACB protein kinase, cAMP-dependent, catalytic, beta 0.0227859
SRSF11 serine/arginine-rich splicing factor 11 0.0225582
CS citrate synthase 0.0224775
TCP1 t-complex 1 0.022367
MTMR3 myotubularin related protein 3 0.0223547
SGCE sarcoglycan, epsilon 0.0223547
SMG7 SMG7 nonsense mediated mRNA decay factor 0.022348
ATG10 autophagy related 10 0.0222297
MPRIP myosin phosphatase Rho interacting protein 0.0221571
BAZ1B bromodomain adjacent to zinc finger domain, 1B 0.0220438
SS18 synovial sarcoma translocation, chromosome 18 0.0220403
FN1 fibronectin 1 0.0219836
GMPS guanine monphosphate synthase 0.0219164
NLN neurolysin (metallopeptidase M3 family) 0.0218375
CEP250 centrosomal protein 250kDa 0.021638
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0215492
OLA1 Obg-like ATPase 1 0.0213919
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0213894
SFTPA2 surfactant protein A2 0.0211215

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.175243
PTMA prothymosin, alpha -0.111194
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0779412
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0683941
HMGA2 high mobility group AT-hook 2 -0.0663575
RPS27A ribosomal protein S27a -0.0612299
IER3 immediate early response 3 -0.0592581
IGF2R insulin-like growth factor 2 receptor -0.057661
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0559379
TMSB10 thymosin beta 10 -0.0552163
RAB7A RAB7A, member RAS oncogene family -0.0541926
FLNB filamin B, beta -0.0536212
CANX calnexin -0.0523915
PEG10 paternally expressed 10 -0.0515427
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0474219
ANO6 anoctamin 6 -0.0466664
PRKG1 protein kinase, cGMP-dependent, type I -0.0462377
MXI1 MAX interactor 1, dimerization protein -0.0460017
UBC ubiquitin C -0.0459603
RPS6 ribosomal protein S6 -0.0450748
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0449271
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0442667
NAMPT nicotinamide phosphoribosyltransferase -0.0432608
WSB1 WD repeat and SOCS box containing 1 -0.0425147
SLC38A2 solute carrier family 38, member 2 -0.039742
SMYD3 SET and MYND domain containing 3 -0.0395191
NAP1L1 nucleosome assembly protein 1-like 1 -0.0389976
AHNAK AHNAK nucleoprotein -0.0385573
RPL23 ribosomal protein L23 -0.0383866
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0360681
NDRG1 N-myc downstream regulated 1 -0.0357561
INTS6 integrator complex subunit 6 -0.0354201
ZEB1 zinc finger E-box binding homeobox 1 -0.0351241
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0349338
CTBP2 C-terminal binding protein 2 -0.0347062
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0343778
NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3 -0.0341446
ADIPOR2 adiponectin receptor 2 -0.0339953
NT5C2 5'-nucleotidase, cytosolic II -0.0339653
PLS3 plastin 3 -0.0336216
PHF21A PHD finger protein 21A -0.0336041
SPPL3 signal peptide peptidase like 3 -0.0333371
PUM2 pumilio RNA-binding family member 2 -0.0332725
PGK1 phosphoglycerate kinase 1 -0.0331881
MYOF myoferlin -0.0331856
RFX2 regulatory factor X, 2 (influences HLA class II expression) -0.0329514
ACTG1 actin gamma 1 -0.0328528
KDM5B lysine (K)-specific demethylase 5B -0.0328379
ANKRD12 ankyrin repeat domain 12 -0.0323673
PHIP pleckstrin homology domain interacting protein -0.0323383
RPL26 ribosomal protein L26 -0.0318145
SMAD3 SMAD family member 3 -0.0317849
TPST1 tyrosylprotein sulfotransferase 1 -0.0315998
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0315346
FOXO3 forkhead box O3 -0.031527
PHF3 PHD finger protein 3 -0.0309916
HMGB2 high mobility group box 2 -0.0309702
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0309619
JMJD1C jumonji domain containing 1C -0.0301052
FBXL2 F-box and leucine-rich repeat protein 2 -0.0295614
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0295332
CADM2 cell adhesion molecule 2 -0.0293656
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0291725
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0290061
UST uronyl-2-sulfotransferase -0.0288805
SBNO1 strawberry notch homolog 1 (Drosophila) -0.0288101
HBP1 HMG-box transcription factor 1 -0.0286295
JARID2 jumonji, AT rich interactive domain 2 -0.0284238
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0283537
ENO1 enolase 1, (alpha) -0.0280552
SMC4 structural maintenance of chromosomes 4 -0.0279573
NSD3 nuclear receptor binding SET domain protein 3 -0.0279008
RHEB Ras homolog enriched in brain -0.0277232
PKM pyruvate kinase, muscle -0.0277198
CNNM2 cyclin and CBS domain divalent metal cation transport mediator 2 -0.0276788
CLIP2 CAP-GLY domain containing linker protein 2 -0.0276441
OGA O-GlcNAcase -0.0273755
RPL37A ribosomal protein L37a -0.0271143
DMXL1 Dmx-like 1 -0.027006
AKAP12 A kinase (PRKA) anchor protein 12 -0.0269634
ERBIN erbb2 interacting protein -0.0266634
FAM13B family with sequence similarity 13, member B -0.0262746
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0262579
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -0.026109
RPLP2 ribosomal protein, large, P2 -0.0257959
RAI1 retinoic acid induced 1 -0.0257543
ARHGAP12 Rho GTPase activating protein 12 -0.0256716
RPS12 ribosomal protein S12 -0.0254385
RPS10 ribosomal protein S10 -0.0252142
PRLR prolactin receptor -0.0251939
LMO4 LIM domain only 4 -0.0251726
KMT2E lysine (K)-specific methyltransferase 2E -0.0246877
FUS FUS RNA binding protein -0.024577
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0245137
TSC22D2 TSC22 domain family, member 2 -0.02439
FBXO11 F-box protein 11 -0.0242099
UVRAG UV radiation resistance associated -0.024056
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0239959
ZYG11B zyg-11 family member B, cell cycle regulator -0.0239805
TRA2A transformer 2 alpha homolog (Drosophila) -0.0237419