Phenytoin (sodium)_AsPC-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in AsPC-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_AsPC-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.226291
NDRG1 N-myc downstream regulated 1 0.187484
PLEC plectin 0.159749
POTEF POTE ankyrin domain family, member F 0.141387
LOC112694756 uncharaterized LOC112694756 0.139998
IGFBP3 insulin-like growth factor binding protein 3 0.122717
FTH1 ferritin, heavy polypeptide 1 0.0916701
MUC17 mucin 17, cell surface associated 0.0901142
GRB10 growth factor receptor-bound protein 10 0.0871022
EZR ezrin 0.0843816
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0833351
MPRIP myosin phosphatase Rho interacting protein 0.0783399
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0659112
FAM107B family with sequence similarity 107, member B 0.0658846
EEF2 eukaryotic translation elongation factor 2 0.0656252
ERRFI1 ERBB receptor feedback inhibitor 1 0.0613243
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0607119
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0604894
ESYT2 extended synaptotagmin-like protein 2 0.0599554
HSPA8 heat shock 70kDa protein 8 0.0595785
UBA6 ubiquitin-like modifier activating enzyme 6 0.0568037
MYH9 myosin, heavy chain 9, non-muscle 0.0540506
DSPP dentin sialophosphoprotein 0.0531493
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.052832
SRRM2 serine/arginine repetitive matrix 2 0.0508624
TSC22D2 TSC22 domain family, member 2 0.0505205
LDHA lactate dehydrogenase A 0.0484364
TNIP1 TNFAIP3 interacting protein 1 0.048331
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0480638
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0467721
APLP2 amyloid beta (A4) precursor-like protein 2 0.0462952
OPTN optineurin 0.0460623
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0457338
MCL1 myeloid cell leukemia 1 0.0454853
ANXA2 annexin A2 0.0443664
MXD1 MAX dimerization protein 1 0.04423
ARRDC3 arrestin domain containing 3 0.0436799
FAM13A family with sequence similarity 13, member A 0.0433918
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0430195
PCBP2 poly(rC) binding protein 2 0.0427353
NCOR2 nuclear receptor corepressor 2 0.0425634
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0421302
SPAG9 sperm associated antigen 9 0.041377
RIOK3 RIO kinase 3 0.0409118
BAIAP2L1 BAI1-associated protein 2-like 1 0.0407574
CAPRIN2 caprin family member 2 0.0405209
PICALM phosphatidylinositol binding clathrin assembly protein 0.0393596
RNASE1 ribonuclease, RNase A family, 1 (pancreatic) 0.0393551
TPM3 tropomyosin 3 0.0391208
CTBP2 C-terminal binding protein 2 0.0377714
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0370805
NUP58 nucleoporin 58 0.0368856
EIF4H eukaryotic translation initiation factor 4H 0.0361434
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0355828
DHRS9 dehydrogenase/reductase (SDR family) member 9 0.0352333
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0334656
MSN moesin 0.0332693
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0330126
RCOR1 REST corepressor 1 0.0328923
FXR1 fragile X mental retardation, autosomal homolog 1 0.0285432
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.028421
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0278825
DNAJB6 DnaJ (Hsp40) homolog, subfamily B, member 6 0.0277308
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0272737
PMM2 phosphomannomutase 2 0.0269725
ITGB4 integrin, beta 4 0.0265771
CD59 CD59 molecule, complement regulatory protein 0.0265441
NBAS neuroblastoma amplified sequence 0.0264463
RHOA ras homolog family member A 0.0263895
ATG16L1 autophagy related 16-like 1 (S. cerevisiae) 0.0258563
KIF16B kinesin family member 16B 0.0257976
CCNY cyclin Y 0.0254499
EPHA2 EPH receptor A2 0.0252597
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.025148
EGR1 early growth response 1 0.0251474
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0249137
DSG2 desmoglein 2 0.0249101
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0246676
NAB1 NGFI-A binding protein 1 (EGR1 binding protein 1) 0.0244287
ZMIZ1 zinc finger, MIZ-type containing 1 0.0237983
BHLHE40 basic helix-loop-helix family, member e40 0.0237805
PPARD peroxisome proliferator-activated receptor delta 0.0237375
SUCO SUN domain containing ossification factor 0.0235855
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0234847
FA2H fatty acid 2-hydroxylase 0.0232534
SLK STE20-like kinase 0.023016
HPCAL1 hippocalcin-like 1 0.0229394
ITPRID2 ITPR interacting domain containing 2 0.0229336
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0228692
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0227412
MED15 mediator complex subunit 15 0.0227303
HSPG2 heparan sulfate proteoglycan 2 0.022551
JUP junction plakoglobin 0.0223393
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0220602
CORO1C coronin, actin binding protein, 1C 0.0219003
MXI1 MAX interactor 1, dimerization protein 0.0218181
AHNAK2 AHNAK nucleoprotein 2 0.0216828
DPYSL2 dihydropyrimidinase-like 2 0.0215859
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0214188
ZEB1 zinc finger E-box binding homeobox 1 0.0214074

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.200313
TPT1 tumor protein, translationally-controlled 1 -0.122183
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 -0.0951833
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0807707
VCAN versican -0.0686956
VIM vimentin -0.0657077
ASPH aspartate beta-hydroxylase -0.0630252
S100A10 S100 calcium binding protein A10 -0.0617157
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0557655
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0546921
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.0493877
PTMA prothymosin, alpha -0.0479532
PTPRR protein tyrosine phosphatase, receptor type, R -0.0460972
RPS24 ribosomal protein S24 -0.0453405
RPLP2 ribosomal protein, large, P2 -0.0452268
ARHGAP5 Rho GTPase activating protein 5 -0.0450521
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0438607
ZBTB20 zinc finger and BTB domain containing 20 -0.0424681
CDCP1 CUB domain containing protein 1 -0.0393217
PLAUR plasminogen activator, urokinase receptor -0.0379483
CAB39 calcium binding protein 39 -0.0376037
TXNRD1 thioredoxin reductase 1 -0.0373936
FTL ferritin, light polypeptide -0.0365182
EHBP1 EH domain binding protein 1 -0.0361736
RPS8 ribosomal protein S8 -0.0357857
RPL35A ribosomal protein L35a -0.0352847
GREB1L growth regulation by estrogen in breast cancer-like -0.0350745
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.035068
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0340123
RBM25 RNA binding motif protein 25 -0.0337497
RPL23 ribosomal protein L23 -0.0337372
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.03366
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0334582
CD2AP CD2-associated protein -0.0334081
RPL12 ribosomal protein L12 -0.0333764
RPL9 ribosomal protein L9 -0.0326117
RPLP1 ribosomal protein, large, P1 -0.0324003
OXR1 oxidation resistance 1 -0.031661
RPS6 ribosomal protein S6 -0.0310711
RPL8 ribosomal protein L8 -0.0308925
RPS23 ribosomal protein S23 -0.0308512
SDC4 syndecan 4 -0.0306207
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.030493
EFNA5 ephrin-A5 -0.0304698
VMP1 vacuole membrane protein 1 -0.0302484
MYOF myoferlin -0.0302356
RESF1 retroelement silencing factor 1 -0.0301067
NT5C2 5'-nucleotidase, cytosolic II -0.0297798
RPL36A ribosomal protein L36a -0.0297747
WASF2 WAS protein family, member 2 -0.0297067
KLF6 Kruppel-like factor 6 -0.0295556
PDE4D phosphodiesterase 4D, cAMP-specific -0.0292013
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0291634
DOCK5 dedicator of cytokinesis 5 -0.0287129
RAD21 RAD21 homolog (S. pombe) -0.0284792
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.028426
MT2A metallothionein 2A -0.0281188
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 -0.0278896
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0275367
EIF1 eukaryotic translation initiation factor 1 -0.0272247
ATG12 autophagy related 12 -0.0270878
SAMD9 sterile alpha motif domain containing 9 -0.027068
ZNFX1 zinc finger, NFX1-type containing 1 -0.027034
LY6E lymphocyte antigen 6 complex, locus E -0.0270309
FUS FUS RNA binding protein -0.0269676
RPL28 ribosomal protein L28 -0.0266577
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0263067
HIBADH 3-hydroxyisobutyrate dehydrogenase -0.0261655
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0260805
RPL7A ribosomal protein L7a -0.0260722
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0260203
RPL37A ribosomal protein L37a -0.0257365
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0256613
S100A4 S100 calcium binding protein A4 -0.0254472
NEK7 NIMA-related kinase 7 -0.0254325
RPL31 ribosomal protein L31 -0.0251641
PRELID2 PRELI domain containing 2 -0.025157
RPS13 ribosomal protein S13 -0.0248026
RIGI RNA sensor RIG-I -0.0247907
RPL26 ribosomal protein L26 -0.0247278
SMYD3 SET and MYND domain containing 3 -0.0245412
MIDN midnolin -0.0241556
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0240514
ERBIN erbb2 interacting protein -0.0238748
BCL2L1 BCL2-like 1 -0.0238382
RPL11 ribosomal protein L11 -0.0237983
RRBP1 ribosome binding protein 1 -0.023788
RPS25 ribosomal protein S25 -0.0234577
MYO6 myosin VI -0.0234377
CDK13 cyclin-dependent kinase 13 -0.0233501
MYL12B myosin, light chain 12B, regulatory -0.0230364
DST dystonin -0.0228162
MAPK8 mitogen-activated protein kinase 8 -0.0227084
LMO7 LIM domain 7 -0.0226714
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0226508
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0224367
S100A11 S100 calcium binding protein A11 -0.022145
TNPO1 transportin 1 -0.0220199
CELF1 CUGBP, Elav-like family member 1 -0.0220032
RAB10 RAB10, member RAS oncogene family -0.0218944