Phenytoin (sodium)_C-33 A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in C-33 A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_C-33 A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ZNF608 zinc finger protein 608 0.0735888
USP9X ubiquitin specific peptidase 9, X-linked 0.0691483
ARID2 AT rich interactive domain 2 (ARID, RFX-like) 0.0597532
DST dystonin 0.0591341
CABIN1 calcineurin binding protein 1 0.0590189
SMYD3 SET and MYND domain containing 3 0.0580576
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0571406
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0555412
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0544199
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0533141
ATRN attractin 0.0527058
PIAS2 protein inhibitor of activated STAT, 2 0.0522712
NUP58 nucleoporin 58 0.0506252
ADGRG6 adhesion G protein-coupled receptor G6 0.0500611
KMT2C lysine (K)-specific methyltransferase 2C 0.0498745
ZNF292 zinc finger protein 292 0.0489501
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0487528
NGLY1 N-glycanase 1 0.0461467
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0458208
KDM3A lysine (K)-specific demethylase 3A 0.0453248
JMJD1C jumonji domain containing 1C 0.0432338
ATP11A ATPase, class VI, type 11A 0.0426986
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0423439
HELZ helicase with zinc finger 0.0408525
WAC WW domain containing adaptor with coiled-coil 0.0407335
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0397138
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0394635
COL5A2 collagen, type V, alpha 2 0.0392365
MED13L mediator complex subunit 13-like 0.0390123
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0388951
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0383571
AUTS2 autism susceptibility candidate 2 0.0375807
PDK3 pyruvate dehydrogenase kinase, isozyme 3 0.0375258
ZNF638 zinc finger protein 638 0.0364934
NFIA nuclear factor I/A 0.0364726
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0358836
FOXO3 forkhead box O3 0.0356793
KDM6A lysine (K)-specific demethylase 6A 0.0353156
TTC28 tetratricopeptide repeat domain 28 0.0340867
ADNP activity-dependent neuroprotector homeobox 0.0340855
PTK2 protein tyrosine kinase 2 0.0336179
BIRC6 baculoviral IAP repeat containing 6 0.0333043
KDM2A lysine (K)-specific demethylase 2A 0.0329896
CHSY1 chondroitin sulfate synthase 1 0.0325216
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0321838
USP3 ubiquitin specific peptidase 3 0.0320654
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.031596
GSK3B glycogen synthase kinase 3 beta 0.0313226
VCL vinculin 0.0308979
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0308565
PARD3 par-3 family cell polarity regulator 0.0304821
KIAA1958 KIAA1958 0.0304728
MAP3K2 mitogen-activated protein kinase kinase kinase 2 0.0304381
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0303435
DENND5A DENN/MADD domain containing 5A 0.0303127
SUN1 Sad1 and UNC84 domain containing 1 0.0297852
RLF rearranged L-myc fusion 0.0297288
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0295306
KDM1A lysine (K)-specific demethylase 1A 0.0287319
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0285116
PHIP pleckstrin homology domain interacting protein 0.0284726
VMP1 vacuole membrane protein 1 0.0284524
ZFAND3 zinc finger, AN1-type domain 3 0.0284339
TENT4A terminal nucleotidyltransferase 4A 0.0283862
PHF21A PHD finger protein 21A 0.0282
SPRED2 sprouty-related, EVH1 domain containing 2 0.0280442
INSIG2 insulin induced gene 2 0.0278615
SMAP1 small ArfGAP 1 0.0276439
SPRED1 sprouty-related, EVH1 domain containing 1 0.0274374
ZEB1 zinc finger E-box binding homeobox 1 0.0272878
CDC73 cell division cycle 73 0.0270548
SRPK2 SRSF protein kinase 2 0.0269187
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) 0.0267973
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0266817
WDPCP WD repeat containing planar cell polarity effector 0.026457
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0261729
QKI QKI, KH domain containing, RNA binding 0.0260157
TBK1 TANK-binding kinase 1 0.0259993
RTN4 reticulon 4 0.0258145
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.025784
JAM3 junctional adhesion molecule 3 0.0257579
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0257074
CHD7 chromodomain helicase DNA binding protein 7 0.025433
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0254254
PTBP2 polypyrimidine tract binding protein 2 0.0254146
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0254135
ARFGEF3 ARFGEF family member 3 0.025365
EXOC6B exocyst complex component 6B 0.0248414
DIDO1 death inducer-obliterator 1 0.0248144
ELOVL5 ELOVL fatty acid elongase 5 0.0247532
RBM33 RNA binding motif protein 33 0.0246833
TM9SF3 transmembrane 9 superfamily member 3 0.0245639
RPL3 ribosomal protein L3 0.0245499
BBX bobby sox homolog (Drosophila) 0.0245162
YEATS2 YEATS domain containing 2 0.0244581
PRRC2A proline-rich coiled-coil 2A 0.0244108
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0243688
AGTPBP1 ATP/GTP binding protein 1 0.0243109
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0242498
ATXN7 ataxin 7 0.0242187

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.136137
PTMA prothymosin, alpha -0.112423
TMSB10 thymosin beta 10 -0.0997476
RPL11 ribosomal protein L11 -0.0900741
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0885239
RPL34 ribosomal protein L34 -0.082925
RPL37A ribosomal protein L37a -0.0827045
RPS8 ribosomal protein S8 -0.0824294
RPS6 ribosomal protein S6 -0.0805947
RPL12 ribosomal protein L12 -0.0754445
ACTG1 actin gamma 1 -0.075283
CTNNA3 catenin (cadherin-associated protein), alpha 3 -0.0714837
RPL35A ribosomal protein L35a -0.0708514
RPL23 ribosomal protein L23 -0.0703202
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0690428
RPLP1 ribosomal protein, large, P1 -0.067598
RPL26 ribosomal protein L26 -0.0668135
KTN1 kinectin 1 (kinesin receptor) -0.0666926
RPS19 ribosomal protein S19 -0.0592473
RPS3 ribosomal protein S3 -0.056033
RPS21 ribosomal protein S21 -0.0558277
TENM3 teneurin transmembrane protein 3 -0.0526961
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0520847
RPL36 ribosomal protein L36 -0.0512028
RPS13 ribosomal protein S13 -0.0478112
RPS12 ribosomal protein S12 -0.0472429
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0471888
RPS27A ribosomal protein S27a -0.0469478
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0459587
RPL18 ribosomal protein L18 -0.0457872
SLIT2 slit homolog 2 (Drosophila) -0.0451666
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0448104
RPL9 ribosomal protein L9 -0.0441451
SOX4 SRY (sex determining region Y)-box 4 -0.0438097
RPL35 ribosomal protein L35 -0.0431751
RPLP2 ribosomal protein, large, P2 -0.0430105
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.042577
RPL5 ribosomal protein L5 -0.0423736
TPT1 tumor protein, translationally-controlled 1 -0.0420991
RBM25 RNA binding motif protein 25 -0.0412542
IFI6 interferon, alpha-inducible protein 6 -0.0407206
EIF1 eukaryotic translation initiation factor 1 -0.0403498
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0382511
RPL13A ribosomal protein L13a -0.0374922
RPL31 ribosomal protein L31 -0.0372802
BNC2 basonuclin 2 -0.0372199
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0370756
RPL19 ribosomal protein L19 -0.0367844
RPS17 ribosomal protein S17 -0.0367303
RPL7 ribosomal protein L7 -0.0366242
RPS5 ribosomal protein S5 -0.0365858
CANX calnexin -0.0358915
EIF5B eukaryotic translation initiation factor 5B -0.034227
RACK1 receptor for activated C kinase 1 -0.0339042
FTL ferritin, light polypeptide -0.0330237
GNAS GNAS complex locus -0.0323926
CADM2 cell adhesion molecule 2 -0.0314638
NPAS3 neuronal PAS domain protein 3 -0.0314585
RPS27 ribosomal protein S27 -0.0308129
S100A9 S100 calcium binding protein A9 -0.0308035
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0306673
RPS14 ribosomal protein S14 -0.0303284
TOM1L2 target of myb1-like 2 (chicken) -0.0303135
PABPN1 poly(A) binding protein, nuclear 1 -0.0299027
RPS28 ribosomal protein S28 -0.029817
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0294778
RPS24 ribosomal protein S24 -0.0291933
NRG1 neuregulin 1 -0.0290503
DEK DEK proto-oncogene -0.0289001
RPS29 ribosomal protein S29 -0.0288155
RPL38 ribosomal protein L38 -0.0283962
PRICKLE1 prickle homolog 1 (Drosophila) -0.0281273
RPL28 ribosomal protein L28 -0.0278906
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0276791
RPS16 ribosomal protein S16 -0.0270016
ITSN1 intersectin 1 (SH3 domain protein) -0.0266082
RPS25 ribosomal protein S25 -0.0264561
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0263515
TPM4 tropomyosin 4 -0.0263185
SERBP1 SERPINE1 mRNA binding protein 1 -0.0255985
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0255656
NT5C2 5'-nucleotidase, cytosolic II -0.0253757
PFN1 profilin 1 -0.0252003
CALR calreticulin -0.0251201
B2M beta-2-microglobulin -0.0249436
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0248466
HLA-B major histocompatibility complex, class I, B -0.0245186
EIF3A eukaryotic translation initiation factor 3, subunit A -0.0244326
RPL37 ribosomal protein L37 -0.0237143
GOLGA4 golgin A4 -0.0236254
PA2G4 proliferation-associated 2G4, 38kDa -0.0236154
SOX2 SRY (sex determining region Y)-box 2 -0.0235441
ZMYM4 zinc finger, MYM-type 4 -0.023461
RPL36A ribosomal protein L36a -0.0232353
RPL32 ribosomal protein L32 -0.0230501
DCAF7 DDB1 and CUL4 associated factor 7 -0.0229623
TAF15 TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa -0.0229575
WSB1 WD repeat and SOCS box containing 1 -0.0228655
CDH18 cadherin 18, type 2 -0.0227698
LARS1 leucyl-tRNA synthetase 1 -0.0227147