Phenytoin (sodium)_C32 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in C32 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_C32 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.126665
LOC112694756 uncharaterized LOC112694756 0.0748965
NAMPT nicotinamide phosphoribosyltransferase 0.0714776
CDC73 cell division cycle 73 0.0634313
CD109 CD109 molecule 0.0566896
LEF1 lymphoid enhancer-binding factor 1 0.0446343
NDRG1 N-myc downstream regulated 1 0.0403569
NAV2 neuron navigator 2 0.0392771
FBXO7 F-box protein 7 0.0377129
EIF4H eukaryotic translation initiation factor 4H 0.0358769
EGLN1 egl-9 family hypoxia-inducible factor 1 0.0356652
CHSY1 chondroitin sulfate synthase 1 0.0330675
TMEM178B transmembrane protein 178B 0.0327297
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0318124
BHLHE40 basic helix-loop-helix family, member e40 0.0316561
MIDEAS mitotic deacetylase associated SANT domain protein 0.0310838
NUP58 nucleoporin 58 0.0300563
FYN FYN proto-oncogene, Src family tyrosine kinase 0.0283323
DDIT4 DNA-damage-inducible transcript 4 0.0282317
IL1RAP interleukin 1 receptor accessory protein 0.028114
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0278987
RBM33 RNA binding motif protein 33 0.0278671
ICAM1 intercellular adhesion molecule 1 0.0267165
ARRDC3 arrestin domain containing 3 0.0260594
A2M alpha-2-macroglobulin 0.0244218
RNF145 ring finger protein 145 0.0225204
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.0210109
EEF2 eukaryotic translation elongation factor 2 0.0202126
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0201718
CABIN1 calcineurin binding protein 1 0.0187791
FLNA filamin A, alpha 0.0186756
AFDN afadin, adherens junction formation factor 0.0185581
HELZ helicase with zinc finger 0.0183196
RIPK4 receptor-interacting serine-threonine kinase 4 0.0180061
MRTFA myocardin related transcription factor A 0.0176155
ESYT2 extended synaptotagmin-like protein 2 0.01757
RPL3 ribosomal protein L3 0.0175272
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0171744
HLA-C major histocompatibility complex, class I, C 0.0171525
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent) 0.0169409
SETBP1 SET binding protein 1 0.0168285
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0162487
PPME1 protein phosphatase methylesterase 1 0.0161704
SPRED1 sprouty-related, EVH1 domain containing 1 0.0160199
FOSL1 FOS-like antigen 1 0.0159451
SAMTOR S-adenosylmethionine sensor upstream of mTORC1 0.0154975
HBP1 HMG-box transcription factor 1 0.0154606
BIRC2 baculoviral IAP repeat containing 2 0.0154234
CUL3 cullin 3 0.0154113
DCAF8 DDB1 and CUL4 associated factor 8 0.0153832
ANO6 anoctamin 6 0.0153472
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0153131
NBAS neuroblastoma amplified sequence 0.0151314
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0150153
STOM stomatin 0.0149454
PLEC plectin 0.0147169
GAS7 growth arrest-specific 7 0.0146256
MKRN1 makorin ring finger protein 1 0.0146208
HOOK2 hook microtubule-tethering protein 2 0.0145886
PPFIA4 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 4 0.0143698
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.014253
CNOT4 CCR4-NOT transcription complex, subunit 4 0.0142179
INPP5F inositol polyphosphate-5-phosphatase F 0.0142044
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0141448
SSBP3 single stranded DNA binding protein 3 0.0141062
NEK7 NIMA-related kinase 7 0.013629
CAPRIN1 cell cycle associated protein 1 0.0135322
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0131026
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0130873
WDR45B WD repeat domain 45B 0.0129756
SMAD3 SMAD family member 3 0.0128765
HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 0.0127892
KDM6A lysine (K)-specific demethylase 6A 0.0127742
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0126815
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0125488
ANXA5 annexin A5 0.0125136
COPA coatomer protein complex, subunit alpha 0.0124792
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0123798
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta 0.012326
TENT4A terminal nucleotidyltransferase 4A 0.0122145
PRRC2A proline-rich coiled-coil 2A 0.01205
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0116339
ANXA2 annexin A2 0.0115043
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0115012
IL6ST interleukin 6 signal transducer 0.0110832
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0108946
VGLL4 vestigial-like family member 4 0.0108883
TOP2B topoisomerase (DNA) II beta 180kDa 0.0108208
RAB8B RAB8B, member RAS oncogene family 0.010797
SRRM2 serine/arginine repetitive matrix 2 0.0107605
FOXJ3 forkhead box J3 0.0107105
IQGAP3 IQ motif containing GTPase activating protein 3 0.0106159
NUMA1 nuclear mitotic apparatus protein 1 0.0104816
ETV3 ets variant 3 0.0103969
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0102621
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0102454
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0101305
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 0.0100922
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0100606
TFG TRK-fused gene 0.010049

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.324053
VIM vimentin -0.222174
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.20204
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.189087
GPC6 glypican 6 -0.173332
IGFBP5 insulin-like growth factor binding protein 5 -0.158213
NLGN1 neuroligin 1 -0.150191
HLA-B major histocompatibility complex, class I, B -0.118955
TMSB10 thymosin beta 10 -0.117474
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.116244
PTMA prothymosin, alpha -0.0966647
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0898232
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0871624
FMN1 formin 1 -0.0803534
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0772075
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0732758
S100A6 S100 calcium binding protein A6 -0.0710054
AKAP12 A kinase (PRKA) anchor protein 12 -0.0667568
VGF VGF nerve growth factor inducible -0.0645151
FRMD4A FERM domain containing 4A -0.0591908
CUX1 cut-like homeobox 1 -0.0587563
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0573217
NPAS2 neuronal PAS domain protein 2 -0.0567663
ASPH aspartate beta-hydroxylase -0.0559084
CALD1 caldesmon 1 -0.055528
IFI16 interferon, gamma-inducible protein 16 -0.055382
TPT1 tumor protein, translationally-controlled 1 -0.0552176
TIMP3 TIMP metallopeptidase inhibitor 3 -0.053802
ACTG1 actin gamma 1 -0.0534326
MACROD2 MACRO domain containing 2 -0.0521792
COL19A1 collagen, type XIX, alpha 1 -0.0521075
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0510452
FTL ferritin, light polypeptide -0.0488334
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.048643
EHBP1 EH domain binding protein 1 -0.0483508
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0483165
PTK2 protein tyrosine kinase 2 -0.0455821
ENO1 enolase 1, (alpha) -0.0453346
NPC1 Niemann-Pick disease, type C1 -0.0444727
MT2A metallothionein 2A -0.044451
RPS8 ribosomal protein S8 -0.0442984
RPL35A ribosomal protein L35a -0.043429
BACE2 beta-site APP-cleaving enzyme 2 -0.0428942
IER3 immediate early response 3 -0.0427507
HMGA2 high mobility group AT-hook 2 -0.0416689
SCFD2 sec1 family domain containing 2 -0.0395617
MAML3 mastermind-like 3 (Drosophila) -0.0393704
GDF15 growth differentiation factor 15 -0.0389736
PTCHD4 patched domain containing 4 -0.0389024
SOX5 SRY (sex determining region Y)-box 5 -0.0382113
B2M beta-2-microglobulin -0.0377531
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.03766
IFI6 interferon, alpha-inducible protein 6 -0.0376147
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0369554
RPLP1 ribosomal protein, large, P1 -0.0369331
RPS6 ribosomal protein S6 -0.0369173
PCDH7 protocadherin 7 -0.0363362
DCT dopachrome tautomerase -0.0363045
AKAP9 A kinase (PRKA) anchor protein 9 -0.036274
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0362353
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0358605
MTDH metadherin -0.0357662
HILPDA hypoxia inducible lipid droplet-associated -0.0353446
EXT1 exostosin glycosyltransferase 1 -0.0353313
PTPRD protein tyrosine phosphatase, receptor type, D -0.0350184
EGR1 early growth response 1 -0.0345328
WSB1 WD repeat and SOCS box containing 1 -0.0344667
NAV3 neuron navigator 3 -0.0343492
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0343377
RUNX1 runt-related transcription factor 1 -0.0340785
LAMB1 laminin, beta 1 -0.0337249
CDK14 cyclin-dependent kinase 14 -0.0335974
RNF24 ring finger protein 24 -0.0335521
ANKRD12 ankyrin repeat domain 12 -0.0334475
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0333819
TRIM2 tripartite motif containing 2 -0.0327088
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0324573
KTN1 kinectin 1 (kinesin receptor) -0.0324517
RPL37A ribosomal protein L37a -0.0322806
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0320511
SFTPA2 surfactant protein A2 -0.0315471
RPL34 ribosomal protein L34 -0.0313561
ARHGAP5 Rho GTPase activating protein 5 -0.0312577
OXR1 oxidation resistance 1 -0.0308596
RPLP2 ribosomal protein, large, P2 -0.0306868
ENO2 enolase 2 (gamma, neuronal) -0.030663
ZNF704 zinc finger protein 704 -0.030632
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0305491
UBE3C ubiquitin protein ligase E3C -0.0303421
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa -0.0302985
S100A10 S100 calcium binding protein A10 -0.0299592
FBXO11 F-box protein 11 -0.0295594
S100A9 S100 calcium binding protein A9 -0.0295368
ZMYND8 zinc finger, MYND-type containing 8 -0.0291639
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0289376
CD63 CD63 molecule -0.0285694
BPTF bromodomain PHD finger transcription factor -0.0284013
RPS19 ribosomal protein S19 -0.0281346
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0279638
RPL31 ribosomal protein L31 -0.0274712