Phenytoin (sodium)_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.15045
FMN1 formin 1 0.114357
MEIS2 Meis homeobox 2 0.104769
EXT1 exostosin glycosyltransferase 1 0.104643
LPIN1 lipin 1 0.101982
NALF1 NALCN channel auxiliary factor 1 0.0913038
LSAMP limbic system-associated membrane protein 0.0855222
NRG1 neuregulin 1 0.0771431
RNF213 ring finger protein 213 0.073943
MSI2 musashi RNA-binding protein 2 0.0720139
TRIO trio Rho guanine nucleotide exchange factor 0.066109
ANTXR1 anthrax toxin receptor 1 0.062032
RPTOR regulatory associated protein of MTOR, complex 1 0.0601529
EEF2 eukaryotic translation elongation factor 2 0.0566928
SMAD3 SMAD family member 3 0.0534489
NCOR2 nuclear receptor corepressor 2 0.0487314
PTEN phosphatase and tensin homolog 0.0484459
KLHL13 kelch-like family member 13 0.0468055
THSD4 thrombospondin, type I, domain containing 4 0.046741
FRMD4A FERM domain containing 4A 0.0451892
SMYD3 SET and MYND domain containing 3 0.0438332
FNDC3B fibronectin type III domain containing 3B 0.043505
SEPTIN9 septin 9 0.0431475
ADARB1 adenosine deaminase, RNA-specific, B1 0.0427704
MYH9 myosin, heavy chain 9, non-muscle 0.0424482
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0417267
MAPK10 mitogen-activated protein kinase 10 0.0416642
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0399297
PRRC2B proline-rich coiled-coil 2B 0.0391648
VCL vinculin 0.0387932
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0360819
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0356673
BCAS3 breast carcinoma amplified sequence 3 0.0352883
MBNL2 muscleblind-like splicing regulator 2 0.0344449
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0344307
IGF1R insulin-like growth factor 1 receptor 0.034271
NRP1 neuropilin 1 0.0335876
TLE4 transducin-like enhancer of split 4 0.0332529
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0328435
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0327416
ZMIZ1 zinc finger, MIZ-type containing 1 0.032547
COL4A2 collagen, type IV, alpha 2 0.0325378
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0325055
PRKCE protein kinase C, epsilon 0.0323131
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0322923
CHD9 chromodomain helicase DNA binding protein 9 0.0321038
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0318223
ZNF638 zinc finger protein 638 0.0317226
MX2 MX dynamin-like GTPase 2 0.0314515
MED13L mediator complex subunit 13-like 0.03128
PRKCA protein kinase C, alpha 0.0311324
PDE8A phosphodiesterase 8A 0.0310939
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0309767
LPP LIM domain containing preferred translocation partner in lipoma 0.0305903
UNC5C unc-5 homolog C (C. elegans) 0.0303824
NFIB nuclear factor I/B 0.0300929
COL18A1 collagen, type XVIII, alpha 1 0.0295732
PTPRK protein tyrosine phosphatase, receptor type, K 0.029409
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0293587
TENM4 teneurin transmembrane protein 4 0.0293319
SSBP3 single stranded DNA binding protein 3 0.0292732
TPM1 tropomyosin 1 (alpha) 0.028917
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0288353
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0283545
PARD3 par-3 family cell polarity regulator 0.0278896
RAD51B RAD51 paralog B 0.0277308
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0276783
RBM20 RNA binding motif protein 20 0.0276739
PSD3 pleckstrin and Sec7 domain containing 3 0.027431
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.0271996
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0271927
ARHGAP9 Rho GTPase activating protein 9 0.027167
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0271247
PDE10A phosphodiesterase 10A 0.0269717
GLI2 GLI family zinc finger 2 0.0269289
PLEC plectin 0.0267724
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0267349
PCBP2 poly(rC) binding protein 2 0.0266157
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0265884
ENAH enabled homolog (Drosophila) 0.0264585
RIGI RNA sensor RIG-I 0.0264153
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0263909
DNAH14 dynein, axonemal, heavy chain 14 0.0263227
ANKS1A ankyrin repeat and sterile alpha motif domain containing 1A 0.0262748
ZFAND3 zinc finger, AN1-type domain 3 0.0262433
CADM1 cell adhesion molecule 1 0.0261571
LRP1B low density lipoprotein receptor-related protein 1B 0.0261211
BCAT1 branched chain amino-acid transaminase 1, cytosolic 0.0259609
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0259159
HSPA8 heat shock 70kDa protein 8 0.0258546
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0255952
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0255709
CCDC91 coiled-coil domain containing 91 0.025404
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0251226
UBAP2L ubiquitin associated protein 2-like 0.0246205
LRPPRC leucine-rich pentatricopeptide repeat containing 0.0245291
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0241229
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0240115
GREM2 gremlin 2, DAN family BMP antagonist 0.0239844
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0238758

decreased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 -0.239779
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.201483
PTMA prothymosin, alpha -0.152293
VIM vimentin -0.087829
RPS6 ribosomal protein S6 -0.0861412
RPL23 ribosomal protein L23 -0.0771894
RPL34 ribosomal protein L34 -0.07705
RPL19 ribosomal protein L19 -0.0765976
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0731075
RPS24 ribosomal protein S24 -0.0690227
RPL35A ribosomal protein L35a -0.0668477
RPLP1 ribosomal protein, large, P1 -0.0644112
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0545455
RPL31 ribosomal protein L31 -0.0540336
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0506038
RPS3 ribosomal protein S3 -0.0496902
DCAF7 DDB1 and CUL4 associated factor 7 -0.0495958
RPS19 ribosomal protein S19 -0.0492332
TPT1 tumor protein, translationally-controlled 1 -0.0487499
FTL ferritin, light polypeptide -0.0486976
EIF1 eukaryotic translation initiation factor 1 -0.047618
SYT1 synaptotagmin I -0.0473519
MAP1B microtubule-associated protein 1B -0.0438049
S100A6 S100 calcium binding protein A6 -0.0405827
B2M beta-2-microglobulin -0.0404109
RPLP0 ribosomal protein, large, P0 -0.0400775
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0390219
RPS8 ribosomal protein S8 -0.0390184
TMSB10 thymosin beta 10 -0.0387777
FAM162A family with sequence similarity 162, member A -0.038641
RACK1 receptor for activated C kinase 1 -0.0382446
HAND2 heart and neural crest derivatives expressed 2 -0.0369761
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.036504
RPL35 ribosomal protein L35 -0.0357673
RPS12 ribosomal protein S12 -0.0351071
GDF15 growth differentiation factor 15 -0.0349061
PKM pyruvate kinase, muscle -0.0345511
RPS17 ribosomal protein S17 -0.0344105
RPL12 ribosomal protein L12 -0.0342644
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0333494
RPS13 ribosomal protein S13 -0.03332
RPL26 ribosomal protein L26 -0.0331471
ZNF292 zinc finger protein 292 -0.0320189
RPS5 ribosomal protein S5 -0.0309906
RPL18 ribosomal protein L18 -0.0305816
RPL27 ribosomal protein L27 -0.0303344
OGA O-GlcNAcase -0.0300302
RPL32 ribosomal protein L32 -0.0295037
NME2 NME/NM23 nucleoside diphosphate kinase 2 -0.0293113
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0291556
RPLP2 ribosomal protein, large, P2 -0.0287426
LMNA lamin A/C -0.0284336
RPL36 ribosomal protein L36 -0.0281546
RPL38 ribosomal protein L38 -0.0280135
RPS11 ribosomal protein S11 -0.0275652
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0274175
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0271432
GNAS GNAS complex locus -0.0269743
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0269477
PRR11 proline rich 11 -0.0267838
CCDC47 coiled-coil domain containing 47 -0.026375
IER3 immediate early response 3 -0.0259706
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0259439
KMT2A lysine (K)-specific methyltransferase 2A -0.0257671
RPS27A ribosomal protein S27a -0.0256008
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0253559
PFN1 profilin 1 -0.0247792
RIOK3 RIO kinase 3 -0.0247709
ZNF654 zinc finger protein 654 -0.0241577
RPL37A ribosomal protein L37a -0.0236998
SRP54 signal recognition particle 54kDa -0.0236157
RPL30 ribosomal protein L30 -0.0235361
NIPBL Nipped-B homolog (Drosophila) -0.0234327
MARCKS myristoylated alanine-rich protein kinase C substrate -0.023095
ERRFI1 ERBB receptor feedback inhibitor 1 -0.022885
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0228067
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0227703
PAFAH1B1 platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa) -0.0223592
SEPTIN2 septin 2 -0.0223381
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0222358
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0219919
NUP58 nucleoporin 58 -0.02176
LUM lumican -0.0216742
ARL6IP5 ADP-ribosylation factor-like 6 interacting protein 5 -0.0214116
ARF1 ADP-ribosylation factor 1 -0.0213017
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0212541
RPL13A ribosomal protein L13a -0.021113
CBX3 chromobox homolog 3 -0.0211007
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0209913
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0209772
RNF145 ring finger protein 145 -0.0209304
UBE2B ubiquitin-conjugating enzyme E2B -0.0207915
SCAF11 SR-related CTD-associated factor 11 -0.0206865
RPL8 ribosomal protein L8 -0.0204798
PCDH9 protocadherin 9 -0.0203598
HMBOX1 homeobox containing 1 -0.0202089
RPS14 ribosomal protein S14 -0.0201701
IPO7 importin 7 -0.0201014
GARS1 glycyl-tRNA synthetase 1 -0.0200463
FAM13A family with sequence similarity 13, member A -0.0200105