Phenytoin (sodium)_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
BTBD9 BTB (POZ) domain containing 9 0.152151
EPSTI1 epithelial stromal interaction 1 (breast) 0.106828
ZMYND8 zinc finger, MYND-type containing 8 0.104909
NDRG1 N-myc downstream regulated 1 0.0853189
ARHGAP26 Rho GTPase activating protein 26 0.0827984
MBNL2 muscleblind-like splicing regulator 2 0.0821039
PHF3 PHD finger protein 3 0.0780259
PRKCA protein kinase C, alpha 0.0706458
TXNIP thioredoxin interacting protein 0.0637428
SQSTM1 sequestosome 1 0.0570455
SORBS1 sorbin and SH3 domain containing 1 0.0562168
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0557909
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0545494
FNDC3B fibronectin type III domain containing 3B 0.0525555
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0519652
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0514772
LOC112694756 uncharaterized LOC112694756 0.0513298
MBOAT2 membrane bound O-acyltransferase domain containing 2 0.0512959
KIF16B kinesin family member 16B 0.0508602
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) 0.0506426
FMN1 formin 1 0.0496978
CMIP c-Maf inducing protein 0.0493798
MYH9 myosin, heavy chain 9, non-muscle 0.0483164
RAD51B RAD51 paralog B 0.047261
NCKAP5 NCK-associated protein 5 0.0466322
RUNX1 runt-related transcription factor 1 0.0460343
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0453872
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.045363
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.045089
IRF1 interferon regulatory factor 1 0.0445119
FAT1 FAT atypical cadherin 1 0.0443914
MSI2 musashi RNA-binding protein 2 0.0438066
BCLAF1 BCL2-associated transcription factor 1 0.0437044
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 0.042563
SH3PXD2A SH3 and PX domains 2A 0.0425556
EZR ezrin 0.0423136
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0418416
UBAC2 UBA domain containing 2 0.0414207
TRIO trio Rho guanine nucleotide exchange factor 0.0412601
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0411888
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0409015
EGLN3 egl-9 family hypoxia-inducible factor 3 0.0408767
ATXN1 ataxin 1 0.0408004
ERRFI1 ERBB receptor feedback inhibitor 1 0.0406877
ARHGEF10L Rho guanine nucleotide exchange factor (GEF) 10-like 0.0406749
PDIA3 protein disulfide isomerase family A, member 3 0.0403482
AHNAK AHNAK nucleoprotein 0.0402221
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0401746
KLF5 Kruppel-like factor 5 (intestinal) 0.0400948
IFNGR1 interferon gamma receptor 1 0.0400898
GRK3 G protein-coupled receptor kinase 3 0.0397412
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.039584
PGK1 phosphoglycerate kinase 1 0.0393763
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 0.0392646
AFF1 AF4/FMR2 family, member 1 0.0392243
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 0.038684
PTBP3 polypyrimidine tract binding protein 3 0.037972
UBR2 ubiquitin protein ligase E3 component n-recognin 2 0.0374976
HDAC4 histone deacetylase 4 0.0374373
RBM39 RNA binding motif protein 39 0.037204
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0371948
EHF ets homologous factor 0.0371376
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0368516
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0365219
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0363187
RAB1A RAB1A, member RAS oncogene family 0.0361491
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0359956
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0354219
FOS FBJ murine osteosarcoma viral oncogene homolog 0.035329
PRELID2 PRELI domain containing 2 0.0352872
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0347325
RREB1 ras responsive element binding protein 1 0.0347323
SLC22A23 solute carrier family 22, member 23 0.0346419
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0346174
PTEN phosphatase and tensin homolog 0.0341586
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0339574
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0336797
ESYT2 extended synaptotagmin-like protein 2 0.0333469
IRS2 insulin receptor substrate 2 0.0332875
ABHD2 abhydrolase domain containing 2 0.033267
NR6A1 nuclear receptor subfamily 6, group A, member 1 0.0332596
SCARB1 scavenger receptor class B, member 1 0.0331509
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0329329
NPSR1 neuropeptide S receptor 1 0.0329163
DSPP dentin sialophosphoprotein 0.0328791
PARP4 poly (ADP-ribose) polymerase family, member 4 0.03239
STS steroid sulfatase (microsomal), isozyme S 0.0323827
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0322163
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) 0.0317847
AHI1 Abelson helper integration site 1 0.0314354
EPHB2 EPH receptor B2 0.0310156
OARD1 O-acyl-ADP-ribose deacylase 1 0.0309876
PATJ PATJ crumbs cell polarity complex component 0.0309366
UBL3 ubiquitin-like 3 0.0308596
RAB11FIP1 RAB11 family interacting protein 1 (class I) 0.0307917
TMEM51 transmembrane protein 51 0.0305405
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0303863
ARHGAP32 Rho GTPase activating protein 32 0.0302711
MACC1 metastasis associated in colon cancer 1 0.0302263
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0298232

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.098293
TPT1 tumor protein, translationally-controlled 1 -0.0918108
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0717398
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0681963
LCN2 lipocalin 2 -0.0659523
RPL35A ribosomal protein L35a -0.065641
B2M beta-2-microglobulin -0.0652334
AREG amphiregulin -0.0649186
INTS6 integrator complex subunit 6 -0.0621287
FTL ferritin, light polypeptide -0.0587991
VCL vinculin -0.0534416
RPS6 ribosomal protein S6 -0.0507791
RPL23 ribosomal protein L23 -0.0461603
TMSB10 thymosin beta 10 -0.0458379
RPL34 ribosomal protein L34 -0.0456033
RAB7A RAB7A, member RAS oncogene family -0.0432775
RPL31 ribosomal protein L31 -0.042448
RPS8 ribosomal protein S8 -0.0409069
IFI6 interferon, alpha-inducible protein 6 -0.040048
EGR1 early growth response 1 -0.0376115
RPL19 ribosomal protein L19 -0.0355212
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 -0.0351416
MT2A metallothionein 2A -0.0347827
RPL11 ribosomal protein L11 -0.0341631
RPL37A ribosomal protein L37a -0.0329576
C6ORF132 chromosome 6 open reading frame 132 -0.031614
RPS24 ribosomal protein S24 -0.0315343
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0315256
RPS19 ribosomal protein S19 -0.0313775
TJP1 tight junction protein 1 -0.031088
WSB1 WD repeat and SOCS box containing 1 -0.0304037
RPL26 ribosomal protein L26 -0.0299731
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0293293
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa -0.0288069
IER3 immediate early response 3 -0.0281037
RPL9 ribosomal protein L9 -0.02797
GCC2 GRIP and coiled-coil domain containing 2 -0.02784
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0272154
SLC38A2 solute carrier family 38, member 2 -0.0269772
RPS25 ribosomal protein S25 -0.0269019
ACTG1 actin gamma 1 -0.02645
RPS27 ribosomal protein S27 -0.0264419
RPS27A ribosomal protein S27a -0.0261679
RPL7A ribosomal protein L7a -0.0259734
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0258684
XAF1 XIAP associated factor 1 -0.0258511
PRRC2C proline-rich coiled-coil 2C -0.0255881
PLSCR2 phospholipid scramblase 2 -0.0254899
SP100 SP100 nuclear antigen -0.0253931
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.0253732
NT5C2 5'-nucleotidase, cytosolic II -0.0252435
S100A10 S100 calcium binding protein A10 -0.0252251
TNS4 tensin 4 -0.0251899
HLA-B major histocompatibility complex, class I, B -0.0251038
RAB10 RAB10, member RAS oncogene family -0.0247867
RPL7L1 ribosomal protein L7-like 1 -0.0247792
AKAP13 A kinase (PRKA) anchor protein 13 -0.0246208
LOC102724023 ES1 protein homolog, mitochondrial -0.0245015
ATF4 activating transcription factor 4 -0.0244508
RPS13 ribosomal protein S13 -0.0243618
EIF1 eukaryotic translation initiation factor 1 -0.0242006
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0239412
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0238642
TM4SF19 transmembrane 4 L six family member 19 -0.0236963
RPL12 ribosomal protein L12 -0.0235546
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0233823
SLC38A1 solute carrier family 38, member 1 -0.0231795
RPLP1 ribosomal protein, large, P1 -0.0231516
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0230204
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0228802
CATSPERB catsper channel auxiliary subunit beta -0.0226758
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.022464
RPLP2 ribosomal protein, large, P2 -0.0223944
RIGI RNA sensor RIG-I -0.0221314
BCL2L1 BCL2-like 1 -0.0220442
RPS16 ribosomal protein S16 -0.0220346
KTN1 kinectin 1 (kinesin receptor) -0.0220012
RPS29 ribosomal protein S29 -0.0219517
RPS23 ribosomal protein S23 -0.0218341
RPS3 ribosomal protein S3 -0.0217998
RPL36A ribosomal protein L36a -0.0213583
PMP22 peripheral myelin protein 22 -0.0213279
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0206179
VIM vimentin -0.0204741
RPS14 ribosomal protein S14 -0.0203927
PDE4D phosphodiesterase 4D, cAMP-specific -0.0203884
KPNB1 karyopherin (importin) beta 1 -0.020119
RCOR1 REST corepressor 1 -0.0200499
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0196152
ERBIN erbb2 interacting protein -0.0195486
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0195438
MCTP1 multiple C2 domains, transmembrane 1 -0.0190131
RPL37 ribosomal protein L37 -0.0189307
S100A11 S100 calcium binding protein A11 -0.0189124
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0189008
WASF2 WAS protein family, member 2 -0.0188745
UBAP2 ubiquitin associated protein 2 -0.0187514
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0185272
RPS17 ribosomal protein S17 -0.0182669
SERINC5 serine incorporator 5 -0.0182354