Phenytoin (sodium)_H4 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in H4 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_H4 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.250295
IGFBP3 insulin-like growth factor binding protein 3 0.244044
NDRG1 N-myc downstream regulated 1 0.12632
GRB10 growth factor receptor-bound protein 10 0.0824055
LOC112694756 uncharaterized LOC112694756 0.075535
EGFR epidermal growth factor receptor 0.0721067
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0667684
PLEC plectin 0.0630358
FLNA filamin A, alpha 0.0623563
MYH9 myosin, heavy chain 9, non-muscle 0.0590431
SMAD3 SMAD family member 3 0.0556419
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0547526
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0540101
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.052158
COL5A1 collagen, type V, alpha 1 0.0520984
HSPA8 heat shock 70kDa protein 8 0.0490295
SDK1 sidekick cell adhesion molecule 1 0.0456061
MSN moesin 0.0424028
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0419568
FAM13A family with sequence similarity 13, member A 0.0417888
BACE2 beta-site APP-cleaving enzyme 2 0.0408334
RPL3 ribosomal protein L3 0.0401177
TRIO trio Rho guanine nucleotide exchange factor 0.0399772
LPP LIM domain containing preferred translocation partner in lipoma 0.0386702
HELZ helicase with zinc finger 0.0379023
EIF4H eukaryotic translation initiation factor 4H 0.0377206
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 0.0369818
SHB Src homology 2 domain containing adaptor protein B 0.0364248
LOXL2 lysyl oxidase-like 2 0.0355841
DGKD diacylglycerol kinase, delta 130kDa 0.0353189
EEF2 eukaryotic translation elongation factor 2 0.034864
TNIP1 TNFAIP3 interacting protein 1 0.0347332
MAD1L1 MAD1 mitotic arrest deficient-like 1 (yeast) 0.0347328
TNS3 tensin 3 0.0345424
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0341225
MMP12 matrix metallopeptidase 12 0.0330101
MACF1 microtubule-actin crosslinking factor 1 0.0325428
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0324937
NAV2 neuron navigator 2 0.032103
CEMIP cell migration inducing protein, hyaluronan binding 0.031854
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0317194
ACTN1 actinin, alpha 1 0.031593
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0311911
FNDC3B fibronectin type III domain containing 3B 0.0311185
RNF213 ring finger protein 213 0.0310526
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 0.0305451
DTNA dystrobrevin, alpha 0.0298603
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.029721
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0296652
FAM219A family with sequence similarity 219, member A 0.0293486
SRRM2 serine/arginine repetitive matrix 2 0.0292612
VEGFA vascular endothelial growth factor A 0.0289232
TTC3 tetratricopeptide repeat domain 3 0.0288431
ERRFI1 ERBB receptor feedback inhibitor 1 0.0288023
AP2M1 adaptor-related protein complex 2, mu 1 subunit 0.0281587
NFE2L1 nuclear factor, erythroid 2-like 1 0.0276878
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0269092
YEATS2 YEATS domain containing 2 0.0264579
SEC24D SEC24 family member D 0.0262739
NCOR2 nuclear receptor corepressor 2 0.0262101
ARHGAP22 Rho GTPase activating protein 22 0.0258842
RUNX1 runt-related transcription factor 1 0.0258179
GPR107 G protein-coupled receptor 107 0.0256229
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0249669
DPYSL2 dihydropyrimidinase-like 2 0.0248395
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0247223
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0245449
FN1 fibronectin 1 0.0245082
CALU calumenin 0.024433
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0244305
SND1 staphylococcal nuclease and tudor domain containing 1 0.0241032
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0238845
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0237557
ZNF160 zinc finger protein 160 0.0237302
MYLK myosin light chain kinase 0.0237249
HOOK2 hook microtubule-tethering protein 2 0.0236439
PGM3 phosphoglucomutase 3 0.0235711
SEC23A Sec23 homolog A (S. cerevisiae) 0.0235507
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0234956
HDLBP high density lipoprotein binding protein 0.0229806
GLIS3 GLIS family zinc finger 3 0.0227094
FOSL1 FOS-like antigen 1 0.0225168
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0222901
PCBP2 poly(rC) binding protein 2 0.0222643
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0221599
FXR1 fragile X mental retardation, autosomal homolog 1 0.021991
SURF4 surfeit 4 0.0219375
TLN1 talin 1 0.0218542
MYO1B myosin IB 0.021696
SNX13 sorting nexin 13 0.021695
ANKRD36 ankyrin repeat domain 36 0.021589
PMM2 phosphomannomutase 2 0.0215277
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 0.0215054
AFAP1 actin filament associated protein 1 0.02147
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0213207
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0212026
ACTN4 actinin, alpha 4 0.0210668
CORO1C coronin, actin binding protein, 1C 0.0210342
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0210089
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0208767

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.332563
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.226775
FTL ferritin, light polypeptide -0.156475
TMSB10 thymosin beta 10 -0.144807
PTMA prothymosin, alpha -0.100138
MT2A metallothionein 2A -0.0973484
VIM vimentin -0.0925695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0712053
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0667631
RPS8 ribosomal protein S8 -0.0646602
RPL35A ribosomal protein L35a -0.0536719
RPS6 ribosomal protein S6 -0.049119
RPL28 ribosomal protein L28 -0.0449287
STK17A serine/threonine kinase 17a -0.0428628
OSMR oncostatin M receptor -0.0409962
RPLP2 ribosomal protein, large, P2 -0.040077
TPT1 tumor protein, translationally-controlled 1 -0.0386734
PGK1 phosphoglycerate kinase 1 -0.0367752
RPLP1 ribosomal protein, large, P1 -0.0359173
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0358164
TPM4 tropomyosin 4 -0.0356248
CD44 CD44 molecule (Indian blood group) -0.0355518
GNAS GNAS complex locus -0.0347016
RPL23 ribosomal protein L23 -0.0346368
RPL34 ribosomal protein L34 -0.0345331
RPL37A ribosomal protein L37a -0.0344793
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0338952
RPS24 ribosomal protein S24 -0.0330845
RPL9 ribosomal protein L9 -0.0327868
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0327304
RPS27A ribosomal protein S27a -0.0323004
FUS FUS RNA binding protein -0.0316992
EIF1 eukaryotic translation initiation factor 1 -0.0311036
S100A10 S100 calcium binding protein A10 -0.0310523
RPS19 ribosomal protein S19 -0.0307066
TXNRD1 thioredoxin reductase 1 -0.0305301
RPL19 ribosomal protein L19 -0.0300408
NAP1L1 nucleosome assembly protein 1-like 1 -0.0299274
MAP1B microtubule-associated protein 1B -0.0295004
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0294788
RPL31 ribosomal protein L31 -0.0293253
RPL12 ribosomal protein L12 -0.0286596
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.028135
RPS12 ribosomal protein S12 -0.027171
HLA-B major histocompatibility complex, class I, B -0.0270039
ASNS asparagine synthetase (glutamine-hydrolyzing) -0.0268256
RPS16 ribosomal protein S16 -0.0258096
H3-3B H3.3 histone B -0.0255002
RPS13 ribosomal protein S13 -0.0247456
SEPTIN7 septin 7 -0.024695
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0246096
VCL vinculin -0.0245035
MT1X metallothionein 1X -0.0244149
RPS21 ribosomal protein S21 -0.0242894
NALF1 NALCN channel auxiliary factor 1 -0.0242124
RPLP0 ribosomal protein, large, P0 -0.0238778
RPL38 ribosomal protein L38 -0.0236123
KDELR2 KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 2 -0.023208
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0230402
GARS1 glycyl-tRNA synthetase 1 -0.0228532
SEC61G Sec61 gamma subunit -0.0227326
RPL36 ribosomal protein L36 -0.0222687
RPL5 ribosomal protein L5 -0.0219749
WSB1 WD repeat and SOCS box containing 1 -0.0219673
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0219307
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0212425
RPS11 ribosomal protein S11 -0.0211687
RPL26 ribosomal protein L26 -0.0209284
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0206531
RPL32 ribosomal protein L32 -0.0206066
S100A6 S100 calcium binding protein A6 -0.0200353
RPS5 ribosomal protein S5 -0.0200138
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0199255
TIMP1 TIMP metallopeptidase inhibitor 1 -0.019905
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0195419
MORF4L2 mortality factor 4 like 2 -0.0195024
GPHN gephyrin -0.0193767
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0193024
RPS14 ribosomal protein S14 -0.0192829
RAP1B RAP1B, member of RAS oncogene family -0.019176
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.019147
NAMPT nicotinamide phosphoribosyltransferase -0.0188175
NLGN1 neuroligin 1 -0.0186718
FBXO11 F-box protein 11 -0.018625
RPS20 ribosomal protein S20 -0.0185991
RPL36A ribosomal protein L36a -0.0184903
RAD21 RAD21 homolog (S. pombe) -0.0184228
PSMA2 proteasome (prosome, macropain) subunit, alpha type, 2 -0.0183824
CKAP4 cytoskeleton-associated protein 4 -0.01838
MKI67 marker of proliferation Ki-67 -0.018349
RRBP1 ribosome binding protein 1 -0.0183267
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0183151
RAB7A RAB7A, member RAS oncogene family -0.0180501
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0179316
IER3 immediate early response 3 -0.0178306
NCOA7 nuclear receptor coactivator 7 -0.0178066
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0177787
PALLD palladin, cytoskeletal associated protein -0.0177279
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0177132
PHIP pleckstrin homology domain interacting protein -0.017295