Phenytoin (sodium)_HEC-1-A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in HEC-1-A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_HEC-1-A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PLEC plectin 0.073813
SMAD3 SMAD family member 3 0.0590137
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0583307
FNDC3B fibronectin type III domain containing 3B 0.0573835
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.053021
FLNA filamin A, alpha 0.052861
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0526908
MYH9 myosin, heavy chain 9, non-muscle 0.0508836
ANKRD11 ankyrin repeat domain 11 0.049737
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0466625
ANKRD10 ankyrin repeat domain 10 0.045636
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.045431
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0452958
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0432213
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 0.0411682
ZFAND3 zinc finger, AN1-type domain 3 0.0384938
MPRIP myosin phosphatase Rho interacting protein 0.0379615
ACTN4 actinin, alpha 4 0.0379426
IARS1 isoleucyl-tRNA synthetase 1 0.0372745
KDM6A lysine (K)-specific demethylase 6A 0.0371135
AFDN afadin, adherens junction formation factor 0.036757
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0365758
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0358867
APP amyloid beta (A4) precursor protein 0.0357728
CTBP2 C-terminal binding protein 2 0.035246
VCL vinculin 0.0352077
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0332791
EIF4H eukaryotic translation initiation factor 4H 0.0331564
WWC1 WW and C2 domain containing 1 0.0328204
PRRC2B proline-rich coiled-coil 2B 0.0327326
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0315912
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0312669
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0296378
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.02956
WDR43 WD repeat domain 43 0.0291195
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.028588
SEPTIN9 septin 9 0.0285269
DSCAML1 Down syndrome cell adhesion molecule like 1 0.0279056
RPL3 ribosomal protein L3 0.0277191
TRIM2 tripartite motif containing 2 0.0274031
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked 0.0271949
PTK2 protein tyrosine kinase 2 0.0271217
ANKRD17 ankyrin repeat domain 17 0.0267778
EWSR1 EWS RNA-binding protein 1 0.0266307
ZNF644 zinc finger protein 644 0.0260299
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0254944
ANXA11 annexin A11 0.0253343
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0251085
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0250801
TNFAIP2 tumor necrosis factor, alpha-induced protein 2 0.0244584
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0239553
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0238055
SRSF1 serine/arginine-rich splicing factor 1 0.0236725
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0236512
PSD3 pleckstrin and Sec7 domain containing 3 0.0236283
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0235473
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 0.0235453
ZSWIM6 zinc finger, SWIM-type containing 6 0.0233423
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0231664
RANBP2 RAN binding protein 2 0.0231301
MACF1 microtubule-actin crosslinking factor 1 0.0229418
ACACA acetyl-CoA carboxylase alpha 0.0228922
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0228693
TJP1 tight junction protein 1 0.0227321
ANKRD36 ankyrin repeat domain 36 0.0225014
FXR1 fragile X mental retardation, autosomal homolog 1 0.0224222
MTMR3 myotubularin related protein 3 0.0224052
WWTR1 WW domain containing transcription regulator 1 0.0222431
LRRFIP2 leucine rich repeat (in FLII) interacting protein 2 0.0220291
CSNK1A1 casein kinase 1, alpha 1 0.0219541
YAP1 Yes-associated protein 1 0.0219523
GLS2 glutaminase 2 (liver, mitochondrial) 0.0217155
PLCB4 phospholipase C, beta 4 0.0216339
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0214942
NCOR2 nuclear receptor corepressor 2 0.0214828
GPR39 G protein-coupled receptor 39 0.0214237
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0213911
DOCK1 dedicator of cytokinesis 1 0.0212483
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0211929
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0211777
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0211537
SVIL supervillin 0.0209189
OSBPL10 oxysterol binding protein-like 10 0.0205638
CUL3 cullin 3 0.0204404
CLIP2 CAP-GLY domain containing linker protein 2 0.0204162
EHMT1 euchromatic histone-lysine N-methyltransferase 1 0.0203596
STC2 stanniocalcin 2 0.0203285
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0201653
LARP4B La ribonucleoprotein domain family, member 4B 0.0201421
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0200581
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0200556
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 0.0198946
SFPQ splicing factor proline/glutamine-rich 0.019829
ESRP1 epithelial splicing regulatory protein 1 0.0198271
BHLHE40 basic helix-loop-helix family, member e40 0.0197077
MYO5B myosin VB 0.0196328
NCKAP1 NCK-associated protein 1 0.019456
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0194452
TBC1D22A TBC1 domain family, member 22A 0.0192932
PUM1 pumilio RNA-binding family member 1 0.0192765

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.222797
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.178234
FTL ferritin, light polypeptide -0.146266
ACTG1 actin gamma 1 -0.111825
B2M beta-2-microglobulin -0.0970448
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0899718
RPS19 ribosomal protein S19 -0.0876074
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0858008
TMSB10 thymosin beta 10 -0.0805365
RPS6 ribosomal protein S6 -0.0731278
PTMA prothymosin, alpha -0.0728356
RPL12 ribosomal protein L12 -0.0703014
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.06819
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0674505
RPL35A ribosomal protein L35a -0.065209
ENO1 enolase 1, (alpha) -0.0632619
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0605511
RPS8 ribosomal protein S8 -0.0601976
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0577074
RPL19 ribosomal protein L19 -0.0576805
RPL32 ribosomal protein L32 -0.0545766
MT1X metallothionein 1X -0.0545365
RPLP1 ribosomal protein, large, P1 -0.0539743
RPL35 ribosomal protein L35 -0.0533084
S100A9 S100 calcium binding protein A9 -0.0522916
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0521846
TPI1 triosephosphate isomerase 1 -0.0495657
CBX3 chromobox homolog 3 -0.0480315
RPL23 ribosomal protein L23 -0.0478747
EGR1 early growth response 1 -0.0464147
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0455311
RPLP0 ribosomal protein, large, P0 -0.0449345
RPS12 ribosomal protein S12 -0.0447785
S100A6 S100 calcium binding protein A6 -0.0444821
RPL18 ribosomal protein L18 -0.0440578
PGK1 phosphoglycerate kinase 1 -0.0423177
SEPTIN7 septin 7 -0.0416794
LDHA lactate dehydrogenase A -0.0410967
NDRG1 N-myc downstream regulated 1 -0.0397745
SMC4 structural maintenance of chromosomes 4 -0.0396548
KTN1 kinectin 1 (kinesin receptor) -0.0394152
POTEF POTE ankyrin domain family, member F -0.0394094
CDCP1 CUB domain containing protein 1 -0.0390964
TPM4 tropomyosin 4 -0.0390468
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0387114
PKM pyruvate kinase, muscle -0.03869
HMGA1 high mobility group AT-hook 1 -0.0377009
BPTF bromodomain PHD finger transcription factor -0.0359547
S100A10 S100 calcium binding protein A10 -0.035617
GSTP1 glutathione S-transferase pi 1 -0.0351464
YBX1 Y box binding protein 1 -0.0349686
GNAS GNAS complex locus -0.0349578
RPL36 ribosomal protein L36 -0.0345308
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0339696
RPL34 ribosomal protein L34 -0.0335696
RPS3 ribosomal protein S3 -0.0330836
PFN1 profilin 1 -0.0324879
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0319108
RPS14 ribosomal protein S14 -0.0315836
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0311551
TUBA1B tubulin, alpha 1b -0.0305311
RPL9 ribosomal protein L9 -0.0304896
RPS27 ribosomal protein S27 -0.0304743
RPLP2 ribosomal protein, large, P2 -0.0304585
AXL AXL receptor tyrosine kinase -0.0302428
RPL31 ribosomal protein L31 -0.0301133
WASF2 WAS protein family, member 2 -0.0297714
ANLN anillin, actin binding protein -0.0297319
FOSL1 FOS-like antigen 1 -0.0294463
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0292241
RPL11 ribosomal protein L11 -0.0288943
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0286087
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0284675
CCND1 cyclin D1 -0.0284391
RPL26 ribosomal protein L26 -0.0284341
RPS5 ribosomal protein S5 -0.0280679
CCNI cyclin I -0.0279193
LMAN1 lectin, mannose-binding, 1 -0.0278986
DARS1 aspartyl-tRNA synthetase 1 -0.0275694
RACK1 receptor for activated C kinase 1 -0.0275142
DSG2 desmoglein 2 -0.0264845
MYL12B myosin, light chain 12B, regulatory -0.0263662
PERP PERP, TP53 apoptosis effector -0.0262136
MKI67 marker of proliferation Ki-67 -0.0261816
TPT1 tumor protein, translationally-controlled 1 -0.0258396
EIF5B eukaryotic translation initiation factor 5B -0.0257699
MYADM myeloid-associated differentiation marker -0.025325
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0252682
RPL8 ribosomal protein L8 -0.0251259
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0249235
APLP2 amyloid beta (A4) precursor-like protein 2 -0.0245891
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.024409
ANKRD12 ankyrin repeat domain 12 -0.0241287
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.024025
BBX bobby sox homolog (Drosophila) -0.0239423
MIS18BP1 MIS18 binding protein 1 -0.0238173
TUBB4B tubulin, beta 4B class IVb -0.0237437
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0236517
IRS2 insulin receptor substrate 2 -0.0235394
NKTR natural killer cell triggering receptor -0.0235234