Phenytoin (sodium)_HOP62 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in HOP62 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_HOP62 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.147132
NDRG1 N-myc downstream regulated 1 0.139591
TRIO trio Rho guanine nucleotide exchange factor 0.120527
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.120224
PLEC plectin 0.102963
FN1 fibronectin 1 0.0798373
SEPTIN9 septin 9 0.0698731
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0691706
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.068812
COL6A3 collagen, type VI, alpha 3 0.0655072
MYH9 myosin, heavy chain 9, non-muscle 0.0611923
COL6A1 collagen, type VI, alpha 1 0.0604385
COL5A1 collagen, type V, alpha 1 0.0595515
FNDC3B fibronectin type III domain containing 3B 0.0594502
LOC112694756 uncharaterized LOC112694756 0.05853
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0583924
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0548553
FAM13A family with sequence similarity 13, member A 0.0534506
HPCAL1 hippocalcin-like 1 0.0504934
JARID2 jumonji, AT rich interactive domain 2 0.0478706
SHB Src homology 2 domain containing adaptor protein B 0.047485
PRELID2 PRELI domain containing 2 0.0471362
GRB10 growth factor receptor-bound protein 10 0.0464364
CDCP1 CUB domain containing protein 1 0.0462623
MPRIP myosin phosphatase Rho interacting protein 0.0452306
SMAD3 SMAD family member 3 0.0441717
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0441396
FLNA filamin A, alpha 0.0440396
TNS1 tensin 1 0.0435094
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0414382
CD109 CD109 molecule 0.0412324
CDH13 cadherin 13 0.039548
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0382407
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0355443
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0350501
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.034161
RFX8 RFX family member 8, lacking RFX DNA binding domain 0.0338792
NAV1 neuron navigator 1 0.0335081
ZMIZ1 zinc finger, MIZ-type containing 1 0.033491
MYO10 myosin X 0.032166
GLIS3 GLIS family zinc finger 3 0.0321255
ERRFI1 ERBB receptor feedback inhibitor 1 0.0320732
RASA3 RAS p21 protein activator 3 0.0317541
EFNA5 ephrin-A5 0.0315041
PDE10A phosphodiesterase 10A 0.0310946
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0305748
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0301379
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0295654
FLNB filamin B, beta 0.0292147
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0291276
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.028678
PCBP3 poly(rC) binding protein 3 0.0278982
ANXA2 annexin A2 0.0275969
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0273322
MSN moesin 0.0272437
NAV2 neuron navigator 2 0.027221
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0270835
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0268111
AMPD3 adenosine monophosphate deaminase 3 0.0258539
COL7A1 collagen, type VII, alpha 1 0.025841
TAC4 tachykinin 4 (hemokinin) 0.0257917
RUNX1 runt-related transcription factor 1 0.0255422
MCL1 myeloid cell leukemia 1 0.025244
DTNA dystrobrevin, alpha 0.0251968
VEGFA vascular endothelial growth factor A 0.0250768
COL6A2 collagen, type VI, alpha 2 0.0250176
TNIP1 TNFAIP3 interacting protein 1 0.0249643
NALF1 NALCN channel auxiliary factor 1 0.0249132
CHSY1 chondroitin sulfate synthase 1 0.0246601
PTK2 protein tyrosine kinase 2 0.024294
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0242232
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0239569
IGF1R insulin-like growth factor 1 receptor 0.02386
MLPH melanophilin 0.0231476
SDK1 sidekick cell adhesion molecule 1 0.0229982
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0229934
CAPN2 calpain 2, (m/II) large subunit 0.0224506
YEATS2 YEATS domain containing 2 0.0219778
ELL2 elongation factor, RNA polymerase II, 2 0.0218944
HOOK2 hook microtubule-tethering protein 2 0.0218239
LOXL2 lysyl oxidase-like 2 0.0217949
PPARD peroxisome proliferator-activated receptor delta 0.0217741
HSPA8 heat shock 70kDa protein 8 0.0216873
NGLY1 N-glycanase 1 0.0212211
MIDEAS mitotic deacetylase associated SANT domain protein 0.0209969
PRRC2A proline-rich coiled-coil 2A 0.0209302
SP3 Sp3 transcription factor 0.0209021
CLTC clathrin, heavy chain (Hc) 0.0208759
CD44 CD44 molecule (Indian blood group) 0.0207944
IQGAP3 IQ motif containing GTPase activating protein 3 0.0207561
ACTN1 actinin, alpha 1 0.0204556
SAMD4A sterile alpha motif domain containing 4A 0.0202325
NIBAN2 niban apoptosis regulator 2 0.0201529
RPL3 ribosomal protein L3 0.0201423
CAMTA1 calmodulin binding transcription activator 1 0.0200844
PFKP phosphofructokinase, platelet 0.0199509
DOT1L DOT1-like histone H3K79 methyltransferase 0.0196644
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0196216
FAM219A family with sequence similarity 219, member A 0.0194912
CAPRIN2 caprin family member 2 0.0191451

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.461552
VIM vimentin -0.246025
TMSB10 thymosin beta 10 -0.141269
PTMA prothymosin, alpha -0.133233
MT2A metallothionein 2A -0.0902245
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0879613
FTL ferritin, light polypeptide -0.0651991
IGF2 insulin-like growth factor 2 -0.0556983
TPT1 tumor protein, translationally-controlled 1 -0.0531511
RPS6 ribosomal protein S6 -0.0531343
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0514865
RPLP1 ribosomal protein, large, P1 -0.0461059
IER3 immediate early response 3 -0.0433335
RPL35A ribosomal protein L35a -0.041165
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0407357
RPS19 ribosomal protein S19 -0.0354381
RPL12 ribosomal protein L12 -0.0336471
RPS8 ribosomal protein S8 -0.0324757
RPL23 ribosomal protein L23 -0.0317726
S100A10 S100 calcium binding protein A10 -0.0307754
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0300199
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0294649
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.029049
JUN jun proto-oncogene -0.0287791
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0286854
EIF1 eukaryotic translation initiation factor 1 -0.0283289
RPLP2 ribosomal protein, large, P2 -0.0282327
RPL8 ribosomal protein L8 -0.028053
RPL34 ribosomal protein L34 -0.0274631
EGR1 early growth response 1 -0.0273591
RPS24 ribosomal protein S24 -0.026677
MAP1B microtubule-associated protein 1B -0.0253949
GNAS GNAS complex locus -0.0253733
LOC102724023 ES1 protein homolog, mitochondrial -0.0250145
DUSP6 dual specificity phosphatase 6 -0.0247379
RPS13 ribosomal protein S13 -0.0241261
LGALS1 lectin, galactoside-binding, soluble, 1 -0.024123
RPL28 ribosomal protein L28 -0.0238261
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0237562
RPS14 ribosomal protein S14 -0.0235689
UBC ubiquitin C -0.0231081
WSB1 WD repeat and SOCS box containing 1 -0.0229748
WASF2 WAS protein family, member 2 -0.0228936
ACTG1 actin gamma 1 -0.0228383
B2M beta-2-microglobulin -0.0223311
ASTN2 astrotactin 2 -0.0222922
RPS27A ribosomal protein S27a -0.0221999
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0220157
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0218096
RLF rearranged L-myc fusion -0.021108
RPL36A ribosomal protein L36a -0.0210155
RPL19 ribosomal protein L19 -0.0204373
RPS16 ribosomal protein S16 -0.0201573
RPL32 ribosomal protein L32 -0.0200579
RPL5 ribosomal protein L5 -0.020041
MT1X metallothionein 1X -0.0199174
PLAUR plasminogen activator, urokinase receptor -0.0196174
MTDH metadherin -0.0196032
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0195188
STC1 stanniocalcin 1 -0.0190588
S100A9 S100 calcium binding protein A9 -0.0189594
CAVIN1 caveolae associated protein 1 -0.0187553
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0186361
RPL31 ribosomal protein L31 -0.0182825
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0182499
NAP1L1 nucleosome assembly protein 1-like 1 -0.0180695
CCNI cyclin I -0.0179863
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0179821
UGCG UDP-glucose ceramide glucosyltransferase -0.0176508
RPL9 ribosomal protein L9 -0.0176122
MORF4L2 mortality factor 4 like 2 -0.0171016
ADM adrenomedullin -0.0168722
S100A6 S100 calcium binding protein A6 -0.0167364
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.016701
RPS20 ribosomal protein S20 -0.0164151
G0S2 G0/G1 switch 2 -0.0160605
BTG1 B-cell translocation gene 1, anti-proliferative -0.015932
RPS12 ribosomal protein S12 -0.0159172
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0156637
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.015489
RPL7A ribosomal protein L7a -0.0154135
TXNIP thioredoxin interacting protein -0.0152109
TGFB1 transforming growth factor, beta 1 -0.0150782
PGK1 phosphoglycerate kinase 1 -0.0150602
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 -0.0149671
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0149625
RPL35 ribosomal protein L35 -0.0149207
YBX3 Y box binding protein 3 -0.0147592
RPS11 ribosomal protein S11 -0.0147407
UQCRB ubiquinol-cytochrome c reductase binding protein -0.014567
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0145269
TMEM263 transmembrane protein 263 -0.014475
TMSB4X thymosin beta 4, X-linked -0.014459
RPL26 ribosomal protein L26 -0.0143212
PDIA3 protein disulfide isomerase family A, member 3 -0.0142573
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0141226
RPS23 ribosomal protein S23 -0.0140847
RPLP0 ribosomal protein, large, P0 -0.0139036
TXNRD1 thioredoxin reductase 1 -0.0136004
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.01349