Phenytoin (sodium)_HS-578T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in HS-578T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FN1 fibronectin 1 0.22469
NDRG1 N-myc downstream regulated 1 0.124806
MYH9 myosin, heavy chain 9, non-muscle 0.117806
TRIO trio Rho guanine nucleotide exchange factor 0.102694
PLEC plectin 0.0964834
FNDC3B fibronectin type III domain containing 3B 0.0899158
COL6A3 collagen, type VI, alpha 3 0.0887744
VEGFA vascular endothelial growth factor A 0.0817428
CXCL8 chemokine (C-X-C motif) ligand 8 0.0809264
CD44 CD44 molecule (Indian blood group) 0.0708854
SMAD3 SMAD family member 3 0.0703867
ATP13A3 ATPase type 13A3 0.0694399
SLC39A14 solute carrier family 39 (zinc transporter), member 14 0.0688883
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.056147
FTH1 ferritin, heavy polypeptide 1 0.0504137
TNIP1 TNFAIP3 interacting protein 1 0.0503981
FAT1 FAT atypical cadherin 1 0.0498051
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0489544
FLNA filamin A, alpha 0.0471066
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0454941
ARRDC3 arrestin domain containing 3 0.0446584
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0445383
SHB Src homology 2 domain containing adaptor protein B 0.0416266
DPYSL3 dihydropyrimidinase-like 3 0.0391631
EEF2 eukaryotic translation elongation factor 2 0.039128
CAMTA1 calmodulin binding transcription activator 1 0.0387284
LOXL2 lysyl oxidase-like 2 0.0372765
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0371067
SOD2 superoxide dismutase 2, mitochondrial 0.036773
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0353258
CADM1 cell adhesion molecule 1 0.0345326
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0328876
ELL2 elongation factor, RNA polymerase II, 2 0.0320954
LOC112694756 uncharaterized LOC112694756 0.0320624
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0306147
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0304397
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0301255
SPAG9 sperm associated antigen 9 0.0292411
ICAM1 intercellular adhesion molecule 1 0.0286452
ZMIZ1 zinc finger, MIZ-type containing 1 0.0285842
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0284175
RPL3 ribosomal protein L3 0.0280538
HIPK2 homeodomain interacting protein kinase 2 0.0278265
PTK2 protein tyrosine kinase 2 0.0275139
BHLHE40 basic helix-loop-helix family, member e40 0.0272654
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0269798
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0267256
ADAM17 ADAM metallopeptidase domain 17 0.0264059
TFG TRK-fused gene 0.0261527
NAV2 neuron navigator 2 0.0260762
HSPA8 heat shock 70kDa protein 8 0.025813
EGFR epidermal growth factor receptor 0.0253671
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0252267
NAMPT nicotinamide phosphoribosyltransferase 0.0247566
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0246007
SEPTIN9 septin 9 0.024175
NOTCH2 notch 2 0.0241176
PDE10A phosphodiesterase 10A 0.023576
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0233647
MTSS1 metastasis suppressor 1 0.0230495
RASA2 RAS p21 protein activator 2 0.022952
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0229283
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.0229107
EIF4H eukaryotic translation initiation factor 4H 0.0227985
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.022462
IL6 interleukin 6 0.0223857
TNS1 tensin 1 0.0222867
ACTN4 actinin, alpha 4 0.0220214
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0214499
SFPQ splicing factor proline/glutamine-rich 0.0212813
UBA6 ubiquitin-like modifier activating enzyme 6 0.0207879
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0202035
KMT2E lysine (K)-specific methyltransferase 2E 0.0198928
GRB10 growth factor receptor-bound protein 10 0.019696
GOLGA4 golgin A4 0.0196062
CABIN1 calcineurin binding protein 1 0.0194001
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0192168
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 0.0189826
PPP3CC protein phosphatase 3, catalytic subunit, gamma isozyme 0.0189597
CCNL1 cyclin L1 0.0189005
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0188618
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0187993
ADAM9 ADAM metallopeptidase domain 9 0.0187225
CSF1 colony stimulating factor 1 (macrophage) 0.0186009
HOOK2 hook microtubule-tethering protein 2 0.0182692
OPTN optineurin 0.0182162
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0181909
ATP2C1 ATPase, Ca++ transporting, type 2C, member 1 0.0181687
XPO1 exportin 1 0.0181656
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0180494
ELOVL5 ELOVL fatty acid elongase 5 0.0179856
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.017849
PCBP2 poly(rC) binding protein 2 0.0178013
CNOT12 CCR4-NOT transcription complex subunit 12 0.0176721
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0174358
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0174218
ITPR3 inositol 1,4,5-trisphosphate receptor, type 3 0.0173596
ERRFI1 ERBB receptor feedback inhibitor 1 0.0171906
RARB retinoic acid receptor, beta 0.017161
ANKRD11 ankyrin repeat domain 11 0.0170408

decreased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 -0.221167
VIM vimentin -0.194633
TIMP3 TIMP metallopeptidase inhibitor 3 -0.166443
COL1A1 collagen, type I, alpha 1 -0.14592
TMSB10 thymosin beta 10 -0.119706
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.116985
MT2A metallothionein 2A -0.106256
COL1A2 collagen, type I, alpha 2 -0.104931
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0957492
PTMA prothymosin, alpha -0.0846102
PSD3 pleckstrin and Sec7 domain containing 3 -0.0815418
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0782413
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0712366
FTL ferritin, light polypeptide -0.0679121
NKAIN3 Na+/K+ transporting ATPase interacting 3 -0.0665755
ZBTB20 zinc finger and BTB domain containing 20 -0.0615476
FBN1 fibrillin 1 -0.0545799
LOX lysyl oxidase -0.0537957
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.052824
CANX calnexin -0.0517688
TPM4 tropomyosin 4 -0.0510176
TGFBI transforming growth factor, beta-induced, 68kDa -0.0485891
ENO1 enolase 1, (alpha) -0.0461449
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0459115
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0449407
VCAN versican -0.0431816
TRPS1 trichorhinophalangeal syndrome I -0.0426353
HMGA2 high mobility group AT-hook 2 -0.0421278
ASPH aspartate beta-hydroxylase -0.0410981
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0403577
RPL35A ribosomal protein L35a -0.0398873
STC1 stanniocalcin 1 -0.0395402
DPYD dihydropyrimidine dehydrogenase -0.0391318
HLA-B major histocompatibility complex, class I, B -0.0378655
RPS8 ribosomal protein S8 -0.0369245
EGR1 early growth response 1 -0.0368686
ACTG1 actin gamma 1 -0.0366153
B2M beta-2-microglobulin -0.0352786
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.033708
CAVIN1 caveolae associated protein 1 -0.0328617
IER3 immediate early response 3 -0.0328452
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0314672
MAP1B microtubule-associated protein 1B -0.0313087
S100A6 S100 calcium binding protein A6 -0.0312934
S100A9 S100 calcium binding protein A9 -0.0311297
COL3A1 collagen, type III, alpha 1 -0.0309661
LMAN1 lectin, mannose-binding, 1 -0.030909
CLMP CXADR-like membrane protein -0.0303255
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0299938
ABI3BP ABI family, member 3 (NESH) binding protein -0.0293648
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0289377
TM4SF1 transmembrane 4 L six family member 1 -0.0286063
RRBP1 ribosome binding protein 1 -0.0284602
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.027904
SLC38A2 solute carrier family 38, member 2 -0.0277294
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.026514
LTBP1 latent transforming growth factor beta binding protein 1 -0.0264212
CALD1 caldesmon 1 -0.0261091
TPT1 tumor protein, translationally-controlled 1 -0.0260141
RPS19 ribosomal protein S19 -0.0253489
PDE4D phosphodiesterase 4D, cAMP-specific -0.0253307
EIF1 eukaryotic translation initiation factor 1 -0.0249238
PGK1 phosphoglycerate kinase 1 -0.0247928
RPL23 ribosomal protein L23 -0.024791
MTDH metadherin -0.0247622
IFITM3 interferon induced transmembrane protein 3 -0.0243991
OXR1 oxidation resistance 1 -0.0237671
ZFPM2 zinc finger protein, FOG family member 2 -0.0236786
IFI6 interferon, alpha-inducible protein 6 -0.0236636
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0233934
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0229014
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 -0.0227585
CNTN5 contactin 5 -0.0226489
RPL12 ribosomal protein L12 -0.0221081
DST dystonin -0.0220462
S100A10 S100 calcium binding protein A10 -0.021876
RPL19 ribosomal protein L19 -0.0215866
GLIS3 GLIS family zinc finger 3 -0.0214816
RPL34 ribosomal protein L34 -0.0213871
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0213298
CST3 cystatin C -0.0213012
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0209965
CHD9 chromodomain helicase DNA binding protein 9 -0.0208765
NEK10 NIMA-related kinase 10 -0.0208091
H1-0 H1.0 linker histone -0.0206294
RPS6 ribosomal protein S6 -0.0205978
SORBS2 sorbin and SH3 domain containing 2 -0.0205776
SPDYA speedy/RINGO cell cycle regulator family member A -0.0203495
IGFBP7 insulin-like growth factor binding protein 7 -0.0198837
SOX4 SRY (sex determining region Y)-box 4 -0.0198361
PRELID2 PRELI domain containing 2 -0.0197971
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0195717
MYO9A myosin IXA -0.0195073
MBNL1 muscleblind-like splicing regulator 1 -0.0193189
JUN jun proto-oncogene -0.0192961
LAMB3 laminin, beta 3 -0.0192072
WASF2 WAS protein family, member 2 -0.0189265
FAM162A family with sequence similarity 162, member A -0.0187851
TTC3 tetratricopeptide repeat domain 3 -0.0182987
EBF1 early B-cell factor 1 -0.0182801