| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Phenytoin (sodium) perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Phenytoin (sodium)_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.242293 |
| FN1 | fibronectin 1 | 0.195957 |
| APOB | apolipoprotein B | 0.165817 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.142798 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | 0.132703 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.121161 |
| C3 | complement component 3 | 0.120499 |
| FNDC3B | fibronectin type III domain containing 3B | 0.114073 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.108974 |
| LRMDA | leucine rich melanocyte differentiation associated | 0.107996 |
| A2M | alpha-2-macroglobulin | 0.107232 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.10077 |
| RPL11 | ribosomal protein L11 | 0.100382 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0881404 |
| GPC3 | glypican 3 | 0.0743413 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | 0.0674157 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0671309 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0671223 |
| EPAS1 | endothelial PAS domain protein 1 | 0.0655579 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0645932 |
| AFDN | afadin, adherens junction formation factor | 0.0645139 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0629394 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0603515 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0594568 |
| NEDD9 | neural precursor cell expressed, developmentally down-regulated 9 | 0.0576002 |
| RPS12 | ribosomal protein S12 | 0.0562555 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0560733 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0559221 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0546422 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0545547 |
| PEG3 | paternally expressed 3 | 0.0524646 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | 0.052255 |
| DSPP | dentin sialophosphoprotein | 0.0494115 |
| MATR3 | matrin 3 | 0.0493173 |
| CFB | complement factor B | 0.0489372 |
| SDC4 | syndecan 4 | 0.048697 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0474785 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0461568 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0460004 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0459508 |
| TF | transferrin | 0.045697 |
| IQSEC1 | IQ motif and Sec7 domain 1 | 0.0450222 |
| ENO1 | enolase 1, (alpha) | 0.0449357 |
| VPS54 | vacuolar protein sorting 54 homolog (S. cerevisiae) | 0.0448876 |
| SMAD3 | SMAD family member 3 | 0.0444037 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0442894 |
| SORL1 | sortilin-related receptor, L(DLR class) A repeats containing | 0.0441808 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0437823 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0432881 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0430172 |
| RPL3 | ribosomal protein L3 | 0.0418806 |
| RPL13A | ribosomal protein L13a | 0.0412395 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0408546 |
| RACK1 | receptor for activated C kinase 1 | 0.0405542 |
| TNS1 | tensin 1 | 0.0391246 |
| PTP4A1 | protein tyrosine phosphatase type IVA, member 1 | 0.0385454 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0377262 |
| RELL1 | RELT-like 1 | 0.0376506 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0372931 |
| MSI2 | musashi RNA-binding protein 2 | 0.0369543 |
| CEMIP2 | cell migration inducing hyaluronidase 2 | 0.0366968 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0366886 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.036536 |
| DOCK4 | dedicator of cytokinesis 4 | 0.0364985 |
| PARD3 | par-3 family cell polarity regulator | 0.0362241 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0356208 |
| ABAT | 4-aminobutyrate aminotransferase | 0.0355158 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0354922 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0354497 |
| RPL37 | ribosomal protein L37 | 0.0352773 |
| RNF213 | ring finger protein 213 | 0.0352528 |
| PCBP2 | poly(rC) binding protein 2 | 0.0350795 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0349693 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0349334 |
| RPS8 | ribosomal protein S8 | 0.0345009 |
| FAT1 | FAT atypical cadherin 1 | 0.0344851 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0333624 |
| TBC1D22A | TBC1 domain family, member 22A | 0.032793 |
| ACSL5 | acyl-CoA synthetase long-chain family member 5 | 0.0325721 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0325437 |
| RPL5 | ribosomal protein L5 | 0.0323882 |
| WDR45B | WD repeat domain 45B | 0.0321866 |
| RPL37A | ribosomal protein L37a | 0.031865 |
| AHSG | alpha-2-HS-glycoprotein | 0.0317283 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0316686 |
| CMIP | c-Maf inducing protein | 0.0315554 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0315042 |
| RPL34 | ribosomal protein L34 | 0.0313294 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0312097 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.0311884 |
| ANO6 | anoctamin 6 | 0.0310062 |
| PDE8A | phosphodiesterase 8A | 0.0309794 |
| RPL10A | ribosomal protein L10a | 0.0308782 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0306458 |
| RPS27A | ribosomal protein S27a | 0.0302225 |
| RPS29 | ribosomal protein S29 | 0.029998 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0298982 |
| NCKAP1 | NCK-associated protein 1 | 0.0298669 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0297716 |
| DHRS2 | dehydrogenase/reductase (SDR family) member 2 | 0.0294504 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGF2 | insulin-like growth factor 2 | -0.259782 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.0694317 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.055688 |
| VCL | vinculin | -0.0524978 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.050468 |
| ITGAV | integrin, alpha V | -0.0441207 |
| GPC6 | glypican 6 | -0.0374984 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0292511 |
| STK17A | serine/threonine kinase 17a | -0.0272653 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0270851 |
| ASPH | aspartate beta-hydroxylase | -0.0268318 |
| TMEM123 | transmembrane protein 123 | -0.0265152 |
| CP | ceruloplasmin (ferroxidase) | -0.0239902 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | -0.0238355 |
| ANXA3 | annexin A3 | -0.0233609 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.0224242 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0224186 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0220055 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0219607 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0199559 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | -0.0196628 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0190004 |
| EGR1 | early growth response 1 | -0.018797 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0185288 |
| PTCHD4 | patched domain containing 4 | -0.0182845 |
| LMCD1 | LIM and cysteine-rich domains 1 | -0.0181768 |
| ATF6 | activating transcription factor 6 | -0.0181094 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | -0.0180942 |
| PCNX4 | pecanex 4 | -0.0176839 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.017496 |
| NABP1 | nucleic acid binding protein 1 | -0.0174438 |
| TMSB10 | thymosin beta 10 | -0.0168298 |
| CAMK2N1 | calcium/calmodulin-dependent protein kinase II inhibitor 1 | -0.0163529 |
| WWC2 | WW and C2 domain containing 2 | -0.0158782 |
| PALLD | palladin, cytoskeletal associated protein | -0.0158647 |
| RAB10 | RAB10, member RAS oncogene family | -0.0156192 |
| NEK7 | NIMA-related kinase 7 | -0.0155097 |
| APOA2 | apolipoprotein A-II | -0.0155005 |
| THBS1 | thrombospondin 1 | -0.0154731 |
| BPTF | bromodomain PHD finger transcription factor | -0.0153294 |
| ADIPOR2 | adiponectin receptor 2 | -0.0152738 |
| INTS6 | integrator complex subunit 6 | -0.0150192 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | -0.0146267 |
| PPP1CC | protein phosphatase 1, catalytic subunit, gamma isozyme | -0.0145922 |
| SERTAD2 | SERTA domain containing 2 | -0.014545 |
| PTMA | prothymosin, alpha | -0.0145004 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0144695 |
| BCL2L1 | BCL2-like 1 | -0.0143671 |
| KALRN | kalirin, RhoGEF kinase | -0.0143502 |
| SHOC2 | soc-2 suppressor of clear homolog (C. elegans) | -0.0143474 |
| INSR | insulin receptor | -0.0143126 |
| PERP | PERP, TP53 apoptosis effector | -0.0141018 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | -0.0140466 |
| ASXL1 | additional sex combs like transcriptional regulator 1 | -0.0139237 |
| MAP4 | microtubule-associated protein 4 | -0.0137296 |
| MAP2K4 | mitogen-activated protein kinase kinase 4 | -0.01371 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0135752 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.013519 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0133626 |
| CSTB | cystatin B (stefin B) | -0.0133557 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0132652 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0132643 |
| MYO1E | myosin IE | -0.0132028 |
| ZFYVE16 | zinc finger, FYVE domain containing 16 | -0.0130764 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0128834 |
| RASAL2 | RAS protein activator like 2 | -0.0128553 |
| UBXN4 | UBX domain protein 4 | -0.0128247 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0127341 |
| ABHD3 | abhydrolase domain containing 3 | -0.0126983 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0126126 |
| RSBN1L | round spermatid basic protein 1-like | -0.0125843 |
| MYO6 | myosin VI | -0.0125521 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0124831 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0122795 |
| DAAM1 | dishevelled associated activator of morphogenesis 1 | -0.0121416 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | -0.0121216 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0120893 |
| CD109 | CD109 molecule | -0.0120672 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | -0.011982 |
| HNMT | histamine N-methyltransferase | -0.011913 |
| VIM | vimentin | -0.0119116 |
| AFF1 | AF4/FMR2 family, member 1 | -0.0118924 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0117822 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0117663 |
| SKAP2 | src kinase associated phosphoprotein 2 | -0.0117489 |
| YARS1 | tyrosyl-tRNA synthetase 1 | -0.0117485 |
| AGO3 | argonaute RISC catalytic component 3 | -0.011735 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0115631 |
| RAB14 | RAB14, member RAS oncogene family | -0.011555 |
| TMEM87A | transmembrane protein 87A | -0.0114977 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0114598 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0113574 |
| VCAN | versican | -0.0113364 |
| MYSM1 | Myb-like, SWIRM and MPN domains 1 | -0.0113158 |
| PPP3CB | protein phosphatase 3, catalytic subunit, beta isozyme | -0.0112209 |
| OXR1 | oxidation resistance 1 | -0.0112038 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0111452 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0111148 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | -0.0110738 |
| ETNK1 | ethanolamine kinase 1 | -0.0110347 |
