Phenytoin (sodium)_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FLNB filamin B, beta 0.254087
PLEC plectin 0.162256
NDRG1 N-myc downstream regulated 1 0.155193
LOC112694756 uncharaterized LOC112694756 0.136628
TRIO trio Rho guanine nucleotide exchange factor 0.135068
KRT6A keratin 6A, type II 0.117753
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.115527
MEF2A myocyte enhancer factor 2A 0.102098
PODXL podocalyxin-like 0.09925
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0932281
ANXA2 annexin A2 0.0931362
FN1 fibronectin 1 0.0898482
MYH9 myosin, heavy chain 9, non-muscle 0.0876469
SULF1 sulfatase 1 0.0860794
MYOF myoferlin 0.080367
FLNA filamin A, alpha 0.0793515
CEMIP cell migration inducing protein, hyaluronan binding 0.0784212
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0730302
ENO1 enolase 1, (alpha) 0.0725545
TIMP3 TIMP metallopeptidase inhibitor 3 0.0717519
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0704241
KRT17 keratin 17, type I 0.0700207
TMSB4X thymosin beta 4, X-linked 0.0680397
AHNAK AHNAK nucleoprotein 0.0680122
EMP1 epithelial membrane protein 1 0.0653385
LDHA lactate dehydrogenase A 0.0652358
TPM3 tropomyosin 3 0.0602335
MYO10 myosin X 0.0597819
NAMPT nicotinamide phosphoribosyltransferase 0.0596089
HSPG2 heparan sulfate proteoglycan 2 0.0583992
KIAA1217 KIAA1217 0.0544463
STC1 stanniocalcin 1 0.0503638
NCOR2 nuclear receptor corepressor 2 0.0501284
ANKRD33B ankyrin repeat domain 33B 0.0499909
SMAD3 SMAD family member 3 0.0491751
LMNA lamin A/C 0.0491751
HLA-E major histocompatibility complex, class I, E 0.0487554
BLCAP bladder cancer associated protein 0.0476539
PGK1 phosphoglycerate kinase 1 0.0474137
SRRM2 serine/arginine repetitive matrix 2 0.0459684
AFAP1 actin filament associated protein 1 0.0458823
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0454796
HSPA8 heat shock 70kDa protein 8 0.0435153
CAV1 caveolin 1, caveolae protein, 22kDa 0.0434479
NAV2 neuron navigator 2 0.0422894
MCL1 myeloid cell leukemia 1 0.042143
EFHD2 EF-hand domain family, member D2 0.0417921
EIF4H eukaryotic translation initiation factor 4H 0.0416557
CD44 CD44 molecule (Indian blood group) 0.0415548
RIN2 Ras and Rab interactor 2 0.041387
TNIP1 TNFAIP3 interacting protein 1 0.0407977
BHLHE40 basic helix-loop-helix family, member e40 0.0405081
MTSS1 metastasis suppressor 1 0.0398084
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0397767
ZMIZ1 zinc finger, MIZ-type containing 1 0.0395072
MSN moesin 0.0393812
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0391342
PRELID2 PRELI domain containing 2 0.038882
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0375506
GRK5 G protein-coupled receptor kinase 5 0.03748
EEF2 eukaryotic translation elongation factor 2 0.0374712
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0372811
SQLE squalene epoxidase 0.037031
ARRDC3 arrestin domain containing 3 0.0368713
DOK5 docking protein 5 0.0366162
GRB10 growth factor receptor-bound protein 10 0.0359651
HLA-C major histocompatibility complex, class I, C 0.0359341
RACK1 receptor for activated C kinase 1 0.0358229
HDLBP high density lipoprotein binding protein 0.0358209
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0352601
DOCK9 dedicator of cytokinesis 9 0.0351506
LOXL2 lysyl oxidase-like 2 0.0350188
ITGA6 integrin, alpha 6 0.0349712
MACF1 microtubule-actin crosslinking factor 1 0.0349331
NRG1 neuregulin 1 0.0345301
CAPN2 calpain 2, (m/II) large subunit 0.0339901
WDFY1 WD repeat and FYVE domain containing 1 0.0338272
EHBP1L1 EH domain binding protein 1-like 1 0.0337804
RICTOR RPTOR independent companion of MTOR, complex 2 0.0337225
CUL4B cullin 4B 0.0335771
SQSTM1 sequestosome 1 0.0335136
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0333991
FOXO1 forkhead box O1 0.0331638
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 0.0328357
CSDE1 cold shock domain containing E1, RNA-binding 0.0326548
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0322783
DSTN destrin (actin depolymerizing factor) 0.0318739
TPM4 tropomyosin 4 0.0317915
DPYSL2 dihydropyrimidinase-like 2 0.0315764
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0314762
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0314118
FTH1 ferritin, heavy polypeptide 1 0.0312615
OGA O-GlcNAcase 0.0311241
CD59 CD59 molecule, complement regulatory protein 0.0309908
ESYT2 extended synaptotagmin-like protein 2 0.0308782
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0307363
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0306134
PRRC2C proline-rich coiled-coil 2C 0.030568
COL17A1 collagen, type XVII, alpha 1 0.0303453
CLU clusterin 0.0301995

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12225
MT2A metallothionein 2A -0.0939283
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0606353
INTS6 integrator complex subunit 6 -0.0564746
RPLP2 ribosomal protein, large, P2 -0.0463504
RPS6 ribosomal protein S6 -0.0444698
TMSB10 thymosin beta 10 -0.0419577
S100A10 S100 calcium binding protein A10 -0.0361234
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0351466
WASF2 WAS protein family, member 2 -0.0333401
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0303217
CYB5R3 cytochrome b5 reductase 3 -0.0302625
FTL ferritin, light polypeptide -0.0301834
HMGA2 high mobility group AT-hook 2 -0.0298512
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0284462
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0282506
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0281663
CDK13 cyclin-dependent kinase 13 -0.0275252
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0265085
EXT1 exostosin glycosyltransferase 1 -0.0264632
FNDC3B fibronectin type III domain containing 3B -0.0263877
IFITM3 interferon induced transmembrane protein 3 -0.0258048
SETX senataxin -0.0247997
CDKN2A cyclin-dependent kinase inhibitor 2A -0.0243888
PDE4D phosphodiesterase 4D, cAMP-specific -0.0236654
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0235523
EVI5 ecotropic viral integration site 5 -0.0230412
RPS15 ribosomal protein S15 -0.0229906
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0223492
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0221132
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0216701
VMP1 vacuole membrane protein 1 -0.021664
UBAP2 ubiquitin associated protein 2 -0.0216571
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0215411
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0213939
MDK midkine (neurite growth-promoting factor 2) -0.0212762
YBX3 Y box binding protein 3 -0.0209079
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0207064
SSH2 slingshot protein phosphatase 2 -0.0206598
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0205593
TXNIP thioredoxin interacting protein -0.020514
BRD2 bromodomain containing 2 -0.0203487
IFITM1 interferon induced transmembrane protein 1 -0.0202991
FUS FUS RNA binding protein -0.0201059
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0200106
RPS23 ribosomal protein S23 -0.0199785
PTMA prothymosin, alpha -0.0197166
ASPH aspartate beta-hydroxylase -0.0196348
TIMP2 TIMP metallopeptidase inhibitor 2 -0.0195491
MT1X metallothionein 1X -0.0192184
CNRIP1 cannabinoid receptor interacting protein 1 -0.0191992
CARD16 caspase recruitment domain family, member 16 -0.0191692
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0186254
SPIRE1 spire-type actin nucleation factor 1 -0.018564
GBP2 guanylate binding protein 2, interferon-inducible -0.0184532
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0184275
NBEAL1 neurobeachin-like 1 -0.018261
RPL8 ribosomal protein L8 -0.0181929
ATP5F1E ATP synthase F1 subunit epsilon -0.018013
DGKH diacylglycerol kinase, eta -0.0176607
CDKAL1 CDK5 regulatory subunit associated protein 1-like 1 -0.0175647
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0175527
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0174827
TAS2R14 taste receptor, type 2, member 14 -0.0173413
RPL28 ribosomal protein L28 -0.0172406
WSB1 WD repeat and SOCS box containing 1 -0.0172275
ABLIM1 actin binding LIM protein 1 -0.0170198
NT5C2 5'-nucleotidase, cytosolic II -0.017015
ARF4 ADP-ribosylation factor 4 -0.0168771
SOX5 SRY (sex determining region Y)-box 5 -0.0168402
RBM25 RNA binding motif protein 25 -0.01668
BRD4 bromodomain containing 4 -0.0166036
DHFR dihydrofolate reductase -0.0165753
RAP1B RAP1B, member of RAS oncogene family -0.0162631
SCAF11 SR-related CTD-associated factor 11 -0.0162306
MOSMO modulator of smoothened -0.0161208
SHOC2 soc-2 suppressor of clear homolog (C. elegans) -0.0161178
RPS19 ribosomal protein S19 -0.0160864
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0159005
RB1 retinoblastoma 1 -0.0157056
PCNX4 pecanex 4 -0.0156256
BPTF bromodomain PHD finger transcription factor -0.0156118
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0155873
EHMT1 euchromatic histone-lysine N-methyltransferase 1 -0.0155287
RNF111 ring finger protein 111 -0.0154187
PLCE1 phospholipase C, epsilon 1 -0.0153556
MYADM myeloid-associated differentiation marker -0.0153397
RAPGEF6 Rap guanine nucleotide exchange factor (GEF) 6 -0.0153383
HLA-B major histocompatibility complex, class I, B -0.0152671
NUCB2 nucleobindin 2 -0.0151922
ARGLU1 arginine and glutamate rich 1 -0.0151851
B4GALT6 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 6 -0.0151621
PCM1 pericentriolar material 1 -0.0151596
PPP4R2 protein phosphatase 4, regulatory subunit 2 -0.0150539
CES2 carboxylesterase 2 -0.0149751
DLGAP4 discs, large (Drosophila) homolog-associated protein 4 -0.0149562
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0149431
KIAA1549L KIAA1549-like -0.0149409
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0148648
RPS29 ribosomal protein S29 -0.0148145