Phenytoin (sodium)_LOX-IMVI Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in LOX-IMVI cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_LOX-IMVI drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
DTNA dystrobrevin, alpha 0.244124
EEF2 eukaryotic translation elongation factor 2 0.122392
LOC112694756 uncharaterized LOC112694756 0.117421
NDRG1 N-myc downstream regulated 1 0.0994044
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0993243
RUNX1 runt-related transcription factor 1 0.0992526
EFNA5 ephrin-A5 0.0988042
TRIO trio Rho guanine nucleotide exchange factor 0.0907321
LSAMP limbic system-associated membrane protein 0.0871307
FLNA filamin A, alpha 0.0839139
HSPA8 heat shock 70kDa protein 8 0.0837883
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.08102
NUP58 nucleoporin 58 0.0785048
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0762894
PBX3 pre-B-cell leukemia homeobox 3 0.073697
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0714374
ANXA2 annexin A2 0.0708778
CD109 CD109 molecule 0.0700737
ADAM9 ADAM metallopeptidase domain 9 0.0667929
MYH9 myosin, heavy chain 9, non-muscle 0.0659722
PLEC plectin 0.0655541
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0650996
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0643396
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.063876
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0636379
FMNL2 formin-like 2 0.0634022
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0613912
MSN moesin 0.0599942
WDR45B WD repeat domain 45B 0.0595104
FNDC3B fibronectin type III domain containing 3B 0.0594129
UBA6 ubiquitin-like modifier activating enzyme 6 0.0577703
ZNF292 zinc finger protein 292 0.0559943
GPC6 glypican 6 0.0559376
SRRM2 serine/arginine repetitive matrix 2 0.0558697
LIMCH1 LIM and calponin homology domains 1 0.0555856
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0553517
KDM3A lysine (K)-specific demethylase 3A 0.0550651
MMP12 matrix metallopeptidase 12 0.0537517
PICALM phosphatidylinositol binding clathrin assembly protein 0.052607
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0525657
PTK2 protein tyrosine kinase 2 0.0523221
HOOK2 hook microtubule-tethering protein 2 0.0515006
RPL3 ribosomal protein L3 0.0502199
GLS2 glutaminase 2 (liver, mitochondrial) 0.0494363
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0489307
FGFR1 fibroblast growth factor receptor 1 0.0482999
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0464177
LDHA lactate dehydrogenase A 0.0458067
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0444643
KIAA1549L KIAA1549-like 0.0443467
MCL1 myeloid cell leukemia 1 0.0437685
PRRC2A proline-rich coiled-coil 2A 0.043551
PCBP2 poly(rC) binding protein 2 0.0433251
TAC4 tachykinin 4 (hemokinin) 0.0427919
HELZ helicase with zinc finger 0.0425755
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0423618
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0421083
PRKCE protein kinase C, epsilon 0.042089
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0415678
RAB8B RAB8B, member RAS oncogene family 0.041301
MYO10 myosin X 0.0404713
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0404168
MYO1B myosin IB 0.04
WAC WW domain containing adaptor with coiled-coil 0.0398596
PKM pyruvate kinase, muscle 0.0397738
NCOR2 nuclear receptor corepressor 2 0.0394801
ZEB1 zinc finger E-box binding homeobox 1 0.0391896
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0391857
POTEF POTE ankyrin domain family, member F 0.0390933
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0389137
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0382136
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0381879
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0375564
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0374585
TPM3 tropomyosin 3 0.0372512
NCKAP1 NCK-associated protein 1 0.0366661
TSC22D2 TSC22 domain family, member 2 0.036342
RAB6A RAB6A, member RAS oncogene family 0.0352973
WDR43 WD repeat domain 43 0.0349678
ASPH aspartate beta-hydroxylase 0.0349589
NBAS neuroblastoma amplified sequence 0.0348889
EIF4B eukaryotic translation initiation factor 4B 0.0343203
BIRC6 baculoviral IAP repeat containing 6 0.0342654
APLP2 amyloid beta (A4) precursor-like protein 2 0.0342382
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0340171
CORO1C coronin, actin binding protein, 1C 0.0339699
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0338871
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0338009
MED13L mediator complex subunit 13-like 0.0337556
MARCHF6 membrane associated ring-CH-type finger 6 0.033538
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0333348
CHD7 chromodomain helicase DNA binding protein 7 0.0329211
PHACTR1 phosphatase and actin regulator 1 0.0329132
YEATS2 YEATS domain containing 2 0.0329042
MXI1 MAX interactor 1, dimerization protein 0.0327296
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0323985
ATP13A3 ATPase type 13A3 0.0320908
CCNY cyclin Y 0.0320246
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0318015
ELL2 elongation factor, RNA polymerase II, 2 0.0314784

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.292742
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0882619
VIM vimentin -0.0814412
PTMA prothymosin, alpha -0.0744631
TMSB10 thymosin beta 10 -0.0710935
VCL vinculin -0.0706549
MT2A metallothionein 2A -0.059852
TPT1 tumor protein, translationally-controlled 1 -0.051653
NABP1 nucleic acid binding protein 1 -0.0505534
FTL ferritin, light polypeptide -0.0472421
RPS6 ribosomal protein S6 -0.046898
PTCHD4 patched domain containing 4 -0.0436851
INTS6 integrator complex subunit 6 -0.0413916
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0410158
ANKRD28 ankyrin repeat domain 28 -0.0379688
ADAM19 ADAM metallopeptidase domain 19 -0.0376474
EXT1 exostosin glycosyltransferase 1 -0.0369983
KYNU kynureninase -0.0368496
RIGI RNA sensor RIG-I -0.0367762
EGR1 early growth response 1 -0.0358066
PTPRK protein tyrosine phosphatase, receptor type, K -0.030467
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0304132
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0296277
WNT2B wingless-type MMTV integration site family, member 2B -0.028167
BPTF bromodomain PHD finger transcription factor -0.0277896
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0275121
FOXP1 forkhead box P1 -0.027453
SAMD3 sterile alpha motif domain containing 3 -0.0274375
RPL12 ribosomal protein L12 -0.0271894
PRKG1 protein kinase, cGMP-dependent, type I -0.0268909
AEBP2 AE binding protein 2 -0.0243851
RPLP2 ribosomal protein, large, P2 -0.0243476
PCDH11X protocadherin 11 X-linked -0.0241986
RPS24 ribosomal protein S24 -0.0238676
RIMS2 regulating synaptic membrane exocytosis 2 -0.0236704
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0236401
WASF2 WAS protein family, member 2 -0.0235106
SLC38A2 solute carrier family 38, member 2 -0.0233459
RPS27A ribosomal protein S27a -0.0228611
RFX8 RFX family member 8, lacking RFX DNA binding domain -0.0226579
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0224678
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0224116
BTG1 B-cell translocation gene 1, anti-proliferative -0.0222091
PDE4D phosphodiesterase 4D, cAMP-specific -0.0221215
SASH1 SAM and SH3 domain containing 1 -0.0220992
HMGA2 high mobility group AT-hook 2 -0.0219111
PMP22 peripheral myelin protein 22 -0.0218332
HDAC9 histone deacetylase 9 -0.0215664
IFI16 interferon, gamma-inducible protein 16 -0.0214616
MAML2 mastermind-like 2 (Drosophila) -0.0212668
SDCCAG8 serologically defined colon cancer antigen 8 -0.0211883
SP100 SP100 nuclear antigen -0.021149
ZBTB20 zinc finger and BTB domain containing 20 -0.0210705
CDK17 cyclin-dependent kinase 17 -0.0210481
FUS FUS RNA binding protein -0.0203587
CD44 CD44 molecule (Indian blood group) -0.0203342
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0200282
FMN1 formin 1 -0.0196581
RPL36A ribosomal protein L36a -0.019538
RAB7A RAB7A, member RAS oncogene family -0.0194376
CD163L1 CD163 molecule-like 1 -0.0193448
RPS8 ribosomal protein S8 -0.0189133
RPL5 ribosomal protein L5 -0.0188488
GNAS GNAS complex locus -0.0187145
RPL19 ribosomal protein L19 -0.0187064
NTM neurotrimin -0.0185633
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.0184386
PCNX4 pecanex 4 -0.0183149
SAMD9 sterile alpha motif domain containing 9 -0.0182751
ZNF217 zinc finger protein 217 -0.0180616
CCNI cyclin I -0.0180299
FER fer (fps/fes related) tyrosine kinase -0.0180193
LOC102724023 ES1 protein homolog, mitochondrial -0.0178666
ETV6 ets variant 6 -0.017792
RPL28 ribosomal protein L28 -0.0175941
GFPT2 glutamine-fructose-6-phosphate transaminase 2 -0.0173047
ATG7 autophagy related 7 -0.0171963
STAT1 signal transducer and activator of transcription 1, 91kDa -0.0171673
RPLP0 ribosomal protein, large, P0 -0.0171284
NETO1 neuropilin (NRP) and tolloid (TLL)-like 1 -0.0170346
EIF1 eukaryotic translation initiation factor 1 -0.0169849
ITGAV integrin, alpha V -0.0169426
RPLP1 ribosomal protein, large, P1 -0.0167844
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.016735
VMP1 vacuole membrane protein 1 -0.0166129
GLMN glomulin, FKBP associated protein -0.0163855
CFAP299 cilia and flagella associated protein 299 -0.0163306
YBX3 Y box binding protein 3 -0.0162908
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0162817
RPL32 ribosomal protein L32 -0.0162615
ENKUR enkurin, TRPC channel interacting protein -0.0162172
COMMD10 COMM domain containing 10 -0.0162044
RASAL2 RAS protein activator like 2 -0.0160179
NSRP1 nuclear speckle splicing regulatory protein 1 -0.0159948
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 -0.0159596
OSMR oncostatin M receptor -0.015892
ZMYM4 zinc finger, MYM-type 4 -0.0156404
CDK12 cyclin-dependent kinase 12 -0.0155955
FBXO11 F-box protein 11 -0.0154402
CAVIN1 caveolae associated protein 1 -0.0153637