Phenytoin (sodium)_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FAT1 FAT atypical cadherin 1 0.174777
EEF2 eukaryotic translation elongation factor 2 0.155217
LOC112694756 uncharaterized LOC112694756 0.135815
MUC6 mucin 6, oligomeric mucus/gel-forming 0.128082
CEMIP cell migration inducing protein, hyaluronan binding 0.120241
KRT18 keratin 18, type I 0.107603
PIGR polymeric immunoglobulin receptor 0.0964629
FTH1 ferritin, heavy polypeptide 1 0.0934236
SRRM2 serine/arginine repetitive matrix 2 0.0932056
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.085237
DSPP dentin sialophosphoprotein 0.0836688
VEGFA vascular endothelial growth factor A 0.0829026
RPL3 ribosomal protein L3 0.0804578
TXNIP thioredoxin interacting protein 0.0800729
HSPA8 heat shock 70kDa protein 8 0.0768293
NDRG1 N-myc downstream regulated 1 0.0759816
FLNB filamin B, beta 0.0754893
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0666713
ITGA6 integrin, alpha 6 0.0654014
PLEC plectin 0.0644682
ANXA2 annexin A2 0.0636286
HDLBP high density lipoprotein binding protein 0.0603769
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0584411
EZR ezrin 0.0561441
MYH9 myosin, heavy chain 9, non-muscle 0.0524918
NCOR2 nuclear receptor corepressor 2 0.0523029
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0512462
ANKRD11 ankyrin repeat domain 11 0.0475986
WDR45B WD repeat domain 45B 0.0470835
DDIT4 DNA-damage-inducible transcript 4 0.0464413
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0462147
MYO5B myosin VB 0.0454906
EIF4H eukaryotic translation initiation factor 4H 0.0442624
DNM2 dynamin 2 0.0440236
MPRIP myosin phosphatase Rho interacting protein 0.0440013
SPTBN1 spectrin, beta, non-erythrocytic 1 0.04346
AFF1 AF4/FMR2 family, member 1 0.0433471
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0428499
HERPUD1 homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1 0.0420002
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0416626
YBX1 Y box binding protein 1 0.041431
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0401898
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0401161
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0399766
WAC WW domain containing adaptor with coiled-coil 0.0397973
CCNY cyclin Y 0.0389593
MED13L mediator complex subunit 13-like 0.0387294
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0383723
KDM4B lysine (K)-specific demethylase 4B 0.0376048
PRELID2 PRELI domain containing 2 0.0373634
MACF1 microtubule-actin crosslinking factor 1 0.0373128
NUMA1 nuclear mitotic apparatus protein 1 0.0372847
TNIP1 TNFAIP3 interacting protein 1 0.0371345
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0371328
ESYT2 extended synaptotagmin-like protein 2 0.0369682
SNX9 sorting nexin 9 0.0364568
ACTG1 actin gamma 1 0.0364311
ENO1 enolase 1, (alpha) 0.0360568
MLEC malectin 0.0355058
EPHA2 EPH receptor A2 0.0354595
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0351339
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0349069
LDHA lactate dehydrogenase A 0.0347454
GRB10 growth factor receptor-bound protein 10 0.0345884
ACADVL acyl-CoA dehydrogenase, very long chain 0.0344867
SLC38A2 solute carrier family 38, member 2 0.0344058
MUC13 mucin 13, cell surface associated 0.0343035
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0340457
EIF4B eukaryotic translation initiation factor 4B 0.0339251
LPP LIM domain containing preferred translocation partner in lipoma 0.0338674
MED13 mediator complex subunit 13 0.0335183
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.033034
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) 0.0324997
CTBP2 C-terminal binding protein 2 0.0318838
TNS4 tensin 4 0.031765
FRYL FRY-like 0.0314911
PTPRF protein tyrosine phosphatase, receptor type, F 0.0308153
TPM3 tropomyosin 3 0.0300851
KIF5B kinesin family member 5B 0.0299101
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1 0.0294951
ANXA1 annexin A1 0.0291723
MCL1 myeloid cell leukemia 1 0.0288917
FLNA filamin A, alpha 0.0287636
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0287635
ACTN4 actinin, alpha 4 0.028668
ABHD2 abhydrolase domain containing 2 0.0284472
KDM6A lysine (K)-specific demethylase 6A 0.027654
PMM2 phosphomannomutase 2 0.0275033
RHOA ras homolog family member A 0.0273832
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0273688
MYH14 myosin, heavy chain 14, non-muscle 0.0273257
RPL11 ribosomal protein L11 0.0272876
ASS1 argininosuccinate synthase 1 0.0271986
RNASE12 ribonuclease, RNase A family, 12 (non-active) 0.0271051
LGALS3 lectin, galactoside-binding, soluble, 3 0.026926
MINK1 misshapen-like kinase 1 0.0268477
TBC1D22A TBC1 domain family, member 22A 0.0266134
CDK5RAP3 CDK5 regulatory subunit associated protein 3 0.0265809
EPHB2 EPH receptor B2 0.0265242
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0261505

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.158349
NPSR1 neuropeptide S receptor 1 -0.121629
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.120666
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.101229
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.0763314
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0706322
NALF1 NALCN channel auxiliary factor 1 -0.056554
TPT1 tumor protein, translationally-controlled 1 -0.056297
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0539119
RPS24 ribosomal protein S24 -0.0527049
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0500253
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0474421
H1-0 H1.0 linker histone -0.0452504
GPHN gephyrin -0.0450999
CADPS Ca++-dependent secretion activator -0.0449814
ANTXR2 anthrax toxin receptor 2 -0.043849
ALCAM activated leukocyte cell adhesion molecule -0.0438463
PRSS3 protease, serine, 3 -0.043819
VCL vinculin -0.0431408
GCC2 GRIP and coiled-coil domain containing 2 -0.039407
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0346101
ANK3 ankyrin 3, node of Ranvier (ankyrin G) -0.0344804
PTPRR protein tyrosine phosphatase, receptor type, R -0.0344357
PCDHB16 protocadherin beta 16 -0.0338744
PDE4D phosphodiesterase 4D, cAMP-specific -0.0337773
SCAF11 SR-related CTD-associated factor 11 -0.0333405
BTBD9 BTB (POZ) domain containing 9 -0.0328896
DLG1 discs, large homolog 1 (Drosophila) -0.0327588
TMSB10 thymosin beta 10 -0.0318704
EREG epiregulin -0.0312253
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0292353
RBM25 RNA binding motif protein 25 -0.0286446
BTG1 B-cell translocation gene 1, anti-proliferative -0.0282303
GMDS GDP-mannose 4,6-dehydratase -0.0278873
IGFL2 IGF-like family member 2 -0.0275266
INSIG1 insulin induced gene 1 -0.0273364
FOXP1 forkhead box P1 -0.0270046
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0268644
POF1B premature ovarian failure, 1B -0.0267483
ARHGAP5 Rho GTPase activating protein 5 -0.026706
ARHGAP32 Rho GTPase activating protein 32 -0.0266629
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 -0.0261434
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0253212
RPL5 ribosomal protein L5 -0.0250707
HMGB1 high mobility group box 1 -0.0250613
TAS2R14 taste receptor, type 2, member 14 -0.0249184
PATJ PATJ crumbs cell polarity complex component -0.024904
PCNP PEST proteolytic signal containing nuclear protein -0.0247268
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0247023
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0246655
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 -0.024297
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0242287
RPL9 ribosomal protein L9 -0.0242229
NKTR natural killer cell triggering receptor -0.0240494
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0237865
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0237636
PERP PERP, TP53 apoptosis effector -0.0230438
FHIT fragile histidine triad -0.0226445
ANKRD28 ankyrin repeat domain 28 -0.0226126
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0225387
NAP1L1 nucleosome assembly protein 1-like 1 -0.0224333
VTI1A vesicle transport through interaction with t-SNAREs 1A -0.0222127
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0221508
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0218849
RAB10 RAB10, member RAS oncogene family -0.0218112
YBX3 Y box binding protein 3 -0.021763
ZBTB20 zinc finger and BTB domain containing 20 -0.0217185
LAMA4 laminin, alpha 4 -0.0216948
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0212475
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) -0.0212254
CD44 CD44 molecule (Indian blood group) -0.0211939
EIF5B eukaryotic translation initiation factor 5B -0.0211692
NT5C2 5'-nucleotidase, cytosolic II -0.0210833
MECOM MDS1 and EVI1 complex locus -0.020945
KLF5 Kruppel-like factor 5 (intestinal) -0.0209206
ZMYM2 zinc finger, MYM-type 2 -0.0207095
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.020692
PHKB phosphorylase kinase, beta -0.0206265
CD46 CD46 molecule, complement regulatory protein -0.0206006
MBD5 methyl-CpG binding domain protein 5 -0.0205948
ETNK1 ethanolamine kinase 1 -0.0205486
EHBP1 EH domain binding protein 1 -0.0203066
RNF43 ring finger protein 43 -0.0202428
GORASP2 golgi reassembly stacking protein 2, 55kDa -0.0201323
SIPA1L1 signal-induced proliferation-associated 1 like 1 -0.020086
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.0200728
IER3 immediate early response 3 -0.0199096
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0198737
EPC1 enhancer of polycomb homolog 1 (Drosophila) -0.0195387
PLAUR plasminogen activator, urokinase receptor -0.0192652
COMMD10 COMM domain containing 10 -0.0192606
PGK1 phosphoglycerate kinase 1 -0.0189454
CAB39 calcium binding protein 39 -0.0188812
SLC20A2 solute carrier family 20 (phosphate transporter), member 2 -0.0188115
ARHGAP6 Rho GTPase activating protein 6 -0.0188016
SLC10A7 solute carrier family 10, member 7 -0.0187775
GADD45A growth arrest and DNA-damage-inducible, alpha -0.0187179
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0186641
CMSS1 cms1 ribosomal small subunit homolog (yeast) -0.0186444
COPB1 coatomer protein complex, subunit beta 1 -0.0185353