Phenytoin (sodium)_NCI-H2030 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in NCI-H2030 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GRAMD1B GRAM domain containing 1B 0.170034
TM4SF1 transmembrane 4 L six family member 1 0.155441
FTH1 ferritin, heavy polypeptide 1 0.121833
PDE4D phosphodiesterase 4D, cAMP-specific 0.0967795
HSPA8 heat shock 70kDa protein 8 0.0966163
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0928239
AKAP12 A kinase (PRKA) anchor protein 12 0.0833542
EEF2 eukaryotic translation elongation factor 2 0.0799571
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0694399
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0669061
PM20D1 peptidase M20 domain containing 1 0.066882
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0650587
ACTG1 actin gamma 1 0.0622822
PTP4A1 protein tyrosine phosphatase type IVA, member 1 0.0566748
MCL1 myeloid cell leukemia 1 0.0562419
RPS12 ribosomal protein S12 0.0552901
LOC112694756 uncharaterized LOC112694756 0.0551165
SAMD4A sterile alpha motif domain containing 4A 0.0533853
FLNA filamin A, alpha 0.0518313
THSD4 thrombospondin, type I, domain containing 4 0.0514521
TFPI2 tissue factor pathway inhibitor 2 0.0512101
CFLAR CASP8 and FADD-like apoptosis regulator 0.0492956
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0480531
PLEC plectin 0.0471938
CMIP c-Maf inducing protein 0.0443612
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0400966
HLA-C major histocompatibility complex, class I, C 0.0392168
MT2A metallothionein 2A 0.0387405
RPL3 ribosomal protein L3 0.0385795
PFDN2 prefoldin subunit 2 0.0384061
RPS3 ribosomal protein S3 0.0381215
RPL23 ribosomal protein L23 0.0378833
SRRM2 serine/arginine repetitive matrix 2 0.0372074
MACF1 microtubule-actin crosslinking factor 1 0.0353183
ERRFI1 ERBB receptor feedback inhibitor 1 0.0351063
PRRC2A proline-rich coiled-coil 2A 0.035044
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0349191
MYH9 myosin, heavy chain 9, non-muscle 0.0333944
RPL37 ribosomal protein L37 0.033117
RPS19 ribosomal protein S19 0.0330426
RPL4 ribosomal protein L4 0.0323197
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.0315569
EIF4H eukaryotic translation initiation factor 4H 0.0315523
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0312813
ACTN1 actinin, alpha 1 0.0312276
RPL19 ribosomal protein L19 0.0312043
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0309122
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0308295
IER3 immediate early response 3 0.0306981
AGO2 argonaute RISC catalytic component 2 0.0305622
RPS21 ribosomal protein S21 0.0300095
RACK1 receptor for activated C kinase 1 0.0298665
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0295461
RPL36 ribosomal protein L36 0.029333
TPM3 tropomyosin 3 0.0293248
IGF1R insulin-like growth factor 1 receptor 0.0292829
SMAD3 SMAD family member 3 0.0291787
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.029124
RPL13A ribosomal protein L13a 0.0289595
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0285152
RPS17 ribosomal protein S17 0.0283733
RPL7 ribosomal protein L7 0.0283087
BMP6 bone morphogenetic protein 6 0.0278136
RPL30 ribosomal protein L30 0.027365
UBASH3B ubiquitin associated and SH3 domain containing B 0.0273579
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0273125
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 0.0269947
RPS27 ribosomal protein S27 0.0269677
NR4A2 nuclear receptor subfamily 4, group A, member 2 0.0268822
PFKP phosphofructokinase, platelet 0.0267557
RPLP1 ribosomal protein, large, P1 0.0267504
ITGB5 integrin, beta 5 0.0267173
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0263858
ANKRD11 ankyrin repeat domain 11 0.0260377
ANXA2 annexin A2 0.0259778
JAK1 Janus kinase 1 0.0257182
OAZ1 ornithine decarboxylase antizyme 1 0.025718
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0256569
CAMTA1 calmodulin binding transcription activator 1 0.024664
ATP11A ATPase, class VI, type 11A 0.0242681
MYOF myoferlin 0.0241114
TUBB tubulin, beta class I 0.0237588
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0237385
RTN4 reticulon 4 0.0235887
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0234667
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0233512
DNMBP dynamin binding protein 0.0227993
DGKD diacylglycerol kinase, delta 130kDa 0.0223196
RPS20 ribosomal protein S20 0.022303
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0222796
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0217447
UPP1 uridine phosphorylase 1 0.0215975
CUL3 cullin 3 0.0212327
CXCL2 chemokine (C-X-C motif) ligand 2 0.0207936
SET SET nuclear proto-oncogene 0.0206617
HMOX1 heme oxygenase 1 0.020607
CDCP1 CUB domain containing protein 1 0.0205886
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0205362
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0205224
MATR3 matrin 3 0.0205093

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.311115
VIM vimentin -0.11079
IGF2 insulin-like growth factor 2 -0.084063
TXNRD1 thioredoxin reductase 1 -0.0791352
FTL ferritin, light polypeptide -0.0665267
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0559504
P4HB prolyl 4-hydroxylase, beta polypeptide -0.053112
PTMA prothymosin, alpha -0.0494223
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0479298
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0430554
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0427528
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0418435
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.040644
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0388989
JMJD1C jumonji domain containing 1C -0.0388824
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 -0.0387581
USP34 ubiquitin specific peptidase 34 -0.0383967
HDAC9 histone deacetylase 9 -0.0382897
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0375196
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0370861
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0347771
LOC102724023 ES1 protein homolog, mitochondrial -0.0340227
SLC38A2 solute carrier family 38, member 2 -0.0320262
SVIL supervillin -0.0313898
SETD5 SET domain containing 5 -0.0301403
ERBIN erbb2 interacting protein -0.0300993
TMSB10 thymosin beta 10 -0.0292192
EYA4 EYA transcriptional coactivator and phosphatase 4 -0.0291711
ASPH aspartate beta-hydroxylase -0.0290373
COPA coatomer protein complex, subunit alpha -0.0285021
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0282327
GLG1 golgi glycoprotein 1 -0.0281111
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0278446
UGCG UDP-glucose ceramide glucosyltransferase -0.0277828
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0277786
ASXL1 additional sex combs like transcriptional regulator 1 -0.0275879
NRG1 neuregulin 1 -0.0272266
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0269305
EHBP1 EH domain binding protein 1 -0.0267479
PKM pyruvate kinase, muscle -0.0247386
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0247041
ITCH itchy E3 ubiquitin protein ligase -0.0243733
ARHGEF12 Rho guanine nucleotide exchange factor (GEF) 12 -0.0242916
MORF4L1 mortality factor 4 like 1 -0.02407
MYADM myeloid-associated differentiation marker -0.0237129
RASAL2 RAS protein activator like 2 -0.0236982
ASTN2 astrotactin 2 -0.0231666
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0230598
S100A6 S100 calcium binding protein A6 -0.0228634
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.022863
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0227234
FOSB FBJ murine osteosarcoma viral oncogene homolog B -0.0225438
NOP58 NOP58 ribonucleoprotein -0.0223898
MAP3K5 mitogen-activated protein kinase kinase kinase 5 -0.0222154
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0221573
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0217994
RAB1A RAB1A, member RAS oncogene family -0.021789
ATF7 activating transcription factor 7 -0.0216979
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0216887
STRN3 striatin, calmodulin binding protein 3 -0.0215765
CHD9 chromodomain helicase DNA binding protein 9 -0.0215428
SPDYA speedy/RINGO cell cycle regulator family member A -0.0214512
IGFBP4 insulin-like growth factor binding protein 4 -0.0214432
PTK2 protein tyrosine kinase 2 -0.0214041
BIRC6 baculoviral IAP repeat containing 6 -0.0213924
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -0.0211226
KCTD9 potassium channel tetramerization domain containing 9 -0.0211085
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.0208375
S100A10 S100 calcium binding protein A10 -0.0206979
ARF4 ADP-ribosylation factor 4 -0.0206634
AKAP13 A kinase (PRKA) anchor protein 13 -0.0206252
EFNA5 ephrin-A5 -0.0204555
PFN1 profilin 1 -0.020247
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0200875
PAWR PRKC, apoptosis, WT1, regulator -0.0200089
NTN4 netrin 4 -0.0200079
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0198513
SIK3 SIK family kinase 3 -0.0197487
PHF20 PHD finger protein 20 -0.0195886
FBXO11 F-box protein 11 -0.0194028
CREBBP CREB binding protein -0.0193786
PSME4 proteasome (prosome, macropain) activator subunit 4 -0.0193645
RPS15 ribosomal protein S15 -0.0193202
AK1 adenylate kinase 1 -0.0192695
YME1L1 YME1-like 1 ATPase -0.0188872
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0187733
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0187028
PRR16 proline rich 16 -0.0185706
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0185258
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0184668
ZNF609 zinc finger protein 609 -0.0184381
NUMB numb homolog (Drosophila) -0.018384
BZW2 basic leucine zipper and W2 domains 2 -0.0183713
FBXL20 F-box and leucine-rich repeat protein 20 -0.0183405
NQO1 NAD(P)H dehydrogenase, quinone 1 -0.0180607
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0179718
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0177653
MYO9A myosin IXA -0.0177039
CFAP73 cilia and flagella associated protein 73 -0.0177022
SSR2 signal sequence receptor, beta (translocon-associated protein beta) -0.0176672