Phenytoin (sodium)_NCI-H2122 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in NCI-H2122 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VIM vimentin 0.127644
TRIO trio Rho guanine nucleotide exchange factor 0.104498
ASPH aspartate beta-hydroxylase 0.104098
RPS6 ribosomal protein S6 0.0964705
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0786682
RPS12 ribosomal protein S12 0.0683181
FN1 fibronectin 1 0.0681866
GNPDA1 glucosamine-6-phosphate deaminase 1 0.066529
B2M beta-2-microglobulin 0.0657558
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0654932
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0653754
TLK1 tousled-like kinase 1 0.0636593
NDRG1 N-myc downstream regulated 1 0.0629134
OGA O-GlcNAcase 0.0611628
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.060596
RPL37A ribosomal protein L37a 0.0597442
MYOF myoferlin 0.0585703
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0577337
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0542536
ZBTB20 zinc finger and BTB domain containing 20 0.0541532
CHD9 chromodomain helicase DNA binding protein 9 0.0540563
CENPF centromere protein F, 350/400kDa 0.0535929
NAMPT nicotinamide phosphoribosyltransferase 0.0534617
SMYD3 SET and MYND domain containing 3 0.051954
FMN1 formin 1 0.0514381
KMT2E lysine (K)-specific methyltransferase 2E 0.0500368
EIF1 eukaryotic translation initiation factor 1 0.0498329
EEF2 eukaryotic translation elongation factor 2 0.0495756
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0493344
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0493301
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0492689
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0488664
PKN2 protein kinase N2 0.0482894
YEATS2 YEATS domain containing 2 0.0478769
GOLGA4 golgin A4 0.047024
ZCCHC7 zinc finger, CCHC domain containing 7 0.0464904
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0460129
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0458765
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0451263
BBX bobby sox homolog (Drosophila) 0.0447477
LPP LIM domain containing preferred translocation partner in lipoma 0.0446441
FAM13A family with sequence similarity 13, member A 0.0440482
TNRC6A trinucleotide repeat containing 6A 0.0440253
FLNA filamin A, alpha 0.0439941
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0432686
KMT2C lysine (K)-specific methyltransferase 2C 0.0432463
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0430899
FLNB filamin B, beta 0.0428893
CERT1 ceramide transporter 1 0.0426101
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0424266
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0423557
AKAP12 A kinase (PRKA) anchor protein 12 0.042338
KDM3A lysine (K)-specific demethylase 3A 0.0420135
RPL30 ribosomal protein L30 0.041711
STXBP5 syntaxin binding protein 5 (tomosyn) 0.0414045
BSG basigin (Ok blood group) 0.0407634
EIF4A2 eukaryotic translation initiation factor 4A2 0.0404774
RPLP1 ribosomal protein, large, P1 0.0402042
RPL35A ribosomal protein L35a 0.039726
PNISR PNN-interacting serine/arginine-rich protein 0.0394499
RPL18 ribosomal protein L18 0.0394004
TMCC1 transmembrane and coiled-coil domain family 1 0.0393037
PGK1 phosphoglycerate kinase 1 0.0390606
TCERG1 transcription elongation regulator 1 0.0389111
KPNB1 karyopherin (importin) beta 1 0.0388673
FTH1 ferritin, heavy polypeptide 1 0.0382943
ANKRD12 ankyrin repeat domain 12 0.0372908
SOD2 superoxide dismutase 2, mitochondrial 0.0371564
DIAPH2 diaphanous-related formin 2 0.0365995
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0362874
CTTN cortactin 0.0362569
TMSB4X thymosin beta 4, X-linked 0.0360912
FMNL2 formin-like 2 0.0359752
WSB1 WD repeat and SOCS box containing 1 0.0347174
ADAM17 ADAM metallopeptidase domain 17 0.03471
MATR3 matrin 3 0.0340082
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0336785
ARHGAP32 Rho GTPase activating protein 32 0.0332982
HM13 histocompatibility (minor) 13 0.032826
SPAG9 sperm associated antigen 9 0.0327999
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0327713
KIF1B kinesin family member 1B 0.0327206
GPHN gephyrin 0.0326618
KTN1 kinectin 1 (kinesin receptor) 0.0323069
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0320495
RPLP2 ribosomal protein, large, P2 0.0320126
METAP2 methionyl aminopeptidase 2 0.0319403
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0318974
RPS19 ribosomal protein S19 0.031453
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0312604
HDAC8 histone deacetylase 8 0.0305954
LOC112694756 uncharaterized LOC112694756 0.0301796
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0299749
PKM pyruvate kinase, muscle 0.0297661
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0294684
PDE4D phosphodiesterase 4D, cAMP-specific 0.0289926
EFNA5 ephrin-A5 0.0289726
WASF2 WAS protein family, member 2 0.0288828
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0282373
PTMA prothymosin, alpha 0.0279731

decreased expression

Symbol Name Standardized Value
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.209749
MYO1E myosin IE -0.175128
LMO7 LIM domain 7 -0.160507
BACE2 beta-site APP-cleaving enzyme 2 -0.144197
SAMD4A sterile alpha motif domain containing 4A -0.13581
CEMIP cell migration inducing protein, hyaluronan binding -0.118083
ATP2C2 ATPase, Ca++ transporting, type 2C, member 2 -0.116395
LAMC2 laminin, gamma 2 -0.0997659
SVIL supervillin -0.09962
GRB10 growth factor receptor-bound protein 10 -0.0966591
DSCAM Down syndrome cell adhesion molecule -0.0917285
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0897902
ATOSA atos homolog A -0.0845332
CMIP c-Maf inducing protein -0.0822299
EZR ezrin -0.0803063
IGF1R insulin-like growth factor 1 receptor -0.0795416
LIMCH1 LIM and calponin homology domains 1 -0.0772187
RAB11FIP1 RAB11 family interacting protein 1 (class I) -0.0770321
SMOC1 SPARC related modular calcium binding 1 -0.0739438
PLAUR plasminogen activator, urokinase receptor -0.0712598
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0694212
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.064239
SLC7A2 solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 -0.0622556
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0622528
ERN1 endoplasmic reticulum to nucleus signaling 1 -0.0620577
F3 coagulation factor III (thromboplastin, tissue factor) -0.0596239
AKAP13 A kinase (PRKA) anchor protein 13 -0.0595405
SYNE2 spectrin repeat containing, nuclear envelope 2 -0.0594177
INTS6 integrator complex subunit 6 -0.0593172
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0593158
GPC6 glypican 6 -0.0592505
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0590998
TC2N tandem C2 domains, nuclear -0.0586327
KLF5 Kruppel-like factor 5 (intestinal) -0.0566797
BMAL2 basic helix-loop-helix ARNT like 2 -0.0565177
BZW1 basic leucine zipper and W2 domains 1 -0.0563509
LAMB3 laminin, beta 3 -0.0547683
MCL1 myeloid cell leukemia 1 -0.054638
KDM2A lysine (K)-specific demethylase 2A -0.053888
MYO6 myosin VI -0.053375
ANTXR2 anthrax toxin receptor 2 -0.0526303
PARD3 par-3 family cell polarity regulator -0.0523728
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0520058
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -0.0514704
CATSPERB catsper channel auxiliary subunit beta -0.0501832
USP53 ubiquitin specific peptidase 53 -0.0490602
AFF1 AF4/FMR2 family, member 1 -0.0486773
DIAPH1 diaphanous-related formin 1 -0.047219
TJP2 tight junction protein 2 -0.0463347
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0456802
EGFR epidermal growth factor receptor -0.0455483
NIPBL Nipped-B homolog (Drosophila) -0.0452487
STAU1 staufen double-stranded RNA binding protein 1 -0.045138
PATJ PATJ crumbs cell polarity complex component -0.0442772
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0440054
MUC16 mucin 16, cell surface associated -0.0435039
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.043233
RBM47 RNA binding motif protein 47 -0.0424226
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0423476
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0422078
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.04207
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0413446
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0413032
STEAP4 STEAP family member 4 -0.0411479
TPT1 tumor protein, translationally-controlled 1 -0.0402979
TAOK3 TAO kinase 3 -0.0402418
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0397004
PDLIM5 PDZ and LIM domain 5 -0.0386766
FOXO1 forkhead box O1 -0.0385053
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0375089
COPA coatomer protein complex, subunit alpha -0.0374252
UBE2H ubiquitin-conjugating enzyme E2H -0.0373219
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase -0.0370341
CDK13 cyclin-dependent kinase 13 -0.0368872
ANXA2 annexin A2 -0.0367758
VMP1 vacuole membrane protein 1 -0.0366596
SETD5 SET domain containing 5 -0.0365056
ARHGAP5 Rho GTPase activating protein 5 -0.0361048
KDM7A lysine (K)-specific demethylase 7A -0.0358426
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.03566
AFDN afadin, adherens junction formation factor -0.0349433
POTEF POTE ankyrin domain family, member F -0.0349114
GOLGB1 golgin B1 -0.0345928
ADNP activity-dependent neuroprotector homeobox -0.0341685
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0340668
ZFAND3 zinc finger, AN1-type domain 3 -0.0337351
MAML2 mastermind-like 2 (Drosophila) -0.0331176
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0327372
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0326482
AK1 adenylate kinase 1 -0.0325509
IGFBP3 insulin-like growth factor binding protein 3 -0.0320847
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0316403
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0313868
MSI2 musashi RNA-binding protein 2 -0.0313591
OFD1 oral-facial-digital syndrome 1 -0.0308768
UBC ubiquitin C -0.0308615
NF1 neurofibromin 1 -0.0303251
SQSTM1 sequestosome 1 -0.0295171
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0293677
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0293042