Phenytoin (sodium)_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.0746315
LOC112694756 uncharaterized LOC112694756 0.0519064
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0482172
PLEC plectin 0.0481279
HSPA8 heat shock 70kDa protein 8 0.0453168
KRT18 keratin 18, type I 0.0434025
TXNRD1 thioredoxin reductase 1 0.0390378
TPI1 triosephosphate isomerase 1 0.0356558
EIF4H eukaryotic translation initiation factor 4H 0.0352061
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.035101
PRRC2A proline-rich coiled-coil 2A 0.0346771
RACK1 receptor for activated C kinase 1 0.034656
TRIO trio Rho guanine nucleotide exchange factor 0.033115
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0319989
RPL35A ribosomal protein L35a 0.0299623
MKI67 marker of proliferation Ki-67 0.0280647
CSDE1 cold shock domain containing E1, RNA-binding 0.0254537
RPS4X ribosomal protein S4, X-linked 0.0249654
ACTG1 actin gamma 1 0.0237929
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.023676
RPL34 ribosomal protein L34 0.0230169
RPL3 ribosomal protein L3 0.0223996
HLA-C major histocompatibility complex, class I, C 0.022193
TUBB tubulin, beta class I 0.0221829
RPL27 ribosomal protein L27 0.0214956
NACA nascent polypeptide-associated complex alpha subunit 0.0213993
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0212943
RPS21 ribosomal protein S21 0.0212724
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0211085
TFPI2 tissue factor pathway inhibitor 2 0.0210739
YES1 YES proto-oncogene 1, Src family tyrosine kinase 0.021024
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0201964
RPL12 ribosomal protein L12 0.0201922
RPL13A ribosomal protein L13a 0.0201852
MARCHF4 membrane associated ring-CH-type finger 4 0.019812
FLNA filamin A, alpha 0.0192521
TMBIM6 transmembrane BAX inhibitor motif containing 6 0.0191058
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0190519
PRRC2C proline-rich coiled-coil 2C 0.0184658
PFDN2 prefoldin subunit 2 0.0181021
PPM1L protein phosphatase, Mg2+/Mn2+ dependent, 1L 0.0179509
RPS3 ribosomal protein S3 0.0178242
NCKAP1 NCK-associated protein 1 0.0176227
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.0173864
RRM2 ribonucleotide reductase M2 0.0171449
RPL41 ribosomal protein L41 0.01711
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0170104
BIRC2 baculoviral IAP repeat containing 2 0.0169313
ARHGEF11 Rho guanine nucleotide exchange factor (GEF) 11 0.0168829
SRRM2 serine/arginine repetitive matrix 2 0.0167268
CENPF centromere protein F, 350/400kDa 0.016586
EIF1 eukaryotic translation initiation factor 1 0.0165539
CEP250 centrosomal protein 250kDa 0.0165464
OAZ1 ornithine decarboxylase antizyme 1 0.0163823
NUMA1 nuclear mitotic apparatus protein 1 0.016379
STIP1 stress-induced phosphoprotein 1 0.0162102
HJURP Holliday junction recognition protein 0.016159
RTN4 reticulon 4 0.0161067
NCAPD2 non-SMC condensin I complex, subunit D2 0.0160707
SP3 Sp3 transcription factor 0.0160535
RUSC2 RUN and SH3 domain containing 2 0.0160149
IGF2BP1 insulin-like growth factor 2 mRNA binding protein 1 0.0154901
MSH6 mutS homolog 6 0.0153609
FKBP4 FK506 binding protein 4, 59kDa 0.0152193
MYH9 myosin, heavy chain 9, non-muscle 0.0148167
RPL11 ribosomal protein L11 0.0144731
EIF4B eukaryotic translation initiation factor 4B 0.0142139
RPS20 ribosomal protein S20 0.0141974
CAPRIN1 cell cycle associated protein 1 0.0141647
CCT3 chaperonin containing TCP1, subunit 3 (gamma) 0.0139291
CCND2 cyclin D2 0.0139149
UBQLN1 ubiquilin 1 0.0138379
PPP3R1 protein phosphatase 3, regulatory subunit B, alpha 0.0138327
CCDC200 coiled-coil domain containing 200 0.0137988
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.013716
RPL18 ribosomal protein L18 0.0137117
CIP2A cellular inhibitor of PP2A 0.0134264
RPL29 ribosomal protein L29 0.0134105
CASC3 cancer susceptibility candidate 3 0.0133734
KHDC4 KH domain containing 4, pre-mRNA splicing factor 0.0133406
MELK maternal embryonic leucine zipper kinase 0.0132007
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0131865
RPLP0 ribosomal protein, large, P0 0.0130354
RPL37 ribosomal protein L37 0.0129064
RPL14 ribosomal protein L14 0.0128464
RPS12 ribosomal protein S12 0.0128447
RPL35 ribosomal protein L35 0.0128404
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0127395
MIS18BP1 MIS18 binding protein 1 0.0126059
DCAF8 DDB1 and CUL4 associated factor 8 0.0125975
ARID1A AT rich interactive domain 1A (SWI-like) 0.0124806
TOP2B topoisomerase (DNA) II beta 180kDa 0.0123276
RPL7 ribosomal protein L7 0.0123126
TGIF1 TGFB-induced factor homeobox 1 0.0122871
CLTC clathrin, heavy chain (Hc) 0.0122677
PKP4 plakophilin 4 0.0122451
ANXA2 annexin A2 0.0121597
SRP9 signal recognition particle 9kDa 0.012031
PRELID3B PRELI domain containing 3B 0.011948
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0117969

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.326732
AKAP12 A kinase (PRKA) anchor protein 12 -0.247581
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.120486
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0822401
UBC ubiquitin C -0.0761845
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0761104
YBX3 Y box binding protein 3 -0.0738933
PTMA prothymosin, alpha -0.0722609
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0607534
PDE4D phosphodiesterase 4D, cAMP-specific -0.0605781
EGR1 early growth response 1 -0.0583956
KDM2A lysine (K)-specific demethylase 2A -0.0580753
EML4 echinoderm microtubule associated protein like 4 -0.057652
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0555798
COPA coatomer protein complex, subunit alpha -0.0541373
RAB7A RAB7A, member RAS oncogene family -0.049456
USP34 ubiquitin specific peptidase 34 -0.0491973
POTEF POTE ankyrin domain family, member F -0.0482537
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0480129
VIM vimentin -0.0470721
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0464419
AFF3 AF4/FMR2 family, member 3 -0.0453863
HLA-B major histocompatibility complex, class I, B -0.0431709
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0431281
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0420474
PCBP2 poly(rC) binding protein 2 -0.0414691
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0402072
SETD5 SET domain containing 5 -0.0398418
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0397746
TMSB10 thymosin beta 10 -0.0395295
OSMR oncostatin M receptor -0.0391848
VMP1 vacuole membrane protein 1 -0.0390902
RSF1 remodeling and spacing factor 1 -0.0382486
RBM39 RNA binding motif protein 39 -0.0382137
GOLGB1 golgin B1 -0.0374943
ATXN1 ataxin 1 -0.0368303
AKAP9 A kinase (PRKA) anchor protein 9 -0.0357205
LOC102724023 ES1 protein homolog, mitochondrial -0.0343899
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0337275
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0332261
PKM pyruvate kinase, muscle -0.0327795
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0327319
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0326478
PDE10A phosphodiesterase 10A -0.0318331
DOCK5 dedicator of cytokinesis 5 -0.0304709
CCNL1 cyclin L1 -0.0296211
JMJD1C jumonji domain containing 1C -0.0295976
ENO1 enolase 1, (alpha) -0.029506
RPS27A ribosomal protein S27a -0.0293574
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0292014
PHF20 PHD finger protein 20 -0.0288504
CANX calnexin -0.0282711
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0278873
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0274898
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0270585
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0265676
ZNF207 zinc finger protein 207 -0.0264845
RPS15 ribosomal protein S15 -0.0263165
TPM2 tropomyosin 2 (beta) -0.0263091
SOS2 son of sevenless homolog 2 (Drosophila) -0.0262745
BRD4 bromodomain containing 4 -0.026062
JUN jun proto-oncogene -0.0260232
MT2A metallothionein 2A -0.0259733
ZBTB20 zinc finger and BTB domain containing 20 -0.0257087
PDIA3 protein disulfide isomerase family A, member 3 -0.0256857
WASF2 WAS protein family, member 2 -0.0255649
EPAS1 endothelial PAS domain protein 1 -0.0254274
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0252373
PDIA6 protein disulfide isomerase family A, member 6 -0.0251525
WSB1 WD repeat and SOCS box containing 1 -0.0249178
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0238815
PFN1 profilin 1 -0.0238207
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0231886
MCL1 myeloid cell leukemia 1 -0.0231282
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0229976
PYGL phosphorylase, glycogen, liver -0.0229783
BPTF bromodomain PHD finger transcription factor -0.0228697
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.0228608
EGFR epidermal growth factor receptor -0.0227027
MCTP1 multiple C2 domains, transmembrane 1 -0.0226046
HMGA2 high mobility group AT-hook 2 -0.0225749
EIF5B eukaryotic translation initiation factor 5B -0.0224737
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0224101
FMNL2 formin-like 2 -0.0224095
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.022346
THOC2 THO complex 2 -0.0220722
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0216114
TPM4 tropomyosin 4 -0.0214311
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0211159
MAP4 microtubule-associated protein 4 -0.0210208
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0209592
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 -0.0209356
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit -0.0209229
PHF21A PHD finger protein 21A -0.0208978
CAMKMT calmodulin-lysine N-methyltransferase -0.0208373
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0207243
NCOA7 nuclear receptor coactivator 7 -0.0206779
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0206766
RPL36A ribosomal protein L36a -0.0206065
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0205945