Phenytoin (sodium)_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

162 genes differentially expressed following the Phenytoin (sodium)_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGFBP3 insulin-like growth factor binding protein 3 0.213513
RUNX1 runt-related transcription factor 1 0.171806
CXCL8 chemokine (C-X-C motif) ligand 8 0.139767
NAMPT nicotinamide phosphoribosyltransferase 0.13009
NAV2 neuron navigator 2 0.11812
GPC6 glypican 6 0.116744
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.112643
TRIO trio Rho guanine nucleotide exchange factor 0.11041
FMNL2 formin-like 2 0.101808
GRB10 growth factor receptor-bound protein 10 0.0913932
FAM13A family with sequence similarity 13, member A 0.0903795
MYOF myoferlin 0.0901402
CHD1 chromodomain helicase DNA binding protein 1 0.0883655
S100A6 S100 calcium binding protein A6 0.0879543
SLC38A1 solute carrier family 38, member 1 0.0822167
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0809324
ANKRD11 ankyrin repeat domain 11 0.0782483
LDHA lactate dehydrogenase A 0.0775984
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.0767308
RERE arginine-glutamic acid dipeptide (RE) repeats 0.07203
FN1 fibronectin 1 0.071622
JARID2 jumonji, AT rich interactive domain 2 0.0706215
RPL31 ribosomal protein L31 0.0702155
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0678282
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) 0.0675804
KMT2C lysine (K)-specific methyltransferase 2C 0.0662033
SRPK2 SRSF protein kinase 2 0.0649074
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0649046
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.063673
ZFAND3 zinc finger, AN1-type domain 3 0.0635612
CCNY cyclin Y 0.0629432
LOC112694756 uncharaterized LOC112694756 0.061549
RPS21 ribosomal protein S21 0.0614659
KMT2E lysine (K)-specific methyltransferase 2E 0.0610968
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0591521
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0587266
ELL2 elongation factor, RNA polymerase II, 2 0.0578272
RPS13 ribosomal protein S13 0.0557532
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0531083
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0515618
EEF2 eukaryotic translation elongation factor 2 0.0513668
NCAM1 neural cell adhesion molecule 1 0.050887
AKAP13 A kinase (PRKA) anchor protein 13 0.0505482
AKAP12 A kinase (PRKA) anchor protein 12 0.0492377
SOD2 superoxide dismutase 2, mitochondrial 0.0483042
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0477103
BIRC6 baculoviral IAP repeat containing 6 0.0453597
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0453281
FNDC3B fibronectin type III domain containing 3B 0.0449412
EXOC6B exocyst complex component 6B 0.0409924
RAP1B RAP1B, member of RAS oncogene family 0.0393198
CEP350 centrosomal protein 350kDa 0.0386464
PGK1 phosphoglycerate kinase 1 0.0377722
RPS8 ribosomal protein S8 0.036913
NF1 neurofibromin 1 0.0359921
MAP2K1 mitogen-activated protein kinase kinase 1 0.0358409
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) 0.0343815
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0342632
CRADD CASP2 and RIPK1 domain containing adaptor with death domain 0.0342558
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0325939
EFNA5 ephrin-A5 0.032496
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0314102
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0309293
PDE4D phosphodiesterase 4D, cAMP-specific 0.0301787
MEMO1 mediator of cell motility 1 0.0291376
ATP13A3 ATPase type 13A3 0.0282662
NKD1 naked cuticle homolog 1 (Drosophila) 0.0281621
RB1CC1 RB1-inducible coiled-coil 1 0.0262104
COL5A2 collagen, type V, alpha 2 0.025377
NDRG1 N-myc downstream regulated 1 0.0245975
METTL15 methyltransferase like 15 0.0232123
GLS2 glutaminase 2 (liver, mitochondrial) 0.0229058
RPS16 ribosomal protein S16 0.0226994
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.0222164
RPL35A ribosomal protein L35a 0.0208315
RPL37A ribosomal protein L37a 0.0188172
PTK2 protein tyrosine kinase 2 0.0182244
COPA coatomer protein complex, subunit alpha 0.0182157
ATXN1 ataxin 1 0.0180539
CAMTA1 calmodulin binding transcription activator 1 0.0154776
PHIP pleckstrin homology domain interacting protein 0.0153447
FNDC3A fibronectin type III domain containing 3A 0.0137029
RICTOR RPTOR independent companion of MTOR, complex 2 0.0129424
FLNB filamin B, beta 0.0103624
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0102941
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.00861812
RTN4 reticulon 4 0.00795134
RPL23 ribosomal protein L23 0.0071087
CSDE1 cold shock domain containing E1, RNA-binding 0.00464547
HOOK2 hook microtubule-tethering protein 2 0.00385301
PRRC2B proline-rich coiled-coil 2B 0.00346642
CUX1 cut-like homeobox 1 0.00345237
RAB7A RAB7A, member RAS oncogene family 0.00340576
SEC31A SEC31 homolog A (S. cerevisiae) 9.90123E-4

decreased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.211627
TPT1 tumor protein, translationally-controlled 1 -0.173282
TXNIP thioredoxin interacting protein -0.139417
CALR calreticulin -0.136996
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.133826
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.13062
EXT1 exostosin glycosyltransferase 1 -0.127623
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.124326
ZNF292 zinc finger protein 292 -0.117192
KIF5B kinesin family member 5B -0.108654
DSCAM Down syndrome cell adhesion molecule -0.107597
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.103219
LOC102724023 ES1 protein homolog, mitochondrial -0.100958
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0854378
SPAG9 sperm associated antigen 9 -0.0854266
LAMA4 laminin, alpha 4 -0.0837979
MORF4L2 mortality factor 4 like 2 -0.0834041
MT2A metallothionein 2A -0.0824416
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0807457
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0789267
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0788275
CANX calnexin -0.0770928
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0754634
HDLBP high density lipoprotein binding protein -0.0741482
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0718929
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0713246
RPL26 ribosomal protein L26 -0.0708986
VIM vimentin -0.0685116
TMSB10 thymosin beta 10 -0.0679265
TXNRD1 thioredoxin reductase 1 -0.0668699
B2M beta-2-microglobulin -0.066187
VMP1 vacuole membrane protein 1 -0.0643953
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.063539
RBM25 RNA binding motif protein 25 -0.0608248
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0597393
RPS6 ribosomal protein S6 -0.0589505
EIF1 eukaryotic translation initiation factor 1 -0.0570307
ADAM10 ADAM metallopeptidase domain 10 -0.0510032
FTH1 ferritin, heavy polypeptide 1 -0.0498955
PTMA prothymosin, alpha -0.0488037
PRRC2C proline-rich coiled-coil 2C -0.0443687
PCBP2 poly(rC) binding protein 2 -0.0405796
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0391649
RPLP1 ribosomal protein, large, P1 -0.0387368
TAS2R14 taste receptor, type 2, member 14 -0.0381478
RBM39 RNA binding motif protein 39 -0.0354217
GOLGA4 golgin A4 -0.0345918
FTL ferritin, light polypeptide -0.0314914
ZBTB20 zinc finger and BTB domain containing 20 -0.0263263
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) -0.0261639
PDE10A phosphodiesterase 10A -0.021095
MED13L mediator complex subunit 13-like -0.0193163
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) -0.0164946
NCOR1 nuclear receptor corepressor 1 -0.0155095
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0133096
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0131607
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase -0.0124579
STC1 stanniocalcin 1 -0.0107143
TP53BP1 tumor protein p53 binding protein 1 -0.0105299
NCOA3 nuclear receptor coactivator 3 -0.00931069
ANXA2 annexin A2 -0.00828254
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.00815085
NBAS neuroblastoma amplified sequence -0.00316328
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.00157294
JMJD1C jumonji domain containing 1C -8.85191E-4
PUM1 pumilio RNA-binding family member 1 -7.26797E-4
ASPH aspartate beta-hydroxylase -1.86706E-4
MAN2A1 mannosidase, alpha, class 2A, member 1 -2.86414E-5