Phenytoin (sodium)_RKO Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in RKO cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_RKO drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.111938
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0823256
LOC112694756 uncharaterized LOC112694756 0.0547375
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0522309
EEF2 eukaryotic translation elongation factor 2 0.0481228
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0479235
RPL3 ribosomal protein L3 0.0458052
PTK2 protein tyrosine kinase 2 0.0457501
FLNA filamin A, alpha 0.0440947
AHNAK AHNAK nucleoprotein 0.0440506
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0437005
ELL2 elongation factor, RNA polymerase II, 2 0.0434579
TXNRD1 thioredoxin reductase 1 0.0423481
NAV2 neuron navigator 2 0.0420594
AGO2 argonaute RISC catalytic component 2 0.0400395
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0393949
KDM6A lysine (K)-specific demethylase 6A 0.0382795
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0381466
USP3 ubiquitin specific peptidase 3 0.0345005
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0344437
HSPA8 heat shock 70kDa protein 8 0.0340613
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0338547
LRMDA leucine rich melanocyte differentiation associated 0.0331365
TSC22D2 TSC22 domain family, member 2 0.0323027
MAPK8 mitogen-activated protein kinase 8 0.0317744
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0302197
UPP1 uridine phosphorylase 1 0.0297823
NCKAP1 NCK-associated protein 1 0.0297677
EXT1 exostosin glycosyltransferase 1 0.0290287
CCNY cyclin Y 0.0286183
CAMTA1 calmodulin binding transcription activator 1 0.028139
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0268618
NBAS neuroblastoma amplified sequence 0.0268364
EWSR1 EWS RNA-binding protein 1 0.0267814
KDM3A lysine (K)-specific demethylase 3A 0.0267412
ACTN1 actinin, alpha 1 0.0266667
CALU calumenin 0.0251995
SETX senataxin 0.0251558
MYH9 myosin, heavy chain 9, non-muscle 0.0247288
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 0.0245654
ADAM17 ADAM metallopeptidase domain 17 0.024542
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0241479
SRRM2 serine/arginine repetitive matrix 2 0.0239133
ZNF207 zinc finger protein 207 0.0237589
SNX9 sorting nexin 9 0.023404
FNDC3B fibronectin type III domain containing 3B 0.023212
TFRC transferrin receptor 0.0231421
CNOT4 CCR4-NOT transcription complex, subunit 4 0.023093
ANXA5 annexin A5 0.0229666
COG5 component of oligomeric golgi complex 5 0.0228096
FAM91A1 family with sequence similarity 91, member A1 0.022807
MTMR3 myotubularin related protein 3 0.0226369
OSBPL9 oxysterol binding protein-like 9 0.0225454
RBM39 RNA binding motif protein 39 0.0222978
SPTLC1 serine palmitoyltransferase, long chain base subunit 1 0.0219925
MKLN1 muskelin 1, intracellular mediator containing kelch motifs 0.0219308
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0218511
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0218455
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0216865
SEC24D SEC24 family member D 0.0214496
CAPRIN2 caprin family member 2 0.0212715
KDM5C lysine (K)-specific demethylase 5C 0.0212688
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0212592
DIP2C DIP2 disco-interacting protein 2 homolog C (Drosophila) 0.0209263
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0207748
PRRC2B proline-rich coiled-coil 2B 0.0207653
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0206684
PICALM phosphatidylinositol binding clathrin assembly protein 0.0206492
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0206328
RLF rearranged L-myc fusion 0.0202826
UBC ubiquitin C 0.0202292
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0200985
NAMPT nicotinamide phosphoribosyltransferase 0.019977
GPCPD1 glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) 0.0197738
SBF2 SET binding factor 2 0.0197615
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0197101
HM13 histocompatibility (minor) 13 0.0196595
SURF4 surfeit 4 0.0195037
BTBD9 BTB (POZ) domain containing 9 0.0193101
MCL1 myeloid cell leukemia 1 0.0192975
USP6NL USP6 N-terminal like 0.0191592
PSME4 proteasome (prosome, macropain) activator subunit 4 0.019156
EIF4H eukaryotic translation initiation factor 4H 0.0191389
AFF4 AF4/FMR2 family, member 4 0.0191192
KLC1 kinesin light chain 1 0.0190828
YEATS2 YEATS domain containing 2 0.0190304
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.018828
PTPN11 protein tyrosine phosphatase, non-receptor type 11 0.0187347
DENND5A DENN/MADD domain containing 5A 0.0187304
CDC73 cell division cycle 73 0.0186347
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0185731
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0184495
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0183201
PRELID2 PRELI domain containing 2 0.018222
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.0182143
ZFAND6 zinc finger, AN1-type domain 6 0.0181861
MARCHF6 membrane associated ring-CH-type finger 6 0.0181739
DIDO1 death inducer-obliterator 1 0.0181322
CCDC50 coiled-coil domain containing 50 0.018132
CREB5 cAMP responsive element binding protein 5 0.018068

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.210065
DLC1 DLC1 Rho GTPase activating protein -0.144041
RPL35A ribosomal protein L35a -0.112716
FRMD6 FERM domain containing 6 -0.106016
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0989284
RPS6 ribosomal protein S6 -0.0839807
ZNF438 zinc finger protein 438 -0.0815365
TMSB10 thymosin beta 10 -0.0797733
HMGA2 high mobility group AT-hook 2 -0.0777721
FTL ferritin, light polypeptide -0.0666342
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0631583
RPS3 ribosomal protein S3 -0.0620022
RPS12 ribosomal protein S12 -0.0604462
PTMA prothymosin, alpha -0.0603779
RPS19 ribosomal protein S19 -0.0601442
NAP1L1 nucleosome assembly protein 1-like 1 -0.0597936
TTR transthyretin -0.0590854
PFN1 profilin 1 -0.0585115
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0566319
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.056048
HDAC9 histone deacetylase 9 -0.0560104
IFI16 interferon, gamma-inducible protein 16 -0.0534699
CALD1 caldesmon 1 -0.0531634
RPS8 ribosomal protein S8 -0.0526415
RPL12 ribosomal protein L12 -0.0517032
RPLP1 ribosomal protein, large, P1 -0.0508415
NAV3 neuron navigator 3 -0.0468757
RPL9 ribosomal protein L9 -0.0462856
RPL23 ribosomal protein L23 -0.0453708
RPL34 ribosomal protein L34 -0.0452372
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0437731
GNAS GNAS complex locus -0.0435827
RBM25 RNA binding motif protein 25 -0.043072
NABP1 nucleic acid binding protein 1 -0.0428133
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0424996
RPL5 ribosomal protein L5 -0.042193
SP100 SP100 nuclear antigen -0.0403854
RPL13A ribosomal protein L13a -0.0402895
RPL35 ribosomal protein L35 -0.0402566
PGK1 phosphoglycerate kinase 1 -0.03993
RPL19 ribosomal protein L19 -0.0394532
MTDH metadherin -0.0388788
RPL37A ribosomal protein L37a -0.038659
HMGA1 high mobility group AT-hook 1 -0.0386023
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0378569
ANTXR2 anthrax toxin receptor 2 -0.0369082
RPS27 ribosomal protein S27 -0.0367861
EIF5B eukaryotic translation initiation factor 5B -0.0367178
RPL31 ribosomal protein L31 -0.0365496
ENO2 enolase 2 (gamma, neuronal) -0.035436
KTN1 kinectin 1 (kinesin receptor) -0.0347096
RAD51B RAD51 paralog B -0.033787
RPL18 ribosomal protein L18 -0.0337408
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0335568
S100A9 S100 calcium binding protein A9 -0.0329913
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0320232
RACK1 receptor for activated C kinase 1 -0.0317084
ASPH aspartate beta-hydroxylase -0.0316499
RPS27A ribosomal protein S27a -0.0314399
TCF12 transcription factor 12 -0.0314162
KRR1 KRR1, small subunit (SSU) processome component, homolog (yeast) -0.0313436
RPLP2 ribosomal protein, large, P2 -0.0311443
RPL36 ribosomal protein L36 -0.0309629
ZBTB20 zinc finger and BTB domain containing 20 -0.0308399
ALCAM activated leukocyte cell adhesion molecule -0.0306692
RPS21 ribosomal protein S21 -0.0305159
RPS13 ribosomal protein S13 -0.0303402
RPL26 ribosomal protein L26 -0.0300907
TRIO trio Rho guanine nucleotide exchange factor -0.0300117
PHF14 PHD finger protein 14 -0.0297243
ZFP36L1 ZFP36 ring finger protein-like 1 -0.0289674
LAMB3 laminin, beta 3 -0.0287652
RPL11 ribosomal protein L11 -0.0278243
MCTP1 multiple C2 domains, transmembrane 1 -0.0277729
SET SET nuclear proto-oncogene -0.0276354
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0275717
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0273498
BNC2 basonuclin 2 -0.0269964
RPL30 ribosomal protein L30 -0.0266766
ANKRD17 ankyrin repeat domain 17 -0.0265477
RPL7A ribosomal protein L7a -0.0264782
ACTG1 actin gamma 1 -0.026433
RPL28 ribosomal protein L28 -0.0263481
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0262068
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0261491
YBX3 Y box binding protein 3 -0.0259396
TPT1 tumor protein, translationally-controlled 1 -0.0257668
BPTF bromodomain PHD finger transcription factor -0.0256304
ATF4 activating transcription factor 4 -0.0253842
RPL32 ribosomal protein L32 -0.024922
B2M beta-2-microglobulin -0.0243221
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0241975
RPS29 ribosomal protein S29 -0.0237894
ARHGEF28 Rho guanine nucleotide exchange factor (GEF) 28 -0.023565
CSNK1A1 casein kinase 1, alpha 1 -0.0234168
PRPF40A PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) -0.0230518
RPS17 ribosomal protein S17 -0.0230463
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0229806
EIF1 eukaryotic translation initiation factor 1 -0.0227357
TPM4 tropomyosin 4 -0.0226625