Phenytoin (sodium)_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF2 eukaryotic translation elongation factor 2 0.196877
LOC112694756 uncharaterized LOC112694756 0.162103
GNPDA1 glucosamine-6-phosphate deaminase 1 0.100304
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0975765
SRRM2 serine/arginine repetitive matrix 2 0.0730743
VCL vinculin 0.0666056
PDE4B phosphodiesterase 4B, cAMP-specific 0.066134
LPP LIM domain containing preferred translocation partner in lipoma 0.0609845
PLXNA1 plexin A1 0.0580912
RPL3 ribosomal protein L3 0.0576701
TMSB4X thymosin beta 4, X-linked 0.056379
HDLBP high density lipoprotein binding protein 0.056247
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0524662
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0517069
CPED1 cadherin-like and PC-esterase domain containing 1 0.050268
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.0473132
EIF4H eukaryotic translation initiation factor 4H 0.0466406
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 0.0464337
LOXL3 lysyl oxidase-like 3 0.0454953
ELOVL5 ELOVL fatty acid elongase 5 0.0451865
CALR calreticulin 0.0427022
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0410932
SLC25A6 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6 0.0405203
ACTG1 actin gamma 1 0.0402305
HLA-C major histocompatibility complex, class I, C 0.0399733
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0388502
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0379209
ZMIZ1 zinc finger, MIZ-type containing 1 0.0375122
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0374492
PRRC2A proline-rich coiled-coil 2A 0.0371154
NFIA nuclear factor I/A 0.0370735
FASN fatty acid synthase 0.0369397
ENO2 enolase 2 (gamma, neuronal) 0.0365908
NPAS2 neuronal PAS domain protein 2 0.0364845
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0358754
FBLN2 fibulin 2 0.0355052
RPL13A ribosomal protein L13a 0.0352576
EIF4A2 eukaryotic translation initiation factor 4A2 0.0341258
AMOTL2 angiomotin like 2 0.0340806
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0339535
FAT1 FAT atypical cadherin 1 0.0339123
PCBP2 poly(rC) binding protein 2 0.0326667
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 0.0323103
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0312802
ANKRD11 ankyrin repeat domain 11 0.0308044
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0307854
PER1 period circadian clock 1 0.0306862
CTIF CBP80/20-dependent translation initiation factor 0.0305199
RPL35A ribosomal protein L35a 0.0303423
HSPA8 heat shock 70kDa protein 8 0.0302652
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0296513
WDR43 WD repeat domain 43 0.0294908
EIF4B eukaryotic translation initiation factor 4B 0.0289491
SAMD4A sterile alpha motif domain containing 4A 0.0289255
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0289178
FLNA filamin A, alpha 0.0283354
CD47 CD47 molecule 0.0278038
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0274934
RHOA ras homolog family member A 0.0274889
FOXP1 forkhead box P1 0.0274398
MSI2 musashi RNA-binding protein 2 0.027428
SSBP2 single-stranded DNA binding protein 2 0.0270844
GLI2 GLI family zinc finger 2 0.0265875
HJURP Holliday junction recognition protein 0.0264283
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0264188
TRERF1 transcriptional regulating factor 1 0.0259045
CAMKMT calmodulin-lysine N-methyltransferase 0.0256142
FKBP10 FK506 binding protein 10, 65 kDa 0.0254632
EPS8 epidermal growth factor receptor pathway substrate 8 0.0252965
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0241097
GANAB glucosidase, alpha; neutral AB 0.0239222
GCNT1 glucosaminyl (N-acetyl) transferase 1, core 2 0.0232663
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 0.0228839
NEBL nebulette 0.0228413
ATP7B ATPase, Cu++ transporting, beta polypeptide 0.0227027
TFG TRK-fused gene 0.0223704
ACTN4 actinin, alpha 4 0.022364
FLNB filamin B, beta 0.022249
ATOSA atos homolog A 0.0221619
CACNB4 calcium channel, voltage-dependent, beta 4 subunit 0.022084
ENTPD6 ectonucleoside triphosphate diphosphohydrolase 6 (putative) 0.0220667
GOLGA2 golgin A2 0.0220078
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0219945
IGF1R insulin-like growth factor 1 receptor 0.0216152
USP36 ubiquitin specific peptidase 36 0.0215353
PYGB phosphorylase, glycogen; brain 0.0213588
SREBF2 sterol regulatory element binding transcription factor 2 0.0210747
NCOR2 nuclear receptor corepressor 2 0.0208778
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0207351
PTTG1IP pituitary tumor-transforming 1 interacting protein 0.020558
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0205085
PDGFC platelet derived growth factor C 0.0202922
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0202681
DDIT4 DNA-damage-inducible transcript 4 0.0202672
NAV2 neuron navigator 2 0.0202485
OAZ1 ornithine decarboxylase antizyme 1 0.0201915
RACK1 receptor for activated C kinase 1 0.0200152
TPI1 triosephosphate isomerase 1 0.0199614
SURF4 surfeit 4 0.0199292
SND1 staphylococcal nuclease and tudor domain containing 1 0.0199001

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.334298
PTMA prothymosin, alpha -0.280578
PDE4D phosphodiesterase 4D, cAMP-specific -0.209211
ADAM10 ADAM metallopeptidase domain 10 -0.085864
TPT1 tumor protein, translationally-controlled 1 -0.0853754
RPS6 ribosomal protein S6 -0.080986
RPS2 ribosomal protein S2 -0.0665245
CCND1 cyclin D1 -0.0621288
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.061094
BMP10 bone morphogenetic protein 10 -0.0546785
PKM pyruvate kinase, muscle -0.052105
USP34 ubiquitin specific peptidase 34 -0.0478258
IFI16 interferon, gamma-inducible protein 16 -0.0448956
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0443736
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0430501
EML4 echinoderm microtubule associated protein like 4 -0.0425847
JMJD1C jumonji domain containing 1C -0.0425701
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0421953
ARL4C ADP-ribosylation factor-like 4C -0.0420296
ANXA1 annexin A1 -0.0417953
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 -0.0410866
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0402442
TXNRD1 thioredoxin reductase 1 -0.0394268
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0390505
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0386819
S100A10 S100 calcium binding protein A10 -0.0379753
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0372799
RPS23 ribosomal protein S23 -0.0369908
RPS8 ribosomal protein S8 -0.0355118
MACROD2 MACRO domain containing 2 -0.0351513
RPL26 ribosomal protein L26 -0.0344371
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0340031
SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila) -0.0334352
NIPBL Nipped-B homolog (Drosophila) -0.0330988
SETD5 SET domain containing 5 -0.0326917
UBC ubiquitin C -0.0325454
TAOK1 TAO kinase 1 -0.0320242
ZNF217 zinc finger protein 217 -0.0299886
SMNDC1 survival motor neuron domain containing 1 -0.0295
ATP9B ATPase, class II, type 9B -0.0288634
TAS2R14 taste receptor, type 2, member 14 -0.02878
MKI67 marker of proliferation Ki-67 -0.0287255
TMEM65 transmembrane protein 65 -0.0286725
GPHN gephyrin -0.0286599
CCNI cyclin I -0.0281689
SPATS2L spermatogenesis associated, serine-rich 2-like -0.0278605
RPL9 ribosomal protein L9 -0.0271852
TM4SF1 transmembrane 4 L six family member 1 -0.026882
RPL7A ribosomal protein L7a -0.0266023
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0264024
SQSTM1 sequestosome 1 -0.0263856
RAB10 RAB10, member RAS oncogene family -0.0261749
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0260387
ALDH1A2 aldehyde dehydrogenase 1 family, member A2 -0.0259582
RPS15 ribosomal protein S15 -0.0259262
RPLP2 ribosomal protein, large, P2 -0.0255269
SENP6 SUMO1/sentrin specific peptidase 6 -0.0253021
WSB1 WD repeat and SOCS box containing 1 -0.0247595
MYO9A myosin IXA -0.0243647
ECPAS Ecm29 proteasome adaptor and scaffold -0.0242313
ANKRD12 ankyrin repeat domain 12 -0.0242113
RPL38 ribosomal protein L38 -0.0240054
ZNF608 zinc finger protein 608 -0.0239288
EIF5B eukaryotic translation initiation factor 5B -0.0236813
FER fer (fps/fes related) tyrosine kinase -0.0236751
NBEAL1 neurobeachin-like 1 -0.0236612
NAP1L1 nucleosome assembly protein 1-like 1 -0.0235425
SDK1 sidekick cell adhesion molecule 1 -0.0231916
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0230373
PHF3 PHD finger protein 3 -0.0229573
H1-4 H1.4 linker histone, cluster member -0.0225016
SPAG9 sperm associated antigen 9 -0.0223793
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0223614
RPS24 ribosomal protein S24 -0.0222846
RSRC1 arginine/serine-rich coiled-coil 1 -0.0219115
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0216748
MAP4 microtubule-associated protein 4 -0.0216686
SOS1 son of sevenless homolog 1 (Drosophila) -0.0214218
S100A11 S100 calcium binding protein A11 -0.0214082
PHIP pleckstrin homology domain interacting protein -0.021369
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0210578
RPS13 ribosomal protein S13 -0.0209486
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase -0.0208688
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0208547
PUM2 pumilio RNA-binding family member 2 -0.0207992
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0206679
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -0.0205847
RPL19 ribosomal protein L19 -0.0205611
BRD2 bromodomain containing 2 -0.0205044
RPS5 ribosomal protein S5 -0.0204555
NAMPT nicotinamide phosphoribosyltransferase -0.0203572
RPL36A ribosomal protein L36a -0.0201643
GALNT5 polypeptide N-acetylgalactosaminyltransferase 5 -0.0201143
RPS10 ribosomal protein S10 -0.0200909
UBXN4 UBX domain protein 4 -0.0200658
B2M beta-2-microglobulin -0.0196517
LOC102724023 ES1 protein homolog, mitochondrial -0.0195187
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0194258
EIF1 eukaryotic translation initiation factor 1 -0.0194148
RPL32 ribosomal protein L32 -0.0193976