Phenytoin (sodium)_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MYH9 myosin, heavy chain 9, non-muscle 0.280023
FN1 fibronectin 1 0.201493
TRIO trio Rho guanine nucleotide exchange factor 0.145188
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.132957
NDRG1 N-myc downstream regulated 1 0.12912
EEF2 eukaryotic translation elongation factor 2 0.127471
ZMIZ1 zinc finger, MIZ-type containing 1 0.115123
NAV2 neuron navigator 2 0.105401
FLNA filamin A, alpha 0.102216
SOD2 superoxide dismutase 2, mitochondrial 0.0947307
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0945603
COL6A3 collagen, type VI, alpha 3 0.0812156
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0806493
VEGFA vascular endothelial growth factor A 0.0796017
MYOF myoferlin 0.0784674
MSN moesin 0.0761622
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0703814
HLA-C major histocompatibility complex, class I, C 0.0684844
LOC112694756 uncharaterized LOC112694756 0.065128
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0646733
PDE10A phosphodiesterase 10A 0.064371
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0566963
PCBP2 poly(rC) binding protein 2 0.0556981
FNDC3B fibronectin type III domain containing 3B 0.0549709
ARRDC3 arrestin domain containing 3 0.0530785
USP9X ubiquitin specific peptidase 9, X-linked 0.0485468
RPS4X ribosomal protein S4, X-linked 0.048437
CEP250 centrosomal protein 250kDa 0.0470931
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0469476
MX1 MX dynamin-like GTPase 1 0.0460395
PRELID2 PRELI domain containing 2 0.0458794
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0453294
TNIP1 TNFAIP3 interacting protein 1 0.0448278
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0441693
OPTN optineurin 0.0438997
FTH1 ferritin, heavy polypeptide 1 0.0430038
DST dystonin 0.0428781
SEPTIN9 septin 9 0.0427734
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0427082
CADM1 cell adhesion molecule 1 0.0405835
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0399117
HSPA8 heat shock 70kDa protein 8 0.038493
NAMPT nicotinamide phosphoribosyltransferase 0.038419
ZNF292 zinc finger protein 292 0.0382094
FHIP1A FHF complex subunit HOOK interacting protein 1A 0.037864
FRMPD4 FERM and PDZ domain containing 4 0.0374966
FMNL2 formin-like 2 0.0372367
SHB Src homology 2 domain containing adaptor protein B 0.0368839
CALR calreticulin 0.0368656
NEK6 NIMA-related kinase 6 0.0366584
SPARC secreted protein, acidic, cysteine-rich (osteonectin) 0.0366565
ESYT2 extended synaptotagmin-like protein 2 0.0365489
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0365356
HELZ helicase with zinc finger 0.036301
MXI1 MAX interactor 1, dimerization protein 0.0362385
EIF4H eukaryotic translation initiation factor 4H 0.0358615
KIRREL3 kin of IRRE like 3 (Drosophila) 0.0358306
ANXA2 annexin A2 0.0353106
SDK1 sidekick cell adhesion molecule 1 0.0349987
GOLGA4 golgin A4 0.0349129
PFKP phosphofructokinase, platelet 0.0348364
PLEC plectin 0.0345299
FLNB filamin B, beta 0.0343608
LOXL2 lysyl oxidase-like 2 0.0343331
SFTPA2 surfactant protein A2 0.033338
SRRM2 serine/arginine repetitive matrix 2 0.0323463
RPL3 ribosomal protein L3 0.0319607
AFF4 AF4/FMR2 family, member 4 0.0314203
ATP13A3 ATPase type 13A3 0.0312819
APLP2 amyloid beta (A4) precursor-like protein 2 0.0307608
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0300423
B2M beta-2-microglobulin 0.029809
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.02979
WDFY1 WD repeat and FYVE domain containing 1 0.0296942
UBA6 ubiquitin-like modifier activating enzyme 6 0.0296871
BACE2 beta-site APP-cleaving enzyme 2 0.0294726
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 0.0293443
TAPBP TAP binding protein (tapasin) 0.0289727
TPM3 tropomyosin 3 0.0286872
NONO non-POU domain containing, octamer-binding 0.0279928
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0278818
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0274689
RNF213 ring finger protein 213 0.0272478
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0270008
FBXO32 F-box protein 32 0.0269295
ADM adrenomedullin 0.0267016
FOXO3 forkhead box O3 0.0266661
MCL1 myeloid cell leukemia 1 0.0264636
RPS12 ribosomal protein S12 0.0263603
ZFAND3 zinc finger, AN1-type domain 3 0.0263192
RPS3 ribosomal protein S3 0.0263046
KDM2A lysine (K)-specific demethylase 2A 0.0262874
KDM6A lysine (K)-specific demethylase 6A 0.0261143
ANXA5 annexin A5 0.0258022
AFAP1 actin filament associated protein 1 0.0257701
SNX9 sorting nexin 9 0.0257114
PGM3 phosphoglucomutase 3 0.0256793
TSC22D2 TSC22 domain family, member 2 0.0252702
GRIN2A glutamate receptor, ionotropic, N-methyl D-aspartate 2A 0.0250751
FAM219A family with sequence similarity 219, member A 0.0249213

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.145386
BICC1 BicC family RNA binding protein 1 -0.124892
GLIS3 GLIS family zinc finger 3 -0.099486
VIM vimentin -0.0865727
VCL vinculin -0.0738242
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0679115
AKAP12 A kinase (PRKA) anchor protein 12 -0.0576869
HMGA2 high mobility group AT-hook 2 -0.0557436
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0533157
KYNU kynureninase -0.0508143
NABP1 nucleic acid binding protein 1 -0.0491144
FTL ferritin, light polypeptide -0.0485521
PALLD palladin, cytoskeletal associated protein -0.0485409
EXT1 exostosin glycosyltransferase 1 -0.0473011
IER3 immediate early response 3 -0.0451002
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0414113
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0405819
PAPPA pregnancy-associated plasma protein A, pappalysin 1 -0.0401569
EGR1 early growth response 1 -0.0392654
TMSB10 thymosin beta 10 -0.0378958
EHBP1 EH domain binding protein 1 -0.0378907
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0376429
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0361544
MKI67 marker of proliferation Ki-67 -0.0344858
SLC38A2 solute carrier family 38, member 2 -0.033792
IFI16 interferon, gamma-inducible protein 16 -0.0330057
DCBLD1 discoidin, CUB and LCCL domain containing 1 -0.032225
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0318322
RIGI RNA sensor RIG-I -0.0307325
RAI14 retinoic acid induced 14 -0.0306049
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0303315
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.029409
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0293268
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0288216
PTMA prothymosin, alpha -0.0277675
BTG1 B-cell translocation gene 1, anti-proliferative -0.0275203
OSMR oncostatin M receptor -0.0268903
ZMYND8 zinc finger, MYND-type containing 8 -0.0267503
PTPRK protein tyrosine phosphatase, receptor type, K -0.0261343
TPT1 tumor protein, translationally-controlled 1 -0.0258571
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.02524
GOPC golgi-associated PDZ and coiled-coil motif containing -0.0245042
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0244681
USP34 ubiquitin specific peptidase 34 -0.0243115
HLA-B major histocompatibility complex, class I, B -0.0242708
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0241729
ZBTB20 zinc finger and BTB domain containing 20 -0.0241581
VMP1 vacuole membrane protein 1 -0.0238124
ARHGAP5 Rho GTPase activating protein 5 -0.0236726
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0236724
SMAD2 SMAD family member 2 -0.02346
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0232472
RBBP6 retinoblastoma binding protein 6 -0.0232113
TUT7 terminal uridylyl transferase 7 -0.0230297
DIAPH2 diaphanous-related formin 2 -0.0229853
SLC38A1 solute carrier family 38, member 1 -0.0225085
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0224057
BPTF bromodomain PHD finger transcription factor -0.021802
RPS6 ribosomal protein S6 -0.0215888
MAML2 mastermind-like 2 (Drosophila) -0.0214762
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B -0.021353
MAP1B microtubule-associated protein 1B -0.0211507
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0208769
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0208083
NTN4 netrin 4 -0.020667
KPNB1 karyopherin (importin) beta 1 -0.0206089
HDAC8 histone deacetylase 8 -0.0202625
SP100 SP100 nuclear antigen -0.0201943
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0201379
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0199559
CASK calcium/calmodulin-dependent serine protein kinase (MAGUK family) -0.0191742
PDLIM5 PDZ and LIM domain 5 -0.019174
CD2AP CD2-associated protein -0.0189416
CEP112 centrosomal protein 112kDa -0.0188742
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) -0.0188629
RPL36A ribosomal protein L36a -0.0187398
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0185456
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0185389
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0184182
CENPF centromere protein F, 350/400kDa -0.018346
GNAS GNAS complex locus -0.0182868
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0180793
JAK2 Janus kinase 2 -0.0179528
DIAPH3 diaphanous-related formin 3 -0.0177891
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0177176
GPATCH8 G patch domain containing 8 -0.017624
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0175447
SMYD3 SET and MYND domain containing 3 -0.0174325
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0174123
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0174093
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0171784
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0170435
NRP1 neuropilin 1 -0.0169179
TRIM55 tripartite motif containing 55 -0.016891
LOX lysyl oxidase -0.0168664
UGCG UDP-glucose ceramide glucosyltransferase -0.0167916
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0166588
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0166065
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0165127
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats -0.0163855