Phenytoin (sodium)_SW 1271 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Phenytoin (sodium) perturbation in SW 1271 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Phenytoin (sodium)_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.138457
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0909306
LOC112694756 uncharaterized LOC112694756 0.0815904
NAV2 neuron navigator 2 0.080131
ENO1 enolase 1, (alpha) 0.0726174
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.061282
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0590185
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0553295
CEP250 centrosomal protein 250kDa 0.0548455
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0522156
IGFBP3 insulin-like growth factor binding protein 3 0.0520025
POTEF POTE ankyrin domain family, member F 0.0518445
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0504083
PBX3 pre-B-cell leukemia homeobox 3 0.0484871
NIBAN2 niban apoptosis regulator 2 0.0482372
PRRC2C proline-rich coiled-coil 2C 0.0463403
HSPA8 heat shock 70kDa protein 8 0.0460361
CENPF centromere protein F, 350/400kDa 0.0456006
MPRIP myosin phosphatase Rho interacting protein 0.0447704
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0443501
PKM pyruvate kinase, muscle 0.0436809
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0435508
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0421349
SLC38A2 solute carrier family 38, member 2 0.0418044
NDRG1 N-myc downstream regulated 1 0.0405275
CENPE centromere protein E, 312kDa 0.0394973
SRRM2 serine/arginine repetitive matrix 2 0.0394032
MACF1 microtubule-actin crosslinking factor 1 0.0388844
PRC1 protein regulator of cytokinesis 1 0.0378232
FNDC3A fibronectin type III domain containing 3A 0.0374824
PYGL phosphorylase, glycogen, liver 0.036219
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) 0.0360409
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0357801
HJURP Holliday junction recognition protein 0.0355092
NCOA6 nuclear receptor coactivator 6 0.0352513
MYH9 myosin, heavy chain 9, non-muscle 0.0344982
ANKRD36 ankyrin repeat domain 36 0.034038
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0335489
BABAM2 BRISC and BRCA1 A complex member 2 0.0332623
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0330369
SPAG9 sperm associated antigen 9 0.032957
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0323145
MGAT5 mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase 0.0319217
MKI67 marker of proliferation Ki-67 0.0318916
RTN4 reticulon 4 0.0316121
ACTG1 actin gamma 1 0.0312081
GOLGA4 golgin A4 0.0310407
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0307702
CALU calumenin 0.0305044
UTRN utrophin 0.0301981
SET SET nuclear proto-oncogene 0.0301341
ESYT2 extended synaptotagmin-like protein 2 0.0294343
HMMR hyaluronan-mediated motility receptor (RHAMM) 0.0293008
TPM3 tropomyosin 3 0.0287652
GABARAPL1 GABA(A) receptor-associated protein like 1 0.028695
CSNK1A1 casein kinase 1, alpha 1 0.0285465
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0284646
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0284281
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0281838
FLNA filamin A, alpha 0.0275613
TNIP1 TNFAIP3 interacting protein 1 0.026802
FAM168A family with sequence similarity 168, member A 0.0265931
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0258133
FXR1 fragile X mental retardation, autosomal homolog 1 0.0256239
PEAK1 pseudopodium-enriched atypical kinase 1 0.0255959
ANKRD11 ankyrin repeat domain 11 0.0254211
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0252943
SNX14 sorting nexin 14 0.025246
RAD23B RAD23 homolog B (S. cerevisiae) 0.0251381
B2M beta-2-microglobulin 0.0248114
RPL3 ribosomal protein L3 0.0246783
EIF4H eukaryotic translation initiation factor 4H 0.0246476
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 0.0246286
SASH1 SAM and SH3 domain containing 1 0.0244104
CDC27 cell division cycle 27 0.0241835
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 0.0239631
AHCTF1 AT hook containing transcription factor 1 0.0239314
RNF213 ring finger protein 213 0.0239229
KIF5B kinesin family member 5B 0.0238954
TUBB tubulin, beta class I 0.0236958
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0236812
SDK1 sidekick cell adhesion molecule 1 0.023673
TNRC6B trinucleotide repeat containing 6B 0.0236213
SLC35F5 solute carrier family 35, member F5 0.0236143
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.02343
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 0.0234062
LMO7 LIM domain 7 0.0232059
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0230436
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0230434
ANLN anillin, actin binding protein 0.0229179
WDR45B WD repeat domain 45B 0.0228674
LGALS1 lectin, galactoside-binding, soluble, 1 0.0228109
MAP2K1 mitogen-activated protein kinase kinase 1 0.0226875
SHB Src homology 2 domain containing adaptor protein B 0.0225733
BSG basigin (Ok blood group) 0.0224603
RIN2 Ras and Rab interactor 2 0.0223372
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0223291
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 0.022195
MSN moesin 0.0220517
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0220294

decreased expression

Symbol Name Standardized Value
DSCAM Down syndrome cell adhesion molecule -0.0728124
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0549289
VIM vimentin -0.0538294
TAS2R14 taste receptor, type 2, member 14 -0.0535805
SMYD3 SET and MYND domain containing 3 -0.0491091
JMJD1C jumonji domain containing 1C -0.0472685
TPT1 tumor protein, translationally-controlled 1 -0.0449455
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0433635
WSB1 WD repeat and SOCS box containing 1 -0.0433234
CD44 CD44 molecule (Indian blood group) -0.0412549
MBD5 methyl-CpG binding domain protein 5 -0.0397903
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0388632
FMNL2 formin-like 2 -0.0383056
OXSR1 oxidative stress responsive 1 -0.0381849
RDX radixin -0.0377163
PALM2AKAP2 PALM2 and AKAP2 fusion -0.0371025
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0362164
AKAP13 A kinase (PRKA) anchor protein 13 -0.0359875
GPC6 glypican 6 -0.0359265
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0354538
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0349156
DERA deoxyribose-phosphate aldolase (putative) -0.0342629
USP34 ubiquitin specific peptidase 34 -0.0336764
RAI14 retinoic acid induced 14 -0.0323404
RPS27A ribosomal protein S27a -0.0317365
ZBTB20 zinc finger and BTB domain containing 20 -0.0316807
ANKRD28 ankyrin repeat domain 28 -0.0315809
ITCH itchy E3 ubiquitin protein ligase -0.0315209
FBXL2 F-box and leucine-rich repeat protein 2 -0.0313143
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) -0.0312127
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0310689
TRIO trio Rho guanine nucleotide exchange factor -0.0307133
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0306722
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0305268
PRH1 proline-rich protein HaeIII subfamily 1 -0.030309
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0301811
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0296731
TENT2 terminal nucleotidyltransferase 2 -0.0295453
SETD5 SET domain containing 5 -0.0295344
ZFAND3 zinc finger, AN1-type domain 3 -0.0288955
TTC3 tetratricopeptide repeat domain 3 -0.0288159
ZC3H12B zinc finger CCCH-type containing 12B -0.0287693
CANX calnexin -0.0286098
ASXL1 additional sex combs like transcriptional regulator 1 -0.0282457
PTMA prothymosin, alpha -0.0278959
PPP1CC protein phosphatase 1, catalytic subunit, gamma isozyme -0.0272705
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0270675
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0269848
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0267134
NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase -0.0264825
TMSB10 thymosin beta 10 -0.0262569
RB1 retinoblastoma 1 -0.0260584
PTBP3 polypyrimidine tract binding protein 3 -0.0258379
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0258147
MON2 MON2 homolog (S. cerevisiae) -0.0257851
ANKRD12 ankyrin repeat domain 12 -0.025711
GNAQ guanine nucleotide binding protein (G protein), q polypeptide -0.0256478
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -0.0255204
TAF1 TAF1 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 250kDa -0.0253197
BTG1 B-cell translocation gene 1, anti-proliferative -0.024635
PLEKHB2 pleckstrin homology domain containing, family B (evectins) member 2 -0.0242052
GNAS GNAS complex locus -0.0241191
ZC3H6 zinc finger CCCH-type containing 6 -0.0240762
EGR1 early growth response 1 -0.0240504
VPS13C vacuolar protein sorting 13 homolog C (S. cerevisiae) -0.0240065
RPL12 ribosomal protein L12 -0.0238766
HDAC9 histone deacetylase 9 -0.0238666
SF1 splicing factor 1 -0.0237316
SCAF11 SR-related CTD-associated factor 11 -0.0236466
DNAH14 dynein, axonemal, heavy chain 14 -0.0236378
NUP153 nucleoporin 153kDa -0.0235093
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 -0.023482
ZBTB44 zinc finger and BTB domain containing 44 -0.0233523
U2SURP U2 snRNP-associated SURP domain containing -0.0233181
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0233087
RNF216 ring finger protein 216 -0.0231283
REST RE1-silencing transcription factor -0.0229716
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.022925
YAP1 Yes-associated protein 1 -0.0225768
PHIP pleckstrin homology domain interacting protein -0.0225485
CEP290 centrosomal protein 290kDa -0.0225402
EFL1 elongation factor like GTPase 1 -0.0220679
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0219676
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase -0.0219414
MAP1B microtubule-associated protein 1B -0.0216776
TBL1X transducin (beta)-like 1X-linked -0.0216454
XRN1 5'-3' exoribonuclease 1 -0.0215132
WDR70 WD repeat domain 70 -0.0215119
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0214799
RPL35A ribosomal protein L35a -0.0214053
LRRC49 leucine rich repeat containing 49 -0.021237
ACTN4 actinin, alpha 4 -0.0212058
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0210915
FER fer (fps/fes related) tyrosine kinase -0.0210396
NABP1 nucleic acid binding protein 1 -0.0209641
PDSS2 prenyl (decaprenyl) diphosphate synthase, subunit 2 -0.0208496
NOP58 NOP58 ribonucleoprotein -0.0208432
PHF14 PHD finger protein 14 -0.0207747
DENND4A DENN/MADD domain containing 4A -0.0207662
MBTD1 mbt domain containing 1 -0.0206431