Phospholipase D signaling pathway Gene Set

Dataset KEGG Pathways 2026
Category structural or functional annotations
Type pathway
Description Phospholipase D (PLD) is an essential enzyme responsible for the production of the lipid second messenger phosphatidic acid (PA), which is involved in fundamental cellular processes, including membrane trafficking, actin cytoskeleton remodeling, cell proliferation and cell survival. PLD activity can be stimulated by a large number of cell surface receptors and is elaborately regulated by intracellular factors, including protein kinase C isoforms, small GTPases of the ARF, Rho and Ras families and the phosphoinositide, phosphatidylinositol 4,5-bisphosphate (PIP2). The PLD-produced PA activates signaling proteins and acts as a node within the membrane to which signaling proteins translocate. Several signaling proteins, including Raf-1 and mTOR, directly bind PA to mediate translocation or activation, respectively. (Kyoto Encyclopedia of Genes and Genomes, hsa04072)
External Link https://www.kegg.jp/entry/hsa04072
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147 proteins participating in the Phospholipase D signaling pathway pathway from the KEGG Pathways 2026 dataset.

Symbol Name
ADCY1 adenylate cyclase 1 (brain)
ADCY2 adenylate cyclase 2 (brain)
ADCY4 adenylate cyclase 4
ADCY5 adenylate cyclase 5
ADCY6 adenylate cyclase 6
ADCY7 adenylate cyclase 7
ADCY8 adenylate cyclase 8 (brain)
ADCY9 adenylate cyclase 9
AGPAT1 1-acylglycerol-3-phosphate O-acyltransferase 1
AGPAT2 1-acylglycerol-3-phosphate O-acyltransferase 2
AGPAT3 1-acylglycerol-3-phosphate O-acyltransferase 3
AGPAT4 1-acylglycerol-3-phosphate O-acyltransferase 4
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5
AGTR1 angiotensin II receptor, type 1
AGXT alanine-glyoxylate aminotransferase
AKT1 v-akt murine thymoma viral oncogene homolog 1
AKT2 v-akt murine thymoma viral oncogene homolog 2
AKT3 v-akt murine thymoma viral oncogene homolog 3
ARF1 ADP-ribosylation factor 1
ARF6 ADP-ribosylation factor 6
AVPR1A arginine vasopressin receptor 1A
AVPR1B arginine vasopressin receptor 1B
AVPR2 arginine vasopressin receptor 2
CLSTN1 calsyntenin 1
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR1 chemokine (C-X-C motif) receptor 1
CXCR2 chemokine (C-X-C motif) receptor 2
CYTH1 cytohesin 1
CYTH2 cytohesin 2
CYTH3 cytohesin 3
CYTH4 cytohesin 4
DGKA diacylglycerol kinase, alpha 80kDa
DGKB diacylglycerol kinase, beta 90kDa
DGKD diacylglycerol kinase, delta 130kDa
DGKE diacylglycerol kinase, epsilon 64kDa
DGKG diacylglycerol kinase, gamma 90kDa
DGKH diacylglycerol kinase, eta
DGKI diacylglycerol kinase, iota
DGKK diacylglycerol kinase, kappa
DGKQ diacylglycerol kinase, theta 110kDa
DGKZ diacylglycerol kinase, zeta
DNM1 dynamin 1
DNM2 dynamin 2
DNM3 dynamin 3
EGF epidermal growth factor
EGFR epidermal growth factor receptor
F2R coagulation factor II (thrombin) receptor
FCER1A Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide
FYN FYN proto-oncogene, Src family tyrosine kinase
GAB2 GRB2-associated binding protein 2
GNA12 guanine nucleotide binding protein (G protein) alpha 12
GNA13 guanine nucleotide binding protein (G protein), alpha 13
GNAS GNAS complex locus
GRB2 growth factor receptor-bound protein 2
GRM1 glutamate receptor, metabotropic 1
GRM2 glutamate receptor, metabotropic 2
GRM3 glutamate receptor, metabotropic 3
GRM4 glutamate receptor, metabotropic 4
GRM5 glutamate receptor, metabotropic 5
GRM6 glutamate receptor, metabotropic 6
GRM7 glutamate receptor, metabotropic 7
GRM8 glutamate receptor, metabotropic 8
HRAS Harvey rat sarcoma viral oncogene homolog
INS insulin
INSR insulin receptor
JMJD7-PLA2G4B JMJD7-PLA2G4B readthrough
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KITLG KIT ligand
LNCEGFL7OS lncRNA EGFL7 opposite strand
LOC102724971 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8
LPAR1 lysophosphatidic acid receptor 1
LPAR2 lysophosphatidic acid receptor 2
LPAR3 lysophosphatidic acid receptor 3
LPAR4 lysophosphatidic acid receptor 4
LPAR5 lysophosphatidic acid receptor 5
LPAR6 lysophosphatidic acid receptor 6
MAP2K1 mitogen-activated protein kinase kinase 1
MAP2K2 mitogen-activated protein kinase kinase 2
MAPK1 mitogen-activated protein kinase 1
MAPK3 mitogen-activated protein kinase 3
MRAS muscle RAS oncogene homolog
MS4A2 membrane-spanning 4-domains, subfamily A, member 2
MTOR mechanistic target of rapamycin (serine/threonine kinase)
NLRP3 NLR family, pyrin domain containing 3
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PDGFA platelet-derived growth factor alpha polypeptide
PDGFB platelet-derived growth factor beta polypeptide
PDGFC platelet derived growth factor C
PDGFD platelet derived growth factor D
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PDGFRB platelet-derived growth factor receptor, beta polypeptide
PIGU phosphatidylinositol glycan anchor biosynthesis, class U
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta)
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma)
PIK3R5 phosphoinositide-3-kinase, regulatory subunit 5
PIK3R6 phosphoinositide-3-kinase, regulatory subunit 6
PIP5K1A phosphatidylinositol-4-phosphate 5-kinase, type I, alpha
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta
PIP5K1C phosphatidylinositol-4-phosphate 5-kinase, type I, gamma
PLA2G4A phospholipase A2, group IVA (cytosolic, calcium-dependent)
PLA2G4B phospholipase A2, group IVB (cytosolic)
PLA2G4C phospholipase A2, group IVC (cytosolic, calcium-independent)
PLA2G4D phospholipase A2, group IVD (cytosolic)
PLA2G4E phospholipase A2, group IVE
PLA2G4F phospholipase A2, group IVF
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)
PLCB2 phospholipase C, beta 2
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PLCB4 phospholipase C, beta 4
PLCG1 phospholipase C, gamma 1
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific)
PLD2 phospholipase D2
PLPP1 phospholipid phosphatase 1
PLPP2 phospholipid phosphatase 2
PLPP3 phospholipid phosphatase 3
PRKCA protein kinase C, alpha
PRKCSH protein kinase C substrate 80K-H
PTGFR prostaglandin F receptor (FP)
PTK2B protein tyrosine kinase 2 beta
PTPN11 protein tyrosine phosphatase, non-receptor type 11
RALA v-ral simian leukemia viral oncogene homolog A (ras related)
RALB v-ral simian leukemia viral oncogene homolog B
RALGDS ral guanine nucleotide dissociation stimulator
RAPGEF3 Rap guanine nucleotide exchange factor (GEF) 3
RAPGEF4 Rap guanine nucleotide exchange factor (GEF) 4
RHEB Ras homolog enriched in brain
RHOA ras homolog family member A
RNASE3 ribonuclease, RNase A family, 3
RRAS related RAS viral (r-ras) oncogene homolog
RRAS2 related RAS viral (r-ras) oncogene homolog 2
SHC1 SHC (Src homology 2 domain containing) transforming protein 1
SHC2 SHC (Src homology 2 domain containing) transforming protein 2
SHC3 SHC (Src homology 2 domain containing) transforming protein 3
SHC4 SHC (Src homology 2 domain containing) family, member 4
SOS1 son of sevenless homolog 1 (Drosophila)
SOS2 son of sevenless homolog 2 (Drosophila)
SPHK1 sphingosine kinase 1
SPHK2 sphingosine kinase 2
SYK spleen tyrosine kinase
TSC1 tuberous sclerosis 1
TSC2 tuberous sclerosis 2
TTF2 transcription termination factor, RNA polymerase II