Phyllodes Tumor Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description A benign, borderline, or malignant fibroepithelial neoplasm arising from the breast and rarely the prostate gland. It may recur following resection. The recurrence rates are higher for borderline and malignant phyllodes tumors. In borderline and malignant phyllodes tumors metastases to distant anatomic sites can occur. The incidence of metastases is higher in malignant phyllodes tumors.|A type of connective tissue neoplasm arising from intralobular stroma of the BREAST. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS.|A type of connective tissue neoplasm typically arising from intralobular stroma of the breast. It is characterized by the rapid enlargement of an asymmetric firm mobile mass. Histologically, its leaf-like stromal clefts are lined by EPITHELIAL CELLS. Rare phyllodes tumor of the prostate is also known. (Experimental Factor Ontology, EFO_0000653)
External Link https://www.disgenet.org/browser/0/1/0/C0010701
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Genes

94 genes associated with the disease Phyllodes Tumor in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ACTB actin, beta
AKT1 v-akt murine thymoma viral oncogene homolog 1
AR androgen receptor
BRCA1 breast cancer 1, early onset
CA9 carbonic anhydrase IX
CCL18 chemokine (C-C motif) ligand 18 (pulmonary and activation-regulated)
CCL19 chemokine (C-C motif) ligand 19
CCL20 chemokine (C-C motif) ligand 20
CCND1 cyclin D1
CD276 CD276 molecule
CD34 CD34 molecule
CDK4 cyclin-dependent kinase 4
CDKN2A cyclin-dependent kinase inhibitor 2A
CKAP4 cytoskeleton-associated protein 4
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL12 chemokine (C-X-C motif) ligand 12
CXCR4 chemokine (C-X-C motif) receptor 4
DCN decorin
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5
DPT dermatopontin
EGFR epidermal growth factor receptor
ERBB2 erb-b2 receptor tyrosine kinase 2
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
FASN fatty acid synthase
FGFR1 fibroblast growth factor receptor 1
FHIT fragile histidine triad
FLNA filamin A, alpha
FOXC2 forkhead box C2
FOXP3 forkhead box P3
GEMIN2 gem (nuclear organelle) associated protein 2
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)
HMGA2 high mobility group AT-hook 2
HOXB13 homeobox B13
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IL21 interleukin 21
IL22 interleukin 22
ILK integrin-linked kinase
IMPACT impact RWD domain protein
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa
KIF22 kinesin family member 22
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog
KMT2D lysine (K)-specific methyltransferase 2D
LOC102724428 serine/threonine-protein kinase SIK1
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase
MED12 mediator complex subunit 12
MLH1 mutL homolog 1
MMP14 matrix metallopeptidase 14 (membrane-inserted)
MMP2 matrix metallopeptidase 2
MMP9 matrix metallopeptidase 9
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MYC v-myc avian myelocytomatosis viral oncogene homolog
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
NTRK1 neurotrophic tyrosine kinase, receptor, type 1
OBP2A odorant binding protein 2A
PDGFRA platelet-derived growth factor receptor, alpha polypeptide
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
POSTN periostin, osteoblast specific factor
PRAME preferentially expressed antigen in melanoma
RARA retinoic acid receptor, alpha
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RBM15 RNA binding motif protein 15
RCAN1 regulator of calcineurin 1
RCAN2 regulator of calcineurin 2
RPE65 retinal pigment epithelium-specific protein 65kDa
S100A4 S100 calcium binding protein A4
SCAF11 SR-related CTD-associated factor 11
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp)
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SETD2 SET domain containing 2
SIK1 salt-inducible kinase 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SSR1 signal sequence receptor, alpha
TERT telomerase reverse transcriptase
TNFRSF25 tumor necrosis factor receptor superfamily, member 25
TOX thymocyte selection-associated high mobility group box
TP53 tumor protein p53
TP63 tumor protein p63
TRAM1 translocation associated membrane protein 1
TSC1 tuberous sclerosis 1
TWIST1 twist family bHLH transcription factor 1
UVRAG UV radiation resistance associated
VIM vimentin
VTCN1 V-set domain containing T cell activation inhibitor 1
ZBED1 zinc finger, BED-type containing 1
ZEB1 zinc finger E-box binding homeobox 1
ZEB2 zinc finger E-box binding homeobox 2
ZNF410 zinc finger protein 410