| Dataset | DeepCoverMOA Drug Mechanisms of Action |
| Category | proteomics |
| Type | drug perturbation |
| External Link | https://pubchem.ncbi.nlm.nih.gov/compound/10071196 |
| Similar Terms | |
| Downloads & Tools |
198 proteins with high or low expression in Pimavanserin relative to other proteins from the DeepCoverMOA Drug Mechanisms of Action dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | 1.76 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | 1.71 |
| APOB | apolipoprotein B | 1.68 |
| DISP1 | dispatched homolog 1 (Drosophila) | 1.67 |
| LAPTM4A | lysosomal protein transmembrane 4 alpha | 1.42 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | 1.37 |
| TRAPPC6B | trafficking protein particle complex 6B | 1.26 |
| IDI1 | isopentenyl-diphosphate delta isomerase 1 | 1.24 |
| SQLE | squalene epoxidase | 1.19 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 1.18 |
| NCOA4 | nuclear receptor coactivator 4 | 1.16 |
| VAV1 | vav 1 guanine nucleotide exchange factor | 1.15 |
| TRPM7 | transient receptor potential cation channel, subfamily M, member 7 | 1.11 |
| INPP5J | inositol polyphosphate-5-phosphatase J | 1.09 |
| NDFIP1 | Nedd4 family interacting protein 1 | 1.09 |
| TMEM59 | transmembrane protein 59 | 1.08 |
| LGALSL | lectin, galactoside-binding-like | 1.07 |
| MSMO1 | methylsterol monooxygenase 1 | 1.03 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.94 |
| ACSS2 | acyl-CoA synthetase short-chain family member 2 | 0.91 |
| STAB1 | stabilin 1 | 0.91 |
| HSD17B7 | hydroxysteroid (17-beta) dehydrogenase 7 | 0.89 |
| LSS | lanosterol synthase (2,3-oxidosqualene-lanosterol cyclase) | 0.86 |
| SC5D | sterol-C5-desaturase | 0.86 |
| LDLR | low density lipoprotein receptor | 0.84 |
| FGFBP1 | fibroblast growth factor binding protein 1 | 0.83 |
| SCNN1A | sodium channel, non voltage gated 1 alpha subunit | 0.83 |
| TSPAN3 | tetraspanin 3 | 0.81 |
| CYP51A1 | cytochrome P450, family 51, subfamily A, polypeptide 1 | 0.8 |
| MVK | mevalonate kinase | 0.79 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | 0.78 |
| DHCR7 | 7-dehydrocholesterol reductase | 0.76 |
| TTLL4 | tubulin tyrosine ligase-like family member 4 | 0.76 |
| NBR1 | neighbor of BRCA1 gene 1 | 0.75 |
| DHCR24 | 24-dehydrocholesterol reductase | 0.74 |
| MAP1LC3B2 | microtubule-associated protein 1 light chain 3 beta 2 | 0.73 |
| ITM2C | integral membrane protein 2C | 0.73 |
| MID1IP1 | MID1 interacting protein 1 | 0.71 |
| LPIN1 | lipin 1 | 0.71 |
| ACAT2 | acetyl-CoA acetyltransferase 2 | 0.7 |
| YIPF1 | Yip1 domain family, member 1 | 0.69 |
| S100A14 | S100 calcium binding protein A14 | 0.68 |
| FAR1 | fatty acyl CoA reductase 1 | 0.67 |
| S100A16 | S100 calcium binding protein A16 | 0.65 |
| FDPS | farnesyl diphosphate synthase | 0.65 |
| TMPPE | transmembrane protein with metallophosphoesterase domain | 0.64 |
| BMERB1 | bMERB domain containing 1 | 0.64 |
| ABLIM3 | actin binding LIM protein family, member 3 | 0.64 |
| PLIN2 | perilipin 2 | 0.64 |
| OPTN | optineurin | 0.63 |
| NEU1 | sialidase 1 (lysosomal sialidase) | 0.63 |
| C1ORF50 | chromosome 1 open reading frame 50 | 0.63 |
| MVD | mevalonate (diphospho) decarboxylase | 0.62 |
| BSDC1 | BSD domain containing 1 | 0.62 |
| KCNN4 | potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 | 0.62 |
| B2M | beta-2-microglobulin | 0.62 |
| SQSTM1 | sequestosome 1 | 0.6 |
| ANXA6 | annexin A6 | 0.6 |
| FADS1 | fatty acid desaturase 1 | 0.6 |
| PCSK9 | proprotein convertase subtilisin/kexin type 9 | 0.59 |
| CALCOCO2 | calcium binding and coiled-coil domain 2 | 0.59 |
| LRP10 | low density lipoprotein receptor-related protein 10 | 0.58 |
| CTSA | cathepsin A | 0.57 |
| AREG | amphiregulin | 0.57 |
| SIKE1 | suppressor of IKBKE 1 | 0.56 |
| CLIC3 | chloride intracellular channel 3 | 0.56 |
| MYH3 | myosin, heavy chain 3, skeletal muscle, embryonic | 0.55 |
| FASN | fatty acid synthase | 0.55 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | 0.55 |
| RNF145 | ring finger protein 145 | 0.54 |
| PLPP2 | phospholipid phosphatase 2 | 0.54 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | 0.54 |
| CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | 0.53 |
| ELK3 | ELK3, ETS-domain protein (SRF accessory protein 2) | 0.53 |
| CD63 | CD63 molecule | 0.52 |
| SRD5A3 | steroid 5 alpha-reductase 3 | 0.52 |
| GVINP1 | GTPase, very large interferon inducible pseudogene 1 | 0.52 |
| TINAGL1 | tubulointerstitial nephritis antigen-like 1 | 0.5 |
| TPM4 | tropomyosin 4 | 0.5 |
| HAS3 | hyaluronan synthase 3 | 0.49 |
| MYT1 | myelin transcription factor 1 | 0.49 |
| P2RX4 | purinergic receptor P2X, ligand gated ion channel, 4 | 0.49 |
| STMN2 | stathmin 2 | 0.49 |
| NDUFAB1 | NADH dehydrogenase (ubiquinone) 1, alpha/beta subcomplex, 1, 8kDa | 0.48 |
| LYPD3 | LY6/PLAUR domain containing 3 | 0.48 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.47 |
| LIME1 | Lck interacting transmembrane adaptor 1 | 0.47 |
| MTRES1 | mitochondrial transcription rescue factor 1 | 0.46 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.46 |
| TACSTD2 | tumor-associated calcium signal transducer 2 | 0.46 |
| ALPK3 | alpha-kinase 3 | 0.46 |
| SLC38A2 | solute carrier family 38, member 2 | 0.46 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.46 |
| F2R | coagulation factor II (thrombin) receptor | 0.46 |
| DBI | diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) | 0.45 |
| PNPLA2 | patatin-like phospholipase domain containing 2 | 0.44 |
| IFNGR1 | interferon gamma receptor 1 | 0.44 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | 0.44 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.44 |
| Symbol | Name | Standardized Value |
|---|---|---|
| COL1A1 | collagen, type I, alpha 1 | -1.73 |
| SBSN | suprabasin | -1.43 |
| ASAH1 | N-acylsphingosine amidohydrolase (acid ceramidase) 1 | -1.16 |
| HIST2H2AA3 | histone cluster 2, H2aa3 | -1.1 |
| TMEM179B | transmembrane protein 179B | -1.04 |
| TMSB10 | thymosin beta 10 | -1.01 |
| BAIAP2 | BAI1-associated protein 2 | -0.91 |
| PIP | prolactin-induced protein | -0.88 |
| AFG1L | AFG1 like ATPase | -0.85 |
| SSPO | SCO-spondin | -0.8 |
| DEF8 | differentially expressed in FDCP 8 homolog (mouse) | -0.73 |
| DOCK4 | dedicator of cytokinesis 4 | -0.72 |
| HIST1H1T | histone cluster 1, H1t | -0.67 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.65 |
| PYCR3 | pyrroline-5-carboxylate reductase 3 | -0.64 |
| MLLT6 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 6 | -0.64 |
| ZNF608 | zinc finger protein 608 | -0.62 |
| TDRD6 | tudor domain containing 6 | -0.61 |
| TTYH3 | tweety family member 3 | -0.6 |
| PPT1 | palmitoyl-protein thioesterase 1 | -0.59 |
| SPPL3 | signal peptide peptidase like 3 | -0.59 |
| ADCY9 | adenylate cyclase 9 | -0.59 |
| FER1L5 | fer-1-like family member 5 | -0.57 |
| VAMP3 | vesicle-associated membrane protein 3 | -0.56 |
| EED | embryonic ectoderm development | -0.52 |
| MICOS10 | mitochondrial contact site and cristae organizing system subunit 10 | -0.5 |
| CCDC138 | coiled-coil domain containing 138 | -0.5 |
| HMCN1 | hemicentin 1 | -0.49 |
| EIF3C | eukaryotic translation initiation factor 3, subunit C | -0.48 |
| KLHL2 | kelch-like family member 2 | -0.48 |
| NPHP1 | nephronophthisis 1 (juvenile) | -0.47 |
| KLHDC3 | kelch domain containing 3 | -0.47 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | -0.46 |
| RCHY1 | ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase | -0.46 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.45 |
| ETAA1 | Ewing tumor-associated antigen 1 | -0.44 |
| MT-ND5 | NADH dehydrogenase, subunit 5 (complex I) | -0.43 |
| ADSS1 | adenylosuccinate synthase 1 | -0.42 |
| TRAM2 | translocation associated membrane protein 2 | -0.41 |
| LYRM1 | LYR motif containing 1 | -0.41 |
| PDE3B | phosphodiesterase 3B, cGMP-inhibited | -0.41 |
| PCGF1 | polycomb group ring finger 1 | -0.41 |
| SDHAF3 | succinate dehydrogenase complex assembly factor 3 | -0.4 |
| SEMA3B | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B | -0.4 |
| PNKD | paroxysmal nonkinesigenic dyskinesia | -0.4 |
| NKAPD1 | NKAP domain containing 1 | -0.39 |
| CCN1 | cellular communication network factor 1 | -0.39 |
| C17ORF53 | chromosome 17 open reading frame 53 | -0.39 |
| SNX25 | sorting nexin 25 | -0.39 |
| ENOX2 | ecto-NOX disulfide-thiol exchanger 2 | -0.39 |
| CLN5 | ceroid-lipofuscinosis, neuronal 5 | -0.39 |
| PEMT | phosphatidylethanolamine N-methyltransferase | -0.38 |
| FYN | FYN proto-oncogene, Src family tyrosine kinase | -0.38 |
| BCAM | basal cell adhesion molecule (Lutheran blood group) | -0.38 |
| TNPO2 | transportin 2 | -0.38 |
| USP8 | ubiquitin specific peptidase 8 | -0.38 |
| VSIR | V-set immunoregulatory receptor | -0.38 |
| ZNF658 | zinc finger protein 658 | -0.38 |
| PEX12 | peroxisomal biogenesis factor 12 | -0.37 |
| CPN1 | carboxypeptidase N, polypeptide 1 | -0.37 |
| SPIN1 | spindlin 1 | -0.37 |
| PES1 | pescadillo ribosomal biogenesis factor 1 | -0.37 |
| KLF3 | Kruppel-like factor 3 (basic) | -0.37 |
| SUPT4H1 | suppressor of Ty 4 homolog 1 (S. cerevisiae) | -0.36 |
| ALG12 | ALG12, alpha-1,6-mannosyltransferase | -0.36 |
| ABCB6 | ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) | -0.36 |
| SETD9 | SET domain containing 9 | -0.36 |
| NPRL3 | nitrogen permease regulator-like 3 (S. cerevisiae) | -0.36 |
| TIPE1 | TNF alpha induced protein 8 like 1 | -0.36 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | -0.36 |
| METTL8 | methyltransferase like 8 | -0.35 |
| ADM | adrenomedullin | -0.35 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | -0.35 |
| SPIRE1 | spire-type actin nucleation factor 1 | -0.35 |
| BBS9 | Bardet-Biedl syndrome 9 | -0.35 |
| ZDBF2 | zinc finger, DBF-type containing 2 | -0.35 |
| SPATA33 | spermatogenesis associated 33 | -0.34 |
| TPPP | tubulin polymerization promoting protein | -0.34 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | -0.34 |
| DNAL4 | dynein, axonemal, light chain 4 | -0.34 |
| FSIP2 | fibrous sheath interacting protein 2 | -0.34 |
| RASSF2 | Ras association (RalGDS/AF-6) domain family member 2 | -0.34 |
| NNT | nicotinamide nucleotide transhydrogenase | -0.34 |
| PPTC7 | PTC7 protein phosphatase homolog (S. cerevisiae) | -0.33 |
| PIGL | phosphatidylinositol glycan anchor biosynthesis, class L | -0.33 |
| NEIL3 | nei endonuclease VIII-like 3 (E. coli) | -0.33 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | -0.33 |
| PUSL1 | pseudouridylate synthase-like 1 | -0.33 |
| MIPOL1 | mirror-image polydactyly 1 | -0.33 |
| COL7A1 | collagen, type VII, alpha 1 | -0.33 |
| CLIC6 | chloride intracellular channel 6 | -0.33 |
| NSUN3 | NOP2/Sun domain family, member 3 | -0.33 |
| STK11IP | serine/threonine kinase 11 interacting protein | -0.33 |
| CFAP58 | cilia and flagella associated protein 58 | -0.33 |
| KHK | ketohexokinase (fructokinase) | -0.32 |
| PSIP1 | PC4 and SFRS1 interacting protein 1 | -0.32 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.32 |
| AGPAT2 | 1-acylglycerol-3-phosphate O-acyltransferase 2 | -0.32 |
| OGG1 | 8-oxoguanine DNA glycosylase | -0.32 |
