| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.227889 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.139688 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.129027 |
| UBC | ubiquitin C | 0.0957279 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0956256 |
| SQSTM1 | sequestosome 1 | 0.0824376 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0781368 |
| HDAC9 | histone deacetylase 9 | 0.0681832 |
| POTEF | POTE ankyrin domain family, member F | 0.0654176 |
| HSPB1 | heat shock 27kDa protein 1 | 0.0621229 |
| LDHA | lactate dehydrogenase A | 0.0571115 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0529384 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.044202 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0435285 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0435149 |
| PKM | pyruvate kinase, muscle | 0.0425212 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.04212 |
| CENPF | centromere protein F, 350/400kDa | 0.0406435 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0402475 |
| FTL | ferritin, light polypeptide | 0.0368772 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0366255 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.0341871 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0327072 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0326611 |
| FOSL1 | FOS-like antigen 1 | 0.0324453 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | 0.0319244 |
| SON | SON DNA binding protein | 0.0311678 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0295266 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.028369 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0283021 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0277265 |
| NAV2 | neuron navigator 2 | 0.0275621 |
| RHOBTB3 | Rho-related BTB domain containing 3 | 0.0268453 |
| TPM3 | tropomyosin 3 | 0.0266409 |
| PRELID2 | PRELI domain containing 2 | 0.0260837 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0255259 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0254921 |
| INTS6 | integrator complex subunit 6 | 0.0244617 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0244502 |
| TUSC3 | tumor suppressor candidate 3 | 0.0244368 |
| FLNA | filamin A, alpha | 0.0234646 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | 0.0233703 |
| NEK7 | NIMA-related kinase 7 | 0.0229151 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0225553 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0225493 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0222584 |
| ENO1 | enolase 1, (alpha) | 0.0217483 |
| RND3 | Rho family GTPase 3 | 0.0215725 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0215676 |
| GPC6 | glypican 6 | 0.0215379 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.0213509 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0208684 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.02085 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.020678 |
| TXNRD1 | thioredoxin reductase 1 | 0.0201685 |
| ASTN2 | astrotactin 2 | 0.0199368 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0198576 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.0196311 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0195277 |
| RPL12 | ribosomal protein L12 | 0.0195155 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0194368 |
| CDK6 | cyclin-dependent kinase 6 | 0.0190012 |
| DTNA | dystrobrevin, alpha | 0.0188455 |
| VCL | vinculin | 0.0188027 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0187999 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0186657 |
| GOLGB1 | golgin B1 | 0.0186032 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0185538 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0185382 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0183339 |
| ARFGEF3 | ARFGEF family member 3 | 0.018261 |
| SCARB2 | scavenger receptor class B, member 2 | 0.0182029 |
| CALR | calreticulin | 0.0181739 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0181725 |
| EGR1 | early growth response 1 | 0.0180112 |
| SET | SET nuclear proto-oncogene | 0.0178443 |
| FXR1 | fragile X mental retardation, autosomal homolog 1 | 0.0178011 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | 0.0177372 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0176881 |
| XKR6 | XK, Kell blood group complex subunit-related family, member 6 | 0.0175238 |
| RPL7 | ribosomal protein L7 | 0.017245 |
| MAGT1 | magnesium transporter 1 | 0.0171316 |
| BAG3 | BCL2-associated athanogene 3 | 0.0170376 |
| MSN | moesin | 0.016829 |
| PCDH10 | protocadherin 10 | 0.0168285 |
| PCBP2 | poly(rC) binding protein 2 | 0.0167967 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | 0.0166998 |
| PTK2 | protein tyrosine kinase 2 | 0.0166961 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | 0.0166551 |
| DST | dystonin | 0.0161869 |
| LYST | lysosomal trafficking regulator | 0.0159426 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0158407 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | 0.0157362 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0157198 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0156475 |
| CLU | clusterin | 0.0155151 |
| LRRC58 | leucine rich repeat containing 58 | 0.0154508 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.0153884 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0152981 |
| FMNL2 | formin-like 2 | 0.015294 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.252887 |
| PODXL | podocalyxin-like | -0.138478 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.135595 |
| PLAT | plasminogen activator, tissue | -0.133833 |
| COL5A1 | collagen, type V, alpha 1 | -0.133382 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.13199 |
| TMSB10 | thymosin beta 10 | -0.115982 |
| VIM | vimentin | -0.114412 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.107049 |
| LOX | lysyl oxidase | -0.103829 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.101792 |
| FN1 | fibronectin 1 | -0.0977176 |
| THBS2 | thrombospondin 2 | -0.0958126 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0867676 |
| LOXL2 | lysyl oxidase-like 2 | -0.0845978 |
| CAVIN1 | caveolae associated protein 1 | -0.0796884 |
| MT2A | metallothionein 2A | -0.0780285 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0750881 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0684513 |
| NAV1 | neuron navigator 1 | -0.0635706 |
| PRSS23 | protease, serine, 23 | -0.063517 |
| S100A6 | S100 calcium binding protein A6 | -0.0630858 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0620006 |
| COL3A1 | collagen, type III, alpha 1 | -0.0616407 |
| HLA-B | major histocompatibility complex, class I, B | -0.0595985 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0535788 |
| CDH13 | cadherin 13 | -0.0484968 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0474308 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | -0.0473472 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0451623 |
| RRBP1 | ribosome binding protein 1 | -0.0443666 |
| RIGI | RNA sensor RIG-I | -0.044358 |
| SAMD9 | sterile alpha motif domain containing 9 | -0.0434263 |
| MT1X | metallothionein 1X | -0.0431044 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.043012 |
| COL1A2 | collagen, type I, alpha 2 | -0.0415978 |
| COL8A1 | collagen, type VIII, alpha 1 | -0.0412706 |
| GNAS | GNAS complex locus | -0.038806 |
| OASL | 2'-5'-oligoadenylate synthetase-like | -0.0386816 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0385879 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0382256 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0369443 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0368938 |
| SPAG9 | sperm associated antigen 9 | -0.0366636 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0366252 |
| S100A4 | S100 calcium binding protein A4 | -0.0357331 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | -0.035464 |
| SORBS2 | sorbin and SH3 domain containing 2 | -0.0354338 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0353215 |
| COL5A2 | collagen, type V, alpha 2 | -0.0352532 |
| CSTB | cystatin B (stefin B) | -0.0347237 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | -0.034397 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0341274 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0326722 |
| FRMD4A | FERM domain containing 4A | -0.0323596 |
| FLT1 | fms-related tyrosine kinase 1 | -0.0316344 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | -0.0315916 |
| IL7R | interleukin 7 receptor | -0.0314827 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0306593 |
| RPS6KC1 | ribosomal protein S6 kinase, 52kDa, polypeptide 1 | -0.0299876 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0299404 |
| MX2 | MX dynamin-like GTPase 2 | -0.0299038 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0298164 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0296357 |
| LMNA | lamin A/C | -0.0295473 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0294 |
| ZNF217 | zinc finger protein 217 | -0.0293267 |
| RPS6KA2 | ribosomal protein S6 kinase, 90kDa, polypeptide 2 | -0.0289319 |
| RNF213 | ring finger protein 213 | -0.0285382 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0280933 |
| HLA-C | major histocompatibility complex, class I, C | -0.0273948 |
| IFIH1 | interferon induced with helicase C domain 1 | -0.0269165 |
| AGPAT3 | 1-acylglycerol-3-phosphate O-acyltransferase 3 | -0.0262453 |
| AUTS2 | autism susceptibility candidate 2 | -0.0260098 |
| FBN1 | fibrillin 1 | -0.0257437 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | -0.0256404 |
| CANX | calnexin | -0.0251614 |
| CD99 | CD99 molecule | -0.024961 |
| SH3BP5 | SH3-domain binding protein 5 (BTK-associated) | -0.0248381 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0246105 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0245698 |
| RAI1 | retinoic acid induced 1 | -0.024522 |
| COL1A1 | collagen, type I, alpha 1 | -0.0241535 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0240808 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0240499 |
| DGKG | diacylglycerol kinase, gamma 90kDa | -0.0234518 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0233943 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0233789 |
| DKK3 | dickkopf WNT signaling pathway inhibitor 3 | -0.0232436 |
| MEIS2 | Meis homeobox 2 | -0.0228797 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.0228242 |
| RIPK1 | receptor (TNFRSF)-interacting serine-threonine kinase 1 | -0.0228005 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0227652 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0226665 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0225178 |
| TUBB6 | tubulin, beta 6 class V | -0.0224274 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0219827 |
| SASH1 | SAM and SH3 domain containing 1 | -0.0215286 |
| ARF1 | ADP-ribosylation factor 1 | -0.0213985 |
| CD59 | CD59 molecule, complement regulatory protein | -0.0212516 |
