Pimitespib_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimitespib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
NLGN1 neuroligin 1 0.228708
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.200256
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.17204
VIM vimentin 0.165624
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.16277
BIRC3 baculoviral IAP repeat containing 3 0.0822238
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 0.080446
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0772553
CALR calreticulin 0.0767121
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0747465
HMGA2 high mobility group AT-hook 2 0.0699096
AHNAK AHNAK nucleoprotein 0.0660841
PCDH7 protocadherin 7 0.0629513
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0622136
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0614318
DST dystonin 0.0604672
CANX calnexin 0.0576026
ENO1 enolase 1, (alpha) 0.0521963
RAB7A RAB7A, member RAS oncogene family 0.051441
YAP1 Yes-associated protein 1 0.05112
ADIPOR2 adiponectin receptor 2 0.0496135
UBC ubiquitin C 0.0483476
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.047506
RIMS2 regulating synaptic membrane exocytosis 2 0.0474323
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0469997
PTGES3 prostaglandin E synthase 3 (cytosolic) 0.0465062
RASAL2 RAS protein activator like 2 0.0459817
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0446998
MMP12 matrix metallopeptidase 12 0.0443563
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0423811
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 0.042221
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0409829
CUBN cubilin (intrinsic factor-cobalamin receptor) 0.0407478
SMC4 structural maintenance of chromosomes 4 0.0395614
LDHA lactate dehydrogenase A 0.0395378
EHBP1 EH domain binding protein 1 0.0389702
NHSL1 NHS-like 1 0.0386939
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0373345
TUBA1B tubulin, alpha 1b 0.0359066
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0342851
PDIA3 protein disulfide isomerase family A, member 3 0.0341977
TPM4 tropomyosin 4 0.0341962
AKAP12 A kinase (PRKA) anchor protein 12 0.0338184
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0333177
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0329223
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0328973
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0328228
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0328004
ANXA1 annexin A1 0.0326461
TPI1 triosephosphate isomerase 1 0.0326344
SNCA synuclein, alpha (non A4 component of amyloid precursor) 0.0316318
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0306935
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0304847
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0300746
ZSWIM6 zinc finger, SWIM-type containing 6 0.0297707
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0297503
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0293588
PDGFC platelet derived growth factor C 0.0293273
HSPH1 heat shock 105kDa/110kDa protein 1 0.028695
LPP LIM domain containing preferred translocation partner in lipoma 0.0280475
CEP112 centrosomal protein 112kDa 0.0279837
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0279056
FNDC3B fibronectin type III domain containing 3B 0.0278966
CDK6 cyclin-dependent kinase 6 0.0277922
SFPQ splicing factor proline/glutamine-rich 0.0276098
CMIP c-Maf inducing protein 0.027491
PCBP2 poly(rC) binding protein 2 0.0271087
PSMD14 proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 0.0270518
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0269391
ANKS1B ankyrin repeat and sterile alpha motif domain containing 1B 0.026862
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0266016
CCT5 chaperonin containing TCP1, subunit 5 (epsilon) 0.0262175
ERBIN erbb2 interacting protein 0.0258794
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0257851
EEF2 eukaryotic translation elongation factor 2 0.025685
SETX senataxin 0.0254746
APLP2 amyloid beta (A4) precursor-like protein 2 0.0249131
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0245678
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 0.0243443
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0242047
DIAPH3 diaphanous-related formin 3 0.0241417
PDE4D phosphodiesterase 4D, cAMP-specific 0.024119
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0241171
PDIA4 protein disulfide isomerase family A, member 4 0.0235858
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0235229
LOC102724023 ES1 protein homolog, mitochondrial 0.0232231
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0230744
MKI67 marker of proliferation Ki-67 0.0230268
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0229462
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0229428
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.022666
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0226579
EDARADD EDAR-associated death domain 0.0226352
UBE2E2 ubiquitin-conjugating enzyme E2E 2 0.0223891
PDIA6 protein disulfide isomerase family A, member 6 0.0221225
DLC1 DLC1 Rho GTPase activating protein 0.0220161
EXOC4 exocyst complex component 4 0.02187
MACF1 microtubule-actin crosslinking factor 1 0.0216546
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0215672
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0214997

decreased expression

Symbol Name Standardized Value
AREG amphiregulin -0.220149
RPS2 ribosomal protein S2 -0.0912871
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 -0.0839635
ATP5F1B ATP synthase F1 subunit beta -0.0520675
RPL37A ribosomal protein L37a -0.0482837
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0481393
RPS29 ribosomal protein S29 -0.0449665
RPL38 ribosomal protein L38 -0.0426291
RPL35A ribosomal protein L35a -0.0415689
RPS23 ribosomal protein S23 -0.0397407
RPS19 ribosomal protein S19 -0.0387011
RPL36 ribosomal protein L36 -0.0380626
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0372668
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0371085
RPL31 ribosomal protein L31 -0.0363403
RPS13 ribosomal protein S13 -0.0358925
RPL11 ribosomal protein L11 -0.0357901
RPL26 ribosomal protein L26 -0.0334928
EIF1 eukaryotic translation initiation factor 1 -0.03344
BIRC2 baculoviral IAP repeat containing 2 -0.0326806
MGAT4C MGAT4 family, member C -0.0324722
ATP11A ATPase, class VI, type 11A -0.0319349
RPL9 ribosomal protein L9 -0.0316651
PNISR PNN-interacting serine/arginine-rich protein -0.03076
RPS6 ribosomal protein S6 -0.0290009
KDM3A lysine (K)-specific demethylase 3A -0.0285922
BRWD3 bromodomain and WD repeat domain containing 3 -0.0277617
KMT2E lysine (K)-specific methyltransferase 2E -0.0270693
CCNL1 cyclin L1 -0.0268032
RPS3 ribosomal protein S3 -0.0266327
CNRIP1 cannabinoid receptor interacting protein 1 -0.0261049
KIF5B kinesin family member 5B -0.0259987
GOLGA4 golgin A4 -0.0258487
RPS25 ribosomal protein S25 -0.0255265
NCOR1 nuclear receptor corepressor 1 -0.0252023
ZBTB20 zinc finger and BTB domain containing 20 -0.0251946
NKTR natural killer cell triggering receptor -0.0247876
RPLP2 ribosomal protein, large, P2 -0.0244898
BIRC6 baculoviral IAP repeat containing 6 -0.0237682
TMEM41B transmembrane protein 41B -0.0229324
PNN pinin, desmosome associated protein -0.0229164
RBM39 RNA binding motif protein 39 -0.0227924
FBXL20 F-box and leucine-rich repeat protein 20 -0.0226825
EGLN1 egl-9 family hypoxia-inducible factor 1 -0.0226718
FEZ2 fasciculation and elongation protein zeta 2 (zygin II) -0.02256
CAMKMT calmodulin-lysine N-methyltransferase -0.0224329
THOC1 THO complex 1 -0.0223678
KLHL24 kelch-like family member 24 -0.02225
CAMTA1 calmodulin binding transcription activator 1 -0.0218235
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0216793
YEATS2 YEATS domain containing 2 -0.0216744
RPL13A ribosomal protein L13a -0.0213684
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0212126
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0211477
RPS27 ribosomal protein S27 -0.0207757
CXADR coxsackie virus and adenovirus receptor -0.0202997
LRP6 low density lipoprotein receptor-related protein 6 -0.0202784
CEP95 centrosomal protein 95kDa -0.0202238
RB1CC1 RB1-inducible coiled-coil 1 -0.0192888
OGA O-GlcNAcase -0.0191484
RPS21 ribosomal protein S21 -0.0187457
ANKRD36 ankyrin repeat domain 36 -0.0187333
TPT1 tumor protein, translationally-controlled 1 -0.0186536
RAB6A RAB6A, member RAS oncogene family -0.0184532
RPS12 ribosomal protein S12 -0.0184381
EIF5B eukaryotic translation initiation factor 5B -0.0183754
RPL19 ribosomal protein L19 -0.0182353
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0182009
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0181963
RSL24D1 ribosomal L24 domain containing 1 -0.0181069
ZNF217 zinc finger protein 217 -0.0180207
SLC38A2 solute carrier family 38, member 2 -0.0178628
RPS15 ribosomal protein S15 -0.0177563
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0176968
BAZ2A bromodomain adjacent to zinc finger domain, 2A -0.0176303
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0174575
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0174567
RPL36A ribosomal protein L36a -0.0173017
NEK7 NIMA-related kinase 7 -0.0172358
EDN1 endothelin 1 -0.0170983
WDR45B WD repeat domain 45B -0.0170982
TNPO1 transportin 1 -0.0169911
RPS8 ribosomal protein S8 -0.0168356
THOC2 THO complex 2 -0.0168062
ZNF292 zinc finger protein 292 -0.0168055
MON2 MON2 homolog (S. cerevisiae) -0.0165926
TMEM39A transmembrane protein 39A -0.0165467
RPS11 ribosomal protein S11 -0.0162567
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0161982
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0161048
PTMA prothymosin, alpha -0.0159379
RPL32 ribosomal protein L32 -0.0158489
CPOX coproporphyrinogen oxidase -0.0157661
PUM2 pumilio RNA-binding family member 2 -0.0155908
GOLT1B golgi transport 1B -0.0154558
BBX bobby sox homolog (Drosophila) -0.0154218
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0151791
NABP1 nucleic acid binding protein 1 -0.0150773
CDK19 cyclin-dependent kinase 19 -0.0150439
NR2F1 nuclear receptor subfamily 2, group F, member 1 -0.0149732