| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | 0.165822 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.112456 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0993427 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0930742 |
| B2M | beta-2-microglobulin | 0.0874857 |
| TSC22D1 | TSC22 domain family, member 1 | 0.0782699 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.067186 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.064851 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0647235 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | 0.0631552 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0566726 |
| LCN2 | lipocalin 2 | 0.0516828 |
| MYO1E | myosin IE | 0.0504093 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0494642 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0491203 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0489577 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0481824 |
| ADAM10 | ADAM metallopeptidase domain 10 | 0.0468475 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0465479 |
| TXNRD1 | thioredoxin reductase 1 | 0.0459852 |
| TMC5 | transmembrane channel-like 5 | 0.0459241 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0454343 |
| SMAD3 | SMAD family member 3 | 0.0445084 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | 0.0438833 |
| EREG | epiregulin | 0.0434741 |
| MAP7 | microtubule-associated protein 7 | 0.0434004 |
| HKDC1 | hexokinase domain containing 1 | 0.0407719 |
| UBC | ubiquitin C | 0.0401781 |
| TJP1 | tight junction protein 1 | 0.039967 |
| PTBP3 | polypyrimidine tract binding protein 3 | 0.039573 |
| IRS2 | insulin receptor substrate 2 | 0.038708 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.038184 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0377271 |
| ZNF292 | zinc finger protein 292 | 0.0370932 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0369174 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0367412 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0365708 |
| DIAPH1 | diaphanous-related formin 1 | 0.0360545 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0360315 |
| LRCH1 | leucine-rich repeats and calponin homology (CH) domain containing 1 | 0.035885 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0354143 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0337279 |
| KYNU | kynureninase | 0.0327551 |
| XDH | xanthine dehydrogenase | 0.0325299 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.032481 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0323684 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0319847 |
| TRIM2 | tripartite motif containing 2 | 0.031763 |
| YBX3 | Y box binding protein 3 | 0.0316432 |
| MYO10 | myosin X | 0.0308409 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.0303855 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0303694 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0300274 |
| PDZD8 | PDZ domain containing 8 | 0.0298844 |
| IFNGR1 | interferon gamma receptor 1 | 0.0296937 |
| APP | amyloid beta (A4) precursor protein | 0.0291338 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | 0.0284506 |
| FTL | ferritin, light polypeptide | 0.0281049 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | 0.0280293 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | 0.0278223 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.0276158 |
| RNF149 | ring finger protein 149 | 0.0274444 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0268727 |
| UBL3 | ubiquitin-like 3 | 0.0266041 |
| MED13 | mediator complex subunit 13 | 0.0264206 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0263672 |
| BCL2L1 | BCL2-like 1 | 0.0257769 |
| ERBIN | erbb2 interacting protein | 0.025662 |
| DSTN | destrin (actin depolymerizing factor) | 0.0254995 |
| EHF | ets homologous factor | 0.0252367 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0251363 |
| TMEM65 | transmembrane protein 65 | 0.0250971 |
| TM4SF19 | transmembrane 4 L six family member 19 | 0.0250454 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0250096 |
| PKM | pyruvate kinase, muscle | 0.0249062 |
| B3GNT5 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 5 | 0.0247437 |
| ASPH | aspartate beta-hydroxylase | 0.024399 |
| ZBTB43 | zinc finger and BTB domain containing 43 | 0.0241175 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | 0.0239426 |
| CMPK1 | cytidine monophosphate (UMP-CMP) kinase 1, cytosolic | 0.0236575 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0235294 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0234738 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.02344 |
| TPM3 | tropomyosin 3 | 0.023381 |
| SIK3 | SIK family kinase 3 | 0.023102 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | 0.0226711 |
| ARL5B | ADP-ribosylation factor-like 5B | 0.0225968 |
| AHI1 | Abelson helper integration site 1 | 0.0220999 |
| ADAR | adenosine deaminase, RNA-specific | 0.0220252 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.021921 |
| RFFL | ring finger and FYVE-like domain containing E3 ubiquitin protein ligase | 0.0215761 |
| DUSP10 | dual specificity phosphatase 10 | 0.0215089 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0214851 |
| OCLN | occludin | 0.0213959 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0213653 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0213333 |
| SLK | STE20-like kinase | 0.0212934 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | 0.0212347 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0209489 |
| SH3RF1 | SH3 domain containing ring finger 1 | 0.0209215 |
| Symbol | Name | Standardized Value |
|---|---|---|
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.144177 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.144157 |
| INTS6 | integrator complex subunit 6 | -0.119417 |
| NPSR1 | neuropeptide S receptor 1 | -0.11478 |
| PTMA | prothymosin, alpha | -0.0950431 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0927617 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0911459 |
| SQSTM1 | sequestosome 1 | -0.0865652 |
| NDRG1 | N-myc downstream regulated 1 | -0.077681 |
| PLSCR2 | phospholipid scramblase 2 | -0.076669 |
| XAF1 | XIAP associated factor 1 | -0.073079 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0708255 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0649564 |
| MUC20 | mucin 20, cell surface associated | -0.0625379 |
| PRKCA | protein kinase C, alpha | -0.0619049 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0617629 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0576431 |
| SP100 | SP100 nuclear antigen | -0.0575102 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0551271 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | -0.0551229 |
| ACTG1 | actin gamma 1 | -0.0540596 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0531808 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0518469 |
| RAD51B | RAD51 paralog B | -0.0518062 |
| AHNAK | AHNAK nucleoprotein | -0.0517167 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0516406 |
| PRELID2 | PRELI domain containing 2 | -0.0513023 |
| RIGI | RNA sensor RIG-I | -0.0512614 |
| HLA-B | major histocompatibility complex, class I, B | -0.0500762 |
| CSTPP1 | centriolar satellite-associated tubulin polyglutamylase complex regulator 1 | -0.0495605 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0456409 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.0449315 |
| RRBP1 | ribosome binding protein 1 | -0.0439471 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0437361 |
| H1-0 | H1.0 linker histone | -0.0429209 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0424259 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0421182 |
| GRIN2B | glutamate receptor, ionotropic, N-methyl D-aspartate 2B | -0.0420177 |
| STS | steroid sulfatase (microsomal), isozyme S | -0.0409377 |
| MT2A | metallothionein 2A | -0.0405821 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0404651 |
| RPL31 | ribosomal protein L31 | -0.0402664 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0393957 |
| SSH2 | slingshot protein phosphatase 2 | -0.0392917 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | -0.0371593 |
| RBM39 | RNA binding motif protein 39 | -0.0371111 |
| RPL35A | ribosomal protein L35a | -0.0367932 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0364774 |
| DSCAML1 | Down syndrome cell adhesion molecule like 1 | -0.0360948 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | -0.0359314 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0350879 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0345608 |
| MLPH | melanophilin | -0.0339568 |
| ANKRD10 | ankyrin repeat domain 10 | -0.0331675 |
| SAMD12 | sterile alpha motif domain containing 12 | -0.0320129 |
| SORBS1 | sorbin and SH3 domain containing 1 | -0.030912 |
| TFRC | transferrin receptor | -0.0306113 |
| JUN | jun proto-oncogene | -0.0295638 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0294914 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0294823 |
| DIAPH3 | diaphanous-related formin 3 | -0.0293125 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | -0.0281797 |
| ACTN4 | actinin, alpha 4 | -0.02809 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0280193 |
| PPARGC1A | peroxisome proliferator-activated receptor gamma, coactivator 1 alpha | -0.0279205 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | -0.0277771 |
| MUC13 | mucin 13, cell surface associated | -0.0275279 |
| RFC3 | replication factor C (activator 1) 3, 38kDa | -0.0273053 |
| FBXO39 | F-box protein 39 | -0.0270803 |
| RPL37A | ribosomal protein L37a | -0.0270306 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -0.027013 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | -0.0269327 |
| HDAC4 | histone deacetylase 4 | -0.026749 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0266618 |
| DENND1A | DENN/MADD domain containing 1A | -0.0262148 |
| B3GALT5 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 5 | -0.0260474 |
| FUS | FUS RNA binding protein | -0.0260133 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0258319 |
| CLYBL | citrate lyase beta like | -0.0257672 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.025634 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0254759 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0254579 |
| LDLRAD4 | low density lipoprotein receptor class A domain containing 4 | -0.025358 |
| EGLN3 | egl-9 family hypoxia-inducible factor 3 | -0.0251186 |
| TSHZ2 | teashirt zinc finger homeobox 2 | -0.0250879 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0249766 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | -0.0249569 |
| STK39 | serine threonine kinase 39 | -0.0248602 |
| POF1B | premature ovarian failure, 1B | -0.0246657 |
| SLC16A3 | solute carrier family 16 (monocarboxylate transporter), member 3 | -0.0246275 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0246257 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0245605 |
| RPLP2 | ribosomal protein, large, P2 | -0.0245465 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0245375 |
| PLA2G2A | phospholipase A2, group IIA (platelets, synovial fluid) | -0.0240642 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0240428 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -0.0239148 |
| VIM | vimentin | -0.0238978 |
| OAS1 | 2'-5'-oligoadenylate synthetase 1, 40/46kDa | -0.0238319 |
| RUNX1 | runt-related transcription factor 1 | -0.0237785 |
