| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| COL6A3 | collagen, type VI, alpha 3 | 0.150309 |
| FN1 | fibronectin 1 | 0.129218 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0699896 |
| COL1A1 | collagen, type I, alpha 1 | 0.0673144 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0664692 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0654491 |
| VCAN | versican | 0.0553142 |
| HMGA2 | high mobility group AT-hook 2 | 0.0525765 |
| ATP13A3 | ATPase type 13A3 | 0.0516877 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0513548 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0507267 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | 0.0420414 |
| ASPH | aspartate beta-hydroxylase | 0.0379661 |
| VEGFC | vascular endothelial growth factor C | 0.0377192 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0367907 |
| PGK1 | phosphoglycerate kinase 1 | 0.0354975 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0352534 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0326353 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0314821 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | 0.0313552 |
| MAP1B | microtubule-associated protein 1B | 0.0312513 |
| DST | dystonin | 0.0311764 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0308731 |
| PTK2 | protein tyrosine kinase 2 | 0.0295353 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | 0.0293454 |
| ZFPM2 | zinc finger protein, FOG family member 2 | 0.0286891 |
| CALD1 | caldesmon 1 | 0.0281225 |
| CALU | calumenin | 0.0276695 |
| HMCN1 | hemicentin 1 | 0.0270793 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0262446 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0261137 |
| NAV3 | neuron navigator 3 | 0.0256074 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | 0.0254714 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0253244 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0243712 |
| FBN1 | fibrillin 1 | 0.0239375 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0235571 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0231946 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.023086 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0228025 |
| RASA2 | RAS p21 protein activator 2 | 0.0224865 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0224348 |
| PLEC | plectin | 0.0222068 |
| TPR | translocated promoter region, nuclear basket protein | 0.0220295 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0219583 |
| APP | amyloid beta (A4) precursor protein | 0.0215764 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0214447 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0213671 |
| PRELID2 | PRELI domain containing 2 | 0.0209839 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0208867 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | 0.0206871 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | 0.0206519 |
| SULF1 | sulfatase 1 | 0.0201465 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0200801 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0199879 |
| EGR1 | early growth response 1 | 0.019893 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0196745 |
| SBF2 | SET binding factor 2 | 0.0195092 |
| RIGI | RNA sensor RIG-I | 0.0192361 |
| FLNB | filamin B, beta | 0.019072 |
| CNTN5 | contactin 5 | 0.0188199 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0187755 |
| ARHGAP29 | Rho GTPase activating protein 29 | 0.017738 |
| EVI5 | ecotropic viral integration site 5 | 0.0175589 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0175471 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0173966 |
| ADAMTS12 | ADAM metallopeptidase with thrombospondin type 1 motif, 12 | 0.0173049 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0170745 |
| RFX8 | RFX family member 8, lacking RFX DNA binding domain | 0.0170252 |
| ARF4 | ADP-ribosylation factor 4 | 0.0169742 |
| FRMD4A | FERM domain containing 4A | 0.0168079 |
| EHBP1 | EH domain binding protein 1 | 0.0167165 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0166055 |
| PKIA | protein kinase (cAMP-dependent, catalytic) inhibitor alpha | 0.0165893 |
| RBFOX2 | RNA binding protein, fox-1 homolog (C. elegans) 2 | 0.0165688 |
| COG5 | component of oligomeric golgi complex 5 | 0.016459 |
| SUPT3H | suppressor of Ty 3 homolog (S. cerevisiae) | 0.0164124 |
| LDHA | lactate dehydrogenase A | 0.0162613 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0162041 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0161405 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.016049 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0156501 |
| LIMA1 | LIM domain and actin binding 1 | 0.0156341 |
| TSPAN5 | tetraspanin 5 | 0.0156138 |
| FNBP1L | formin binding protein 1-like | 0.0154376 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.01538 |
| COL7A1 | collagen, type VII, alpha 1 | 0.0151811 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.015125 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0150951 |
| GJA1 | gap junction protein, alpha 1, 43kDa | 0.0150866 |
| EBF1 | early B-cell factor 1 | 0.0149642 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0148666 |
| UTRN | utrophin | 0.0148474 |
| TNPO1 | transportin 1 | 0.0148326 |
| SPAG9 | sperm associated antigen 9 | 0.0147745 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0147373 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0146906 |
| MSN | moesin | 0.0145932 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0145533 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0142854 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.193594 |
| VIM | vimentin | -0.155186 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.118444 |
| CADM1 | cell adhesion molecule 1 | -0.101974 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0962311 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0930288 |
| NDRG1 | N-myc downstream regulated 1 | -0.0913441 |
| TMSB10 | thymosin beta 10 | -0.0752687 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0740388 |
| FTL | ferritin, light polypeptide | -0.0734222 |
| CD44 | CD44 molecule (Indian blood group) | -0.0733811 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.067981 |
| IER3 | immediate early response 3 | -0.063786 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0571067 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0537333 |
| RPS8 | ribosomal protein S8 | -0.0531955 |
| ACTG1 | actin gamma 1 | -0.0492623 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0492352 |
| UBC | ubiquitin C | -0.0482413 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | -0.0467167 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0452441 |
| VEGFA | vascular endothelial growth factor A | -0.0444265 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0435146 |
| SQSTM1 | sequestosome 1 | -0.0423646 |
| IL6 | interleukin 6 | -0.0419693 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0406141 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0388968 |
| RPS6 | ribosomal protein S6 | -0.0373522 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0361904 |
| MT1X | metallothionein 1X | -0.0361647 |
| MT2A | metallothionein 2A | -0.0359361 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0349388 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0338461 |
| MTDH | metadherin | -0.033541 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0334886 |
| RND3 | Rho family GTPase 3 | -0.0334446 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0333712 |
| HM13 | histocompatibility (minor) 13 | -0.0333325 |
| GOLGB1 | golgin B1 | -0.0327061 |
| RPLP1 | ribosomal protein, large, P1 | -0.0321437 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0291356 |
| CDH13 | cadherin 13 | -0.0290576 |
| INHBA | inhibin, beta A | -0.028458 |
| RPL34 | ribosomal protein L34 | -0.0284117 |
| FGFR1 | fibroblast growth factor receptor 1 | -0.0275793 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0270639 |
| MMP3 | matrix metallopeptidase 3 | -0.0267814 |
| LMNA | lamin A/C | -0.026675 |
| S100A9 | S100 calcium binding protein A9 | -0.0263773 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0262933 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0261933 |
| RPS2 | ribosomal protein S2 | -0.0257831 |
| ST3GAL1 | ST3 beta-galactoside alpha-2,3-sialyltransferase 1 | -0.0256104 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0254149 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0248461 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0247082 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.0245259 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0243393 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0234988 |
| EGFR | epidermal growth factor receptor | -0.0234585 |
| SDC2 | syndecan 2 | -0.0226245 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0225978 |
| FBXO32 | F-box protein 32 | -0.0223201 |
| COL6A1 | collagen, type VI, alpha 1 | -0.0218472 |
| PTMA | prothymosin, alpha | -0.0216812 |
| SEC22A | SEC22 vesicle trafficking protein homolog A (S. cerevisiae) | -0.0214355 |
| RACK1 | receptor for activated C kinase 1 | -0.021167 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.021088 |
| RPL32 | ribosomal protein L32 | -0.0210736 |
| MAP4 | microtubule-associated protein 4 | -0.0210584 |
| RPL12 | ribosomal protein L12 | -0.0210399 |
| AKR1B1 | aldo-keto reductase family 1, member B1 (aldose reductase) | -0.020778 |
| RPL30 | ribosomal protein L30 | -0.0206945 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0206536 |
| RPL28 | ribosomal protein L28 | -0.0205669 |
| RPS14 | ribosomal protein S14 | -0.0201974 |
| RPL19 | ribosomal protein L19 | -0.0201894 |
| HIP1 | huntingtin interacting protein 1 | -0.0199672 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0195252 |
| MYO9B | myosin IXB | -0.0193571 |
| RPS16 | ribosomal protein S16 | -0.0191422 |
| EIF2S2 | eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa | -0.0188687 |
| CSF1 | colony stimulating factor 1 (macrophage) | -0.0184905 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | -0.0183216 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0179377 |
| LGALS1 | lectin, galactoside-binding, soluble, 1 | -0.0179146 |
| PPP3CC | protein phosphatase 3, catalytic subunit, gamma isozyme | -0.0178409 |
| DPYSL2 | dihydropyrimidinase-like 2 | -0.0178099 |
| SEC61G | Sec61 gamma subunit | -0.0174238 |
| HMGB1 | high mobility group box 1 | -0.0174012 |
| RPL8 | ribosomal protein L8 | -0.0173016 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0171986 |
| MYADM | myeloid-associated differentiation marker | -0.0170668 |
| SEPTIN7 | septin 7 | -0.0169822 |
| ZFR | zinc finger RNA binding protein | -0.0168945 |
| CMIP | c-Maf inducing protein | -0.01687 |
| S100A6 | S100 calcium binding protein A6 | -0.0168324 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0167134 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0167035 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0164947 |
