Pimitespib_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimitespib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.112222
SVIL supervillin 0.0901123
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0738277
GPC6 glypican 6 0.0672405
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0639883
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 0.0598653
DST dystonin 0.0592156
FRMD5 FERM domain containing 5 0.0587699
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0567789
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0566002
MAML2 mastermind-like 2 (Drosophila) 0.053619
KYNU kynureninase 0.0529804
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0515881
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0502394
IGFBP1 insulin-like growth factor binding protein 1 0.0493648
EHBP1 EH domain binding protein 1 0.0485896
ATXN1 ataxin 1 0.0478864
ANKRD1 ankyrin repeat domain 1 (cardiac muscle) 0.0469269
FAM107B family with sequence similarity 107, member B 0.0446642
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 0.0412176
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0394022
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0386561
PDLIM5 PDZ and LIM domain 5 0.0376868
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0361863
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0361788
TRIO trio Rho guanine nucleotide exchange factor 0.0345878
SAMD4A sterile alpha motif domain containing 4A 0.0339185
PAWR PRKC, apoptosis, WT1, regulator 0.0333752
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0322559
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0321887
FMNL2 formin-like 2 0.0317805
GMDS GDP-mannose 4,6-dehydratase 0.0315212
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 0.0312545
GRB10 growth factor receptor-bound protein 10 0.0312165
ASPH aspartate beta-hydroxylase 0.0306202
FAT1 FAT atypical cadherin 1 0.0303633
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.029534
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0294247
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0293181
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0293055
ZBTB20 zinc finger and BTB domain containing 20 0.0286075
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0284795
LIMS1 LIM and senescent cell antigen-like domains 1 0.026374
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0245024
DSPP dentin sialophosphoprotein 0.0234365
DOCK4 dedicator of cytokinesis 4 0.0233707
RAD51B RAD51 paralog B 0.0233121
GK glycerol kinase 0.0229734
LPP LIM domain containing preferred translocation partner in lipoma 0.0229445
APLP2 amyloid beta (A4) precursor-like protein 2 0.022771
CNKSR3 CNKSR family member 3 0.0223707
MBNL2 muscleblind-like splicing regulator 2 0.0223625
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0221315
NEDD9 neural precursor cell expressed, developmentally down-regulated 9 0.0220946
ITGAV integrin, alpha V 0.0219881
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0219473
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 0.0216013
KRT18 keratin 18, type I 0.0211724
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.020897
ITGA1 integrin, alpha 1 0.0207542
VCAN versican 0.0205003
MACF1 microtubule-actin crosslinking factor 1 0.0203364
MYH9 myosin, heavy chain 9, non-muscle 0.0201854
MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 0.0200189
DLC1 DLC1 Rho GTPase activating protein 0.0199927
DUSP6 dual specificity phosphatase 6 0.0198558
ADAM9 ADAM metallopeptidase domain 9 0.0197467
CDK6 cyclin-dependent kinase 6 0.0196695
ANO6 anoctamin 6 0.0194848
CSGALNACT2 chondroitin sulfate N-acetylgalactosaminyltransferase 2 0.01944
SOX5 SRY (sex determining region Y)-box 5 0.0193355
VCL vinculin 0.018607
FAM135A family with sequence similarity 135, member A 0.0184329
MSI2 musashi RNA-binding protein 2 0.0183201
LCOR ligand dependent nuclear receptor corepressor 0.018213
FOXP1 forkhead box P1 0.018067
KRT19 keratin 19, type I 0.0180451
TNFAIP8 tumor necrosis factor, alpha-induced protein 8 0.0179687
RASA2 RAS p21 protein activator 2 0.017775
ITGA6 integrin, alpha 6 0.0177155
TPM4 tropomyosin 4 0.0176193
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0173065
PERP PERP, TP53 apoptosis effector 0.0170559
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.016979
RNF213 ring finger protein 213 0.0169511
TF transferrin 0.0168877
NFE2L1 nuclear factor, erythroid 2-like 1 0.0168229
MRTFA myocardin related transcription factor A 0.0167654
AGO2 argonaute RISC catalytic component 2 0.016701
SLK STE20-like kinase 0.0166297
RASAL2 RAS protein activator like 2 0.0166202
THOC2 THO complex 2 0.0162734
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0162487
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 0.016094
MARCKS myristoylated alanine-rich protein kinase C substrate 0.0160487
SKAP2 src kinase associated phosphoprotein 2 0.0159622
ESYT2 extended synaptotagmin-like protein 2 0.0158589
AKAP13 A kinase (PRKA) anchor protein 13 0.0156908
UBXN4 UBX domain protein 4 0.0156856
TXNRD1 thioredoxin reductase 1 0.0156

decreased expression

Symbol Name Standardized Value
APOA2 apolipoprotein A-II -0.126007
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0954769
RPL37A ribosomal protein L37a -0.0882189
TPT1 tumor protein, translationally-controlled 1 -0.0847578
IGF2 insulin-like growth factor 2 -0.0790682
RPS29 ribosomal protein S29 -0.0746403
RPS6 ribosomal protein S6 -0.0727221
FN1 fibronectin 1 -0.0724867
MT2A metallothionein 2A -0.0678684
APOB apolipoprotein B -0.067094
RPLP1 ribosomal protein, large, P1 -0.06562
RPL31 ribosomal protein L31 -0.0648965
RPS8 ribosomal protein S8 -0.0629988
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0591763
RPS19 ribosomal protein S19 -0.0589103
RPS24 ribosomal protein S24 -0.0561944
RPL11 ribosomal protein L11 -0.0555207
RPL35A ribosomal protein L35a -0.0533978
RPL23 ribosomal protein L23 -0.05161
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0511941
RPL38 ribosomal protein L38 -0.0502978
RPS27A ribosomal protein S27a -0.0492107
RPS23 ribosomal protein S23 -0.0485122
RPLP2 ribosomal protein, large, P2 -0.0464737
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0440034
RPL26 ribosomal protein L26 -0.0434338
NDRG1 N-myc downstream regulated 1 -0.043224
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0430729
AMBP alpha-1-microglobulin/bikunin precursor -0.0422367
RPS12 ribosomal protein S12 -0.0412875
RPL36 ribosomal protein L36 -0.040968
RPL19 ribosomal protein L19 -0.0404705
RPS13 ribosomal protein S13 -0.0402444
RPS3 ribosomal protein S3 -0.0399441
RPS10 ribosomal protein S10 -0.0393961
RPL9 ribosomal protein L9 -0.0390604
RACK1 receptor for activated C kinase 1 -0.0373101
GPC3 glypican 3 -0.0366387
RBM39 RNA binding motif protein 39 -0.0364031
PEG3 paternally expressed 3 -0.0363722
RPS14 ribosomal protein S14 -0.0362433
RPS21 ribosomal protein S21 -0.0355922
RBM25 RNA binding motif protein 25 -0.035588
A2M alpha-2-macroglobulin -0.0348669
PTMA prothymosin, alpha -0.0336042
RPS25 ribosomal protein S25 -0.0332019
RPL28 ribosomal protein L28 -0.0329682
DDIT4 DNA-damage-inducible transcript 4 -0.032862
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0327949
RPS16 ribosomal protein S16 -0.0326704
RPS27 ribosomal protein S27 -0.0325585
RPL37 ribosomal protein L37 -0.032556
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.0319109
TMSB10 thymosin beta 10 -0.0311953
RPS11 ribosomal protein S11 -0.0307174
WSB1 WD repeat and SOCS box containing 1 -0.0305132
RPL7A ribosomal protein L7a -0.0301586
RPL34 ribosomal protein L34 -0.0298372
RPL27 ribosomal protein L27 -0.0295317
TRIM26 tripartite motif containing 26 -0.0291597
S100A9 S100 calcium binding protein A9 -0.0288385
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0285507
RPS5 ribosomal protein S5 -0.0279803
CP ceruloplasmin (ferroxidase) -0.0276368
FTL ferritin, light polypeptide -0.0275355
RPL4 ribosomal protein L4 -0.0275228
TM4SF1 transmembrane 4 L six family member 1 -0.0275223
GNAS GNAS complex locus -0.025705
FBF1 Fas (TNFRSF6) binding factor 1 -0.0254897
NKD1 naked cuticle homolog 1 (Drosophila) -0.0252797
ISG15 ISG15 ubiquitin-like modifier -0.0252432
RPL13A ribosomal protein L13a -0.0248458
EIF1 eukaryotic translation initiation factor 1 -0.0248274
RPL32 ribosomal protein L32 -0.0247566
RPS17 ribosomal protein S17 -0.0247023
CPE carboxypeptidase E -0.0239045
C3 complement component 3 -0.0235681
SDC4 syndecan 4 -0.0233359
S100P S100 calcium binding protein P -0.023214
RPL12 ribosomal protein L12 -0.0223015
HLA-A major histocompatibility complex, class I, A -0.0220111
EGR1 early growth response 1 -0.0218805
VPS54 vacuolar protein sorting 54 homolog (S. cerevisiae) -0.0216259
UGDH UDP-glucose 6-dehydrogenase -0.0214912
HLA-B major histocompatibility complex, class I, B -0.0213496
EEF1B2 eukaryotic translation elongation factor 1 beta 2 -0.0212763
WDR45B WD repeat domain 45B -0.0212628
SLC6A14 solute carrier family 6 (amino acid transporter), member 14 -0.0209934
AHSG alpha-2-HS-glycoprotein -0.0209734
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0206778
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0204607
GOLGA4 golgin A4 -0.0200407
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0196855
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0196625
EEF2 eukaryotic translation elongation factor 2 -0.0190619
RPL36A ribosomal protein L36a -0.0186123
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0185103
RPS15 ribosomal protein S15 -0.0184277
CAMTA1 calmodulin binding transcription activator 1 -0.0183023
GLRX glutaredoxin (thioltransferase) -0.0180709