| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in KATO III cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_KATO III drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.12979 |
| FGFR2 | fibroblast growth factor receptor 2 | 0.126177 |
| LMO7 | LIM domain 7 | 0.076239 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0593273 |
| NPSR1 | neuropeptide S receptor 1 | 0.056023 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0538542 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0490173 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0398545 |
| TJP1 | tight junction protein 1 | 0.038329 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0371487 |
| MCU | mitochondrial calcium uniporter | 0.0347975 |
| EMP1 | epithelial membrane protein 1 | 0.0346912 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0341717 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0338515 |
| MYOF | myoferlin | 0.0304247 |
| MYO1E | myosin IE | 0.0301561 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0298121 |
| COBL | cordon-bleu WH2 repeat protein | 0.0296686 |
| ANXA1 | annexin A1 | 0.0296561 |
| TNIK | TRAF2 and NCK interacting kinase | 0.0274448 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0262329 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0260862 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0259095 |
| ITGA6 | integrin, alpha 6 | 0.0255042 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0253437 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0250659 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | 0.0249652 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0244702 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0238867 |
| GDA | guanine deaminase | 0.0236874 |
| HDAC9 | histone deacetylase 9 | 0.0236295 |
| ANXA3 | annexin A3 | 0.0218327 |
| MYO5B | myosin VB | 0.0202353 |
| LCN2 | lipocalin 2 | 0.0198195 |
| RUNX1 | runt-related transcription factor 1 | 0.0196988 |
| ARHGAP32 | Rho GTPase activating protein 32 | 0.0194855 |
| DST | dystonin | 0.0194667 |
| CDK6 | cyclin-dependent kinase 6 | 0.019433 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0193702 |
| SLC20A2 | solute carrier family 20 (phosphate transporter), member 2 | 0.0193564 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0183903 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0183543 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0181796 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0180681 |
| VCL | vinculin | 0.0179809 |
| INTS6 | integrator complex subunit 6 | 0.0176781 |
| PCSK5 | proprotein convertase subtilisin/kexin type 5 | 0.0172208 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0172126 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0170551 |
| SLCO1B3-SLCO1B7 | SLCO1B3-SLCO1B7 readthrough | 0.0169061 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0162316 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0162201 |
| POF1B | premature ovarian failure, 1B | 0.0159561 |
| RASEF | RAS and EF-hand domain containing | 0.0158525 |
| CNKSR3 | CNKSR family member 3 | 0.0157146 |
| SQSTM1 | sequestosome 1 | 0.0155929 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0155759 |
| UBASH3B | ubiquitin associated and SH3 domain containing B | 0.0155317 |
| POTEF | POTE ankyrin domain family, member F | 0.015285 |
| B4GALNT3 | beta-1,4-N-acetyl-galactosaminyl transferase 3 | 0.0148384 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0146792 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0143416 |
| SYNJ2 | synaptojanin 2 | 0.0142516 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0141577 |
| PLSCR1 | phospholipid scramblase 1 | 0.0140888 |
| SIK3 | SIK family kinase 3 | 0.0140749 |
| CLDN4 | claudin 4 | 0.0140426 |
| OSBPL10 | oxysterol binding protein-like 10 | 0.0138785 |
| SERINC5 | serine incorporator 5 | 0.0138706 |
| ATF7IP2 | activating transcription factor 7 interacting protein 2 | 0.0137688 |
| JUN | jun proto-oncogene | 0.0135416 |
| HSPA1B | heat shock 70kDa protein 1B | 0.0133824 |
| EDN1 | endothelin 1 | 0.0133695 |
| PGK1 | phosphoglycerate kinase 1 | 0.0128658 |
| SGMS2 | sphingomyelin synthase 2 | 0.0128201 |
| SLTM | SAFB-like, transcription modulator | 0.0127816 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0125492 |
| RCOR1 | REST corepressor 1 | 0.0123319 |
| ADAM32 | ADAM metallopeptidase domain 32 | 0.0123073 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0123042 |
| MGLL | monoglyceride lipase | 0.0122991 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0122961 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0122739 |
| FNIP1 | folliculin interacting protein 1 | 0.0121993 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0119479 |
| LAMA4 | laminin, alpha 4 | 0.0119349 |
| KLK10 | kallikrein-related peptidase 10 | 0.0116636 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.011611 |
| EXOC4 | exocyst complex component 4 | 0.0116011 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0115532 |
| FBXO11 | F-box protein 11 | 0.0114733 |
| PALLD | palladin, cytoskeletal associated protein | 0.0113845 |
| PERP | PERP, TP53 apoptosis effector | 0.0113166 |
| SPATA13 | spermatogenesis associated 13 | 0.0113055 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.011278 |
| SP100 | SP100 nuclear antigen | 0.0111976 |
| PLEKHA5 | pleckstrin homology domain containing, family A member 5 | 0.011146 |
| CARMIL1 | capping protein regulator and myosin 1 linker 1 | 0.011128 |
| ARHGEF3 | Rho guanine nucleotide exchange factor (GEF) 3 | 0.0111087 |
| ANO1 | anoctamin 1, calcium activated chloride channel | 0.0109648 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.160678 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.15624 |
| TMSB10 | thymosin beta 10 | -0.112721 |
| RPLP1 | ribosomal protein, large, P1 | -0.0699819 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0669524 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0540578 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.052337 |
| RPS6 | ribosomal protein S6 | -0.0522625 |
| AGR2 | anterior gradient 2 | -0.0521647 |
| RPS19 | ribosomal protein S19 | -0.051436 |
| PTMA | prothymosin, alpha | -0.0502569 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0468116 |
| S100P | S100 calcium binding protein P | -0.0404265 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0402096 |
| NDRG1 | N-myc downstream regulated 1 | -0.0398603 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0388014 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0373589 |
| CALR | calreticulin | -0.0366956 |
| CANX | calnexin | -0.0357996 |
| H1-0 | H1.0 linker histone | -0.0351589 |
| RRBP1 | ribosome binding protein 1 | -0.0348886 |
| RPL23 | ribosomal protein L23 | -0.0347693 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0343334 |
| RPS25 | ribosomal protein S25 | -0.0335888 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0335085 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0316921 |
| FTL | ferritin, light polypeptide | -0.0308907 |
| RPL35A | ribosomal protein L35a | -0.0306596 |
| RPLP2 | ribosomal protein, large, P2 | -0.0306532 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0305777 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0299613 |
| RPS16 | ribosomal protein S16 | -0.0292967 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | -0.0291847 |
| RPL19 | ribosomal protein L19 | -0.0289692 |
| RPL28 | ribosomal protein L28 | -0.028962 |
| S100A6 | S100 calcium binding protein A6 | -0.0272004 |
| RPL35 | ribosomal protein L35 | -0.0270692 |
| RPL38 | ribosomal protein L38 | -0.0269445 |
| ATF5 | activating transcription factor 5 | -0.0265722 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0263121 |
| FDFT1 | farnesyl-diphosphate farnesyltransferase 1 | -0.0262238 |
| GNAS | GNAS complex locus | -0.0260587 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | -0.026041 |
| EPCAM | epithelial cell adhesion molecule | -0.0257489 |
| HLA-C | major histocompatibility complex, class I, C | -0.0256513 |
| RPL34 | ribosomal protein L34 | -0.0256094 |
| RPS21 | ribosomal protein S21 | -0.0253426 |
| ACTN4 | actinin, alpha 4 | -0.0252682 |
| RPS29 | ribosomal protein S29 | -0.0250692 |
| RPL36A | ribosomal protein L36a | -0.0247793 |
| RPL8 | ribosomal protein L8 | -0.0246465 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0241667 |
| RPL32 | ribosomal protein L32 | -0.0237482 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0234387 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0234249 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | -0.0234053 |
| RPS8 | ribosomal protein S8 | -0.0232984 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0231136 |
| RPS24 | ribosomal protein S24 | -0.0231038 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0230912 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0229935 |
| INSIG1 | insulin induced gene 1 | -0.0228924 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0227492 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | -0.0224959 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0218835 |
| WDR45B | WD repeat domain 45B | -0.0218444 |
| SELENOK | selenoprotein K | -0.02167 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0215717 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0214669 |
| RSF1 | remodeling and spacing factor 1 | -0.0213634 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0212962 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0212252 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0212022 |
| RPL7A | ribosomal protein L7a | -0.0211548 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0210112 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0209777 |
| RPS2 | ribosomal protein S2 | -0.0209588 |
| ANLN | anillin, actin binding protein | -0.0205564 |
| RPL36 | ribosomal protein L36 | -0.0205441 |
| HYOU1 | hypoxia up-regulated 1 | -0.0205358 |
| ACACA | acetyl-CoA carboxylase alpha | -0.0204089 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0203831 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0203503 |
| TMEM45B | transmembrane protein 45B | -0.0202804 |
| RPL27 | ribosomal protein L27 | -0.0201563 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.02008 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0200794 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | -0.0200677 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0200025 |
| SERF2 | small EDRK-rich factor 2 | -0.0196892 |
| S100A10 | S100 calcium binding protein A10 | -0.0196624 |
| RPS27 | ribosomal protein S27 | -0.0196332 |
| RPL18 | ribosomal protein L18 | -0.0195666 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0193684 |
| PRRC2B | proline-rich coiled-coil 2B | -0.019276 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0192169 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | -0.0191828 |
| RPS27A | ribosomal protein S27a | -0.0191456 |
| S100A9 | S100 calcium binding protein A9 | -0.0191428 |
| TUBB4B | tubulin, beta 4B class IVb | -0.0189432 |
