| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in LS 180 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.157102 |
| FTL | ferritin, light polypeptide | 0.0503569 |
| EXT1 | exostosin glycosyltransferase 1 | 0.047727 |
| MT2A | metallothionein 2A | 0.0436768 |
| RPL35A | ribosomal protein L35a | 0.0417171 |
| LDHA | lactate dehydrogenase A | 0.0369758 |
| EMP1 | epithelial membrane protein 1 | 0.0328409 |
| KRT18 | keratin 18, type I | 0.0327626 |
| MARCHF3 | membrane associated ring-CH-type finger 3 | 0.0303606 |
| SQSTM1 | sequestosome 1 | 0.0290827 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0276043 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.026535 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0260626 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0260474 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0251887 |
| EGFR | epidermal growth factor receptor | 0.0248407 |
| PGK1 | phosphoglycerate kinase 1 | 0.0244059 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0243561 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0240719 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0237194 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0237152 |
| ACTG1 | actin gamma 1 | 0.0228535 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0225165 |
| NAB1 | NGFI-A binding protein 1 (EGR1 binding protein 1) | 0.0221488 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0215692 |
| LAMA4 | laminin, alpha 4 | 0.0209873 |
| SVIL | supervillin | 0.0196323 |
| TPM4 | tropomyosin 4 | 0.0192589 |
| RPL7 | ribosomal protein L7 | 0.018634 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.018506 |
| UNC13B | unc-13 homolog B (C. elegans) | 0.0183745 |
| ANXA1 | annexin A1 | 0.0182295 |
| RIGI | RNA sensor RIG-I | 0.0177791 |
| CRY1 | cryptochrome circadian clock 1 | 0.0177665 |
| RPL9 | ribosomal protein L9 | 0.0175227 |
| INTS6 | integrator complex subunit 6 | 0.0170498 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0168627 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0166409 |
| MT1X | metallothionein 1X | 0.0163484 |
| RPS8 | ribosomal protein S8 | 0.0161762 |
| TUBB4B | tubulin, beta 4B class IVb | 0.0161459 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0157706 |
| RPS13 | ribosomal protein S13 | 0.0157303 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.015583 |
| PPP3CA | protein phosphatase 3, catalytic subunit, alpha isozyme | 0.0152682 |
| MUC17 | mucin 17, cell surface associated | 0.0152144 |
| UBC | ubiquitin C | 0.0151326 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0151155 |
| KRT19 | keratin 19, type I | 0.0149565 |
| RPL23 | ribosomal protein L23 | 0.014592 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0142341 |
| JUN | jun proto-oncogene | 0.0138773 |
| TUBA1B | tubulin, alpha 1b | 0.0138444 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | 0.0137499 |
| WHRN | whirlin | 0.0136214 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0134964 |
| TRIB1 | tribbles pseudokinase 1 | 0.0134836 |
| RPL31 | ribosomal protein L31 | 0.0133924 |
| CATSPERB | catsper channel auxiliary subunit beta | 0.0131622 |
| LMNA | lamin A/C | 0.0131036 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0127263 |
| PRDX1 | peroxiredoxin 1 | 0.0126756 |
| HBEGF | heparin-binding EGF-like growth factor | 0.0124587 |
| ENO1 | enolase 1, (alpha) | 0.0122448 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0121998 |
| HLA-A | major histocompatibility complex, class I, A | 0.0121717 |
| MRPS6 | mitochondrial ribosomal protein S6 | 0.0121337 |
| MLF1 | myeloid leukemia factor 1 | 0.0121275 |
| RPLP0 | ribosomal protein, large, P0 | 0.0118931 |
| S100A10 | S100 calcium binding protein A10 | 0.0118101 |
| MT1E | metallothionein 1E | 0.0114501 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0114479 |
| RPS10 | ribosomal protein S10 | 0.0112515 |
| SGMS2 | sphingomyelin synthase 2 | 0.0112276 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0111594 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | 0.0110778 |
| PRDX2 | peroxiredoxin 2 | 0.0110369 |
| LURAP1L | leucine rich adaptor protein 1-like | 0.0107441 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0105655 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.01056 |
| RPS23 | ribosomal protein S23 | 0.0104027 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0103795 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0102968 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0101318 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.0101096 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0100753 |
| PRG2 | proteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein) | 0.00996709 |
| IL33 | interleukin 33 | 0.00994278 |
| CYSTM1 | cysteine-rich transmembrane module containing 1 | 0.0096324 |
| IER3 | immediate early response 3 | 0.00963112 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.00959826 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.00952653 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.00951179 |
| CLDN4 | claudin 4 | 0.00947634 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | 0.00946919 |
| OAZ1 | ornithine decarboxylase antizyme 1 | 0.00943356 |
| UBB | ubiquitin B | 0.0093555 |
| AFF1 | AF4/FMR2 family, member 1 | 0.00928021 |
| SIK3 | SIK family kinase 3 | 0.00923863 |
| MYADM | myeloid-associated differentiation marker | 0.00919124 |
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS2 | ribosomal protein S2 | -0.10285 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0975571 |
| TNS4 | tensin 4 | -0.096642 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0923033 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0899446 |
| GPHN | gephyrin | -0.0868488 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0843413 |
| GOLGA4 | golgin A4 | -0.0829998 |
| RNF43 | ring finger protein 43 | -0.0743801 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0672889 |
| RPS6 | ribosomal protein S6 | -0.0663298 |
| PTMA | prothymosin, alpha | -0.0658498 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0646432 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0619099 |
| NPSR1 | neuropeptide S receptor 1 | -0.0618182 |
| RBM39 | RNA binding motif protein 39 | -0.0608593 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0591414 |
| MED13L | mediator complex subunit 13-like | -0.0573865 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0547983 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0540137 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0536509 |
| NDRG1 | N-myc downstream regulated 1 | -0.0534335 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0530051 |
| SETD5 | SET domain containing 5 | -0.0529165 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0508375 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.050643 |
| FLNB | filamin B, beta | -0.0503796 |
| ZNF292 | zinc finger protein 292 | -0.0501958 |
| DSPP | dentin sialophosphoprotein | -0.0494123 |
| NCOR1 | nuclear receptor corepressor 1 | -0.0477091 |
| ITGA6 | integrin, alpha 6 | -0.0464253 |
| PRSS3 | protease, serine, 3 | -0.0459451 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | -0.0459041 |
| EPCAM | epithelial cell adhesion molecule | -0.0453703 |
| PRELID2 | PRELI domain containing 2 | -0.0446095 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0446084 |
| FAM13A | family with sequence similarity 13, member A | -0.0441753 |
| ANTXR2 | anthrax toxin receptor 2 | -0.0439688 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0435567 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0434963 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0434393 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0434326 |
| MUC6 | mucin 6, oligomeric mucus/gel-forming | -0.0426083 |
| NFIA | nuclear factor I/A | -0.0416618 |
| PIGR | polymeric immunoglobulin receptor | -0.041385 |
| SHROOM3 | shroom family member 3 | -0.0413064 |
| SBF2 | SET binding factor 2 | -0.041246 |
| HSD17B12 | hydroxysteroid (17-beta) dehydrogenase 12 | -0.0408479 |
| TXNIP | thioredoxin interacting protein | -0.0407971 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0407519 |
| COG5 | component of oligomeric golgi complex 5 | -0.0406406 |
| KDM7A | lysine (K)-specific demethylase 7A | -0.0395949 |
| VMP1 | vacuole membrane protein 1 | -0.0394425 |
| ABHD2 | abhydrolase domain containing 2 | -0.0394119 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0393358 |
| CD46 | CD46 molecule, complement regulatory protein | -0.0390433 |
| RNF145 | ring finger protein 145 | -0.0389624 |
| TRIM2 | tripartite motif containing 2 | -0.0385443 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0384507 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0382011 |
| CADPS | Ca++-dependent secretion activator | -0.0381626 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0381305 |
| PTEN | phosphatase and tensin homolog | -0.0381163 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0381155 |
| NF1 | neurofibromin 1 | -0.0380416 |
| ARHGAP32 | Rho GTPase activating protein 32 | -0.0380278 |
| ESRP1 | epithelial splicing regulatory protein 1 | -0.0374878 |
| ARL15 | ADP-ribosylation factor-like 15 | -0.037475 |
| DSG2 | desmoglein 2 | -0.0374028 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0373775 |
| CTNNB1 | catenin (cadherin-associated protein), beta 1, 88kDa | -0.0372864 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0367628 |
| PTBP3 | polypyrimidine tract binding protein 3 | -0.0366173 |
| KIF5B | kinesin family member 5B | -0.0363337 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0354293 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0353099 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0350786 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | -0.0350577 |
| EREG | epiregulin | -0.034608 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0346048 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0345814 |
| CLTC | clathrin, heavy chain (Hc) | -0.0345018 |
| ZMYM2 | zinc finger, MYM-type 2 | -0.0344913 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0344645 |
| ANXA2 | annexin A2 | -0.0344215 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0343295 |
| RHPN2 | rhophilin, Rho GTPase binding protein 2 | -0.0342697 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0341223 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0341192 |
| NKTR | natural killer cell triggering receptor | -0.0340427 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | -0.0339236 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | -0.0338168 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0337569 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | -0.0335563 |
| TNKS | tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase | -0.0334257 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0330773 |
| USP34 | ubiquitin specific peptidase 34 | -0.0330477 |
| ABHD17C | abhydrolase domain containing 17C | -0.0328575 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0327338 |
| OGA | O-GlcNAcase | -0.0327272 |
