| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.195619 |
| TP63 | tumor protein p63 | 0.115825 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.102084 |
| FTL | ferritin, light polypeptide | 0.0770726 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0492744 |
| CADM2 | cell adhesion molecule 2 | 0.0469589 |
| RPS8 | ribosomal protein S8 | 0.0461188 |
| ZDHHC14 | zinc finger, DHHC-type containing 14 | 0.0441243 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0438381 |
| RPS12 | ribosomal protein S12 | 0.0433512 |
| RPL12 | ribosomal protein L12 | 0.0420688 |
| MT1X | metallothionein 1X | 0.0420515 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.041652 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0414768 |
| HDAC9 | histone deacetylase 9 | 0.0408112 |
| RPL35A | ribosomal protein L35a | 0.0384244 |
| RPL26 | ribosomal protein L26 | 0.0375159 |
| DST | dystonin | 0.037062 |
| HLA-B | major histocompatibility complex, class I, B | 0.0367669 |
| SQSTM1 | sequestosome 1 | 0.0364312 |
| CSMD3 | CUB and Sushi multiple domains 3 | 0.0358606 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0344509 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0343078 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0342811 |
| B2M | beta-2-microglobulin | 0.0328075 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0321182 |
| UBC | ubiquitin C | 0.0312201 |
| HOMER1 | homer scaffolding protein 1 | 0.0287962 |
| RPLP0 | ribosomal protein, large, P0 | 0.0279973 |
| DPH6 | diphthamine biosynthesis 6 | 0.0274554 |
| OSBPL8 | oxysterol binding protein-like 8 | 0.0273163 |
| RPL18 | ribosomal protein L18 | 0.0266593 |
| PRKCE | protein kinase C, epsilon | 0.0255926 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0255902 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0251828 |
| ARL4C | ADP-ribosylation factor-like 4C | 0.0248339 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0240989 |
| PRELID2 | PRELI domain containing 2 | 0.024095 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0240754 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0240394 |
| CAPRIN2 | caprin family member 2 | 0.0239006 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.023545 |
| PLIN2 | perilipin 2 | 0.0232836 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0231482 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0231316 |
| TMSB4X | thymosin beta 4, X-linked | 0.0225519 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0225393 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0218927 |
| SP100 | SP100 nuclear antigen | 0.0217376 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.02126 |
| INTS6 | integrator complex subunit 6 | 0.0212197 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0207539 |
| RPS6 | ribosomal protein S6 | 0.0205977 |
| MCTP1 | multiple C2 domains, transmembrane 1 | 0.0205158 |
| NEK10 | NIMA-related kinase 10 | 0.020071 |
| EREG | epiregulin | 0.0200694 |
| PABPN1 | poly(A) binding protein, nuclear 1 | 0.0197724 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0194937 |
| SYAP1 | synapse associated protein 1 | 0.0192153 |
| RPL11 | ribosomal protein L11 | 0.0191507 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | 0.0189126 |
| DDX41 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 | 0.0189037 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0187876 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0186473 |
| CTBP2 | C-terminal binding protein 2 | 0.0185348 |
| PTP4A2 | protein tyrosine phosphatase type IVA, member 2 | 0.0182881 |
| ADM | adrenomedullin | 0.0181349 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0178433 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0177652 |
| IFRD1 | interferon-related developmental regulator 1 | 0.0176428 |
| ITGB3BP | integrin beta 3 binding protein (beta3-endonexin) | 0.01736 |
| HIVEP1 | human immunodeficiency virus type I enhancer binding protein 1 | 0.0171381 |
| RPS25 | ribosomal protein S25 | 0.0169063 |
| SON | SON DNA binding protein | 0.0168884 |
| DNER | delta/notch-like EGF repeat containing | 0.0168769 |
| MEF2A | myocyte enhancer factor 2A | 0.0168034 |
| CEP290 | centrosomal protein 290kDa | 0.0167684 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0166191 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0164745 |
| LRRC23 | leucine rich repeat containing 23 | 0.016435 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0163569 |
| TGM2 | transglutaminase 2 | 0.016153 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0161435 |
| RPS4X | ribosomal protein S4, X-linked | 0.016126 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0161184 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0160809 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0160589 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0156869 |
| ZNF148 | zinc finger protein 148 | 0.0156498 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0154141 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0153243 |
| PIAS2 | protein inhibitor of activated STAT, 2 | 0.0147043 |
| RPL23 | ribosomal protein L23 | 0.0147018 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0146234 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0146211 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0145232 |
| SMAP1 | small ArfGAP 1 | 0.0142987 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | 0.0141373 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0141058 |
| TMEM14B | transmembrane protein 14B | 0.013999 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | -0.164279 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0871629 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0850319 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | -0.0714606 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.070487 |
| ACTG1 | actin gamma 1 | -0.0696431 |
| RAI1 | retinoic acid induced 1 | -0.0690048 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0592808 |
| EHBP1 | EH domain binding protein 1 | -0.0580243 |
| CD44 | CD44 molecule (Indian blood group) | -0.0563538 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0514072 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0474864 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0452988 |
| POTEF | POTE ankyrin domain family, member F | -0.0452009 |
| EGR1 | early growth response 1 | -0.0431042 |
| CANX | calnexin | -0.0419967 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0415744 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.041379 |
| CENPF | centromere protein F, 350/400kDa | -0.0407672 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0404823 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0393762 |
| RTN4 | reticulon 4 | -0.0390733 |
| FLNB | filamin B, beta | -0.0386637 |
| USP34 | ubiquitin specific peptidase 34 | -0.037599 |
| MKI67 | marker of proliferation Ki-67 | -0.0365942 |
| EZR | ezrin | -0.0365073 |
| JMJD1C | jumonji domain containing 1C | -0.036362 |
| TMEM41B | transmembrane protein 41B | -0.0359488 |
| APP | amyloid beta (A4) precursor protein | -0.0352214 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.034602 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0332178 |
| CEP170 | centrosomal protein 170kDa | -0.0329331 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.032346 |
| SLC20A1 | solute carrier family 20 (phosphate transporter), member 1 | -0.0321379 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.031528 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0315087 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0302166 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0301631 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0299164 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0298003 |
| TPM4 | tropomyosin 4 | -0.0289962 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0289588 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.028894 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.0285439 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0285217 |
| OSMR | oncostatin M receptor | -0.0284216 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0281407 |
| CAPN2 | calpain 2, (m/II) large subunit | -0.0277238 |
| WDR26 | WD repeat domain 26 | -0.0276633 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | -0.0272978 |
| YES1 | YES proto-oncogene 1, Src family tyrosine kinase | -0.0272904 |
| SMAD3 | SMAD family member 3 | -0.0271973 |
| EXOC4 | exocyst complex component 4 | -0.026885 |
| ZNF217 | zinc finger protein 217 | -0.0268398 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.026819 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0266924 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0261705 |
| RPL37A | ribosomal protein L37a | -0.0261224 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.025759 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0255798 |
| DIAPH3 | diaphanous-related formin 3 | -0.0253377 |
| SPRY4 | sprouty homolog 4 (Drosophila) | -0.024995 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | -0.0249048 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.024869 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0244521 |
| SERPINB9 | serpin peptidase inhibitor, clade B (ovalbumin), member 9 | -0.0244075 |
| BRAF | B-Raf proto-oncogene, serine/threonine kinase | -0.0241071 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0240641 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.024011 |
| LOXL2 | lysyl oxidase-like 2 | -0.0238556 |
| SETX | senataxin | -0.0237801 |
| RPS6KA3 | ribosomal protein S6 kinase, 90kDa, polypeptide 3 | -0.023766 |
| SERPINB1 | serpin peptidase inhibitor, clade B (ovalbumin), member 1 | -0.0236812 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0235528 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0233769 |
| DENND5A | DENN/MADD domain containing 5A | -0.023363 |
| BPTF | bromodomain PHD finger transcription factor | -0.0233344 |
| CMIP | c-Maf inducing protein | -0.0230936 |
| RPS15 | ribosomal protein S15 | -0.0230698 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | -0.0230696 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0228818 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0228721 |
| PARP4 | poly (ADP-ribose) polymerase family, member 4 | -0.0228108 |
| SGK1 | serum/glucocorticoid regulated kinase 1 | -0.0227504 |
| BMERB1 | bMERB domain containing 1 | -0.0227475 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0225478 |
| RPS23 | ribosomal protein S23 | -0.0225404 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | -0.0222765 |
| ANXA1 | annexin A1 | -0.0220464 |
| ZNF644 | zinc finger protein 644 | -0.021986 |
| RPL28 | ribosomal protein L28 | -0.0219026 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0217838 |
| RASAL2 | RAS protein activator like 2 | -0.021493 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0214308 |
| PYGB | phosphorylase, glycogen; brain | -0.0214049 |
| AHNAK | AHNAK nucleoprotein | -0.0213932 |
| SEC14L1 | SEC14-like 1 (S. cerevisiae) | -0.0213604 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | -0.0212745 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.021273 |
| ANKRD50 | ankyrin repeat domain 50 | -0.0212599 |
