| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| EGFR | epidermal growth factor receptor | 0.378543 |
| THSD4 | thrombospondin, type I, domain containing 4 | 0.138772 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.135705 |
| GRAMD1B | GRAM domain containing 1B | 0.114855 |
| ASPH | aspartate beta-hydroxylase | 0.110933 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.107826 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | 0.10333 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.096766 |
| LMO7 | LIM domain 7 | 0.0957839 |
| CEACAM6 | carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) | 0.0839387 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0749636 |
| LDHA | lactate dehydrogenase A | 0.0720213 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0705879 |
| TXNRD1 | thioredoxin reductase 1 | 0.0697609 |
| ENO1 | enolase 1, (alpha) | 0.0678648 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | 0.0678415 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0662232 |
| MYOF | myoferlin | 0.0651193 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0643729 |
| ANXA2 | annexin A2 | 0.0642641 |
| TMSB10 | thymosin beta 10 | 0.0621474 |
| UBC | ubiquitin C | 0.0597841 |
| S100A10 | S100 calcium binding protein A10 | 0.0585223 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0583028 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0563217 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | 0.0560921 |
| RNF213 | ring finger protein 213 | 0.0540095 |
| AHNAK | AHNAK nucleoprotein | 0.0535596 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0534158 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | 0.0529645 |
| KRT18 | keratin 18, type I | 0.0520959 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0473288 |
| MYO1E | myosin IE | 0.0470179 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0463421 |
| SMYD3 | SET and MYND domain containing 3 | 0.0461321 |
| SCEL | sciellin | 0.0459913 |
| LGALS12 | lectin, galactoside-binding, soluble, 12 | 0.0457275 |
| KRT7 | keratin 7, type II | 0.0451261 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.044287 |
| FOXP1 | forkhead box P1 | 0.0440638 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0433941 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0433887 |
| INTS6 | integrator complex subunit 6 | 0.0430624 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0427882 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0426761 |
| PDLIM5 | PDZ and LIM domain 5 | 0.040758 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0403325 |
| SLTM | SAFB-like, transcription modulator | 0.0402982 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0395428 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0373242 |
| EFNA5 | ephrin-A5 | 0.0371577 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0365022 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0355578 |
| CCND1 | cyclin D1 | 0.035348 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0351561 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0348078 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0346814 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0342996 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0334209 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0333706 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0332841 |
| PKM | pyruvate kinase, muscle | 0.0332542 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0331594 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0329424 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0322253 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0319623 |
| STC1 | stanniocalcin 1 | 0.0316938 |
| TRAPPC9 | trafficking protein particle complex 9 | 0.0316937 |
| CMIP | c-Maf inducing protein | 0.0316407 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0311532 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.030264 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0302637 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0302068 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0301145 |
| IGF1R | insulin-like growth factor 1 receptor | 0.0293806 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0292872 |
| SMAD3 | SMAD family member 3 | 0.0286539 |
| RAD51B | RAD51 paralog B | 0.0285296 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.028481 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0273218 |
| CUX1 | cut-like homeobox 1 | 0.0266993 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0266682 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0264199 |
| SLC35F3 | solute carrier family 35, member F3 | 0.0264122 |
| HOMER1 | homer scaffolding protein 1 | 0.0263102 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0256892 |
| DSPP | dentin sialophosphoprotein | 0.0253446 |
| ABCC3 | ATP-binding cassette, sub-family C (CFTR/MRP), member 3 | 0.0251411 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0249972 |
| RAB10 | RAB10, member RAS oncogene family | 0.0243965 |
| SVIL | supervillin | 0.024016 |
| SP100 | SP100 nuclear antigen | 0.0238488 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0237882 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.023618 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0235481 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0233938 |
| TPM4 | tropomyosin 4 | 0.023376 |
| TJP1 | tight junction protein 1 | 0.0233196 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0233014 |
| EMP1 | epithelial membrane protein 1 | 0.023052 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.158752 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0945344 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0747523 |
| MT2A | metallothionein 2A | -0.0601951 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0487608 |
| TMEM165 | transmembrane protein 165 | -0.0474156 |
| FAM13A | family with sequence similarity 13, member A | -0.0423305 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0396757 |
| MKI67 | marker of proliferation Ki-67 | -0.0389953 |
| RUNX1 | runt-related transcription factor 1 | -0.0386527 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0359416 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0355488 |
| NGLY1 | N-glycanase 1 | -0.0348908 |
| RBM39 | RNA binding motif protein 39 | -0.0344804 |
| CCNL1 | cyclin L1 | -0.0343412 |
| DTNA | dystrobrevin, alpha | -0.0338023 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0334101 |
| RPS2 | ribosomal protein S2 | -0.032764 |
| WDR45B | WD repeat domain 45B | -0.0311797 |
| ARRDC3 | arrestin domain containing 3 | -0.0311697 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0307359 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0304246 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0298034 |
| SUCO | SUN domain containing ossification factor | -0.0288212 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0287588 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0286321 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0285495 |
| HELZ | helicase with zinc finger | -0.0285072 |
| RPL37A | ribosomal protein L37a | -0.0277071 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0276686 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0271416 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0269651 |
| GOLGA4 | golgin A4 | -0.0268558 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0267603 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0261346 |
| JMJD1C | jumonji domain containing 1C | -0.0260816 |
| USP34 | ubiquitin specific peptidase 34 | -0.0260133 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0256902 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.025676 |
| ADAM17 | ADAM metallopeptidase domain 17 | -0.0256582 |
| RPS3 | ribosomal protein S3 | -0.0252732 |
| CES1 | carboxylesterase 1 | -0.0252148 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0252023 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0244757 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0244167 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0243287 |
| NPTN | neuroplastin | -0.0241758 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0239142 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0238755 |
| ZNF292 | zinc finger protein 292 | -0.0236441 |
| NUP58 | nucleoporin 58 | -0.023607 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0233566 |
| SPAG9 | sperm associated antigen 9 | -0.0233104 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0232655 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0231556 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | -0.0230644 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0227599 |
| OGA | O-GlcNAcase | -0.022599 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0225082 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0224797 |
| KCMF1 | potassium channel modulatory factor 1 | -0.0224354 |
| RASA2 | RAS p21 protein activator 2 | -0.0224046 |
| PAPOLA | poly(A) polymerase alpha | -0.0221048 |
| SETD5 | SET domain containing 5 | -0.0220508 |
| UVRAG | UV radiation resistance associated | -0.0219447 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0219431 |
| ATF4 | activating transcription factor 4 | -0.0217304 |
| EP300 | E1A binding protein p300 | -0.021416 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0211504 |
| RLF | rearranged L-myc fusion | -0.0209703 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0209328 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0208549 |
| SEC24D | SEC24 family member D | -0.0207724 |
| MARK3 | MAP/microtubule affinity-regulating kinase 3 | -0.0207301 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0207011 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0206659 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0205535 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0204574 |
| RPS6 | ribosomal protein S6 | -0.0204213 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0203337 |
| NDE1 | nudE neurodevelopment protein 1 | -0.019861 |
| RPS23 | ribosomal protein S23 | -0.0194095 |
| SMG1 | SMG1 phosphatidylinositol 3-kinase-related kinase | -0.0186634 |
| YEATS2 | YEATS domain containing 2 | -0.0185688 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0185286 |
| NEK7 | NIMA-related kinase 7 | -0.0184772 |
| ANKRD37 | ankyrin repeat domain 37 | -0.0184348 |
| SRP54 | signal recognition particle 54kDa | -0.0184309 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0184176 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0177678 |
| TMF1 | TATA element modulatory factor 1 | -0.0177402 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0177024 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0174398 |
| FAM193A | family with sequence similarity 193, member A | -0.0174279 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.017278 |
| RPL11 | ribosomal protein L11 | -0.0171144 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0170815 |
| SLMAP | sarcolemma associated protein | -0.0170598 |
| NUMB | numb homolog (Drosophila) | -0.0170523 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.016883 |
