| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0766403 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0682348 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0593753 |
| DPYD | dihydropyrimidine dehydrogenase | 0.0589611 |
| HMGA2 | high mobility group AT-hook 2 | 0.057756 |
| SIPA1L1 | signal-induced proliferation-associated 1 like 1 | 0.0559188 |
| SDK1 | sidekick cell adhesion molecule 1 | 0.0540878 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.053728 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | 0.0501973 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0484217 |
| GRB10 | growth factor receptor-bound protein 10 | 0.048187 |
| NRG1 | neuregulin 1 | 0.0461392 |
| GLCCI1 | glucocorticoid induced 1 | 0.04219 |
| GLIS3 | GLIS family zinc finger 3 | 0.0412966 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0359698 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0341707 |
| ZNF804A | zinc finger protein 804A | 0.0332691 |
| AADAC | arylacetamide deacetylase | 0.0322635 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0314119 |
| FAM20C | family with sequence similarity 20, member C | 0.0310565 |
| MSRB3 | methionine sulfoxide reductase B3 | 0.0307364 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0301403 |
| RASAL2 | RAS protein activator like 2 | 0.0291669 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | 0.0290572 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0289079 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0273498 |
| RAD51B | RAD51 paralog B | 0.0270251 |
| DST | dystonin | 0.0267981 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0260965 |
| STXBP5 | syntaxin binding protein 5 (tomosyn) | 0.0258124 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0256738 |
| RAI14 | retinoic acid induced 14 | 0.0255353 |
| SP100 | SP100 nuclear antigen | 0.0251675 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0248495 |
| INTS6 | integrator complex subunit 6 | 0.0245844 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0245561 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0244199 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0237893 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0233964 |
| KYNU | kynureninase | 0.0231005 |
| PTK2 | protein tyrosine kinase 2 | 0.022823 |
| IFI44L | interferon-induced protein 44-like | 0.0217898 |
| CDK14 | cyclin-dependent kinase 14 | 0.021783 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0217084 |
| ATXN1 | ataxin 1 | 0.0212883 |
| SUMF1 | sulfatase modifying factor 1 | 0.0212096 |
| NTN4 | netrin 4 | 0.0211081 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0207377 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.020685 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0201254 |
| EFNA5 | ephrin-A5 | 0.0200483 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0196407 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0194652 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0191743 |
| GPHN | gephyrin | 0.0189211 |
| GALNT18 | polypeptide N-acetylgalactosaminyltransferase 18 | 0.0187807 |
| SVIL | supervillin | 0.0187229 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0184652 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | 0.0182076 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 0.017739 |
| PRH1 | proline-rich protein HaeIII subfamily 1 | 0.0173342 |
| GPC6 | glypican 6 | 0.0173238 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0171894 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.0171118 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0169799 |
| PLIN2 | perilipin 2 | 0.0168975 |
| PTPRB | protein tyrosine phosphatase, receptor type, B | 0.0166026 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0165178 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0164921 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.0164623 |
| LGALS3 | lectin, galactoside-binding, soluble, 3 | 0.0163628 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.0163236 |
| MYO10 | myosin X | 0.0162332 |
| NBEA | neurobeachin | 0.0161964 |
| KSR1 | kinase suppressor of ras 1 | 0.0161883 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0160783 |
| PHF14 | PHD finger protein 14 | 0.0159661 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | 0.0157967 |
| ANXA10 | annexin A10 | 0.0155644 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0151217 |
| KAT6B | K(lysine) acetyltransferase 6B | 0.015015 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0150054 |
| PHF3 | PHD finger protein 3 | 0.014852 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0147814 |
| RPL35A | ribosomal protein L35a | 0.0146135 |
| GREB1L | growth regulation by estrogen in breast cancer-like | 0.0145628 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0144874 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0144065 |
| TRPS1 | trichorhinophalangeal syndrome I | 0.0143429 |
| WWC2 | WW and C2 domain containing 2 | 0.0142316 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0141111 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.0140952 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0140485 |
| CDH13 | cadherin 13 | 0.0138832 |
| CFAP96 | cilia and flagella associated protein 96 | 0.0138608 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0137246 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0136036 |
| LRRFIP2 | leucine rich repeat (in FLII) interacting protein 2 | 0.0134376 |
| TMSB4X | thymosin beta 4, X-linked | 0.0133958 |
| CYB5R3 | cytochrome b5 reductase 3 | 0.0133218 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.190564 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.169659 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.130548 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.107675 |
| TMSB10 | thymosin beta 10 | -0.0860371 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0783853 |
| PCBP2 | poly(rC) binding protein 2 | -0.0690008 |
| VIM | vimentin | -0.0675992 |
| GOLGA4 | golgin A4 | -0.0642459 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0626702 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0605829 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0597335 |
| UBC | ubiquitin C | -0.0584593 |
| MT2A | metallothionein 2A | -0.0561946 |
| ENO1 | enolase 1, (alpha) | -0.0524553 |
| PTMA | prothymosin, alpha | -0.0506369 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0493653 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0463604 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0453633 |
| CALU | calumenin | -0.0401284 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.0394994 |
| NDRG1 | N-myc downstream regulated 1 | -0.0394279 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0387092 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0384883 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0380424 |
| CALR | calreticulin | -0.0374999 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0357153 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0356831 |
| FLNB | filamin B, beta | -0.0353641 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0350409 |
| OGA | O-GlcNAcase | -0.034987 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0329616 |
| RPLP2 | ribosomal protein, large, P2 | -0.0325463 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0317123 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0316414 |
| CANX | calnexin | -0.0308645 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0306995 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0306825 |
| TMEM263 | transmembrane protein 263 | -0.030351 |
| CD44 | CD44 molecule (Indian blood group) | -0.0301631 |
| HDLBP | high density lipoprotein binding protein | -0.0298582 |
| RPL31 | ribosomal protein L31 | -0.0290699 |
| SRP54 | signal recognition particle 54kDa | -0.0284366 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0284295 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0281128 |
| SEC23A | Sec23 homolog A (S. cerevisiae) | -0.0277901 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | -0.0273242 |
| SPAG9 | sperm associated antigen 9 | -0.0271314 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0268174 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0267484 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0263515 |
| FN1 | fibronectin 1 | -0.0263184 |
| GNAS | GNAS complex locus | -0.0261773 |
| AHNAK | AHNAK nucleoprotein | -0.0258225 |
| SBF2 | SET binding factor 2 | -0.0255968 |
| ACTG1 | actin gamma 1 | -0.0252743 |
| EIF3B | eukaryotic translation initiation factor 3, subunit B | -0.0251608 |
| POTEF | POTE ankyrin domain family, member F | -0.0251502 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | -0.0250635 |
| IER3 | immediate early response 3 | -0.0249927 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0249605 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.024936 |
| LOX | lysyl oxidase | -0.0247349 |
| SPRED1 | sprouty-related, EVH1 domain containing 1 | -0.024526 |
| RBM39 | RNA binding motif protein 39 | -0.0243888 |
| ZNF292 | zinc finger protein 292 | -0.0242436 |
| FAM13A | family with sequence similarity 13, member A | -0.0238997 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0238689 |
| SEC24A | SEC24 family member A | -0.0238131 |
| FOXO3 | forkhead box O3 | -0.0237398 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.023659 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0235978 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | -0.0232681 |
| COPA | coatomer protein complex, subunit alpha | -0.0231901 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0231843 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0230176 |
| CD109 | CD109 molecule | -0.0224191 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | -0.0218901 |
| GDI2 | GDP dissociation inhibitor 2 | -0.0218091 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0217666 |
| CLTC | clathrin, heavy chain (Hc) | -0.0217482 |
| RPS27A | ribosomal protein S27a | -0.0216026 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0215154 |
| MCL1 | myeloid cell leukemia 1 | -0.0212038 |
| KLF7 | Kruppel-like factor 7 (ubiquitous) | -0.0209062 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0206415 |
| SUCO | SUN domain containing ossification factor | -0.0203962 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0203129 |
| RPS3 | ribosomal protein S3 | -0.0203043 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0203015 |
| FTL | ferritin, light polypeptide | -0.0201981 |
| ATP13A3 | ATPase type 13A3 | -0.0201343 |
| RPS29 | ribosomal protein S29 | -0.0200933 |
| RPS19 | ribosomal protein S19 | -0.0200585 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0200304 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0199722 |
| APP | amyloid beta (A4) precursor protein | -0.0199376 |
| GLG1 | golgi glycoprotein 1 | -0.0198994 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.019858 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0194912 |
