| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.194686 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0938524 |
| VIM | vimentin | 0.0747924 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0661634 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0549769 |
| PM20D1 | peptidase M20 domain containing 1 | 0.053973 |
| GRAMD1B | GRAM domain containing 1B | 0.0529987 |
| HDAC9 | histone deacetylase 9 | 0.0484744 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | 0.0393905 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0392848 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0346567 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0340925 |
| NRG1 | neuregulin 1 | 0.0333769 |
| KYNU | kynureninase | 0.033279 |
| NTN4 | netrin 4 | 0.0331082 |
| S100A6 | S100 calcium binding protein A6 | 0.0326308 |
| KIF5B | kinesin family member 5B | 0.0318609 |
| LDHA | lactate dehydrogenase A | 0.0316017 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0313259 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.030122 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0290106 |
| RPL7 | ribosomal protein L7 | 0.0268899 |
| SVIL | supervillin | 0.0262791 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0242454 |
| PAWR | PRKC, apoptosis, WT1, regulator | 0.0233191 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0227907 |
| ERBIN | erbb2 interacting protein | 0.0227004 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0218839 |
| CTSL | cathepsin L | 0.0218355 |
| PPP2R2A | protein phosphatase 2, regulatory subunit B, alpha | 0.0217551 |
| TPM3 | tropomyosin 3 | 0.0216434 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0206216 |
| MTHFD2L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2-like | 0.0205494 |
| FGB | fibrinogen beta chain | 0.0204694 |
| RPLP0 | ribosomal protein, large, P0 | 0.0203325 |
| TPD52 | tumor protein D52 | 0.0196238 |
| SIK3 | SIK family kinase 3 | 0.0195932 |
| APP | amyloid beta (A4) precursor protein | 0.0195633 |
| ASTN2 | astrotactin 2 | 0.0195359 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0192151 |
| SFTPA2 | surfactant protein A2 | 0.019207 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0188536 |
| XRCC5 | X-ray repair complementing defective repair in Chinese hamster cells 5 (double-strand-break rejoining) | 0.0188527 |
| ENO1 | enolase 1, (alpha) | 0.0185501 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0185227 |
| ANKRD28 | ankyrin repeat domain 28 | 0.01839 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0183525 |
| SRGN | serglycin | 0.018325 |
| USP3 | ubiquitin specific peptidase 3 | 0.0181433 |
| ASPH | aspartate beta-hydroxylase | 0.018112 |
| MKI67 | marker of proliferation Ki-67 | 0.0178954 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.0177743 |
| SSB | Sjogren syndrome antigen B (autoantigen La) | 0.0175943 |
| RHOA | ras homolog family member A | 0.0172613 |
| WDR43 | WD repeat domain 43 | 0.0170766 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0169912 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | 0.0168433 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0167315 |
| FTL | ferritin, light polypeptide | 0.016114 |
| TMEM123 | transmembrane protein 123 | 0.0161078 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0160422 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0157863 |
| ECT2 | epithelial cell transforming 2 | 0.0157007 |
| ACTR2 | ARP2 actin-related protein 2 homolog (yeast) | 0.0155765 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | 0.0154086 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.015334 |
| UBC | ubiquitin C | 0.015274 |
| YBX3 | Y box binding protein 3 | 0.0152584 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0151715 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | 0.015116 |
| PPP2R5E | protein phosphatase 2, regulatory subunit B', epsilon isoform | 0.0149942 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0149871 |
| FGG | fibrinogen gamma chain | 0.014841 |
| TCF12 | transcription factor 12 | 0.0147429 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.014669 |
| DDX24 | DEAD (Asp-Glu-Ala-Asp) box helicase 24 | 0.0146015 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0145248 |
| S100A10 | S100 calcium binding protein A10 | 0.0144373 |
| LAMB1 | laminin, beta 1 | 0.0143457 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0142002 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0141364 |
| NNMT | nicotinamide N-methyltransferase | 0.0141212 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0140854 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0140533 |
| HNRNPR | heterogeneous nuclear ribonucleoprotein R | 0.0140375 |
| YME1L1 | YME1-like 1 ATPase | 0.014029 |
| INO80 | INO80 complex subunit | 0.0139656 |
| CHN1 | chimerin 1 | 0.0139358 |
| ACACA | acetyl-CoA carboxylase alpha | 0.0138764 |
| TNPO1 | transportin 1 | 0.0138077 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0135236 |
| SF3B2 | splicing factor 3b, subunit 2, 145kDa | 0.0135152 |
| YBX1 | Y box binding protein 1 | 0.0134851 |
| RPL23 | ribosomal protein L23 | 0.013456 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | 0.0134104 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0133858 |
| NOLC1 | nucleolar and coiled-body phosphoprotein 1 | 0.0133626 |
| CLU | clusterin | 0.0133547 |
| GNAI1 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 | 0.0133477 |
| TAX1BP1 | Tax1 (human T-cell leukemia virus type I) binding protein 1 | 0.0132558 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.146111 |
| MT2A | metallothionein 2A | -0.138394 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0713696 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0652301 |
| ACTG1 | actin gamma 1 | -0.0647011 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0583951 |
| POTEF | POTE ankyrin domain family, member F | -0.0540107 |
| TMSB10 | thymosin beta 10 | -0.053141 |
| MCL1 | myeloid cell leukemia 1 | -0.0528641 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0527265 |
| DOCK4 | dedicator of cytokinesis 4 | -0.049575 |
| EGR1 | early growth response 1 | -0.04818 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0477751 |
| CMIP | c-Maf inducing protein | -0.047527 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0459752 |
| FMNL2 | formin-like 2 | -0.044499 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0422715 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0415461 |
| FLNB | filamin B, beta | -0.0410923 |
| SMOC1 | SPARC related modular calcium binding 1 | -0.037759 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0369465 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0362975 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0357363 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0352107 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0343973 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0324497 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0317051 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0317023 |
| ACTN1 | actinin, alpha 1 | -0.0312698 |
| EGFR | epidermal growth factor receptor | -0.0311772 |
| PYGL | phosphorylase, glycogen, liver | -0.0300709 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0296793 |
| NDRG1 | N-myc downstream regulated 1 | -0.0296078 |
| RPS29 | ribosomal protein S29 | -0.0294909 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0276427 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0271846 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0265542 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0263037 |
| FLNA | filamin A, alpha | -0.0261251 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0251417 |
| RPL36 | ribosomal protein L36 | -0.0245297 |
| MYO1E | myosin IE | -0.0241448 |
| ATXN1 | ataxin 1 | -0.0236702 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0230534 |
| TPM1 | tropomyosin 1 (alpha) | -0.0227885 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0227122 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0223495 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0223344 |
| PRKCE | protein kinase C, epsilon | -0.0222872 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0215715 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0209897 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0207799 |
| CTBP2 | C-terminal binding protein 2 | -0.0203809 |
| DST | dystonin | -0.0200824 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0197411 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0192967 |
| NLK | nemo-like kinase | -0.019295 |
| SMAD3 | SMAD family member 3 | -0.0190532 |
| SEL1L | sel-1 suppressor of lin-12-like (C. elegans) | -0.0189747 |
| RAD51B | RAD51 paralog B | -0.0187109 |
| BRD2 | bromodomain containing 2 | -0.0183374 |
| SLC35F3 | solute carrier family 35, member F3 | -0.0182743 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | -0.0179826 |
| LAMC2 | laminin, gamma 2 | -0.0178985 |
| GLIS3 | GLIS family zinc finger 3 | -0.0177616 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0176594 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0176248 |
| TASOR2 | transcription activation suppressor family member 2 | -0.0174841 |
| IGF2 | insulin-like growth factor 2 | -0.0174262 |
| COPA | coatomer protein complex, subunit alpha | -0.0173463 |
| GNAS | GNAS complex locus | -0.0172334 |
| COTL1 | coactosin-like F-actin binding protein 1 | -0.0172009 |
| CFDP1 | craniofacial development protein 1 | -0.0169701 |
| PFKP | phosphofructokinase, platelet | -0.0169519 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.016917 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0168622 |
| NF1 | neurofibromin 1 | -0.0166936 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0165057 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0164596 |
| INTS6 | integrator complex subunit 6 | -0.0164516 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0164336 |
| LOXL2 | lysyl oxidase-like 2 | -0.0163954 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | -0.0161236 |
| NEGR1 | neuronal growth regulator 1 | -0.0161088 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0160387 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0160265 |
| ATP2A2 | ATPase, Ca++ transporting, cardiac muscle, slow twitch 2 | -0.0159402 |
| PDE8A | phosphodiesterase 8A | -0.0158894 |
| VMP1 | vacuole membrane protein 1 | -0.0157435 |
| PMM2 | phosphomannomutase 2 | -0.0157056 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0156329 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0154701 |
| CCNYL1 | cyclin Y-like 1 | -0.0152685 |
| DHRSX | dehydrogenase/reductase (SDR family) X-linked | -0.0152646 |
| ARHGAP12 | Rho GTPase activating protein 12 | -0.0152512 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0151505 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0147881 |
| FBXO11 | F-box protein 11 | -0.0147741 |
| CYTH1 | cytohesin 1 | -0.0146569 |
| CBFB | core-binding factor, beta subunit | -0.0146564 |
