| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.117671 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.106895 |
| RSAD2 | radical S-adenosyl methionine domain containing 2 | 0.0939697 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0792456 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0679625 |
| EGFR | epidermal growth factor receptor | 0.0663946 |
| B2M | beta-2-microglobulin | 0.0640198 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0582759 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0574421 |
| STK17A | serine/threonine kinase 17a | 0.0564355 |
| TXNRD1 | thioredoxin reductase 1 | 0.0558873 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0534027 |
| ACSL3 | acyl-CoA synthetase long-chain family member 3 | 0.0521631 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0517703 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0499082 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0488035 |
| SPAG9 | sperm associated antigen 9 | 0.0480718 |
| FAT1 | FAT atypical cadherin 1 | 0.0464222 |
| RIGI | RNA sensor RIG-I | 0.043763 |
| OASL | 2'-5'-oligoadenylate synthetase-like | 0.0435722 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.043506 |
| TENM1 | teneurin transmembrane protein 1 | 0.0421891 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0421022 |
| SMYD3 | SET and MYND domain containing 3 | 0.041459 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0410019 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0409611 |
| RNF149 | ring finger protein 149 | 0.0404318 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0400039 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0398274 |
| UBE3C | ubiquitin protein ligase E3C | 0.0389141 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0388212 |
| GRB10 | growth factor receptor-bound protein 10 | 0.038571 |
| ZNFX1 | zinc finger, NFX1-type containing 1 | 0.0381581 |
| WWOX | WW domain containing oxidoreductase | 0.0381469 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0380036 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0375858 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0375749 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0374923 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0371476 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | 0.0369657 |
| ZNF292 | zinc finger protein 292 | 0.0364234 |
| CREBBP | CREB binding protein | 0.0363675 |
| RPS19 | ribosomal protein S19 | 0.0361348 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0359351 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0359125 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0357856 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.0356851 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0355159 |
| RTN4 | reticulon 4 | 0.0353485 |
| XPR1 | xenotropic and polytropic retrovirus receptor 1 | 0.0350308 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0344145 |
| HS6ST3 | heparan sulfate 6-O-sulfotransferase 3 | 0.0343022 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0334779 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0334604 |
| FHIT | fragile histidine triad | 0.0334386 |
| NOP58 | NOP58 ribonucleoprotein | 0.0330684 |
| PCBP3 | poly(rC) binding protein 3 | 0.0328893 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0327837 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0325756 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0325456 |
| PLAU | plasminogen activator, urokinase | 0.0322108 |
| VCL | vinculin | 0.0318804 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | 0.0318726 |
| APP | amyloid beta (A4) precursor protein | 0.0316102 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0315286 |
| HLA-A | major histocompatibility complex, class I, A | 0.0314207 |
| NBAS | neuroblastoma amplified sequence | 0.0312996 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0307988 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0304535 |
| CDC27 | cell division cycle 27 | 0.030444 |
| ADAR | adenosine deaminase, RNA-specific | 0.0303959 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.030388 |
| DIAPH2 | diaphanous-related formin 2 | 0.0303323 |
| H3-3B | H3.3 histone B | 0.0302298 |
| NRG1 | neuregulin 1 | 0.0300765 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0300646 |
| PAPOLA | poly(A) polymerase alpha | 0.029429 |
| FRMD5 | FERM domain containing 5 | 0.0293126 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0292688 |
| TANC1 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | 0.0289402 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | 0.0287823 |
| NEDD1 | neural precursor cell expressed, developmentally down-regulated 1 | 0.0284581 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0281759 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0280446 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | 0.0272419 |
| FOXP1 | forkhead box P1 | 0.0270252 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0268985 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0267461 |
| MYO1E | myosin IE | 0.0266059 |
| CDCP1 | CUB domain containing protein 1 | 0.0264998 |
| UBN2 | ubinuclein 2 | 0.0264776 |
| CUL3 | cullin 3 | 0.0263664 |
| HLA-B | major histocompatibility complex, class I, B | 0.0262901 |
| FGF13 | fibroblast growth factor 13 | 0.0262793 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0261699 |
| MIB1 | mindbomb E3 ubiquitin protein ligase 1 | 0.0259077 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0256842 |
| CTBP2 | C-terminal binding protein 2 | 0.0255251 |
| RPLP2 | ribosomal protein, large, P2 | 0.0253929 |
| TAS2R14 | taste receptor, type 2, member 14 | 0.0250632 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.177704 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.141826 |
| KRT17 | keratin 17, type I | -0.0859084 |
| ANXA2 | annexin A2 | -0.0847697 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0847281 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0791299 |
| ATOSA | atos homolog A | -0.0646336 |
| LOC112694756 | uncharaterized LOC112694756 | -0.062322 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0621177 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0592697 |
| EZR | ezrin | -0.0585918 |
| NDRG1 | N-myc downstream regulated 1 | -0.0585147 |
| JMJD1C | jumonji domain containing 1C | -0.0579204 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0566118 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0562603 |
| VMP1 | vacuole membrane protein 1 | -0.0552311 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0520833 |
| VIM | vimentin | -0.0520557 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.051869 |
| MUC16 | mucin 16, cell surface associated | -0.0494539 |
| POTEF | POTE ankyrin domain family, member F | -0.0490481 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0487122 |
| SETD5 | SET domain containing 5 | -0.0480475 |
| MAML2 | mastermind-like 2 (Drosophila) | -0.0451367 |
| ACTG1 | actin gamma 1 | -0.0448101 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0441442 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0432374 |
| TMSB10 | thymosin beta 10 | -0.0431387 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0430781 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0412215 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0398589 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.03963 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0391211 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0390828 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0389567 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | -0.0383264 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0382359 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.037941 |
| RPS8 | ribosomal protein S8 | -0.0369049 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0357706 |
| PKM | pyruvate kinase, muscle | -0.0356331 |
| ARRDC3 | arrestin domain containing 3 | -0.0353061 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0344178 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0342407 |
| IGF2 | insulin-like growth factor 2 | -0.0333953 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0331432 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0329702 |
| NCOA3 | nuclear receptor coactivator 3 | -0.0329665 |
| MCL1 | myeloid cell leukemia 1 | -0.0324843 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0323901 |
| DST | dystonin | -0.0323623 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0321539 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.031905 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0317818 |
| SYNGAP1 | synaptic Ras GTPase activating protein 1 | -0.031775 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0315083 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0313636 |
| ARF1 | ADP-ribosylation factor 1 | -0.030969 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0309466 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0306897 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0306853 |
| S100A9 | S100 calcium binding protein A9 | -0.0304756 |
| USP53 | ubiquitin specific peptidase 53 | -0.0304402 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0302861 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0299126 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0297876 |
| SEC24A | SEC24 family member A | -0.0297633 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0297096 |
| FNIP1 | folliculin interacting protein 1 | -0.029701 |
| INTS6 | integrator complex subunit 6 | -0.0294048 |
| CDH13 | cadherin 13 | -0.0292935 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0292015 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0291255 |
| DIAPH1 | diaphanous-related formin 1 | -0.0286671 |
| MYL12B | myosin, light chain 12B, regulatory | -0.0279521 |
| NCOA2 | nuclear receptor coactivator 2 | -0.0278043 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0275295 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.027502 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0273529 |
| CALU | calumenin | -0.027137 |
| C1GALT1 | core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 | -0.0271278 |
| ZNF609 | zinc finger protein 609 | -0.026758 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | -0.0266973 |
| MAP7 | microtubule-associated protein 7 | -0.026425 |
| SOS2 | son of sevenless homolog 2 (Drosophila) | -0.02608 |
| WAC | WW domain containing adaptor with coiled-coil | -0.0260732 |
| SMAD3 | SMAD family member 3 | -0.0260197 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.025759 |
| NAV2 | neuron navigator 2 | -0.0255794 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.025551 |
| ITGB4 | integrin, beta 4 | -0.0255344 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0255027 |
| KDM2A | lysine (K)-specific demethylase 2A | -0.0254133 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0252763 |
| GPR107 | G protein-coupled receptor 107 | -0.0250683 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0247968 |
| LMO7 | LIM domain 7 | -0.0241977 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0241523 |
| STK4 | serine/threonine kinase 4 | -0.0238524 |
| FAM13B | family with sequence similarity 13, member B | -0.023694 |
