Pimitespib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimitespib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.308823
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.130774
YBX3 Y box binding protein 3 0.103705
THSD4 thrombospondin, type I, domain containing 4 0.0846407
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.076871
GRAMD1B GRAM domain containing 1B 0.0723746
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0709101
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0625503
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0584888
HSPA1A heat shock 70kDa protein 1A 0.0583545
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0548102
KTN1 kinectin 1 (kinesin receptor) 0.054103
PRKDC protein kinase, DNA-activated, catalytic polypeptide 0.0520491
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0517434
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 0.0491853
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0483351
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0465519
PDE4D phosphodiesterase 4D, cAMP-specific 0.0461541
ERRFI1 ERBB receptor feedback inhibitor 1 0.0459111
TXNRD1 thioredoxin reductase 1 0.0446772
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0443646
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0442475
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0426462
RIMS2 regulating synaptic membrane exocytosis 2 0.04016
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0401393
DOCK5 dedicator of cytokinesis 5 0.0397913
EXOC4 exocyst complex component 4 0.0396137
OSMR oncostatin M receptor 0.0374026
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0373924
TPM3 tropomyosin 3 0.0363313
WWOX WW domain containing oxidoreductase 0.0349445
FMNL2 formin-like 2 0.0346272
ZSWIM6 zinc finger, SWIM-type containing 6 0.033736
ATP11A ATPase, class VI, type 11A 0.0336862
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0333123
ZCCHC7 zinc finger, CCHC domain containing 7 0.0317806
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0312502
MCL1 myeloid cell leukemia 1 0.0305524
SFPQ splicing factor proline/glutamine-rich 0.0302911
PDE10A phosphodiesterase 10A 0.0302872
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.029989
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0296566
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0292586
PDLIM5 PDZ and LIM domain 5 0.0290418
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0288152
LOC102724023 ES1 protein homolog, mitochondrial 0.0287617
FAF1 Fas (TNFRSF6) associated factor 1 0.0284103
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0278621
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0274216
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0272273
FNDC3B fibronectin type III domain containing 3B 0.0272112
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0271833
MACF1 microtubule-actin crosslinking factor 1 0.0268988
HSPA1B heat shock 70kDa protein 1B 0.026882
SVIL supervillin 0.0267726
RAB7A RAB7A, member RAS oncogene family 0.0265868
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0265064
ATXN1 ataxin 1 0.0264615
CDK17 cyclin-dependent kinase 17 0.0264544
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0264527
IGF1R insulin-like growth factor 1 receptor 0.0259717
PRKCE protein kinase C, epsilon 0.0259434
DST dystonin 0.0257551
NIPBL Nipped-B homolog (Drosophila) 0.0254308
VCL vinculin 0.0249347
EXT1 exostosin glycosyltransferase 1 0.0248307
TAS2R14 taste receptor, type 2, member 14 0.0247061
JMJD1C jumonji domain containing 1C 0.0246824
TIAM1 T-cell lymphoma invasion and metastasis 1 0.0245433
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0243309
RABGAP1L RAB GTPase activating protein 1-like 0.0240661
PRH1 proline-rich protein HaeIII subfamily 1 0.0240055
ELL2 elongation factor, RNA polymerase II, 2 0.0232614
TRIP12 thyroid hormone receptor interactor 12 0.0229656
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0228645
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0226535
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0226113
PYGL phosphorylase, glycogen, liver 0.0225289
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0224502
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0224299
HSPH1 heat shock 105kDa/110kDa protein 1 0.0224141
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.022274
GOLGB1 golgin B1 0.021926
YAP1 Yes-associated protein 1 0.0218248
ANO6 anoctamin 6 0.0215081
GPHN gephyrin 0.0214714
HOMER1 homer scaffolding protein 1 0.0206414
IL6ST interleukin 6 signal transducer 0.0206035
TPM4 tropomyosin 4 0.0204169
DSPP dentin sialophosphoprotein 0.020341
AEBP2 AE binding protein 2 0.020121
MYH9 myosin, heavy chain 9, non-muscle 0.0197241
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 0.0196553
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0196336
R3HDM2 R3H domain containing 2 0.0195035
SERBP1 SERPINE1 mRNA binding protein 1 0.0194785
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.019397
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0190759
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.0189853
RAD51B RAD51 paralog B 0.018959

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.139087
PTMA prothymosin, alpha -0.0966887
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0719119
RPS29 ribosomal protein S29 -0.0699785
RPL37A ribosomal protein L37a -0.06979
TMSB10 thymosin beta 10 -0.0640991
RPS3 ribosomal protein S3 -0.056587
MT2A metallothionein 2A -0.0522218
RPS15 ribosomal protein S15 -0.0510155
RPL37 ribosomal protein L37 -0.0497647
RPS19 ribosomal protein S19 -0.049328
TPT1 tumor protein, translationally-controlled 1 -0.0485676
RPLP2 ribosomal protein, large, P2 -0.0469673
RPS21 ribosomal protein S21 -0.0427963
RPL36 ribosomal protein L36 -0.0420724
RPS27 ribosomal protein S27 -0.0403999
WSB1 WD repeat and SOCS box containing 1 -0.0367463
RPL26 ribosomal protein L26 -0.0363982
RPS10 ribosomal protein S10 -0.0363699
RPS8 ribosomal protein S8 -0.0354901
RPL35A ribosomal protein L35a -0.034544
MYL12B myosin, light chain 12B, regulatory -0.0341043
EIF1 eukaryotic translation initiation factor 1 -0.0335609
RPS27A ribosomal protein S27a -0.0332865
RPL31 ribosomal protein L31 -0.0331919
RPL38 ribosomal protein L38 -0.0325958
RPS23 ribosomal protein S23 -0.032584
VIM vimentin -0.0307813
FTL ferritin, light polypeptide -0.0306195
KDM3A lysine (K)-specific demethylase 3A -0.0296812
RPL32 ribosomal protein L32 -0.028504
GNAS GNAS complex locus -0.0282014
RPL12 ribosomal protein L12 -0.0275622
RPL19 ribosomal protein L19 -0.0269578
RPL34 ribosomal protein L34 -0.0256806
RPL9 ribosomal protein L9 -0.0243891
RPS17 ribosomal protein S17 -0.024354
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0236402
RPS25 ribosomal protein S25 -0.0234119
RPL8 ribosomal protein L8 -0.0229737
RPL13A ribosomal protein L13a -0.022847
EGR1 early growth response 1 -0.022478
RPS14 ribosomal protein S14 -0.0222727
RPLP1 ribosomal protein, large, P1 -0.0217709
RPL23 ribosomal protein L23 -0.0216636
ATP5F1B ATP synthase F1 subunit beta -0.021043
RPS6 ribosomal protein S6 -0.0203188
RPS16 ribosomal protein S16 -0.0194921
GOLGA4 golgin A4 -0.019438
RPL28 ribosomal protein L28 -0.0186161
RPL5 ribosomal protein L5 -0.0175716
ZFR zinc finger RNA binding protein -0.0174075
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0169589
RPS13 ribosomal protein S13 -0.0167137
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0164384
ZNF292 zinc finger protein 292 -0.0161529
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0155777
HMGA1 high mobility group AT-hook 1 -0.0155735
GSTP1 glutathione S-transferase pi 1 -0.0153262
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.015302
PHIP pleckstrin homology domain interacting protein -0.0151271
MON2 MON2 homolog (S. cerevisiae) -0.0149736
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0149168
RPL11 ribosomal protein L11 -0.0149145
H1-0 H1.0 linker histone -0.0145395
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 -0.0144699
TRPC4AP transient receptor potential cation channel, subfamily C, member 4 associated protein -0.0143662
WASF2 WAS protein family, member 2 -0.0142643
RPL36A ribosomal protein L36a -0.0141989
RACK1 receptor for activated C kinase 1 -0.0141726
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0141001
RPL10A ribosomal protein L10a -0.0140846
RPS11 ribosomal protein S11 -0.0138522
VDAC1 voltage-dependent anion channel 1 -0.0136451
OGA O-GlcNAcase -0.0136094
TMEM165 transmembrane protein 165 -0.0135491
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0133676
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0130364
FSCN1 fascin actin-bundling protein 1 -0.0129547
RPL7A ribosomal protein L7a -0.0127338
SINHCAF SIN3-HDAC complex associated factor -0.0124967
MARCHF6 membrane associated ring-CH-type finger 6 -0.0124777
NDUFA1 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 1, 7.5kDa -0.0124355
IGF2 insulin-like growth factor 2 -0.0124349
CBFA2T2 core-binding factor, runt domain, alpha subunit 2; translocated to, 2 -0.0124147
UQCRH ubiquinol-cytochrome c reductase hinge protein -0.0123673
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0122888
TRMT112 tRNA methyltransferase 11-2 homolog (S. cerevisiae) -0.0121838
S100A9 S100 calcium binding protein A9 -0.011881
PDCD5 programmed cell death 5 -0.011876
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0118632
RPL27 ribosomal protein L27 -0.0118408
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.0117337
WDR45B WD repeat domain 45B -0.0117314
ZNF217 zinc finger protein 217 -0.0117183
RPL15 ribosomal protein L15 -0.0116745
LAMTOR5 late endosomal/lysosomal adaptor, MAPK and MTOR activator 5 -0.011586
RPL35 ribosomal protein L35 -0.0115808
NDRG1 N-myc downstream regulated 1 -0.0114592
RPS24 ribosomal protein S24 -0.011434