Pimitespib_NCI-H2347 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in NCI-H2347 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pimitespib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.165917
SAMD4A sterile alpha motif domain containing 4A 0.125645
EXT1 exostosin glycosyltransferase 1 0.108194
IGFBP3 insulin-like growth factor binding protein 3 0.101279
LPP LIM domain containing preferred translocation partner in lipoma 0.084985
GRB10 growth factor receptor-bound protein 10 0.0812935
ZSWIM6 zinc finger, SWIM-type containing 6 0.0796726
RPL35A ribosomal protein L35a 0.0773379
IFI27 interferon, alpha-inducible protein 27 0.0691598
LIMCH1 LIM and calponin homology domains 1 0.0685583
FTL ferritin, light polypeptide 0.0659965
FBXO32 F-box protein 32 0.0585674
GOLGB1 golgin B1 0.0580536
EFNA5 ephrin-A5 0.0553243
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0511193
ALCAM activated leukocyte cell adhesion molecule 0.0487974
ERBIN erbb2 interacting protein 0.0479
SH3KBP1 SH3-domain kinase binding protein 1 0.046986
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase 0.0469335
IFI6 interferon, alpha-inducible protein 6 0.0468124
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0458415
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0454615
ACTG1 actin gamma 1 0.0454208
MX2 MX dynamin-like GTPase 2 0.0433377
AHNAK AHNAK nucleoprotein 0.0430961
IFI16 interferon, gamma-inducible protein 16 0.0429712
ZBTB20 zinc finger and BTB domain containing 20 0.0427089
FNIP1 folliculin interacting protein 1 0.0412907
PGBD5 piggyBac transposable element derived 5 0.0407091
SOX4 SRY (sex determining region Y)-box 4 0.0406936
AKAP13 A kinase (PRKA) anchor protein 13 0.0399499
RAI14 retinoic acid induced 14 0.0397641
MX1 MX dynamin-like GTPase 1 0.0394918
VCL vinculin 0.0394336
SP100 SP100 nuclear antigen 0.0391434
RNF213 ring finger protein 213 0.0386432
PDLIM5 PDZ and LIM domain 5 0.0383111
ISG15 ISG15 ubiquitin-like modifier 0.038268
HLA-A major histocompatibility complex, class I, A 0.0380577
SEC31A SEC31 homolog A (S. cerevisiae) 0.0379031
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 0.0374065
RALGPS2 Ral GEF with PH domain and SH3 binding motif 2 0.0366656
PLSCR1 phospholipid scramblase 1 0.0363332
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 0.036098
MYO1E myosin IE 0.0359645
HDAC9 histone deacetylase 9 0.0358942
INTS6 integrator complex subunit 6 0.0356769
KRT7 keratin 7, type II 0.0355592
APLP2 amyloid beta (A4) precursor-like protein 2 0.0350706
SQSTM1 sequestosome 1 0.0343453
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0342462
LMO7 LIM domain 7 0.0340704
ANKRD17 ankyrin repeat domain 17 0.0340489
RASAL2 RAS protein activator like 2 0.0336807
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0329748
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0329553
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) 0.0325494
ANXA2 annexin A2 0.0321364
TTC3 tetratricopeptide repeat domain 3 0.0321279
IFITM3 interferon induced transmembrane protein 3 0.0321129
ARHGAP20 Rho GTPase activating protein 20 0.0318581
VIM vimentin 0.031848
MAP3K13 mitogen-activated protein kinase kinase kinase 13 0.0317289
RIGI RNA sensor RIG-I 0.0315517
MACC1 metastasis associated in colon cancer 1 0.0314071
RPL23 ribosomal protein L23 0.0313123
RBM47 RNA binding motif protein 47 0.0312844
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0311362
HLA-B major histocompatibility complex, class I, B 0.0310651
TIMP2 TIMP metallopeptidase inhibitor 2 0.0306315
EGFR epidermal growth factor receptor 0.030122
KDM2A lysine (K)-specific demethylase 2A 0.0299696
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0299377
ETV6 ets variant 6 0.0295682
FBXL2 F-box and leucine-rich repeat protein 2 0.0292405
SH3RF1 SH3 domain containing ring finger 1 0.0292284
UBE2H ubiquitin-conjugating enzyme E2H 0.0291334
ARF4 ADP-ribosylation factor 4 0.0287069
MAP1B microtubule-associated protein 1B 0.0284857
ARHGAP5 Rho GTPase activating protein 5 0.0284299
RAB7A RAB7A, member RAS oncogene family 0.0281468
PALLD palladin, cytoskeletal associated protein 0.0280357
MCU mitochondrial calcium uniporter 0.027963
SVIL supervillin 0.0278872
ARHGEF3 Rho guanine nucleotide exchange factor (GEF) 3 0.0278388
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0277597
ATXN1 ataxin 1 0.0277072
IFITM1 interferon induced transmembrane protein 1 0.0271656
RERE arginine-glutamic acid dipeptide (RE) repeats 0.026819
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0267365
NR3C2 nuclear receptor subfamily 3, group C, member 2 0.0264975
WWTR1 WW domain containing transcription regulator 1 0.0264752
CTBP2 C-terminal binding protein 2 0.0262717
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0262463
BLZF1 basic leucine zipper nuclear factor 1 0.0262274
ANKRD12 ankyrin repeat domain 12 0.0259352
NIPBL Nipped-B homolog (Drosophila) 0.0255571
VGLL3 vestigial-like family member 3 0.0253918
RAB10 RAB10, member RAS oncogene family 0.0252638
RAD51B RAD51 paralog B 0.0251332

decreased expression

Symbol Name Standardized Value
NDRG1 N-myc downstream regulated 1 -0.248653
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.189185
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.148392
FN1 fibronectin 1 -0.14124
NAMPT nicotinamide phosphoribosyltransferase -0.133232
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.131349
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0992543
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0846953
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa -0.0825067
ASPH aspartate beta-hydroxylase -0.0809498
RPS2 ribosomal protein S2 -0.0665781
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) -0.0563618
GOLGA4 golgin A4 -0.0530796
BHLHE40 basic helix-loop-helix family, member e40 -0.052928
LAMC2 laminin, gamma 2 -0.0525269
TFG TRK-fused gene -0.0510264
CCNL1 cyclin L1 -0.0504439
RNF145 ring finger protein 145 -0.0499712
ELL2 elongation factor, RNA polymerase II, 2 -0.049576
HMGB2 high mobility group box 2 -0.0487834
TSC22D2 TSC22 domain family, member 2 -0.0462901
MARCHF6 membrane associated ring-CH-type finger 6 -0.0457395
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0448902
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0443655
S100A6 S100 calcium binding protein A6 -0.044
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.043235
MSMO1 methylsterol monooxygenase 1 -0.0428955
MT2A metallothionein 2A -0.0425351
HMGA1 high mobility group AT-hook 1 -0.0420023
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.041591
PTMA prothymosin, alpha -0.041225
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0410387
KDM3A lysine (K)-specific demethylase 3A -0.0404321
HSPA8 heat shock 70kDa protein 8 -0.0403158
RPS6 ribosomal protein S6 -0.0398446
PAPOLA poly(A) polymerase alpha -0.0397789
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0392592
DHX9 DEAH (Asp-Glu-Ala-His) box helicase 9 -0.0385115
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0380041
ANLN anillin, actin binding protein -0.0378332
DSTN destrin (actin depolymerizing factor) -0.0371463
MATR3 matrin 3 -0.0369087
UGCG UDP-glucose ceramide glucosyltransferase -0.0368406
MKI67 marker of proliferation Ki-67 -0.0364397
CLINT1 clathrin interactor 1 -0.0355898
POTEF POTE ankyrin domain family, member F -0.033858
USP3 ubiquitin specific peptidase 3 -0.0327315
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0326576
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.032303
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0321166
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha -0.0320296
CDK17 cyclin-dependent kinase 17 -0.0317975
NCKAP1 NCK-associated protein 1 -0.0315847
ZNF292 zinc finger protein 292 -0.0314878
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0310051
ECT2 epithelial cell transforming 2 -0.0308887
TPT1 tumor protein, translationally-controlled 1 -0.0307306
RAD21 RAD21 homolog (S. pombe) -0.0299807
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 -0.0299545
SDC4 syndecan 4 -0.0299323
SEPTIN7 septin 7 -0.0298907
SMC4 structural maintenance of chromosomes 4 -0.0298298
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0297586
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.029566
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0295069
FXR1 fragile X mental retardation, autosomal homolog 1 -0.0294993
SLC38A1 solute carrier family 38, member 1 -0.0294524
GNAS GNAS complex locus -0.0290984
NAP1L1 nucleosome assembly protein 1-like 1 -0.0280513
RYBP RING1 and YY1 binding protein -0.0280323
CPNE8 copine VIII -0.0279948
RHEB Ras homolog enriched in brain -0.0279532
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0279488
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0277767
CKAP5 cytoskeleton associated protein 5 -0.0276941
MIS18BP1 MIS18 binding protein 1 -0.0276862
CENPF centromere protein F, 350/400kDa -0.0276405
TXNRD1 thioredoxin reductase 1 -0.0275558
YBX3 Y box binding protein 3 -0.0273514
CDC73 cell division cycle 73 -0.0269849
GARS1 glycyl-tRNA synthetase 1 -0.0269281
UBE2D3 ubiquitin-conjugating enzyme E2D 3 -0.0269083
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 -0.0268957
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0262646
TPX2 TPX2, microtubule-associated -0.0262085
H1-4 H1.4 linker histone, cluster member -0.0260014
SMG7 SMG7 nonsense mediated mRNA decay factor -0.0259963
RLF rearranged L-myc fusion -0.0257027
FAM162A family with sequence similarity 162, member A -0.0256521
ANXA5 annexin A5 -0.0253613
FAM13A family with sequence similarity 13, member A -0.0253455
CNBP CCHC-type zinc finger, nucleic acid binding protein -0.0250476
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0248213
GOLT1B golgi transport 1B -0.0247396
ATP13A3 ATPase type 13A3 -0.0243337
ICAM1 intercellular adhesion molecule 1 -0.0243281
QKI QKI, KH domain containing, RNA binding -0.0242567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0241665
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 -0.0241016
TRA2B transformer 2 beta homolog (Drosophila) -0.0240325