| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.343281 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.19256 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.10827 |
| VIM | vimentin | 0.10734 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0752752 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0727767 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | 0.069259 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | 0.0649789 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0615936 |
| RPL35A | ribosomal protein L35a | 0.0564915 |
| RPLP0 | ribosomal protein, large, P0 | 0.0556273 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0549351 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.053135 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | 0.0526722 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0521272 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0497219 |
| FTL | ferritin, light polypeptide | 0.0494762 |
| SMAD2 | SMAD family member 2 | 0.047373 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0469949 |
| RPS8 | ribosomal protein S8 | 0.0448479 |
| KYNU | kynureninase | 0.0441547 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0432792 |
| SQSTM1 | sequestosome 1 | 0.0429919 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0420578 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0394599 |
| RPL12 | ribosomal protein L12 | 0.0386298 |
| INHBA | inhibin, beta A | 0.0383127 |
| RPLP1 | ribosomal protein, large, P1 | 0.0378636 |
| MAP7 | microtubule-associated protein 7 | 0.0376755 |
| LDHA | lactate dehydrogenase A | 0.0372354 |
| S100A10 | S100 calcium binding protein A10 | 0.0361968 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0361777 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | 0.0359998 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0354187 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0352116 |
| CDH13 | cadherin 13 | 0.0349025 |
| LSAMP | limbic system-associated membrane protein | 0.0332686 |
| UBC | ubiquitin C | 0.0322127 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0312929 |
| XYLT1 | xylosyltransferase I | 0.0309896 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0298349 |
| NR4A2 | nuclear receptor subfamily 4, group A, member 2 | 0.0296138 |
| ASTN2 | astrotactin 2 | 0.0295568 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0287821 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0285744 |
| RPS4X | ribosomal protein S4, X-linked | 0.0283636 |
| DNER | delta/notch-like EGF repeat containing | 0.0282413 |
| AGTPBP1 | ATP/GTP binding protein 1 | 0.027834 |
| LMNA | lamin A/C | 0.0273377 |
| PGK1 | phosphoglycerate kinase 1 | 0.0272191 |
| RAB7A | RAB7A, member RAS oncogene family | 0.026896 |
| RPL34 | ribosomal protein L34 | 0.0259392 |
| TMSB10 | thymosin beta 10 | 0.0255265 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0254683 |
| CTIF | CBP80/20-dependent translation initiation factor | 0.0254149 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | 0.0251045 |
| ANXA2 | annexin A2 | 0.0247203 |
| OXSR1 | oxidative stress responsive 1 | 0.0245268 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0243638 |
| CHD1 | chromodomain helicase DNA binding protein 1 | 0.0243166 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0240844 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0239123 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0224183 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0218053 |
| CANX | calnexin | 0.0216579 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0216122 |
| RPL23 | ribosomal protein L23 | 0.0216057 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0209759 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.0203487 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0203113 |
| P3H2 | prolyl 3-hydroxylase 2 | 0.020159 |
| RPL26 | ribosomal protein L26 | 0.0197964 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0194577 |
| ADARB2 | adenosine deaminase, RNA-specific, B2 (non-functional) | 0.019412 |
| NRXN3 | neurexin 3 | 0.0194004 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0189287 |
| IL6 | interleukin 6 | 0.0188518 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0188488 |
| RPL7 | ribosomal protein L7 | 0.0188141 |
| PCDH9 | protocadherin 9 | 0.0187469 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | 0.0186456 |
| NEFL | neurofilament, light polypeptide | 0.018533 |
| RPS24 | ribosomal protein S24 | 0.0185106 |
| RAD51B | RAD51 paralog B | 0.0183712 |
| NR4A1 | nuclear receptor subfamily 4, group A, member 1 | 0.0183587 |
| HLA-A | major histocompatibility complex, class I, A | 0.018256 |
| SLC2A13 | solute carrier family 2 (facilitated glucose transporter), member 13 | 0.0181358 |
| SFTPA2 | surfactant protein A2 | 0.018112 |
| RPL39 | ribosomal protein L39 | 0.0180792 |
| INTS6 | integrator complex subunit 6 | 0.0180374 |
| IARS1 | isoleucyl-tRNA synthetase 1 | 0.0176342 |
| FNDC3A | fibronectin type III domain containing 3A | 0.0175291 |
| AHNAK | AHNAK nucleoprotein | 0.0173008 |
| ANTXR1 | anthrax toxin receptor 1 | 0.0171289 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0170118 |
| RIGI | RNA sensor RIG-I | 0.0169067 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0167304 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.016641 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0163415 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0162859 |
| Symbol | Name | Standardized Value |
|---|---|---|
| EFNA5 | ephrin-A5 | -0.159046 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | -0.115595 |
| GDA | guanine deaminase | -0.107841 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0878859 |
| ASPH | aspartate beta-hydroxylase | -0.0839717 |
| TXNRD1 | thioredoxin reductase 1 | -0.0792129 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0753488 |
| GRAMD1B | GRAM domain containing 1B | -0.0722137 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | -0.0711847 |
| RPS2 | ribosomal protein S2 | -0.0695912 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0683671 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0657978 |
| NEK7 | NIMA-related kinase 7 | -0.0604142 |
| PCBP3 | poly(rC) binding protein 3 | -0.0600448 |
| RTN4 | reticulon 4 | -0.0581102 |
| MFF | mitochondrial fission factor | -0.0533034 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0530545 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0530418 |
| MCL1 | myeloid cell leukemia 1 | -0.0526665 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0507406 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0503395 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0496671 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0485677 |
| NRCAM | neuronal cell adhesion molecule | -0.0458407 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0449415 |
| FN1 | fibronectin 1 | -0.0429887 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0426397 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.041951 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0409781 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0409382 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0408319 |
| FLNB | filamin B, beta | -0.0401196 |
| AGFG1 | ArfGAP with FG repeats 1 | -0.0399011 |
| MT2A | metallothionein 2A | -0.0396861 |
| ZFC3H1 | zinc finger, C3H1-type containing | -0.0389297 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0387666 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.038466 |
| RBM39 | RNA binding motif protein 39 | -0.0381342 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0380583 |
| CENPF | centromere protein F, 350/400kDa | -0.0378832 |
| NDRG1 | N-myc downstream regulated 1 | -0.0377965 |
| TNPO1 | transportin 1 | -0.037512 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0363904 |
| MYOF | myoferlin | -0.0358242 |
| PDE10A | phosphodiesterase 10A | -0.0357407 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0356909 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0355714 |
| MKI67 | marker of proliferation Ki-67 | -0.0347489 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.034225 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0341113 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.0338154 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0337715 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0337025 |
| LAMC1 | laminin, gamma 1 (formerly LAMB2) | -0.0334719 |
| PUM2 | pumilio RNA-binding family member 2 | -0.0327172 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.032472 |
| CTSC | cathepsin C | -0.0323986 |
| SRPK2 | SRSF protein kinase 2 | -0.0323944 |
| COL4A6 | collagen, type IV, alpha 6 | -0.0322075 |
| CSNK1A1 | casein kinase 1, alpha 1 | -0.0319749 |
| MSN | moesin | -0.0319032 |
| VMP1 | vacuole membrane protein 1 | -0.031836 |
| RPL37A | ribosomal protein L37a | -0.0314071 |
| AVL9 | AVL9 homolog (S. cerevisiase) | -0.0311934 |
| ATP13A3 | ATPase type 13A3 | -0.0309332 |
| PTGR1 | prostaglandin reductase 1 | -0.030882 |
| ASPM | asp (abnormal spindle) homolog, microcephaly associated (Drosophila) | -0.0305589 |
| WDFY2 | WD repeat and FYVE domain containing 2 | -0.0303737 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0295691 |
| LAMB1 | laminin, beta 1 | -0.0295256 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | -0.0289047 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0284117 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | -0.028351 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0281162 |
| ANLN | anillin, actin binding protein | -0.0279457 |
| COL4A5 | collagen, type IV, alpha 5 | -0.0274613 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0274338 |
| ENAH | enabled homolog (Drosophila) | -0.0271297 |
| GOLGA4 | golgin A4 | -0.0267739 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0267442 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0267067 |
| DST | dystonin | -0.0266538 |
| HEATR1 | HEAT repeat containing 1 | -0.0264533 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0263974 |
| CLTC | clathrin, heavy chain (Hc) | -0.0260643 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0258803 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0257461 |
| GPRIN3 | GPRIN family member 3 | -0.0254895 |
| NBAS | neuroblastoma amplified sequence | -0.0254219 |
| MED13L | mediator complex subunit 13-like | -0.0254127 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0253176 |
| CDK17 | cyclin-dependent kinase 17 | -0.0252271 |
| RPL38 | ribosomal protein L38 | -0.0252075 |
| BTAF1 | BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa | -0.0251943 |
| CDC73 | cell division cycle 73 | -0.0249009 |
| XPO1 | exportin 1 | -0.0248554 |
| DPY19L1 | dpy-19-like 1 (C. elegans) | -0.0245017 |
| SETD5 | SET domain containing 5 | -0.0239476 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0238711 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | -0.0237837 |
