| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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194 genes differentially expressed following the Pimitespib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.186204 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.119173 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | 0.104753 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0975584 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0923092 |
| ASPH | aspartate beta-hydroxylase | 0.0909995 |
| EHBP1 | EH domain binding protein 1 | 0.0858208 |
| GPC6 | glypican 6 | 0.0789571 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0788219 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0778824 |
| NLGN1 | neuroligin 1 | 0.0767373 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | 0.0749172 |
| TMTC2 | transmembrane and tetratricopeptide repeat containing 2 | 0.0742615 |
| RPL19 | ribosomal protein L19 | 0.073877 |
| MYO1E | myosin IE | 0.0736063 |
| ANXA2 | annexin A2 | 0.0708648 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0691287 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0684505 |
| DST | dystonin | 0.0664488 |
| KMT2C | lysine (K)-specific methyltransferase 2C | 0.0660878 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0651062 |
| RPL35A | ribosomal protein L35a | 0.064403 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | 0.0631737 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0628944 |
| PTK2 | protein tyrosine kinase 2 | 0.0626807 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0610331 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0609641 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0597539 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0565611 |
| USP34 | ubiquitin specific peptidase 34 | 0.0559434 |
| RPS8 | ribosomal protein S8 | 0.0551447 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0531856 |
| ANKRD11 | ankyrin repeat domain 11 | 0.0521778 |
| PDE10A | phosphodiesterase 10A | 0.050974 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0501861 |
| JMJD1C | jumonji domain containing 1C | 0.0483287 |
| FRMD4A | FERM domain containing 4A | 0.0404738 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0397406 |
| SMYD3 | SET and MYND domain containing 3 | 0.0386997 |
| NBAS | neuroblastoma amplified sequence | 0.0376099 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | 0.0365645 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0364383 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.035837 |
| KRT8 | keratin 8, type II | 0.0316196 |
| BIRC6 | baculoviral IAP repeat containing 6 | 0.0310608 |
| BRIP1 | BRCA1 interacting protein C-terminal helicase 1 | 0.0298337 |
| SMAD3 | SMAD family member 3 | 0.0297771 |
| KRT18 | keratin 18, type I | 0.0276452 |
| PRELID2 | PRELI domain containing 2 | 0.0256181 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0238347 |
| CANX | calnexin | 0.0227569 |
| LDHA | lactate dehydrogenase A | 0.0219542 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0208134 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.020714 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0204741 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0197645 |
| PMEPA1 | prostate transmembrane protein, androgen induced 1 | 0.0187744 |
| RPL23 | ribosomal protein L23 | 0.0187301 |
| RPL11 | ribosomal protein L11 | 0.0178679 |
| TPM4 | tropomyosin 4 | 0.0178319 |
| MED13 | mediator complex subunit 13 | 0.0167941 |
| ANKRD12 | ankyrin repeat domain 12 | 0.0163595 |
| PKM | pyruvate kinase, muscle | 0.0153604 |
| MCL1 | myeloid cell leukemia 1 | 0.0152251 |
| OXR1 | oxidation resistance 1 | 0.0152076 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0147864 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0144986 |
| FLNB | filamin B, beta | 0.014326 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0134481 |
| S100A9 | S100 calcium binding protein A9 | 0.0132408 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0131669 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0118804 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0116845 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0111005 |
| SRPK2 | SRSF protein kinase 2 | 0.0110302 |
| FOXO3 | forkhead box O3 | 0.0110095 |
| B2M | beta-2-microglobulin | 0.0104861 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0101979 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.00914401 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.00839838 |
| RPS29 | ribosomal protein S29 | 0.00759074 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.00670234 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.00569483 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.00554745 |
| HLA-A | major histocompatibility complex, class I, A | 0.00504764 |
| RAB7A | RAB7A, member RAS oncogene family | 0.00472163 |
| RPS6 | ribosomal protein S6 | 0.00400545 |
| RPLP0 | ribosomal protein, large, P0 | 0.00362344 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0028286 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.00235044 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0016977 |
| RPL12 | ribosomal protein L12 | 0.00144038 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 8.20132E-4 |
| LMO7 | LIM domain 7 | 8.12947E-4 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.210035 |
| VIM | vimentin | -0.164919 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.111469 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0809576 |
| ZNF292 | zinc finger protein 292 | -0.0759583 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0756013 |
| TXNIP | thioredoxin interacting protein | -0.0737571 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0700777 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0699585 |
| RPL26 | ribosomal protein L26 | -0.0676971 |
| NDRG1 | N-myc downstream regulated 1 | -0.0675199 |
| RPS16 | ribosomal protein S16 | -0.0650268 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.06404 |
| COPA | coatomer protein complex, subunit alpha | -0.0609113 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0593064 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0587628 |
| CHD9 | chromodomain helicase DNA binding protein 9 | -0.058446 |
| HDLBP | high density lipoprotein binding protein | -0.0579868 |
| IGFBP5 | insulin-like growth factor binding protein 5 | -0.0532949 |
| KIF5B | kinesin family member 5B | -0.0527822 |
| OGA | O-GlcNAcase | -0.0525475 |
| MT2A | metallothionein 2A | -0.052328 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0520259 |
| EGFR | epidermal growth factor receptor | -0.0514474 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.05135 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0495729 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0491624 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0486755 |
| ACTG1 | actin gamma 1 | -0.0484916 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0479233 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0471868 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0468068 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0468039 |
| CALR | calreticulin | -0.0466354 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0451044 |
| RBM39 | RNA binding motif protein 39 | -0.0444385 |
| S100A10 | S100 calcium binding protein A10 | -0.0444155 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0442219 |
| LAMB3 | laminin, beta 3 | -0.0431387 |
| EIF3E | eukaryotic translation initiation factor 3, subunit E | -0.0424869 |
| MORF4L2 | mortality factor 4 like 2 | -0.0420239 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0404551 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0400051 |
| PGK1 | phosphoglycerate kinase 1 | -0.0397872 |
| RACK1 | receptor for activated C kinase 1 | -0.0395796 |
| SLK | STE20-like kinase | -0.0390361 |
| TTC17 | tetratricopeptide repeat domain 17 | -0.0377102 |
| GIGYF2 | GRB10 interacting GYF protein 2 | -0.0365933 |
| CDK19 | cyclin-dependent kinase 19 | -0.0364181 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0359245 |
| NKTR | natural killer cell triggering receptor | -0.0356884 |
| SBF2 | SET binding factor 2 | -0.0341601 |
| POTEF | POTE ankyrin domain family, member F | -0.0329579 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0326293 |
| CD44 | CD44 molecule (Indian blood group) | -0.0320236 |
| RASA3 | RAS p21 protein activator 3 | -0.0316005 |
| RBM25 | RNA binding motif protein 25 | -0.0311643 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0284685 |
| PARD3 | par-3 family cell polarity regulator | -0.0281946 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0278029 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0250351 |
| BPTF | bromodomain PHD finger transcription factor | -0.0244627 |
| IPO7 | importin 7 | -0.0241424 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0237919 |
| RPS27 | ribosomal protein S27 | -0.0235552 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0225545 |
| VMP1 | vacuole membrane protein 1 | -0.0203533 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0200319 |
| ACTN4 | actinin, alpha 4 | -0.0193432 |
| GOLGA4 | golgin A4 | -0.0190395 |
| ENO1 | enolase 1, (alpha) | -0.0190084 |
| RPS13 | ribosomal protein S13 | -0.0185247 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0183283 |
| MEF2A | myocyte enhancer factor 2A | -0.0182169 |
| RPL37 | ribosomal protein L37 | -0.0176849 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0158849 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0153775 |
| FTL | ferritin, light polypeptide | -0.0149541 |
| RPLP1 | ribosomal protein, large, P1 | -0.0147805 |
| TAOK3 | TAO kinase 3 | -0.0147132 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0141175 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.013955 |
| RPL37A | ribosomal protein L37a | -0.0137119 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0135882 |
| TMSB10 | thymosin beta 10 | -0.013583 |
| VCL | vinculin | -0.013483 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | -0.0130132 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0123165 |
| MYO9A | myosin IXA | -0.0108664 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0105378 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0094145 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.00811094 |
| RAI14 | retinoic acid induced 14 | -0.00752136 |
| AREG | amphiregulin | -0.00697255 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.00678973 |
| MAP2K1 | mitogen-activated protein kinase kinase 1 | -0.00527168 |
| PHF3 | PHD finger protein 3 | -0.00455288 |
| SSH2 | slingshot protein phosphatase 2 | -0.00431845 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.00400542 |
| AHNAK | AHNAK nucleoprotein | -0.00370722 |
