Pimitespib_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pimitespib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL5A2 collagen, type V, alpha 2 0.113214
CADM2 cell adhesion molecule 2 0.085527
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.0845037
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0786697
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0759572
PEG10 paternally expressed 10 0.0739269
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.072405
GPC3 glypican 3 0.0675422
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0631662
ZNF292 zinc finger protein 292 0.0614698
ADGRV1 adhesion G protein-coupled receptor V1 0.0597899
LOC102724023 ES1 protein homolog, mitochondrial 0.0591812
COL11A1 collagen, type XI, alpha 1 0.0522812
PCLO piccolo presynaptic cytomatrix protein 0.050736
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0498538
TMSB10 thymosin beta 10 0.0489857
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0458913
ENO1 enolase 1, (alpha) 0.045257
NCAM2 neural cell adhesion molecule 2 0.0449951
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0448993
EEF2 eukaryotic translation elongation factor 2 0.0442763
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0434199
PGK1 phosphoglycerate kinase 1 0.0429729
PRTG protogenin 0.0420375
ZFAND3 zinc finger, AN1-type domain 3 0.0413946
HS3ST5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 0.0411917
VIM vimentin 0.0406203
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0390112
NTM neurotrimin 0.0387514
RPS6 ribosomal protein S6 0.0380191
PLPP1 phospholipid phosphatase 1 0.0378937
RPS19 ribosomal protein S19 0.0373558
ADAM10 ADAM metallopeptidase domain 10 0.0370824
ENAH enabled homolog (Drosophila) 0.0370737
LIN28B lin-28 homolog B (C. elegans) 0.0369224
MKI67 marker of proliferation Ki-67 0.0361671
RPLP1 ribosomal protein, large, P1 0.0356223
TUBA1B tubulin, alpha 1b 0.0354295
DNAH14 dynein, axonemal, heavy chain 14 0.0351805
STAG2 stromal antigen 2 0.0351587
RPS16 ribosomal protein S16 0.0346886
RPL7 ribosomal protein L7 0.0345086
RHOBTB3 Rho-related BTB domain containing 3 0.0345076
NEBL nebulette 0.0343138
SYT1 synaptotagmin I 0.033946
TAS2R14 taste receptor, type 2, member 14 0.0335231
RPS12 ribosomal protein S12 0.0334097
RBM20 RNA binding motif protein 20 0.0334023
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0333922
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0331579
APP amyloid beta (A4) precursor protein 0.032697
CENPF centromere protein F, 350/400kDa 0.0322567
HDAC9 histone deacetylase 9 0.031358
FOXP2 forkhead box P2 0.0308482
PCDH9 protocadherin 9 0.030766
RPL30 ribosomal protein L30 0.0306309
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0305752
KIF4A kinesin family member 4A 0.0305429
GMDS GDP-mannose 4,6-dehydratase 0.0305169
RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 0.0297844
FUS FUS RNA binding protein 0.0293739
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0293469
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0290227
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0289211
STMN1 stathmin 1 0.0288811
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0280171
LOC112694756 uncharaterized LOC112694756 0.0279127
PHIP pleckstrin homology domain interacting protein 0.0277056
TXNRD1 thioredoxin reductase 1 0.0276357
PDIA3 protein disulfide isomerase family A, member 3 0.0273369
USP25 ubiquitin specific peptidase 25 0.0269885
ZNF608 zinc finger protein 608 0.0264344
ASXL1 additional sex combs like transcriptional regulator 1 0.0258893
FST follistatin 0.0256704
ATXN1 ataxin 1 0.0256223
SMYD3 SET and MYND domain containing 3 0.0256056
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0255946
PPP1R12A protein phosphatase 1, regulatory subunit 12A 0.0254499
COL1A2 collagen, type I, alpha 2 0.0250546
TMSB4X thymosin beta 4, X-linked 0.0250097
XPO1 exportin 1 0.0249768
CDH19 cadherin 19, type 2 0.0247986
RPL5 ribosomal protein L5 0.0245887
ADGRL2 adhesion G protein-coupled receptor L2 0.0245057
MEIS2 Meis homeobox 2 0.0242891
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0241932
GSE1 Gse1 coiled-coil protein 0.0241212
MEF2C myocyte enhancer factor 2C 0.023863
MBD5 methyl-CpG binding domain protein 5 0.0238443
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0237123
FBXO17 F-box protein 17 0.0235881
BRMS1L breast cancer metastasis-suppressor 1-like 0.0232042
CSMD3 CUB and Sushi multiple domains 3 0.0230228
KIF20B kinesin family member 20B 0.0229618
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0228701
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0228083
RSRC1 arginine/serine-rich coiled-coil 1 0.022695
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0226063
RFC3 replication factor C (activator 1) 3, 38kDa 0.0225347
YBX1 Y box binding protein 1 0.0223777

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0896915
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0796095
PTMA prothymosin, alpha -0.0679209
AHNAK AHNAK nucleoprotein -0.0571084
EMP1 epithelial membrane protein 1 -0.0514919
SETD5 SET domain containing 5 -0.0438733
FNDC3B fibronectin type III domain containing 3B -0.0422429
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.041603
SEC31A SEC31 homolog A (S. cerevisiae) -0.0370242
KDM3A lysine (K)-specific demethylase 3A -0.0362548
SF3B1 splicing factor 3b, subunit 1, 155kDa -0.0334662
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0331992
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.0323813
COPA coatomer protein complex, subunit alpha -0.0317471
ZNF385D zinc finger protein 385D -0.0316694
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0303974
FTL ferritin, light polypeptide -0.0299926
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0298036
PTBP3 polypyrimidine tract binding protein 3 -0.0288421
WDR43 WD repeat domain 43 -0.028681
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0279251
STRN3 striatin, calmodulin binding protein 3 -0.0277144
NPEPPS aminopeptidase puromycin sensitive -0.0275345
PTPRJ protein tyrosine phosphatase, receptor type, J -0.0273087
USP34 ubiquitin specific peptidase 34 -0.0270722
SOX5 SRY (sex determining region Y)-box 5 -0.0269757
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0267193
KHDRBS1 KH domain containing, RNA binding, signal transduction associated 1 -0.0267039
FNBP4 formin binding protein 4 -0.0266024
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0263498
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0261744
CCNY cyclin Y -0.025617
UBR4 ubiquitin protein ligase E3 component n-recognin 4 -0.0254417
IFRD1 interferon-related developmental regulator 1 -0.0254072
EFNA5 ephrin-A5 -0.0253871
RPS25 ribosomal protein S25 -0.0250995
MRPS6 mitochondrial ribosomal protein S6 -0.0249618
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0246961
RBM39 RNA binding motif protein 39 -0.0245811
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0245011
NAMPT nicotinamide phosphoribosyltransferase -0.0243566
ASPH aspartate beta-hydroxylase -0.0237779
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0235853
RTN4 reticulon 4 -0.0234831
JMJD1C jumonji domain containing 1C -0.0232748
PTPN11 protein tyrosine phosphatase, non-receptor type 11 -0.0230557
SHROOM3 shroom family member 3 -0.0229733
RAB2A RAB2A, member RAS oncogene family -0.0225293
ZFPM2 zinc finger protein, FOG family member 2 -0.0223938
SUGT1 SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) -0.0222728
TCEA1 transcription elongation factor A (SII), 1 -0.0220994
UBA6 ubiquitin-like modifier activating enzyme 6 -0.0217442
BBX bobby sox homolog (Drosophila) -0.0215094
ITGAV integrin, alpha V -0.0215062
GOLGA4 golgin A4 -0.0213667
RNF145 ring finger protein 145 -0.0213556
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.02124
FUBP3 far upstream element (FUSE) binding protein 3 -0.0211984
LDHB lactate dehydrogenase B -0.0209696
KLF10 Kruppel-like factor 10 -0.0209343
FIP1L1 factor interacting with PAPOLA and CPSF1 -0.0208002
YTHDC1 YTH domain containing 1 -0.0206833
ODR4 odr-4 GPCR localization factor homolog -0.0206824
PRRC2B proline-rich coiled-coil 2B -0.0206475
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0204661
FBXO11 F-box protein 11 -0.0204402
VPS13A vacuolar protein sorting 13 homolog A (S. cerevisiae) -0.0202256
NDRG1 N-myc downstream regulated 1 -0.0201635
BCL9 B-cell CLL/lymphoma 9 -0.0200782
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta -0.0200542
COG5 component of oligomeric golgi complex 5 -0.0199746
CERT1 ceramide transporter 1 -0.0198693
AQR aquarius intron-binding spliceosomal factor -0.019747
FBXO34 F-box protein 34 -0.0196855
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0194997
EIF3E eukaryotic translation initiation factor 3, subunit E -0.019459
RHOA ras homolog family member A -0.0193053
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0191673
HMGA1 high mobility group AT-hook 1 -0.019131
RPL19 ribosomal protein L19 -0.0191104
PSMD11 proteasome (prosome, macropain) 26S subunit, non-ATPase, 11 -0.0189984
SON SON DNA binding protein -0.0188336
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0187018
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0185766
NFE2L1 nuclear factor, erythroid 2-like 1 -0.0185635
MAP1B microtubule-associated protein 1B -0.0184916
IPO7 importin 7 -0.018484
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0184796
TM4SF1 transmembrane 4 L six family member 1 -0.0183549
DHX15 DEAH (Asp-Glu-Ala-His) box helicase 15 -0.0183042
FLNB filamin B, beta -0.0182344
NKTR natural killer cell triggering receptor -0.0182257
CXCL8 chemokine (C-X-C motif) ligand 8 -0.018086
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0179692
LONP2 lon peptidase 2, peroxisomal -0.0179191
TP53BP2 tumor protein p53 binding protein 2 -0.0179127
SRRM1 serine/arginine repetitive matrix 1 -0.0178328
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.017816
CORO1C coronin, actin binding protein, 1C -0.0177796
RPL11 ribosomal protein L11 -0.0177405