Pimitespib_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimitespib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0850959
HDAC9 histone deacetylase 9 0.0792824
ADAM10 ADAM metallopeptidase domain 10 0.0731368
FOXP1 forkhead box P1 0.0662428
TXNRD1 thioredoxin reductase 1 0.065881
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0567154
PDE4D phosphodiesterase 4D, cAMP-specific 0.0514034
ENOX1 ecto-NOX disulfide-thiol exchanger 1 0.0486539
EGFR epidermal growth factor receptor 0.0441197
TGFBR3 transforming growth factor, beta receptor III 0.0433497
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.0424832
TBC1D5 TBC1 domain family, member 5 0.0410216
FLNB filamin B, beta 0.0406748
SMYD3 SET and MYND domain containing 3 0.0393118
ANK2 ankyrin 2, neuronal 0.0358645
EXOC6B exocyst complex component 6B 0.0337856
TMEM65 transmembrane protein 65 0.0335796
PDE4B phosphodiesterase 4B, cAMP-specific 0.0321699
ZBTB20 zinc finger and BTB domain containing 20 0.0317026
AHCYL2 adenosylhomocysteinase-like 2 0.0310047
RHBDD1 rhomboid domain containing 1 0.0306259
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) 0.0301369
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0296737
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0292789
ZCCHC7 zinc finger, CCHC domain containing 7 0.0284629
DOCK3 dedicator of cytokinesis 3 0.0276252
NBEA neurobeachin 0.0275633
PARD3 par-3 family cell polarity regulator 0.0274413
XKR6 XK, Kell blood group complex subunit-related family, member 6 0.0273241
LPP LIM domain containing preferred translocation partner in lipoma 0.0273065
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0269964
PICALM phosphatidylinositol binding clathrin assembly protein 0.0266758
RBM39 RNA binding motif protein 39 0.026
EML4 echinoderm microtubule associated protein like 4 0.0258935
DOCK1 dedicator of cytokinesis 1 0.0248474
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0241461
SAMD4A sterile alpha motif domain containing 4A 0.0239889
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0239067
CD47 CD47 molecule 0.0238326
PTPRG protein tyrosine phosphatase, receptor type, G 0.0236486
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0234616
SOX6 SRY (sex determining region Y)-box 6 0.0233262
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0232798
PTK2 protein tyrosine kinase 2 0.0230529
USP34 ubiquitin specific peptidase 34 0.0228446
NT5C2 5'-nucleotidase, cytosolic II 0.0227105
SBF2 SET binding factor 2 0.0225552
WDFY3 WD repeat and FYVE domain containing 3 0.022548
OSMR oncostatin M receptor 0.0223777
TRIM44 tripartite motif containing 44 0.0222028
RERE arginine-glutamic acid dipeptide (RE) repeats 0.022175
FER fer (fps/fes related) tyrosine kinase 0.0221721
DGKH diacylglycerol kinase, eta 0.0220756
MEIS2 Meis homeobox 2 0.0218594
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0217258
BTBD9 BTB (POZ) domain containing 9 0.0216611
ZFAND3 zinc finger, AN1-type domain 3 0.0216274
MBD5 methyl-CpG binding domain protein 5 0.0215602
FXR1 fragile X mental retardation, autosomal homolog 1 0.021559
CTIF CBP80/20-dependent translation initiation factor 0.0215377
SFPQ splicing factor proline/glutamine-rich 0.0213687
RFX3 regulatory factor X, 3 (influences HLA class II expression) 0.0210733
TCF12 transcription factor 12 0.0210442
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0209452
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0206957
PYGB phosphorylase, glycogen; brain 0.0204721
PHF21A PHD finger protein 21A 0.0204491
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0204228
ECT2 epithelial cell transforming 2 0.020295
MLLT10 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10 0.0194664
TDRD3 tudor domain containing 3 0.0193733
MNAT1 MNAT CDK-activating kinase assembly factor 1 0.0190597
SRPK2 SRSF protein kinase 2 0.0189941
NFIA nuclear factor I/A 0.0189503
ZNF207 zinc finger protein 207 0.0188888
ATXN7 ataxin 7 0.018836
EIF4B eukaryotic translation initiation factor 4B 0.0185644
PDIA3 protein disulfide isomerase family A, member 3 0.0183194
APP amyloid beta (A4) precursor protein 0.0182256
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.017978
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0179016
MED13 mediator complex subunit 13 0.0177653
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 0.0177088
BIRC6 baculoviral IAP repeat containing 6 0.0175429
PLPP3 phospholipid phosphatase 3 0.0173758
PGK1 phosphoglycerate kinase 1 0.0173406
TMEM41B transmembrane protein 41B 0.0173358
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0173233
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0172821
RFX7 regulatory factor X, 7 0.0172792
PDGFC platelet derived growth factor C 0.0172653
SCMH1 sex comb on midleg homolog 1 (Drosophila) 0.0172018
ANKRD17 ankyrin repeat domain 17 0.0171323
RNF145 ring finger protein 145 0.0170177
TRIM25 tripartite motif containing 25 0.0169761
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0169196
GPHN gephyrin 0.0168921
COX16 COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) 0.0168762
ZNF609 zinc finger protein 609 0.0168324
TTC28 tetratricopeptide repeat domain 28 0.016786

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.307696
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.242222
TPT1 tumor protein, translationally-controlled 1 -0.124915
RPS6 ribosomal protein S6 -0.116191
RPS8 ribosomal protein S8 -0.0985565
ACTG1 actin gamma 1 -0.0814629
BMP10 bone morphogenetic protein 10 -0.0802538
RPL34 ribosomal protein L34 -0.0653916
RPL31 ribosomal protein L31 -0.0630811
RPL35A ribosomal protein L35a -0.0627995
RPS19 ribosomal protein S19 -0.0570923
RPLP1 ribosomal protein, large, P1 -0.055931
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0549397
RPLP2 ribosomal protein, large, P2 -0.0531995
RPL19 ribosomal protein L19 -0.052046
RPL37A ribosomal protein L37a -0.0499427
RPL7A ribosomal protein L7a -0.044926
HSPB1 heat shock 27kDa protein 1 -0.0448163
TM4SF1 transmembrane 4 L six family member 1 -0.0439307
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0436172
RPL26 ribosomal protein L26 -0.0430539
RPS25 ribosomal protein S25 -0.0425544
ARL4C ADP-ribosylation factor-like 4C -0.0417207
RACK1 receptor for activated C kinase 1 -0.0416628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0409486
SLC38A2 solute carrier family 38, member 2 -0.0395097
NAP1L1 nucleosome assembly protein 1-like 1 -0.0389261
RPS23 ribosomal protein S23 -0.0388893
RPS13 ribosomal protein S13 -0.038062
RPS2 ribosomal protein S2 -0.0377659
RPL9 ribosomal protein L9 -0.0365055
RPS3 ribosomal protein S3 -0.036178
RPS24 ribosomal protein S24 -0.0361335
RPL36 ribosomal protein L36 -0.035476
RPL32 ribosomal protein L32 -0.0347652
TNFRSF11B tumor necrosis factor receptor superfamily, member 11b -0.033972
KPNB1 karyopherin (importin) beta 1 -0.0332246
TMSB10 thymosin beta 10 -0.0331472
RPL37 ribosomal protein L37 -0.0330726
RPL23 ribosomal protein L23 -0.0321021
CCND1 cyclin D1 -0.0320578
AHNAK AHNAK nucleoprotein -0.0319952
RPS16 ribosomal protein S16 -0.0315276
RPS27A ribosomal protein S27a -0.0309498
ZNF217 zinc finger protein 217 -0.0301268
RPS11 ribosomal protein S11 -0.0299327
GNAS GNAS complex locus -0.0296574
EIF1 eukaryotic translation initiation factor 1 -0.0289623
S100A10 S100 calcium binding protein A10 -0.0286401
ANLN anillin, actin binding protein -0.0285731
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.028307
RPS12 ribosomal protein S12 -0.0282751
PFN1 profilin 1 -0.0276959
MKI67 marker of proliferation Ki-67 -0.0275803
WSB1 WD repeat and SOCS box containing 1 -0.0275278
MYL12B myosin, light chain 12B, regulatory -0.0272615
RPL5 ribosomal protein L5 -0.0272327
RPL38 ribosomal protein L38 -0.0272053
RPS14 ribosomal protein S14 -0.0271824
RSL1D1 ribosomal L1 domain containing 1 -0.0271101
RPS21 ribosomal protein S21 -0.0270008
RPL12 ribosomal protein L12 -0.0268997
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0266465
TMSB4X thymosin beta 4, X-linked -0.0263812
RPL36A ribosomal protein L36a -0.0256947
RPL18 ribosomal protein L18 -0.0254627
EBNA1BP2 EBNA1 binding protein 2 -0.0246669
FTL ferritin, light polypeptide -0.0245748
RPL30 ribosomal protein L30 -0.0243869
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0243657
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0238334
AKAP12 A kinase (PRKA) anchor protein 12 -0.0236853
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0236175
RPL35 ribosomal protein L35 -0.0235834
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0235005
TPI1 triosephosphate isomerase 1 -0.022951
RPL11 ribosomal protein L11 -0.0227601
RPS10 ribosomal protein S10 -0.0226706
RPS29 ribosomal protein S29 -0.0224864
CAMKMT calmodulin-lysine N-methyltransferase -0.0224806
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0224191
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0220811
S100A9 S100 calcium binding protein A9 -0.0216889
RPL10A ribosomal protein L10a -0.0215067
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0212762
ANXA1 annexin A1 -0.0211156
VIM vimentin -0.0207442
RPS27 ribosomal protein S27 -0.0207047
RSF1 remodeling and spacing factor 1 -0.0201536
RPS17 ribosomal protein S17 -0.0200461
RPS15 ribosomal protein S15 -0.0196366
FN1 fibronectin 1 -0.0194783
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.019462
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0193063
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0191796
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.019159
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0186665
S100A4 S100 calcium binding protein A4 -0.0186081
SMC4 structural maintenance of chromosomes 4 -0.0184768
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0183628