| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0976362 |
| HDAC9 | histone deacetylase 9 | 0.0637325 |
| LDHA | lactate dehydrogenase A | 0.062091 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0582224 |
| NAV2 | neuron navigator 2 | 0.0552367 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0544928 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.052395 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0516945 |
| FN1 | fibronectin 1 | 0.0499329 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0455374 |
| EGR1 | early growth response 1 | 0.0452625 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | 0.0443088 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0430166 |
| GPC6 | glypican 6 | 0.0423491 |
| MSN | moesin | 0.0418148 |
| B2M | beta-2-microglobulin | 0.0415702 |
| VEGFA | vascular endothelial growth factor A | 0.0408893 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0405091 |
| PKM | pyruvate kinase, muscle | 0.0395267 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0385067 |
| ARRDC3 | arrestin domain containing 3 | 0.0371309 |
| VCAN | versican | 0.0364904 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.035727 |
| SVIL | supervillin | 0.0351476 |
| ASPH | aspartate beta-hydroxylase | 0.0350499 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0350297 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | 0.0343271 |
| RPS12 | ribosomal protein S12 | 0.0339061 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0338928 |
| COL6A3 | collagen, type VI, alpha 3 | 0.033884 |
| RUNX1 | runt-related transcription factor 1 | 0.0335854 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0333442 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0330818 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0329474 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0325035 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.032313 |
| ANKRD1 | ankyrin repeat domain 1 (cardiac muscle) | 0.030959 |
| RPL7 | ribosomal protein L7 | 0.0287852 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0285956 |
| ZMIZ1 | zinc finger, MIZ-type containing 1 | 0.0282613 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0279636 |
| ZNF292 | zinc finger protein 292 | 0.0274636 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0267219 |
| CD44 | CD44 molecule (Indian blood group) | 0.0266279 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.026605 |
| FOSL1 | FOS-like antigen 1 | 0.0264733 |
| CENPF | centromere protein F, 350/400kDa | 0.0258845 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.025042 |
| THBS1 | thrombospondin 1 | 0.0250128 |
| RPL21 | ribosomal protein L21 | 0.0246725 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0246205 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.024263 |
| SMAD3 | SMAD family member 3 | 0.0238875 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0234651 |
| PCBP2 | poly(rC) binding protein 2 | 0.0232487 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0231927 |
| RAD51B | RAD51 paralog B | 0.0231746 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0229169 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0226949 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | 0.0226462 |
| TPM3 | tropomyosin 3 | 0.0223806 |
| SYNJ2 | synaptojanin 2 | 0.0222449 |
| PTK2 | protein tyrosine kinase 2 | 0.0220585 |
| MX1 | MX dynamin-like GTPase 1 | 0.0220408 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0220295 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0220062 |
| RPL3 | ribosomal protein L3 | 0.0219537 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.02195 |
| FAM120A | family with sequence similarity 120A | 0.0218812 |
| ENO1 | enolase 1, (alpha) | 0.0216703 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0212939 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0211753 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0209221 |
| SFTPA2 | surfactant protein A2 | 0.0208939 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0204429 |
| WWOX | WW domain containing oxidoreductase | 0.0204314 |
| MYO10 | myosin X | 0.0203292 |
| CDK19 | cyclin-dependent kinase 19 | 0.0202312 |
| YBX1 | Y box binding protein 1 | 0.0199139 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.0199083 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0194138 |
| RPS18 | ribosomal protein S18 | 0.0192751 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0190345 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0189917 |
| FLNA | filamin A, alpha | 0.0187618 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0186038 |
| TAGLN2 | transgelin 2 | 0.0185266 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | 0.0183369 |
| TPM1 | tropomyosin 1 (alpha) | 0.0180975 |
| FHIT | fragile histidine triad | 0.0180839 |
| MCL1 | myeloid cell leukemia 1 | 0.0180123 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.017401 |
| PDCD4 | programmed cell death 4 (neoplastic transformation inhibitor) | 0.0173313 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0170017 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0169838 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0168042 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | 0.0167685 |
| RBFOX1 | RNA binding protein, fox-1 homolog (C. elegans) 1 | 0.0167545 |
| METTL15 | methyltransferase like 15 | 0.0166647 |
| SSRP1 | structure specific recognition protein 1 | 0.0165297 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.248166 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.134318 |
| VIM | vimentin | -0.129568 |
| IER3 | immediate early response 3 | -0.126466 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.110095 |
| HLA-B | major histocompatibility complex, class I, B | -0.106807 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0995712 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.09884 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0881922 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0845566 |
| PTMA | prothymosin, alpha | -0.0832899 |
| GNAS | GNAS complex locus | -0.0720864 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0695796 |
| TMSB10 | thymosin beta 10 | -0.0694801 |
| VCL | vinculin | -0.0692931 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0630496 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0615281 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0597725 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0567306 |
| FTL | ferritin, light polypeptide | -0.0561972 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.056123 |
| MT2A | metallothionein 2A | -0.0515665 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0501607 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0494496 |
| CADM1 | cell adhesion molecule 1 | -0.0494086 |
| CANX | calnexin | -0.0486971 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0473853 |
| FRMD4A | FERM domain containing 4A | -0.0446497 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0443432 |
| AHNAK | AHNAK nucleoprotein | -0.0441801 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0435371 |
| RPS24 | ribosomal protein S24 | -0.0433434 |
| NABP1 | nucleic acid binding protein 1 | -0.043053 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0430269 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0430261 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0429865 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0429214 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0423229 |
| PHF3 | PHD finger protein 3 | -0.0412009 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0407286 |
| CAVIN1 | caveolae associated protein 1 | -0.0404943 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0401489 |
| GOLGA4 | golgin A4 | -0.0392683 |
| PALLD | palladin, cytoskeletal associated protein | -0.0388437 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0387189 |
| RPL37A | ribosomal protein L37a | -0.0383563 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0380923 |
| ACTG1 | actin gamma 1 | -0.0370352 |
| DST | dystonin | -0.0366753 |
| SMYD3 | SET and MYND domain containing 3 | -0.035353 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0349964 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0349452 |
| RRBP1 | ribosome binding protein 1 | -0.0347924 |
| HLA-E | major histocompatibility complex, class I, E | -0.0343287 |
| RPL38 | ribosomal protein L38 | -0.0342404 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0330392 |
| COL1A1 | collagen, type I, alpha 1 | -0.0326742 |
| OGA | O-GlcNAcase | -0.0325372 |
| HDLBP | high density lipoprotein binding protein | -0.0323203 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0322795 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0321388 |
| WTAP | Wilms tumor 1 associated protein | -0.031938 |
| RPL31 | ribosomal protein L31 | -0.031866 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0318637 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0316186 |
| RND3 | Rho family GTPase 3 | -0.0315736 |
| RBM39 | RNA binding motif protein 39 | -0.0314656 |
| MAP4 | microtubule-associated protein 4 | -0.0311309 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0310488 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0299289 |
| TPM4 | tropomyosin 4 | -0.0296496 |
| RAI14 | retinoic acid induced 14 | -0.0295804 |
| HM13 | histocompatibility (minor) 13 | -0.0295737 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0294455 |
| RPLP2 | ribosomal protein, large, P2 | -0.0293584 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0292662 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0292142 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0286331 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | -0.0285317 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0284508 |
| RPL34 | ribosomal protein L34 | -0.0281252 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.027864 |
| FBXO11 | F-box protein 11 | -0.0276906 |
| THBS2 | thrombospondin 2 | -0.0276569 |
| PGK1 | phosphoglycerate kinase 1 | -0.027538 |
| WDFY1 | WD repeat and FYVE domain containing 1 | -0.027405 |
| PRRC2C | proline-rich coiled-coil 2C | -0.0272608 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0271086 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.02686 |
| INHBA | inhibin, beta A | -0.0267367 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.026622 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | -0.0265653 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0263819 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0263016 |
| TMEM263 | transmembrane protein 263 | -0.0262861 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0260733 |
| PJA2 | praja ring finger 2, E3 ubiquitin protein ligase | -0.0258715 |
| OSBPL8 | oxysterol binding protein-like 8 | -0.025825 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0258151 |
| GOPC | golgi-associated PDZ and coiled-coil motif containing | -0.0255174 |
