Pimitespib_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimitespib perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimitespib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.113064
KYNU kynureninase 0.0782903
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0780113
TGFBI transforming growth factor, beta-induced, 68kDa 0.0742818
CD44 CD44 molecule (Indian blood group) 0.0666457
ZSWIM6 zinc finger, SWIM-type containing 6 0.0632451
SOD2 superoxide dismutase 2, mitochondrial 0.0611001
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0564797
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0553505
NRXN3 neurexin 3 0.0511548
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0508358
FBXL7 F-box and leucine-rich repeat protein 7 0.0503569
MYH9 myosin, heavy chain 9, non-muscle 0.0493793
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0493297
MACF1 microtubule-actin crosslinking factor 1 0.0484392
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 0.0476075
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0464839
FTH1 ferritin, heavy polypeptide 1 0.0447111
IGFBP3 insulin-like growth factor binding protein 3 0.0430864
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0409344
FNDC3B fibronectin type III domain containing 3B 0.0398218
PRELID2 PRELI domain containing 2 0.0398089
AUTS2 autism susceptibility candidate 2 0.0395741
INTS6 integrator complex subunit 6 0.0389685
IGFBP7 insulin-like growth factor binding protein 7 0.038159
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0362965
MBD5 methyl-CpG binding domain protein 5 0.035965
RBFOX2 RNA binding protein, fox-1 homolog (C. elegans) 2 0.0357206
ASPH aspartate beta-hydroxylase 0.0355653
CDK6 cyclin-dependent kinase 6 0.0344616
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.033872
PTK2 protein tyrosine kinase 2 0.0334701
PDLIM5 PDZ and LIM domain 5 0.0319531
GOLGB1 golgin B1 0.0312809
ZBTB20 zinc finger and BTB domain containing 20 0.0299608
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0295515
LGALS1 lectin, galactoside-binding, soluble, 1 0.0291828
VEGFC vascular endothelial growth factor C 0.0289021
AKT3 v-akt murine thymoma viral oncogene homolog 3 0.0288824
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0287236
LDHA lactate dehydrogenase A 0.0284936
TTC3 tetratricopeptide repeat domain 3 0.028253
BBS9 Bardet-Biedl syndrome 9 0.028229
CLIP2 CAP-GLY domain containing linker protein 2 0.0279791
VCL vinculin 0.0276646
CLIC4 chloride intracellular channel 4 0.0273107
EXOC6B exocyst complex component 6B 0.0271642
NCAPG2 non-SMC condensin II complex, subunit G2 0.0269254
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A 0.0263994
METTL15 methyltransferase like 15 0.026252
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0253267
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0253158
SEPTIN7 septin 7 0.0252663
RAD51B RAD51 paralog B 0.0251553
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0251133
BPNT2 3'(2'), 5'-bisphosphate nucleotidase 2 0.0250479
GTDC1 glycosyltransferase-like domain containing 1 0.0247726
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 0.0244107
WDPCP WD repeat containing planar cell polarity effector 0.024391
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0242629
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 0.0239345
MATR3 matrin 3 0.0235193
GSE1 Gse1 coiled-coil protein 0.0234993
TLN1 talin 1 0.0232753
SCFD1 sec1 family domain containing 1 0.0232118
PALLD palladin, cytoskeletal associated protein 0.0231825
PTPRM protein tyrosine phosphatase, receptor type, M 0.0229956
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0225055
GPATCH2L G patch domain containing 2-like 0.0224261
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0223418
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 0.0221956
ARHGAP24 Rho GTPase activating protein 24 0.0219416
ZMIZ1 zinc finger, MIZ-type containing 1 0.0218023
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 0.0216193
VCAM1 vascular cell adhesion molecule 1 0.0215721
ATXN1 ataxin 1 0.0212764
SHISA5 shisa family member 5 0.0211514
UBA6 ubiquitin-like modifier activating enzyme 6 0.02109
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.02095
SON SON DNA binding protein 0.0207982
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 0.0206864
DST dystonin 0.0205758
JPH2 junctophilin 2 0.0205271
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 0.0204604
CDK14 cyclin-dependent kinase 14 0.0202344
UBC ubiquitin C 0.0201449
PTPRK protein tyrosine phosphatase, receptor type, K 0.0200745
TAOK1 TAO kinase 1 0.0200229
PCDH7 protocadherin 7 0.0200133
FERMT2 fermitin family member 2 0.0198972
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0198901
MAP3K20 mitogen-activated protein kinase kinase kinase 20 0.0198849
HSPA8 heat shock 70kDa protein 8 0.0196345
HMGA2 high mobility group AT-hook 2 0.0194077
HSPA13 heat shock protein 70kDa family, member 13 0.0192936
AEBP2 AE binding protein 2 0.0192434
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.0192007
ATRX alpha thalassemia/mental retardation syndrome X-linked 0.0191632
ANKRD11 ankyrin repeat domain 11 0.0189306
ZNF407 zinc finger protein 407 0.0189079

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.181349
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.134655
NAMPT nicotinamide phosphoribosyltransferase -0.102588
MT2A metallothionein 2A -0.0973648
TMSB10 thymosin beta 10 -0.0945685
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0825202
MT1X metallothionein 1X -0.0786243
AKAP12 A kinase (PRKA) anchor protein 12 -0.0751733
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0688203
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -0.0621321
CDH13 cadherin 13 -0.0620712
F3 coagulation factor III (thromboplastin, tissue factor) -0.0568907
CAVIN1 caveolae associated protein 1 -0.0535631
HLA-B major histocompatibility complex, class I, B -0.0532956
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0526735
LAMB3 laminin, beta 3 -0.0504297
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0497984
WSB1 WD repeat and SOCS box containing 1 -0.0484283
ZMYND8 zinc finger, MYND-type containing 8 -0.0480516
RRBP1 ribosome binding protein 1 -0.0455434
VIM vimentin -0.0440579
EGFR epidermal growth factor receptor -0.0435332
RPL34 ribosomal protein L34 -0.0429406
INHBA inhibin, beta A -0.0414913
MAP1B microtubule-associated protein 1B -0.038714
GNAS GNAS complex locus -0.037257
RLF rearranged L-myc fusion -0.0370066
RTN4 reticulon 4 -0.0368456
COL5A1 collagen, type V, alpha 1 -0.0355598
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II -0.0354487
RBM39 RNA binding motif protein 39 -0.034935
GOLGA4 golgin A4 -0.0349183
FTL ferritin, light polypeptide -0.0337284
PTPRF protein tyrosine phosphatase, receptor type, F -0.0334901
SETD5 SET domain containing 5 -0.0323266
LOXL2 lysyl oxidase-like 2 -0.0322329
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0320091
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0320063
PLAUR plasminogen activator, urokinase receptor -0.0318778
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.031469
DLG1 discs, large homolog 1 (Drosophila) -0.0314099
MINDY2 MINDY lysine 48 deubiquitinase 2 -0.0313716
NOP58 NOP58 ribonucleoprotein -0.0311017
ARF4 ADP-ribosylation factor 4 -0.0309734
EIF1 eukaryotic translation initiation factor 1 -0.0306585
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0297685
RPL4 ribosomal protein L4 -0.0293589
KDM3A lysine (K)-specific demethylase 3A -0.0292739
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0291056
ACTG1 actin gamma 1 -0.0287825
SLC38A1 solute carrier family 38, member 1 -0.0285009
HLA-C major histocompatibility complex, class I, C -0.0284648
S100A6 S100 calcium binding protein A6 -0.0282778
PRSS23 protease, serine, 23 -0.0281101
ZBTB38 zinc finger and BTB domain containing 38 -0.028045
HM13 histocompatibility (minor) 13 -0.0277473
RAI14 retinoic acid induced 14 -0.0274728
IARS1 isoleucyl-tRNA synthetase 1 -0.0267124
RPS19 ribosomal protein S19 -0.0266752
COPB1 coatomer protein complex, subunit beta 1 -0.0265428
S100A9 S100 calcium binding protein A9 -0.0262704
PNISR PNN-interacting serine/arginine-rich protein -0.0259372
TPM4 tropomyosin 4 -0.0257105
COL6A3 collagen, type VI, alpha 3 -0.0256644
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0254641
JAZF1 JAZF zinc finger 1 -0.025389
RPS6 ribosomal protein S6 -0.0251146
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0249918
HIPK2 homeodomain interacting protein kinase 2 -0.0249793
PDIA3 protein disulfide isomerase family A, member 3 -0.0249622
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.0247117
GCC2 GRIP and coiled-coil domain containing 2 -0.0244745
IFI6 interferon, alpha-inducible protein 6 -0.0241513
SERF2 small EDRK-rich factor 2 -0.0240645
RINT1 RAD50 interactor 1 -0.02395
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 -0.0239194
RPL27A ribosomal protein L27a -0.0238717
USP34 ubiquitin specific peptidase 34 -0.023655
ATP13A3 ATPase type 13A3 -0.0236299
TM4SF1 transmembrane 4 L six family member 1 -0.0236051
CALU calumenin -0.0235589
KCTD9 potassium channel tetramerization domain containing 9 -0.0231129
PDE4D phosphodiesterase 4D, cAMP-specific -0.0230385
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 -0.0228512
TRPM7 transient receptor potential cation channel, subfamily M, member 7 -0.0228083
FNBP4 formin binding protein 4 -0.0227423
TNS3 tensin 3 -0.0227301
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.022714
DNAAF9 dynein axonemal assembly factor 9 -0.0225839
TMEM41B transmembrane protein 41B -0.0225307
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -0.0224063
YIPF5 Yip1 domain family, member 5 -0.0222945
STK17A serine/threonine kinase 17a -0.0219172
MXI1 MAX interactor 1, dimerization protein -0.0219023
TRIO trio Rho guanine nucleotide exchange factor -0.021815
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0216771
ELF2 E74-like factor 2 (ets domain transcription factor) -0.0216766
KDM5B lysine (K)-specific demethylase 5B -0.0216385
TPT1 tumor protein, translationally-controlled 1 -0.0215484
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0212991