| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Pimitespib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.280082 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.137463 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0926865 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0881962 |
| PKM | pyruvate kinase, muscle | 0.0746189 |
| INTS6 | integrator complex subunit 6 | 0.0733253 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.068692 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0678055 |
| B2M | beta-2-microglobulin | 0.0628255 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0603001 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0602887 |
| SQSTM1 | sequestosome 1 | 0.0596591 |
| CD44 | CD44 molecule (Indian blood group) | 0.0556994 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0539196 |
| ENO1 | enolase 1, (alpha) | 0.0519472 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0514927 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0514737 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0514126 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0506205 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0495571 |
| RORA | RAR-related orphan receptor A | 0.0467655 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0465717 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | 0.0461207 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0458402 |
| GOLGB1 | golgin B1 | 0.045762 |
| ASPH | aspartate beta-hydroxylase | 0.0452823 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.0451601 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.0426497 |
| TPI1 | triosephosphate isomerase 1 | 0.0423219 |
| SLC38A2 | solute carrier family 38, member 2 | 0.04201 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0409821 |
| AHNAK | AHNAK nucleoprotein | 0.0395205 |
| OXSR1 | oxidative stress responsive 1 | 0.038974 |
| PTK2 | protein tyrosine kinase 2 | 0.0386928 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0374866 |
| BABAM2 | BRISC and BRCA1 A complex member 2 | 0.0369595 |
| TXNIP | thioredoxin interacting protein | 0.0354415 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | 0.0353351 |
| TES | testin LIM domain protein | 0.0352773 |
| EFL1 | elongation factor like GTPase 1 | 0.0352375 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0351995 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | 0.0350294 |
| NAV3 | neuron navigator 3 | 0.0348287 |
| EMP1 | epithelial membrane protein 1 | 0.0345509 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0344462 |
| LDHA | lactate dehydrogenase A | 0.0337632 |
| UBC | ubiquitin C | 0.0336617 |
| SCAPER | S-phase cyclin A-associated protein in the ER | 0.0336437 |
| RTN4 | reticulon 4 | 0.0334773 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0333744 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0323104 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0322934 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0321405 |
| RPL7 | ribosomal protein L7 | 0.0317205 |
| DENND4A | DENN/MADD domain containing 4A | 0.0315567 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0314973 |
| CNKSR3 | CNKSR family member 3 | 0.0312754 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0308804 |
| ITGA6 | integrin, alpha 6 | 0.0302727 |
| MAP1B | microtubule-associated protein 1B | 0.0301184 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0300568 |
| SREK1 | splicing regulatory glutamine/lysine-rich protein 1 | 0.0296566 |
| CPNE1 | copine I | 0.0296476 |
| ERCC6L2 | excision repair cross-complementation group 6-like 2 | 0.029515 |
| KIF1B | kinesin family member 1B | 0.0288086 |
| NSUN6 | NOP2/Sun domain family, member 6 | 0.0281528 |
| GTF2F2 | general transcription factor IIF, polypeptide 2, 30kDa | 0.0280356 |
| HSPA1A | heat shock 70kDa protein 1A | 0.0277279 |
| TOR1AIP2 | torsin A interacting protein 2 | 0.0276614 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0275593 |
| EGR1 | early growth response 1 | 0.0274698 |
| OTUD4 | OTU deubiquitinase 4 | 0.0274283 |
| TM9SF4 | transmembrane 9 superfamily protein member 4 | 0.0274093 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0270548 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0268413 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.026696 |
| NIPBL | Nipped-B homolog (Drosophila) | 0.026504 |
| GPHN | gephyrin | 0.0264163 |
| MED13L | mediator complex subunit 13-like | 0.0262375 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0260509 |
| SIK2 | salt-inducible kinase 2 | 0.0258716 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0252258 |
| VPS13D | vacuolar protein sorting 13 homolog D (S. cerevisiae) | 0.02518 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.024739 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0246555 |
| RPS12 | ribosomal protein S12 | 0.0245052 |
| MTPN | myotrophin | 0.0243543 |
| RPS3 | ribosomal protein S3 | 0.0243023 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.0241807 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0241276 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0240263 |
| ATXN7 | ataxin 7 | 0.0240035 |
| SMAP1 | small ArfGAP 1 | 0.0239568 |
| NR4A3 | nuclear receptor subfamily 4, group A, member 3 | 0.0235728 |
| DEK | DEK proto-oncogene | 0.0235684 |
| RPL21 | ribosomal protein L21 | 0.0234258 |
| PEAK1 | pseudopodium-enriched atypical kinase 1 | 0.0232715 |
| RPS6 | ribosomal protein S6 | 0.0231399 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | 0.0230846 |
| SKIL | SKI-like proto-oncogene | 0.0228888 |
| Symbol | Name | Standardized Value |
|---|---|---|
| VIM | vimentin | -0.100816 |
| TMSB10 | thymosin beta 10 | -0.069273 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0681384 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0579921 |
| RBM39 | RNA binding motif protein 39 | -0.0577412 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0557979 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0534844 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0530712 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0516033 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0509945 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0474013 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0454537 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0454474 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0448945 |
| CAPRIN2 | caprin family member 2 | -0.042881 |
| MT2A | metallothionein 2A | -0.041556 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0413872 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0403827 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0387895 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0381185 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.037743 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0369998 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0362006 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0361853 |
| LMO7 | LIM domain 7 | -0.0358852 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.035609 |
| GNAS | GNAS complex locus | -0.0352836 |
| IL1RAP | interleukin 1 receptor accessory protein | -0.0347445 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0346116 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | -0.0338633 |
| RBM25 | RNA binding motif protein 25 | -0.0331147 |
| IGF2 | insulin-like growth factor 2 | -0.0328796 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | -0.0325717 |
| UBE2K | ubiquitin-conjugating enzyme E2K | -0.0325662 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0321495 |
| CHD1 | chromodomain helicase DNA binding protein 1 | -0.031934 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0318901 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | -0.0316242 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0310678 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | -0.0306529 |
| CEP170 | centrosomal protein 170kDa | -0.030463 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | -0.0303513 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0302591 |
| XRN1 | 5'-3' exoribonuclease 1 | -0.0300862 |
| KIAA1328 | KIAA1328 | -0.02979 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0296781 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0293003 |
| ACTN1 | actinin, alpha 1 | -0.0290309 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0288212 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0284543 |
| ABI1 | abl-interactor 1 | -0.0283505 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0280297 |
| ARHGEF28 | Rho guanine nucleotide exchange factor (GEF) 28 | -0.0279112 |
| NAV2 | neuron navigator 2 | -0.0278138 |
| RIN2 | Ras and Rab interactor 2 | -0.027735 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.0277281 |
| SDC4 | syndecan 4 | -0.027708 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0276774 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0276429 |
| IGF2BP3 | insulin-like growth factor 2 mRNA binding protein 3 | -0.027611 |
| KIF5B | kinesin family member 5B | -0.0274517 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0272996 |
| PTMA | prothymosin, alpha | -0.0271243 |
| NALCN | sodium leak channel, non selective | -0.0270766 |
| PCCA | propionyl CoA carboxylase, alpha polypeptide | -0.026588 |
| PARD3 | par-3 family cell polarity regulator | -0.0263249 |
| GCC2 | GRIP and coiled-coil domain containing 2 | -0.0261233 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0260392 |
| GPC6 | glypican 6 | -0.0258134 |
| ANLN | anillin, actin binding protein | -0.025811 |
| PBX3 | pre-B-cell leukemia homeobox 3 | -0.0257668 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0256657 |
| LRCH3 | leucine-rich repeats and calponin homology (CH) domain containing 3 | -0.0256325 |
| RNF213 | ring finger protein 213 | -0.0256043 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | -0.0255098 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | -0.0254924 |
| NDRG1 | N-myc downstream regulated 1 | -0.0253752 |
| RTN3 | reticulon 3 | -0.0253135 |
| PDCD6IP | programmed cell death 6 interacting protein | -0.0251606 |
| ITSN2 | intersectin 2 | -0.0250884 |
| RB1CC1 | RB1-inducible coiled-coil 1 | -0.0250452 |
| ELF2 | E74-like factor 2 (ets domain transcription factor) | -0.0249642 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0249376 |
| CAVIN1 | caveolae associated protein 1 | -0.0248671 |
| HDLBP | high density lipoprotein binding protein | -0.0248591 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0248515 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0245772 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | -0.0244234 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.0244197 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0242734 |
| NEMF | nuclear export mediator factor | -0.0242123 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0241351 |
| NF1 | neurofibromin 1 | -0.024034 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0240209 |
| BHLHE40 | basic helix-loop-helix family, member e40 | -0.0239561 |
| PLEKHB2 | pleckstrin homology domain containing, family B (evectins) member 2 | -0.0238383 |
| MYOF | myoferlin | -0.0237562 |
| TMEM123 | transmembrane protein 123 | -0.0237499 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.02289 |
| TMEM44 | transmembrane protein 44 | -0.0228894 |
