| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Pimitespib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Pimitespib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.054129 |
| STC2 | stanniocalcin 2 | 0.0439775 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0367662 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0359121 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0333793 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0332639 |
| PKM | pyruvate kinase, muscle | 0.0323255 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0307063 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0306517 |
| GRB10 | growth factor receptor-bound protein 10 | 0.0301743 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0291489 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0290155 |
| GLIS3 | GLIS family zinc finger 3 | 0.0285365 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0282466 |
| GPATCH2L | G patch domain containing 2-like | 0.027418 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0264081 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | 0.0259307 |
| TXNIP | thioredoxin interacting protein | 0.0255718 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0252149 |
| ASPH | aspartate beta-hydroxylase | 0.0252144 |
| EREG | epiregulin | 0.0243008 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0233578 |
| B2M | beta-2-microglobulin | 0.0230408 |
| ESYT2 | extended synaptotagmin-like protein 2 | 0.0224005 |
| INTS6 | integrator complex subunit 6 | 0.022378 |
| FOSL1 | FOS-like antigen 1 | 0.022256 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.0219305 |
| TIPARP | TCDD-inducible poly(ADP-ribose) polymerase | 0.0212271 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0211685 |
| AGPAT4 | 1-acylglycerol-3-phosphate O-acyltransferase 4 | 0.0210667 |
| GPC6 | glypican 6 | 0.0208635 |
| FAT1 | FAT atypical cadherin 1 | 0.0206129 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0206095 |
| ATXN1 | ataxin 1 | 0.0205115 |
| SEPTIN9 | septin 9 | 0.0187304 |
| SFTPA2 | surfactant protein A2 | 0.0184129 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0183382 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0183146 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0179416 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0173031 |
| VEGFA | vascular endothelial growth factor A | 0.0172287 |
| MAP1B | microtubule-associated protein 1B | 0.0170355 |
| PTK2 | protein tyrosine kinase 2 | 0.0170109 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | 0.0170104 |
| EIF5 | eukaryotic translation initiation factor 5 | 0.0169337 |
| AHRR | aryl-hydrocarbon receptor repressor | 0.0168816 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | 0.0166442 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.016558 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0165447 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0164567 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0159873 |
| C6ORF62 | chromosome 6 open reading frame 62 | 0.015477 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.015459 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0153278 |
| SGMS2 | sphingomyelin synthase 2 | 0.0152189 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.015203 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.015041 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0149147 |
| SHC1 | SHC (Src homology 2 domain containing) transforming protein 1 | 0.0147419 |
| KDM4C | lysine (K)-specific demethylase 4C | 0.0147237 |
| RFX3 | regulatory factor X, 3 (influences HLA class II expression) | 0.0145728 |
| NEK1 | NIMA-related kinase 1 | 0.0145206 |
| RND3 | Rho family GTPase 3 | 0.0144212 |
| ATP9A | ATPase, class II, type 9A | 0.014095 |
| EGR1 | early growth response 1 | 0.0140245 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0139344 |
| MTR | 5-methyltetrahydrofolate-homocysteine methyltransferase | 0.0135557 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.013541 |
| LRP5 | low density lipoprotein receptor-related protein 5 | 0.0132137 |
| CRY1 | cryptochrome circadian clock 1 | 0.0131846 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0131812 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0131305 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0131021 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0127781 |
| TTC19 | tetratricopeptide repeat domain 19 | 0.0126336 |
| SOS1 | son of sevenless homolog 1 (Drosophila) | 0.0125442 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | 0.0125123 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0124445 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.0122373 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0122282 |
| ECE1 | endothelin converting enzyme 1 | 0.0121923 |
| RASAL2 | RAS protein activator like 2 | 0.0120507 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0120429 |
| NDRG1 | N-myc downstream regulated 1 | 0.0117895 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0117548 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0117085 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0116578 |
| MYADM | myeloid-associated differentiation marker | 0.0115328 |
| DDX60 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 | 0.0115174 |
| SVIL | supervillin | 0.0114729 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0114253 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0114125 |
| RPS10 | ribosomal protein S10 | 0.0113907 |
| RPL35A | ribosomal protein L35a | 0.0113134 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0111007 |
| FHIT | fragile histidine triad | 0.0110994 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0110543 |
| BPNT2 | 3'(2'), 5'-bisphosphate nucleotidase 2 | 0.0110381 |
| VEGFC | vascular endothelial growth factor C | 0.0107801 |
| PHC2 | polyhomeotic homolog 2 (Drosophila) | 0.010748 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.307596 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.198073 |
| PTMA | prothymosin, alpha | -0.174162 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.155454 |
| CANX | calnexin | -0.128338 |
| FN1 | fibronectin 1 | -0.0775103 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | -0.0753903 |
| S100A6 | S100 calcium binding protein A6 | -0.0721195 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0707765 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0688973 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0673098 |
| ITGA1 | integrin, alpha 1 | -0.0668216 |
| TMSB10 | thymosin beta 10 | -0.0624151 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.05748 |
| SQSTM1 | sequestosome 1 | -0.0574588 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0555948 |
| AHR | aryl hydrocarbon receptor | -0.0530052 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.052025 |
| OSMR | oncostatin M receptor | -0.0509418 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.050594 |
| H1-0 | H1.0 linker histone | -0.0469693 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0465208 |
| BZW1 | basic leucine zipper and W2 domains 1 | -0.0462545 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.045836 |
| OGA | O-GlcNAcase | -0.0458192 |
| RPS27A | ribosomal protein S27a | -0.0456289 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0435049 |
| BASP1 | brain abundant, membrane attached signal protein 1 | -0.0425036 |
| IER3 | immediate early response 3 | -0.0424723 |
| ZNF217 | zinc finger protein 217 | -0.0424368 |
| GNAS | GNAS complex locus | -0.0419623 |
| AHNAK | AHNAK nucleoprotein | -0.0402953 |
| NRG1 | neuregulin 1 | -0.0399787 |
| TMEM263 | transmembrane protein 263 | -0.0396075 |
| PRRC2C | proline-rich coiled-coil 2C | -0.038745 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0382938 |
| ARF1 | ADP-ribosylation factor 1 | -0.0380382 |
| HDLBP | high density lipoprotein binding protein | -0.037994 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0379291 |
| CALU | calumenin | -0.0376966 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0375494 |
| SOX4 | SRY (sex determining region Y)-box 4 | -0.0374031 |
| TMSB4X | thymosin beta 4, X-linked | -0.0371562 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0369573 |
| HLA-B | major histocompatibility complex, class I, B | -0.0363424 |
| UBC | ubiquitin C | -0.0362241 |
| IFI16 | interferon, gamma-inducible protein 16 | -0.0358487 |
| VCL | vinculin | -0.0357351 |
| IRF2BP2 | interferon regulatory factor 2 binding protein 2 | -0.0349815 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0347774 |
| CENPF | centromere protein F, 350/400kDa | -0.0347238 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0339782 |
| RRBP1 | ribosome binding protein 1 | -0.0335074 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0321182 |
| SPAG9 | sperm associated antigen 9 | -0.0320378 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0319504 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0315786 |
| TPR | translocated promoter region, nuclear basket protein | -0.031401 |
| CALR | calreticulin | -0.0310267 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0306511 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0304168 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.0300517 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0298704 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0297602 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0296509 |
| MT2A | metallothionein 2A | -0.0293497 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.0292436 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0289843 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.028869 |
| RACK1 | receptor for activated C kinase 1 | -0.028648 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0285183 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0284368 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0276261 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0275078 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0270571 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0267871 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.026756 |
| MKI67 | marker of proliferation Ki-67 | -0.0265528 |
| RPL26 | ribosomal protein L26 | -0.0265031 |
| NEK7 | NIMA-related kinase 7 | -0.0263299 |
| SLC25A36 | solute carrier family 25 (pyrimidine nucleotide carrier), member 36 | -0.0262965 |
| RBM39 | RNA binding motif protein 39 | -0.0262613 |
| RPS24 | ribosomal protein S24 | -0.0258991 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0256743 |
| VIM | vimentin | -0.0256578 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0256224 |
| ARHGAP35 | Rho GTPase activating protein 35 | -0.0253426 |
| AHNAK2 | AHNAK nucleoprotein 2 | -0.0252104 |
| PALLD | palladin, cytoskeletal associated protein | -0.0251899 |
| SDC4 | syndecan 4 | -0.0251098 |
| RBM25 | RNA binding motif protein 25 | -0.0250515 |
| ANLN | anillin, actin binding protein | -0.02478 |
| NPC1 | Niemann-Pick disease, type C1 | -0.0246888 |
| ACTN4 | actinin, alpha 4 | -0.0246237 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0245776 |
| STAU1 | staufen double-stranded RNA binding protein 1 | -0.0244502 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.024235 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0240839 |
| RAD21 | RAD21 homolog (S. pombe) | -0.0240574 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0240447 |
