Pimozide_A-427 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in A-427 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
EEF1G eukaryotic translation elongation factor 1 gamma 0.101468
EEF2 eukaryotic translation elongation factor 2 0.070043
PCBP2 poly(rC) binding protein 2 0.0617615
RRM2 ribonucleotide reductase M2 0.0614822
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0580725
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0534933
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0522848
ASPH aspartate beta-hydroxylase 0.0517183
HMGA2 high mobility group AT-hook 2 0.0485905
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0438781
USP34 ubiquitin specific peptidase 34 0.0430006
WNK1 WNK lysine deficient protein kinase 1 0.0429916
EHBP1 EH domain binding protein 1 0.0423036
YAP1 Yes-associated protein 1 0.041714
ANKRD17 ankyrin repeat domain 17 0.0393656
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.03904
SPATS2 spermatogenesis associated, serine-rich 2 0.0361419
CCNL1 cyclin L1 0.0345042
MBD5 methyl-CpG binding domain protein 5 0.0343848
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.0340399
KDM4C lysine (K)-specific demethylase 4C 0.0339605
ANKRD12 ankyrin repeat domain 12 0.0336062
NHSL1 NHS-like 1 0.0332249
UBC ubiquitin C 0.0328965
PPP6R3 protein phosphatase 6, regulatory subunit 3 0.0307912
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0307235
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0303658
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0297121
GSE1 Gse1 coiled-coil protein 0.029584
BIRC6 baculoviral IAP repeat containing 6 0.0294841
APLP2 amyloid beta (A4) precursor-like protein 2 0.029166
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0289097
PDGFC platelet derived growth factor C 0.0287481
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0285678
PARD3 par-3 family cell polarity regulator 0.0284754
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0283206
SMYD3 SET and MYND domain containing 3 0.0282315
INTS6 integrator complex subunit 6 0.0281196
RAD51B RAD51 paralog B 0.0278708
VTI1A vesicle transport through interaction with t-SNAREs 1A 0.0278577
ARID1A AT rich interactive domain 1A (SWI-like) 0.0277461
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0276928
RCOR1 REST corepressor 1 0.0276382
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0273068
TRIO trio Rho guanine nucleotide exchange factor 0.0270555
PRKCE protein kinase C, epsilon 0.0269907
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0268859
ZNF207 zinc finger protein 207 0.0264968
CEP192 centrosomal protein 192kDa 0.0264779
EPHA6 EPH receptor A6 0.0263972
KMT2D lysine (K)-specific methyltransferase 2D 0.0263891
CCN2 cellular communication network factor 2 0.0261992
EPHA5 EPH receptor A5 0.026152
WWOX WW domain containing oxidoreductase 0.0260663
GABARAPL1 GABA(A) receptor-associated protein like 1 0.0260387
POTEF POTE ankyrin domain family, member F 0.0257575
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0255873
NR5A2 nuclear receptor subfamily 5, group A, member 2 0.0255612
UBAP2 ubiquitin associated protein 2 0.0252499
NUP58 nucleoporin 58 0.025195
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0250853
TENM3 teneurin transmembrane protein 3 0.0249565
DENND5A DENN/MADD domain containing 5A 0.0248055
DSCAM Down syndrome cell adhesion molecule 0.0247209
FXR1 fragile X mental retardation, autosomal homolog 1 0.0245125
NONO non-POU domain containing, octamer-binding 0.0244153
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 0.0242412
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0241161
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0239882
TRA2B transformer 2 beta homolog (Drosophila) 0.0237004
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 0.023299
STIP1 stress-induced phosphoprotein 1 0.0231572
FLNA filamin A, alpha 0.0230768
MED13L mediator complex subunit 13-like 0.0230165
AUTS2 autism susceptibility candidate 2 0.0229093
HMGA1 high mobility group AT-hook 1 0.0226273
EGR1 early growth response 1 0.0225468
PGK1 phosphoglycerate kinase 1 0.022487
ZNF292 zinc finger protein 292 0.0222438
PHF21A PHD finger protein 21A 0.0219768
KSR2 kinase suppressor of ras 2 0.0218196
PUM2 pumilio RNA-binding family member 2 0.0216792
MGAT4C MGAT4 family, member C 0.0209797
BRD2 bromodomain containing 2 0.0208945
PHC3 polyhomeotic homolog 3 (Drosophila) 0.0208452
EXOC4 exocyst complex component 4 0.020662
KCMF1 potassium channel modulatory factor 1 0.0206059
CCSER1 coiled-coil serine-rich protein 1 0.0205548
ZNF638 zinc finger protein 638 0.0203643
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0202455
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0201736
NBAS neuroblastoma amplified sequence 0.0201641
BABAM2 BRISC and BRCA1 A complex member 2 0.0200071
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit 0.0196402
YEATS2 YEATS domain containing 2 0.0196193
TNRC18 trinucleotide repeat containing 18 0.0195209
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0194129
KDM6A lysine (K)-specific demethylase 6A 0.0193682
CLDND1 claudin domain containing 1 0.0192277
MTCL1 microtubule crosslinking factor 1 0.0190573

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.238605
TMSB10 thymosin beta 10 -0.176649
AREG amphiregulin -0.118838
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.109546
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0898147
FTL ferritin, light polypeptide -0.0834244
MYL12B myosin, light chain 12B, regulatory -0.0650749
CUBN cubilin (intrinsic factor-cobalamin receptor) -0.065056
ALDH1A1 aldehyde dehydrogenase 1 family, member A1 -0.0633726
CELF2 CUGBP, Elav-like family member 2 -0.0594987
PTMA prothymosin, alpha -0.0572947
TPT1 tumor protein, translationally-controlled 1 -0.0536874
EIF1 eukaryotic translation initiation factor 1 -0.0524947
BIRC3 baculoviral IAP repeat containing 3 -0.0520514
PDE4D phosphodiesterase 4D, cAMP-specific -0.0502708
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0492102
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0478715
RPS24 ribosomal protein S24 -0.0445866
NAP1L1 nucleosome assembly protein 1-like 1 -0.0438939
RPL35A ribosomal protein L35a -0.0415463
AHNAK AHNAK nucleoprotein -0.0411691
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 -0.0409796
IFIH1 interferon induced with helicase C domain 1 -0.0407867
BIRC2 baculoviral IAP repeat containing 2 -0.0404679
KLF6 Kruppel-like factor 6 -0.0396547
CLDN1 claudin 1 -0.0381447
CCT4 chaperonin containing TCP1, subunit 4 (delta) -0.0377143
RPL31 ribosomal protein L31 -0.037472
RPS8 ribosomal protein S8 -0.0364493
LMO7 LIM domain 7 -0.0363987
RPL19 ribosomal protein L19 -0.0362864
EDN1 endothelin 1 -0.0344661
TXNRD1 thioredoxin reductase 1 -0.0338751
RPS3 ribosomal protein S3 -0.0337365
RPL26 ribosomal protein L26 -0.0335656
RPS6 ribosomal protein S6 -0.0333744
RPLP1 ribosomal protein, large, P1 -0.0331406
DST dystonin -0.0328241
CENPF centromere protein F, 350/400kDa -0.03215
RPL34 ribosomal protein L34 -0.0317025
CDK6 cyclin-dependent kinase 6 -0.0293482
DLC1 DLC1 Rho GTPase activating protein -0.0289932
KPNB1 karyopherin (importin) beta 1 -0.0289205
RPLP0 ribosomal protein, large, P0 -0.0289141
RPL12 ribosomal protein L12 -0.0286262
RPS12 ribosomal protein S12 -0.0284958
RSL1D1 ribosomal L1 domain containing 1 -0.0280353
CCND1 cyclin D1 -0.0273342
CXADR coxsackie virus and adenovirus receptor -0.0272317
ZNF804A zinc finger protein 804A -0.0272215
MYPN myopalladin -0.0270717
MMP12 matrix metallopeptidase 12 -0.0267251
RPS14 ribosomal protein S14 -0.0264292
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0262641
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0262191
SCLT1 sodium channel and clathrin linker 1 -0.0253876
PCDH7 protocadherin 7 -0.0253483
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0252457
OXR1 oxidation resistance 1 -0.0249253
RPL32 ribosomal protein L32 -0.0247873
RPL5 ribosomal protein L5 -0.0247684
MTAP methylthioadenosine phosphorylase -0.0246445
ATP5F1B ATP synthase F1 subunit beta -0.0243038
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0240313
TMEM41B transmembrane protein 41B -0.02378
ERBB4 erb-b2 receptor tyrosine kinase 4 -0.0234078
NFE2L2 nuclear factor, erythroid 2-like 2 -0.0232852
EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 1 -0.0230547
S100A10 S100 calcium binding protein A10 -0.0229138
ZNF217 zinc finger protein 217 -0.0227892
CALM1 calmodulin 1 (phosphorylase kinase, delta) -0.0226814
GJA1 gap junction protein, alpha 1, 43kDa -0.022548
TMEM123 transmembrane protein 123 -0.0224415
EDARADD EDAR-associated death domain -0.0223896
CLPTM1L CLPTM1-like -0.0221785
RPL37A ribosomal protein L37a -0.0221622
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) -0.0220411
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.0219549
SQSTM1 sequestosome 1 -0.0217775
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0213977
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0213512
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0210816
RPLP2 ribosomal protein, large, P2 -0.0210721
RPS5 ribosomal protein S5 -0.0207256
RPS19 ribosomal protein S19 -0.0206833
RPS16 ribosomal protein S16 -0.0205733
DPYD dihydropyrimidine dehydrogenase -0.0204915
LARP1 La ribonucleoprotein domain family, member 1 -0.0204503
PARK7 parkinson protein 7 -0.019834
KIF5B kinesin family member 5B -0.0195814
NOLC1 nucleolar and coiled-body phosphoprotein 1 -0.0191547
RPL38 ribosomal protein L38 -0.0190883
CAVIN1 caveolae associated protein 1 -0.0190488
RPL27A ribosomal protein L27a -0.0189925
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.018958
ANXA1 annexin A1 -0.0189372
ROCK2 Rho-associated, coiled-coil containing protein kinase 2 -0.0188838
PLK2 polo-like kinase 2 -0.0188417
GM2A GM2 ganglioside activator -0.0185708
H3-3B H3.3 histone B -0.0184949