Pimozide_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in CHP-212 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Pimozide_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FNDC3B fibronectin type III domain containing 3B 0.0578697
LGR5 leucine-rich repeat containing G protein-coupled receptor 5 0.0505143
FAM13A family with sequence similarity 13, member A 0.0483476
TENT5A terminal nucleotidyltransferase 5A 0.0417826
HELZ helicase with zinc finger 0.0407559
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0407256
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive 0.040546
EEF1G eukaryotic translation elongation factor 1 gamma 0.0353332
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0351008
EEF2 eukaryotic translation elongation factor 2 0.0326216
DST dystonin 0.0292514
ADGRG6 adhesion G protein-coupled receptor G6 0.0273681
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.0268569
AKAP12 A kinase (PRKA) anchor protein 12 0.0261857
NFE2L1 nuclear factor, erythroid 2-like 1 0.025977
TPST1 tyrosylprotein sulfotransferase 1 0.0257233
ARID5B AT rich interactive domain 5B (MRF1-like) 0.0256589
ZFC3H1 zinc finger, C3H1-type containing 0.0251053
SOS1 son of sevenless homolog 1 (Drosophila) 0.0248544
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0238554
BIRC6 baculoviral IAP repeat containing 6 0.0230986
SCN9A sodium channel, voltage gated, type IX alpha subunit 0.0228448
OGA O-GlcNAcase 0.0220608
MBNL2 muscleblind-like splicing regulator 2 0.0218031
FKBP10 FK506 binding protein 10, 65 kDa 0.0217523
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0214739
TLE4 transducin-like enhancer of split 4 0.0209907
PHLDA1 pleckstrin homology-like domain, family A, member 1 0.0208633
PRPF8 pre-mRNA processing factor 8 0.0208388
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type 0.0207939
WDR45B WD repeat domain 45B 0.0204884
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0198006
CNOT1 CCR4-NOT transcription complex, subunit 1 0.0195349
ADARB1 adenosine deaminase, RNA-specific, B1 0.0192681
CDH10 cadherin 10, type 2 (T2-cadherin) 0.0192421
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0192377
ANKRD17 ankyrin repeat domain 17 0.0188599
FOXO3 forkhead box O3 0.0187009
P4HB prolyl 4-hydroxylase, beta polypeptide 0.018653
MON2 MON2 homolog (S. cerevisiae) 0.0184626
MMP2 matrix metallopeptidase 2 0.0183626
CLTC clathrin, heavy chain (Hc) 0.0179148
FMN1 formin 1 0.017877
CSNK1G1 casein kinase 1, gamma 1 0.0176231
MBD5 methyl-CpG binding domain protein 5 0.0175487
DSCAM Down syndrome cell adhesion molecule 0.017442
CCNL1 cyclin L1 0.0170172
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0169463
RPL4 ribosomal protein L4 0.0166316
ESYT2 extended synaptotagmin-like protein 2 0.0165319
MEF2A myocyte enhancer factor 2A 0.0165208
PGK1 phosphoglycerate kinase 1 0.016434
PPP1R15B protein phosphatase 1, regulatory subunit 15B 0.0162338
HOOK2 hook microtubule-tethering protein 2 0.0160585
WAC WW domain containing adaptor with coiled-coil 0.015914
TET2 tet methylcytosine dioxygenase 2 0.0157574
SLITRK6 SLIT and NTRK-like family, member 6 0.0155962
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0155533
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.015544
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0154892
NUP58 nucleoporin 58 0.015343
PFKFB4 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 0.0152989
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa 0.0152907
GNG2 guanine nucleotide binding protein (G protein), gamma 2 0.0150676
PHF3 PHD finger protein 3 0.0147362
CCNY cyclin Y 0.0147087
SNX13 sorting nexin 13 0.014659
TENT4A terminal nucleotidyltransferase 4A 0.0146422
CD36 CD36 molecule (thrombospondin receptor) 0.0146291
SETD5 SET domain containing 5 0.0144227
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0143779
TOB1 transducer of ERBB2, 1 0.0143015
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) 0.014273
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0141888
ASCC3 activating signal cointegrator 1 complex subunit 3 0.0141627
YTHDC1 YTH domain containing 1 0.0140589
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0139234
ZNF148 zinc finger protein 148 0.0139131
PAPOLA poly(A) polymerase alpha 0.0138946
TNKS tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 0.0135141
MAP1B microtubule-associated protein 1B 0.0134791
GNPDA1 glucosamine-6-phosphate deaminase 1 0.0134111
AFDN afadin, adherens junction formation factor 0.013256
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 0.0131156
LMAN1 lectin, mannose-binding, 1 0.013048
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 0.0129876
RAB30 RAB30, member RAS oncogene family 0.0129696
ZNF292 zinc finger protein 292 0.0129523
BTAF1 BTAF1 RNA polymerase II, B-TFIID transcription factor-associated, 170kDa 0.0128228
SUCO SUN domain containing ossification factor 0.0127166
YEATS2 YEATS domain containing 2 0.012651
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 0.0126488
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 0.012504
FNIP1 folliculin interacting protein 1 0.0124875
SEMA6A sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A 0.0124389
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0123452
PJA2 praja ring finger 2, E3 ubiquitin protein ligase 0.0123223
AP3S1 adaptor-related protein complex 3, sigma 1 subunit 0.0123114
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha 0.0122779
SQSTM1 sequestosome 1 0.0122684

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.166951
IGF2 insulin-like growth factor 2 -0.110837
PTMA prothymosin, alpha -0.100627
NALF1 NALCN channel auxiliary factor 1 -0.0982052
VIM vimentin -0.0930917
LSAMP limbic system-associated membrane protein -0.0880384
RPS6 ribosomal protein S6 -0.063984
NRG1 neuregulin 1 -0.0595433
VCL vinculin -0.0587407
RPL35A ribosomal protein L35a -0.0571394
TPT1 tumor protein, translationally-controlled 1 -0.0547137
RPL19 ribosomal protein L19 -0.0515624
RPL23 ribosomal protein L23 -0.0504765
TMSB10 thymosin beta 10 -0.0481442
THSD4 thrombospondin, type I, domain containing 4 -0.0479568
EXT1 exostosin glycosyltransferase 1 -0.0445243
COL1A1 collagen, type I, alpha 1 -0.043669
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0416569
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0415665
RPS19 ribosomal protein S19 -0.0415059
RPS24 ribosomal protein S24 -0.0411101
BCAS3 breast carcinoma amplified sequence 3 -0.0395859
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0393171
B2M beta-2-microglobulin -0.0390112
RPLP1 ribosomal protein, large, P1 -0.03879
RPL34 ribosomal protein L34 -0.0373979
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0346005
ACTG1 actin gamma 1 -0.034531
CRH corticotropin releasing hormone -0.0343728
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.033988
LINGO2 leucine rich repeat and Ig domain containing 2 -0.0339288
RPL37A ribosomal protein L37a -0.0330527
S100A9 S100 calcium binding protein A9 -0.032744
RPS3 ribosomal protein S3 -0.0320787
PRKCA protein kinase C, alpha -0.0317819
PTPRD protein tyrosine phosphatase, receptor type, D -0.031749
BPTF bromodomain PHD finger transcription factor -0.031438
RPL26 ribosomal protein L26 -0.0303366
RPL38 ribosomal protein L38 -0.0294673
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -0.0291964
RPL32 ribosomal protein L32 -0.0284513
RPS23 ribosomal protein S23 -0.0268296
EIF1 eukaryotic translation initiation factor 1 -0.0267618
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 -0.0263775
RPS8 ribosomal protein S8 -0.0260364
H3-3B H3.3 histone B -0.0255374
RPL31 ribosomal protein L31 -0.0255265
SOX4 SRY (sex determining region Y)-box 4 -0.0253516
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0250042
RPL7A ribosomal protein L7a -0.0248847
ZNF804A zinc finger protein 804A -0.0246712
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) -0.0246117
IER3 immediate early response 3 -0.0241208
RPS14 ribosomal protein S14 -0.023757
PRRC2C proline-rich coiled-coil 2C -0.023162
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.023151
GNAS GNAS complex locus -0.0228927
RPL15 ribosomal protein L15 -0.0227599
COL3A1 collagen, type III, alpha 1 -0.0225788
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0224942
FTL ferritin, light polypeptide -0.0218769
GPATCH8 G patch domain containing 8 -0.0218008
RPS27A ribosomal protein S27a -0.0217522
KPNB1 karyopherin (importin) beta 1 -0.0215654
RPS25 ribosomal protein S25 -0.0212346
RPS12 ribosomal protein S12 -0.0211608
PTPRG protein tyrosine phosphatase, receptor type, G -0.0211577
TPM1 tropomyosin 1 (alpha) -0.0210593
IFI16 interferon, gamma-inducible protein 16 -0.0209505
CADM2 cell adhesion molecule 2 -0.0209421
RPL36 ribosomal protein L36 -0.020942
RPL37 ribosomal protein L37 -0.0208036
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0205781
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0205708
RPS17 ribosomal protein S17 -0.0202509
GATA3 GATA binding protein 3 -0.0201091
STXBP5 syntaxin binding protein 5 (tomosyn) -0.0200954
RSL1D1 ribosomal L1 domain containing 1 -0.019985
RPL36A ribosomal protein L36a -0.0199148
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0198345
RPS5 ribosomal protein S5 -0.0197801
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0196118
DCAF7 DDB1 and CUL4 associated factor 7 -0.0194177
RPS27 ribosomal protein S27 -0.0193155
RPL9 ribosomal protein L9 -0.019114
RPS29 ribosomal protein S29 -0.0188593
RACK1 receptor for activated C kinase 1 -0.0188057
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0187587
RPL11 ribosomal protein L11 -0.0187407
TBX2 T-box 2 -0.0184654
EXOC4 exocyst complex component 4 -0.0183363
SYT1 synaptotagmin I -0.0182446
FOXP1 forkhead box P1 -0.018192
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0181543
CUX1 cut-like homeobox 1 -0.0179394
NAP1L1 nucleosome assembly protein 1-like 1 -0.0179146
ASPH aspartate beta-hydroxylase -0.0178868
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0175477
GREM2 gremlin 2, DAN family BMP antagonist -0.0175186
RPL13A ribosomal protein L13a -0.0174573