Pimozide_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Pimozide perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Pimozide_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.251071
FLNB filamin B, beta 0.152406
PODXL podocalyxin-like 0.140077
FTH1 ferritin, heavy polypeptide 1 0.112005
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.103186
HSPG2 heparan sulfate proteoglycan 2 0.0997983
PHLDB2 pleckstrin homology-like domain, family B, member 2 0.0917302
PDLIM5 PDZ and LIM domain 5 0.0883375
FOXO1 forkhead box O1 0.0815831
FLNA filamin A, alpha 0.0812683
MTSS1 metastasis suppressor 1 0.0755676
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0725825
LDHA lactate dehydrogenase A 0.0722597
PDE4D phosphodiesterase 4D, cAMP-specific 0.0680159
LAMA5 laminin, alpha 5 0.066335
PALLD palladin, cytoskeletal associated protein 0.0660666
EEF1G eukaryotic translation elongation factor 1 gamma 0.0655931
PGK1 phosphoglycerate kinase 1 0.0650021
SLC35F3 solute carrier family 35, member F3 0.0618622
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0617889
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0597266
TGM2 transglutaminase 2 0.0578996
PLS3 plastin 3 0.053596
EGR1 early growth response 1 0.0532281
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0517893
LMO7 LIM domain 7 0.0500425
SULF2 sulfatase 2 0.0474218
GRB10 growth factor receptor-bound protein 10 0.047397
NCOR2 nuclear receptor corepressor 2 0.0472195
RASAL2 RAS protein activator like 2 0.0472126
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0457312
STC1 stanniocalcin 1 0.0453126
LOC112694756 uncharaterized LOC112694756 0.0445331
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0443821
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 0.0439842
KRT17 keratin 17, type I 0.0436581
EPHA2 EPH receptor A2 0.0434094
TRIO trio Rho guanine nucleotide exchange factor 0.0413263
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0397472
AMOTL1 angiomotin like 1 0.038878
ESYT2 extended synaptotagmin-like protein 2 0.0385649
C1D C1D nuclear receptor corepressor 0.0383352
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0371981
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0349621
MXRA5 matrix-remodelling associated 5 0.034287
ITGB4 integrin, beta 4 0.0341848
EXT1 exostosin glycosyltransferase 1 0.0341007
SLC38A2 solute carrier family 38, member 2 0.0331356
ALCAM activated leukocyte cell adhesion molecule 0.0328965
MPRIP myosin phosphatase Rho interacting protein 0.0320725
OSMR oncostatin M receptor 0.0319134
RCOR1 REST corepressor 1 0.0315847
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 0.0312056
NAV2 neuron navigator 2 0.0308711
MEGF6 multiple EGF-like-domains 6 0.030742
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0299976
AOPEP aminopeptidase O (putative) 0.029661
GPR176 G protein-coupled receptor 176 0.0294744
IFITM1 interferon induced transmembrane protein 1 0.0293655
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0293208
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0289307
CEMIP cell migration inducing protein, hyaluronan binding 0.0278977
EEF2 eukaryotic translation elongation factor 2 0.0277795
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 0.0276431
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0273854
TJP1 tight junction protein 1 0.0271955
FAM107B family with sequence similarity 107, member B 0.0271431
MRPS6 mitochondrial ribosomal protein S6 0.0270459
PDIA3 protein disulfide isomerase family A, member 3 0.026249
LRRC8A leucine rich repeat containing 8 family, member A 0.0260435
VCL vinculin 0.0259945
LUZP1 leucine zipper protein 1 0.0259339
BHLHE40 basic helix-loop-helix family, member e40 0.0258541
MUC5AC mucin 5AC, oligomeric mucus/gel-forming 0.0257943
AKAP13 A kinase (PRKA) anchor protein 13 0.0254766
RNASEH2A ribonuclease H2, subunit A 0.0250502
MYADM myeloid-associated differentiation marker 0.0248478
ANO1 anoctamin 1, calcium activated chloride channel 0.0248339
IGF2 insulin-like growth factor 2 0.0247014
RNF217 ring finger protein 217 0.0244253
ZNFX1 zinc finger, NFX1-type containing 1 0.0242478
CAV2 caveolin 2 0.0240368
CD44 CD44 molecule (Indian blood group) 0.0239162
EFHD2 EF-hand domain family, member D2 0.0237591
ACTN4 actinin, alpha 4 0.0236054
ANXA2 annexin A2 0.0235184
SLCO1B3 solute carrier organic anion transporter family, member 1B3 0.0234007
DHFR dihydrofolate reductase 0.0233095
SLC45A4 solute carrier family 45, member 4 0.0230588
GANAB glucosidase, alpha; neutral AB 0.0226281
PLEC plectin 0.0226137
CYB5R3 cytochrome b5 reductase 3 0.0224643
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0224635
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0222681
WASF2 WAS protein family, member 2 0.0221541
DOCK5 dedicator of cytokinesis 5 0.0221308
KIAA1671 KIAA1671 0.0217755
PICALM phosphatidylinositol binding clathrin assembly protein 0.0215046
ERGIC1 endoplasmic reticulum-golgi intermediate compartment (ERGIC) 1 0.0213089
PLXNA2 plexin A2 0.0211507

decreased expression

Symbol Name Standardized Value
CLU clusterin -0.109498
PTMA prothymosin, alpha -0.087512
ASPH aspartate beta-hydroxylase -0.0829673
TMSB4X thymosin beta 4, X-linked -0.0775416
AHNAK AHNAK nucleoprotein -0.0772829
NAMPT nicotinamide phosphoribosyltransferase -0.0769277
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0763826
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0736542
ITGA6 integrin, alpha 6 -0.067805
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0646437
CANX calnexin -0.0633685
TMSB10 thymosin beta 10 -0.0632513
TPT1 tumor protein, translationally-controlled 1 -0.0613931
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0603369
CUL4B cullin 4B -0.0603035
NDRG1 N-myc downstream regulated 1 -0.05925
KTN1 kinectin 1 (kinesin receptor) -0.0557252
MEF2A myocyte enhancer factor 2A -0.0536525
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0526325
DSTN destrin (actin depolymerizing factor) -0.0522736
RPS8 ribosomal protein S8 -0.0511127
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0500443
RBM39 RNA binding motif protein 39 -0.0492302
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0490624
NAP1L1 nucleosome assembly protein 1-like 1 -0.0482445
OGA O-GlcNAcase -0.0478984
LMNA lamin A/C -0.0469804
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0460476
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0459039
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.043766
GOLGA4 golgin A4 -0.0436216
EZR ezrin -0.0434062
SERINC3 serine incorporator 3 -0.0430002
RAI14 retinoic acid induced 14 -0.0429058
ANXA1 annexin A1 -0.0426543
RPS3 ribosomal protein S3 -0.0426257
KDM3A lysine (K)-specific demethylase 3A -0.0426057
TPM3 tropomyosin 3 -0.0423319
ZNF292 zinc finger protein 292 -0.0417019
ANLN anillin, actin binding protein -0.0413291
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0402484
EMP1 epithelial membrane protein 1 -0.039229
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0392037
MYOF myoferlin -0.0386245
MATR3 matrin 3 -0.0383978
RPS6 ribosomal protein S6 -0.0374389
RPS24 ribosomal protein S24 -0.037438
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0372505
RLF rearranged L-myc fusion -0.0359363
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0357551
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0357134
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.035586
TOP1 topoisomerase (DNA) I -0.0355698
RPS12 ribosomal protein S12 -0.0350644
KMT2E lysine (K)-specific methyltransferase 2E -0.0347053
TXNRD1 thioredoxin reductase 1 -0.0345419
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0339285
RPLP2 ribosomal protein, large, P2 -0.0328886
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0320912
FOXP1 forkhead box P1 -0.0319755
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0319249
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0316313
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0315566
SET SET nuclear proto-oncogene -0.0313667
S100A10 S100 calcium binding protein A10 -0.0310848
FTL ferritin, light polypeptide -0.030702
PRRC2C proline-rich coiled-coil 2C -0.0301366
RSL1D1 ribosomal L1 domain containing 1 -0.0301313
HSPA9 heat shock 70kDa protein 9 (mortalin) -0.0300204
ENO1 enolase 1, (alpha) -0.0299961
PTK2 protein tyrosine kinase 2 -0.0296683
RPL7A ribosomal protein L7a -0.0294473
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0294453
XPO1 exportin 1 -0.0292463
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0291627
RPL31 ribosomal protein L31 -0.0290175
LNPEP leucyl/cystinyl aminopeptidase -0.029009
YBX1 Y box binding protein 1 -0.0289642
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0288037
TPX2 TPX2, microtubule-associated -0.0283446
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 -0.0283062
SAMD9 sterile alpha motif domain containing 9 -0.0281986
RPL5 ribosomal protein L5 -0.028121
CKAP5 cytoskeleton associated protein 5 -0.0279269
RPS27A ribosomal protein S27a -0.0278278
BZW2 basic leucine zipper and W2 domains 2 -0.0277158
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0276696
SUCO SUN domain containing ossification factor -0.0276257
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0272889
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) -0.0271941
EPRS1 glutamyl-prolyl-tRNA synthetase 1 -0.0270353
ARHGAP29 Rho GTPase activating protein 29 -0.0266127
RPL7 ribosomal protein L7 -0.0260717
DHRS3 dehydrogenase/reductase (SDR family) member 3 -0.0260679
TXNIP thioredoxin interacting protein -0.0259039
MACF1 microtubule-actin crosslinking factor 1 -0.0258149
NPEPPS aminopeptidase puromycin sensitive -0.0256768
ARHGAP5 Rho GTPase activating protein 5 -0.0256495
SEPTIN7 septin 7 -0.0252994
MBNL2 muscleblind-like splicing regulator 2 -0.0252779